| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arvid Carlsson, Maria L Carlsso. A dopaminergic deficit hypothesis of schizophrenia: the path to discovery. Dialogues in clinical neuroscience. vol 8. issue 1. 2006-06-28. PMID:16640125. |
this hypothesis is driven by suggestive evidence for subpopulations of dopamine d2 receptors delivering contrasting forms of dopaminergic transmission: synaptic receptors, responsible for basic dopaminergic function and subject to effective feedback control, and poorly controlled extrasynaptic receptors partly responsible for the positive symptoms of psychosis. |
2006-06-28 |
2023-08-12 |
human |
| Arvid Carlsson, Maria L Carlsso. A dopaminergic deficit hypothesis of schizophrenia: the path to discovery. Dialogues in clinical neuroscience. vol 8. issue 1. 2006-06-28. PMID:16640125. |
since the primary defect is dopamine deficiency, we term this theory the dopaminergic deficit hypothesis of schizophrenia. |
2006-06-28 |
2023-08-12 |
human |
| Samo B Hocevar, Marko Zivin, Aleksandra Milutinovic, Marko Hawlina, Emily Hutton, Bozidar Ogorev. Simultaneous in vivo measurement of dopamine, serotonin and ascorbate in the striatum of experimental rats using voltammetric microprobe. Frontiers in bioscience : a journal and virtual library. vol 11. 2006-06-27. PMID:16720351. |
explicit proof of in vivo dopamine detection at the oppd/cfme was achieved via the absence of the dopamine signal in rats with unilateral lesions of nigrostriatal dopaminergic neurons, which was induced by the use of the selective dopaminergic neurotoxin 6-hydroxydopamine (6-ohda). |
2006-06-27 |
2023-08-12 |
rat |
| Laurie H L Sellings, Lindsey E McQuade, Paul B S Clark. Evidence for multiple sites within rat ventral striatum mediating cocaine-conditioned place preference and locomotor activation. The Journal of pharmacology and experimental therapeutics. vol 317. issue 3. 2006-06-26. PMID:16507711. |
dopaminergic lesion extent was quantified by radioligand binding to the dopamine transporter. |
2006-06-26 |
2023-08-12 |
rat |
| Dag Nyhol. Pharmacokinetic optimisation in the treatment of Parkinson's disease : an update. Clinical pharmacokinetics. vol 45. issue 2. 2006-06-22. PMID:16485914. |
pharmacotherapy for parkinson's disease is focused on dopaminergic drugs, mainly the dopamine precursor levodopa and dopamine receptor agonists. |
2006-06-22 |
2023-08-12 |
Not clear |
| Michael A Johnson, Vignesh Rajan, Charles E Miller, R Mark Wightma. Dopamine release is severely compromised in the R6/2 mouse model of Huntington's disease. Journal of neurochemistry. vol 97. issue 3. 2006-06-22. PMID:16573654. |
striatal dopamine release decreased with age, indicating that progressive alterations in dopaminergic pathways may affect motor activity. |
2006-06-22 |
2023-08-12 |
mouse |
| Paolo S D'Aquila, Francesca Panin, Gino Serr. Chronic valproate fails to prevent imipramine-induced behavioural sensitization to the dopamine D2-like receptor agonist quinpirole. European journal of pharmacology. vol 535. issue 1-3. 2006-06-21. PMID:16533507. |
based on experimental evidence suggesting a relationship between dopamine and mania, we proposed the antidepressant-induced dopaminergic supersensitivity as a model of antidepressant-related mania. |
2006-06-21 |
2023-08-12 |
Not clear |
| Mia Y Summers, Margaret Leighton, Danni Liu, Kevin Pong, Edmund I Grazian. 3-normeridamycin: a potent non-immunosuppressive immunophilin ligand is neuroprotective in dopaminergic neurons. The Journal of antibiotics. vol 59. issue 3. 2006-06-20. PMID:16724459. |
when challenged with the neurotoxin 1-methyl-4-phenylpyridinium (mpp+), known to induce parkinsonism, 1 restored functional dopamine uptake in a concentration-dependent manner, with an ec50 of 110 nm in dopaminergic neurons. |
2006-06-20 |
2023-08-12 |
Not clear |
| Muzamil Ahmad, Seema Yousuf, M Badruzzaman Khan, Md Nasrul Hoda, Abdullah Shafique Ahmad, Mubeen Ahmad Ansari, Tauheed Ishrat, Ashok Kumar Agrawal, Fakhrul Isla. Attenuation by Nardostachys jatamansi of 6-hydroxydopamine-induced parkinsonism in rats: behavioral, neurochemical, and immunohistochemical studies. Pharmacology, biochemistry, and behavior. vol 83. issue 1. 2006-06-19. PMID:16500697. |
a significant decrease in the level of dopamine and its metabolites and an increase in the number of dopaminergic d2 receptors in striatum were observed after 6-ohda injection, and both were significantly recovered following enj treatment. |
2006-06-19 |
2023-08-12 |
rat |
| Andrew H Evans, Nicola Pavese, Andrew D Lawrence, Yen F Tai, Silke Appel, Miroslava Doder, David J Brooks, Andrew J Lees, Paola Piccin. Compulsive drug use linked to sensitized ventral striatal dopamine transmission. Annals of neurology. vol 59. issue 5. 2006-06-14. PMID:16557571. |
a small group of parkinson's disease (pd) patients compulsively use dopaminergic drugs despite causing harmful social, psychological, and physical effects and fulfil core diagnostic and statistical manual (of mental disorders) fourth edition criteria for substance dependence (dopamine dysregulation syndrome [dds]). |
2006-06-14 |
2023-08-12 |
Not clear |
