| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shaik Shavali, Colin K Combs, Manuchair Ebad. Reactive macrophages increase oxidative stress and alpha-synuclein nitration during death of dopaminergic neuronal cells in co-culture: relevance to Parkinson's disease. Neurochemical research. vol 31. issue 1. 2006-07-20. PMID:16475001. |
parkinson's disease (pd) is characterized by progressive degeneration of dopaminergic neurons and a substantial decrease in the neurotransmitter dopamine in the nigro-striatal region of the brain. |
2006-07-20 |
2023-08-12 |
mouse |
| Sara González, Camila Scorticati, Moisés García-Arencibia, Rosario de Miguel, José A Ramos, Javier Fernández-Rui. Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's disease. Brain research. vol 1073-1074. 2006-07-19. PMID:16412990. |
dose-response studies with 6-hydroxydopamine revealed that the application of 200 microg per animal caused hypokinetic signs (decreased ambulatory activity, increased inactivity, and reduced motor coordination), which paralleled several signs of degeneration of nigrostriatal dopaminergic neurons (dopamine depletion in the caudate-putamen, and decreased mrna levels for tyrosine hydroxylase and superoxide dismutase-1 and -2 in the substantia nigra). |
2006-07-19 |
2023-08-12 |
rat |
| Shelly T Yoshida, Shelley A Baella, Nancy M Stuebner, Cynthia A Crawford, Sanders A McDougal. Effects of a partial D2-like receptor agonist on striatal dopamine autoreceptor functioning in preweanling rats. Brain research. vol 1073-1074. 2006-07-19. PMID:16427034. |
to determine whether synthesis modulating dopamine autoreceptors are also affected in an adult atypical manner by partial d2-like agonists, preweanling rats were treated either acutely or repeatedly with reserpine (low dopaminergic tone) or vehicle (high dopaminergic tone). |
2006-07-19 |
2023-08-12 |
rat |
| Subbiah P Sivam, Jeffrey Co. Postnatal administration of D1 dopamine agonist reverses neonatal dopaminergic lesion-induced changes in striatal enkephalin and substance P systems. Brain research. vol 1073-1074. 2006-07-19. PMID:16455064. |
postnatal administration of d1 dopamine agonist reverses neonatal dopaminergic lesion-induced changes in striatal enkephalin and substance p systems. |
2006-07-19 |
2023-08-12 |
rat |
| Aiqun Li, Hong Guo, Xiaoying Luo, Jiansong Sheng, Shuo Yang, Yanqing Yin, Jianwei Zhou, Jiawei Zho. Apomorphine-induced activation of dopamine receptors modulates FGF-2 expression in astrocytic cultures and promotes survival of dopaminergic neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 8. 2006-07-19. PMID:16636101. |
apomorphine-induced activation of dopamine receptors modulates fgf-2 expression in astrocytic cultures and promotes survival of dopaminergic neurons. |
2006-07-19 |
2023-08-12 |
Not clear |
| Thomas S Hnasko, Francisco A Perez, Alex D Scouras, Elizabeth A Stoll, Samuel D Gale, Serge Luquet, Paul E M Phillips, Eric J Kremer, Richard D Palmite. Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 23. 2006-07-19. PMID:16723393. |
this approach offers numerous advantages compared with previous models aimed at examining dopamine signaling in discrete dopaminergic circuits. |
2006-07-19 |
2023-08-12 |
mouse |
| Bárbara Arias, Alessandro Serretti, Cristina Lorenzi, Cristóbal Gastó, Rosa Catalán, Lourdes Fañaná. Analysis of COMT gene (Val 158 Met polymorphism) in the clinical response to SSRIs in depressive patients of European origin. Journal of affective disorders. vol 90. issue 2-3. 2006-07-18. PMID:16356553. |
there is convincing evidence of interactions between serotonergic and dopaminergic systems and it seems that an increase of dopamine concentration in the whole brain could be a limiting factor for the antidepressant like effect of antidepressants. |
2006-07-18 |
2023-08-12 |
Not clear |
| Anita Sidhu, Christophe Wersinger, Charbel E-H Moussa, Philippe Vernie. The role of alpha-synuclein in both neuroprotection and neurodegeneration. Annals of the New York Academy of Sciences. vol 1035. 2006-07-13. PMID:15681812. |
moreover, converging observations suggest that a primary function for alpha-synuclein in dopaminergic neurons may be the regulation of dopamine content and tone at the synapse. |
2006-07-13 |
2023-08-12 |
Not clear |
| Anita Sidhu, Christophe Wersinger, Charbel E-H Moussa, Philippe Vernie. The role of alpha-synuclein in both neuroprotection and neurodegeneration. Annals of the New York Academy of Sciences. vol 1035. 2006-07-13. PMID:15681812. |
in this paper, we review how, indeed, alpha-synuclein regulates both the synthesis of dopamine, its storage into vesicles, its release in the synapse, and its re-uptake into the dopaminergic neurons. |
2006-07-13 |
2023-08-12 |
Not clear |
| Béatrice Blanchard-Fillion, Delphine Prou, Manuela Polydoro, David Spielberg, Elpida Tsika, Zeneng Wang, Stanley L Hazen, Michael Koval, Serge Przedborski, Harry Ischiropoulo. Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 23. 2006-07-07. PMID:16763020. |
