| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L M Harrison, G J LaHost. Rhes, the Ras homolog enriched in striatum, is reduced under conditions of dopamine supersensitivity. Neuroscience. vol 137. issue 2. 2006-05-03. PMID:16352400. |
striatal dopamine receptors become supersensitive when dopaminergic input is removed through either surgical denervation or pharmacological depletion. |
2006-05-03 |
2023-08-12 |
rat |
| I G Sil'ki. [Role of the basal ganglia in the occurrence of paradoxical sleep dreams (hypothetical mechanism)]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 56. issue 1. 2006-05-03. PMID:16583673. |
this disinhibition is promoted by activation of dopaminergic cells by pedunculopontine neurons, subsequent rise in dopamine concentration in the input basal ganglia structure. |
2006-05-03 |
2023-08-12 |
Not clear |
| D S Kim, R D Palmiter, A Cummins, C R Gerfe. Reversal of supersensitive striatal dopamine D1 receptor signaling and extracellular signal-regulated kinase activity in dopamine-deficient mice. Neuroscience. vol 137. issue 4. 2006-05-02. PMID:16388913. |
lesions of dopaminergic nigrostriatal neurons cause supersensitivity to dopamine in the striatum. |
2006-05-02 |
2023-08-12 |
mouse |
| D S Kim, R D Palmiter, A Cummins, C R Gerfe. Reversal of supersensitive striatal dopamine D1 receptor signaling and extracellular signal-regulated kinase activity in dopamine-deficient mice. Neuroscience. vol 137. issue 4. 2006-05-02. PMID:16388913. |
after lesions of dopaminergic neurons, dopamine d1-receptor agonists activate extracellular signal-regulated kinase in the dorsal striatum, something not observed in intact animals. |
2006-05-02 |
2023-08-12 |
mouse |
| D S Kim, R D Palmiter, A Cummins, C R Gerfe. Reversal of supersensitive striatal dopamine D1 receptor signaling and extracellular signal-regulated kinase activity in dopamine-deficient mice. Neuroscience. vol 137. issue 4. 2006-05-02. PMID:16388913. |
dopamine-deficient mice, in which the tyrosine hydroxylase gene is specifically inactivated in dopaminergic neurons, were used to investigate dopamine d1-receptor-mediated activation of extracellular signal-regulated kinase. |
2006-05-02 |
2023-08-12 |
mouse |
| D S Kim, R D Palmiter, A Cummins, C R Gerfe. Reversal of supersensitive striatal dopamine D1 receptor signaling and extracellular signal-regulated kinase activity in dopamine-deficient mice. Neuroscience. vol 137. issue 4. 2006-05-02. PMID:16388913. |
the reversal of dopamine d1-receptor activation of extracellular signal-regulated kinase in dopamine-deficient mice following chronic l-dopa treatment shows that the lack of dopamine, rather than absence of other factors secreted from dopaminergic neurons, is responsible for dopamine supersensitivity. |
2006-05-02 |
2023-08-12 |
mouse |
| José A Apud, Daniel R Weinberge. Pharmacogenetic tools for the development of target-oriented cognitive-enhancing drugs. NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics. vol 3. issue 1. 2006-05-02. PMID:16490417. |
the development of a number of compounds that selectively increase extracellular dopamine (da) concentrations in the dorsolateral prefrontal cortex but not in subcortical areas by either blocking its metabolism or reuptake, or increasing its release, or that directly activate postsynaptic da-1 receptor mechanisms provided powerful pharmacotherapeutic tools to mitigate the cognitive deficits brought about by the dopaminergic alterations of the prefrontal cortex. |
2006-05-02 |
2023-08-12 |
Not clear |
| Sanna Janhunen, Paula Mielikäinen, Päivi Paldánius, Raimo K Tuominen, Liisa Ahtee, Seppo Kaakkol. The effect of nicotine in combination with various dopaminergic drugs on nigrostriatal dopamine in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 371. issue 6. 2006-04-28. PMID:16012872. |
the effect of nicotine in combination with various dopaminergic drugs on nigrostriatal dopamine in rats. |
2006-04-28 |
2023-08-12 |
rat |
| F Fumagalli, G Racagni, M A Riv. Shedding light into the role of BDNF in the pharmacotherapy of Parkinson's disease. The pharmacogenomics journal. vol 6. issue 2. 2006-04-28. PMID:16402079. |
brain-derived neurotrophic factor (bdnf) colocalizes with dopamine neurons in the substantia nigra, where dopaminergic cell bodies are located, and it has recently garnered attention as a molecule crucial for cognition, a function that is also compromised in pd patients. |
2006-04-28 |
2023-08-12 |
Not clear |
| Björn H Schott, Constanze I Seidenbecher, Daniela B Fenker, Corinna J Lauer, Nico Bunzeck, Hans-Gert Bernstein, Wolfgang Tischmeyer, Eckart D Gundelfinger, Hans-Jochen Heinze, Emrah Düze. The dopaminergic midbrain participates in human episodic memory formation: evidence from genetic imaging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 5. 2006-04-27. PMID:16452664. |
we investigated a possible role for the dopaminergic midbrain in human episodic memory by measuring how polymorphisms in dopamine clearance pathways affect encoding-related brain activity (functional magnetic resonance imaging) in an episodic memory task. |