| P Giménez-Xavier, C Gómez-Santos, E Castaño, R Francisco, J Boada, M Unzeta, E Sanz, S Ambrosi. The decrease of NAD(P)H has a prominent role in dopamine toxicity. Biochimica et biophysica acta. vol 1762. issue 5. 2006-06-09. PMID:16574383. |
the break in cell redox equilibrium, not excluding the involvement of free oxygen radicals, could be sufficient to explain the toxicity of dopamine in dopaminergic neurons. |
2006-06-09 |
2023-08-12 |
human |
| Guadalupe Soria, Anna Castañé, Catherine Ledent, Marc Parmentier, Rafael Maldonado, Olga Valverd. The lack of A2A adenosine receptors diminishes the reinforcing efficacy of cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 5. 2006-06-06. PMID:16123743. |
a2a adenosine and d2 dopamine receptors are colocalized in the same neurons in discrete brain areas, and the dopaminergic transmission plays a crucial role in the addictive properties of drugs of abuse, such as cocaine. |
2006-06-06 |
2023-08-12 |
mouse |
| Olle Lindvall, Peter Hagel. Role of cell therapy in Parkinson disease. Neurosurgical focus. vol 13. issue 5. 2006-06-05. PMID:15769071. |
the grafted dopaminergic neurons can reinnervate the denervated striatum, restore regulated dopamine release and movement-related frontal cortical activation, and produce significant symptomatic relief. |
2006-06-05 |
2023-08-12 |
Not clear |
| Heike Bene. Transdermal lisuride: short-term efficacy and tolerability study in patients with severe restless legs syndrome. Sleep medicine. vol 7. issue 1. 2006-06-05. PMID:16194624. |
transdermal application forms of dopamine agonists are expected to lead to a stable plasma concentration of the active drug which could ease treatment for rls patients with daytime symptoms and avoid side effects of oral dopaminergic therapies. |
2006-06-05 |
2023-08-12 |
Not clear |
| Vera Lehmensiek, Eva-Maria Tan, Stefan Liebau, Thomas Lenk, Heinz Zettlmeisl, Johannes Schwarz, Alexander Storc. Dopamine transporter-mediated cytotoxicity of 6-hydroxydopamine in vitro depends on expression of mutant alpha-synucleins related to Parkinson's disease. Neurochemistry international. vol 48. issue 5. 2006-06-01. PMID:16406146. |
mutant (a30p and a53t) alpha-synuclein isoforms cause increased vulnerability of cells towards various toxic insults and enhance dopamine transporter (dat)-mediated toxicity of the selective dopaminergic neurotoxin and mitochondrial complex i inhibitor mpp(+) in vitro. |
2006-06-01 |
2023-08-12 |
human |
| Hyun Jin Choi, So Yeon Lee, Yuri Cho, Haja No, Seong Who Kim, Onyou Hwan. Tetrahydrobiopterin causes mitochondrial dysfunction in dopaminergic cells: implications for Parkinson's disease. Neurochemistry international. vol 48. issue 4. 2006-05-26. PMID:16343695. |
we have previously suggested tetrahydrobiopterin (bh4), an obligatory cofactor for the dopamine synthesis enzyme tyrosine hydroxylase and present selectively in monoaminergic neurons in the brain, as an endogenous molecule that contributes to the dopaminergic neurodegeneration. |
2006-05-26 |
2023-08-12 |
Not clear |
| Giselle M Petzinger, Beth Fisher, Elizabeth Hogg, Avery Abernathy, Pablo Arevalo, Kerry Nixon, Michael W Jakowe. Behavioral motor recovery in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned squirrel monkey (Saimiri sciureus): changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteins. Journal of neuroscience research. vol 83. issue 2. 2006-05-25. PMID:16385585. |
administration to mammals leads to the destruction of nigrostriatal dopaminergic neurons and depletion of striatal dopamine. |
2006-05-25 |
2023-08-12 |
monkey |
| Paul E A Glaser, Stewart P Surgener, Richard Grondin, C R Gash, Mike Palmer, F Xavier Castellanos, Greg A Gerhard. Cerebellar neurotransmission in attention-deficit/hyperactivity disorder: does dopamine neurotransmission occur in the cerebellar vermis? Journal of neuroscience methods. vol 151. issue 1. 2006-05-25. PMID:16451810. |
there is no well-characterized dopaminergic pathway that projects to the posterior-inferior cerebellar vermis, although the dopamine transporter (dat) and tyrosine hydroxylase (th) have been localized in the posterior-inferior vermis in the non-human primate by immunohistochemistry. |
2006-05-25 |
2023-08-12 |
human |
| C Grasshoff, M Herrera-Marschitz, M Goiny, B D Kretschme. Modulation of ventral pallidal dopamine and glutamate release by the intravenous anesthetic propofol studied by in vivo microdialysis. Amino acids. vol 28. issue 2. 2006-05-24. PMID:15714256. |
the reduced dopamine release in ventral pallidum was most probably mediated through a gabaergic feedback loop from the ventral pallidum via the nucleus accumbens to the dopaminergic neurons of the ventral tegmental area or by long loop feedback. |
2006-05-24 |
2023-08-12 |
rat |
| Houbo Jiang, Qian Jiang, Wenhua Liu, Jian Fen. Parkin suppresses the expression of monoamine oxidases. The Journal of biological chemistry. vol 281. issue 13. 2006-05-23. PMID:16455660. |
this function may limit the production of reactive oxygen species generated by mao in dopamine oxidation and would, thus, be beneficial to the survival of dopaminergic neurons. |
2006-05-23 |
2023-08-12 |
mouse |