herein, we show that extracellular 3-nitrotyrosine is transported via the l-aromatic amino acid transporter in nondopaminergic nt2 cells, whereas in dopaminergic pc12 cells, it is transported by both the l-aromatic amino acid and the dopamine transporters. |
2006-07-07 |
2023-08-12 |
rat |
| Henry H Yin, Xiaoxi Zhuang, Bernard W Ballein. Instrumental learning in hyperdopaminergic mice. Neurobiology of learning and memory. vol 85. issue 3. 2006-07-06. PMID:16423542. |
in two experiments we investigated the effects of elevated dopaminergic tone on instrumental learning and performance using dopamine transporter knockdown (dat kd) mice. |
2006-07-06 |
2023-08-12 |
mouse |
| Daryl A Bosco, Douglas M Fowler, Qinghai Zhang, Jorge Nieva, Evan T Powers, Paul Wentworth, Richard A Lerner, Jeffery W Kell. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nature chemical biology. vol 2. issue 5. 2006-07-06. PMID:16565714. |
dopaminergic neurons undergo degeneration in these diseases and are particularly susceptible to oxidative stress because dopamine metabolism itself creates reactive oxygen species. |
2006-07-06 |
2023-08-12 |
Not clear |
| S Tanak. Dopaminergic control of working memory and its relevance to schizophrenia: a circuit dynamics perspective. Neuroscience. vol 139. issue 1. 2006-06-30. PMID:16324800. |
this article argues how dopamine controls working memory and how the dysregulation of the dopaminergic system is related to schizophrenia. |
2006-06-30 |
2023-08-12 |
Not clear |
| S Tanak. Dopaminergic control of working memory and its relevance to schizophrenia: a circuit dynamics perspective. Neuroscience. vol 139. issue 1. 2006-06-30. PMID:16324800. |
to understand the characteristics of the dopaminergic control of working memory, the stability of the circuit dynamics under the influence of dopamine has been studied. |
2006-06-30 |
2023-08-12 |
Not clear |
| Guilherme Polanczyk, Cristian Zeni, Julia P Genro, Tatiana Roman, Mara H Hutz, Luis Augusto Rohd. Attention-deficit/hyperactivity disorder: advancing on pharmacogenomics. Pharmacogenomics. vol 6. issue 3. 2006-06-29. PMID:16013954. |
the majority of studies have focused on individual polymorphisms of the dopaminergic genes, with special emphasis on variants of the dopamine transporter gene (dat1). |
2006-06-29 |
2023-08-12 |
Not clear |
| J D Schulz, E L Hawkes, C A Sha. Cycad toxins, Helicobacter pylori and parkinsonism: cholesterol glucosides as the common denomenator. Medical hypotheses. vol 66. issue 6. 2006-06-29. PMID:16488551. |
specifically, mice fed cycad display behavioural symptoms of parkinsonism such as reduced gait length, as well as neuropathological signs such as a loss of striatal dopaminergic (daergic) terminals and an upregulation of the dopamine d2 receptor. |
2006-06-29 |
2023-08-12 |
mouse |
| Jingjun Cheng, Matthijs G P Feenstr. Individual differences in dopamine efflux in nucleus accumbens shell and core during instrumental learning. Learning & memory (Cold Spring Harbor, N.Y.). vol 13. issue 2. 2006-06-29. PMID:16585792. |
to assess dopaminergic activity, we presented rats with two sessions (30 trials each) of a one-lever appetitive instrumental task and simultaneously measured dopamine efflux in the shell and core accumbens subareas using in vivo microdialysis. |
2006-06-29 |
2023-08-12 |
rat |
| Mikko Airavaara, Jelena Mijatovic, Tanja Vihavainen, Timo Petteri Piepponen, Mart Saarma, Liisa Ahte. In heterozygous GDNF knockout mice the response of striatal dopaminergic system to acute morphine is altered. Synapse (New York, N.Y.). vol 59. issue 6. 2006-06-28. PMID:16437537. |
the finding that reduced gdnf level alters the effects of morphine on striatal dopamine and our previous findings of elevated extracellular striatal dopamine concentrations and fosb/deltafosb expression in the gdnf+/- mice show the importance of gdnf in the regulation of striatal dopaminergic system. |
2006-06-28 |
2023-08-12 |
mouse |
| Bruno R Souza, Renan P Souza, Daniela V F Rosa, Melissa M Guimarães, Humberto Correa, Marco A Romano-Silv. Dopaminergic intracellular signal integrating proteins: relevance to schizophrenia. Dialogues in clinical neuroscience. vol 8. issue 1. 2006-06-28. PMID:16640119. |
changes in dopaminergic function can be regulated by receptor-receptor interaction, or interaction with other proteins with dopamine receptors, and/or elements of the downstream signaling cascades. |
2006-06-28 |
2023-08-12 |
Not clear |
| Arvid Carlsson, Maria L Carlsso. A dopaminergic deficit hypothesis of schizophrenia: the path to discovery. Dialogues in clinical neuroscience. vol 8. issue 1. 2006-06-28. PMID:16640125. |
in contrast to the conventional view of dopamine involvement in schizophrenia, which posits hyperactive dopaminergic transmission, we propose that for unknown developmental and/or biochemical reasons, a primary defect occurs in efficient, tight dopaminergic synaptic transmission, triggering feedback activation and receptor upregulation, and resulting in the well-characterized increase in dopaminergic tone. |
2006-06-28 |
2023-08-12 |
human |