2006-04-27 |
2023-08-12 |
human |
| Björn H Schott, Constanze I Seidenbecher, Daniela B Fenker, Corinna J Lauer, Nico Bunzeck, Hans-Gert Bernstein, Wolfgang Tischmeyer, Eckart D Gundelfinger, Hans-Jochen Heinze, Emrah Düze. The dopaminergic midbrain participates in human episodic memory formation: evidence from genetic imaging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 5. 2006-04-27. PMID:16452664. |
our finding that genetic variations in the dopamine clearance pathways affect encoding-related activation patterns in midbrain and pfc provides strong support for a role of dopaminergic neuromodulation in human episodic memory formation. |
2006-04-27 |
2023-08-12 |
human |
| Ubaldo Bonuccelli, Nicola Paves. Dopamine agonists in the treatment of Parkinson's disease. Expert review of neurotherapeutics. vol 6. issue 1. 2006-04-26. PMID:16466315. |
thus, after a few years of treatment the majority of patients who started on dopamine agonists will be administered levodopa, in a combined dopaminergic therapy, in order to achieve a better control of motor symptoms. |
2006-04-26 |
2023-08-12 |
Not clear |
| Jussi Hirvonen, Theo G M van Erp, Jukka Huttunen, Kjell Någren, Matti Huttunen, Sargo Aalto, Jouko Lönnqvist, Jaakko Kaprio, Tyrone D Cannon, Jarmo Hietal. Striatal dopamine D1 and D2 receptor balance in twins at increased genetic risk for schizophrenia. Psychiatry research. vol 146. issue 1. 2006-04-25. PMID:16361088. |
the dopamine hypothesis of schizophrenia postulates that a dysfunctional dopaminergic system is a major pathophysiological mechanism in the disease. |
2006-04-25 |
2023-08-12 |
Not clear |
| G Govindaiah, Charles L Co. Depression of retinogeniculate synaptic transmission by presynaptic D(2)-like dopamine receptors in rat lateral geniculate nucleus. The European journal of neuroscience. vol 23. issue 2. 2006-04-25. PMID:16420449. |
the dlgn receives dopaminergic innervation from the ventral tegmental area; however, the role of dopamine in synaptic transmission in dlgn has not been explored. |
2006-04-25 |
2023-08-12 |
rat |
| Anya M Y Li. NMDA modulation of dopamine dynamics is diminished in the aged striatum: an in vivo voltametric study. Neurochemistry international. vol 48. issue 2. 2006-04-24. PMID:16271801. |
taken together, with the reduced dopamine release in response to depolarizing stimuli, our in vivo electrochemical data suggest that age-related changes in nmda function contribute to the impaired dopaminergic dynamics, including an attenuation of nmda-evoked dopamine release and a diminished augmentation by k(+) of nmda-induced dopamine release during the normal aging process. |
2006-04-24 |
2023-08-12 |
rat |
| Grazyna Bial. [Behavioral and pharmacological characteristics of mice lacking the dopamine transporter]. Postepy higieny i medycyny doswiadczalnej (Online). vol 58. 2006-04-21. PMID:15765018. |
mice lacking the dopamine transporter (dat knock-out mice) display marked changes in an dopamine homeostasis that result in an elevated dopaminergic level and locomotor hyperactivity. |
2006-04-21 |
2023-08-12 |
mouse |
| Ikuko Miyazaki, Masato Asanuma, Francisco J Diaz-Corrales, Masaya Fukuda, Kiyoyuki Kitaichi, Ko Miyoshi, Norio Ogaw. Methamphetamine-induced dopaminergic neurotoxicity is regulated by quinone-formation-related molecules. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 3. 2006-04-21. PMID:16403784. |
recently, the neurotoxicity of dopamine (da) quinone formation by auto-oxidation of da has focused on dopaminergic neuron-specific oxidative stress. |
2006-04-21 |
2023-08-12 |
mouse |
| Kabrena E Rodda, Brian Dean, Iain M McIntyre, Olaf H Drumme. Brain distribution of selected antipsychotics in schizophrenia. Forensic science international. vol 157. issue 2-3. 2006-04-20. PMID:15936909. |
however, those associated with relatively lower dopaminergic activity were found in the highest concentration in the occipital cortex, a region with a relatively low concentration of dopamine receptors. |
2006-04-20 |
2023-08-12 |
human |
| Sheila A Doggrel. Recent important trials of pharmacotherapy in Parkinson's disease. Expert opinion on pharmacotherapy. vol 6. issue 6. 2006-04-20. PMID:15952930. |
experimental evidence suggests that the dopamine synthesised from levodopa may contribute to the further degeneration of dopaminergic neurons. |
2006-04-20 |
2023-08-12 |
Not clear |
| Mohamed A Elwan, Jason R Richardson, Thomas S Guillot, W Michael Caudle, Gary W Mille. Pyrethroid pesticide-induced alterations in dopamine transporter function. Toxicology and applied pharmacology. vol 211. issue 3. 2006-04-20. PMID:16005927. |
studies from our laboratory and others have demonstrated that certain pesticides increase levels of the dopamine transporter (dat), an integral component of dopaminergic neurotransmission and a gateway for dopaminergic neurotoxins. |
2006-04-20 |
2023-08-12 |
mouse |