| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Warren Olanow, José A Obeso, Fabrizio Stocch. Drug insight: Continuous dopaminergic stimulation in the treatment of Parkinson's disease. Nature clinical practice. Neurology. vol 2. issue 7. 2006-09-15. PMID:16932589. |
dopaminergic neurons in the basal ganglia normally fire in a random but continuous manner, so that striatal dopamine concentrations are maintained at a relatively constant level. |
2006-09-15 |
2023-08-12 |
Not clear |
| C Warren Olanow, José A Obeso, Fabrizio Stocch. Drug insight: Continuous dopaminergic stimulation in the treatment of Parkinson's disease. Nature clinical practice. Neurology. vol 2. issue 7. 2006-09-15. PMID:16932589. |
studies in primate models and patients with parkinson's disease have shown that continuous or long-acting dopaminergic agents are associated with a decreased risk of motor complications compared with short-acting dopamine agonists or levodopa formulations. |
2006-09-15 |
2023-08-12 |
Not clear |
| Griselda Genovese, Mihaela Senek, Nicolás Ortiz, Mariana Regueira, David W Towle, Martín Tresguerres, Carlos M Luque. Dopaminergic regulation of ion transport in gills of the euryhaline semiterrestrial crab Chasmagnathus granulatus: interaction between D1- and D2-like receptors. The Journal of experimental biology. vol 209. issue Pt 14. 2006-09-13. PMID:16809469. |
the effects of dopamine (da) and dopaminergic agonists and antagonists on ion transport were studied in isolated perfused gills of the crab chasmagnathus granulatus. |
2006-09-13 |
2023-08-12 |
Not clear |
| Cristina M Bäckman, Lufei Shan, Ya Jun Zhang, Barry J Hoffer, Sherry Leonard, Juan C Troncoso, Paul Vonsatel, Andreas C Toma. Gene expression patterns for GDNF and its receptors in the human putamen affected by Parkinson's disease: a real-time PCR study. Molecular and cellular endocrinology. vol 252. issue 1-2. 2006-09-12. PMID:16644101. |
these data suggest that the extensive loss of dopaminergic neurons in the substantia nigra, and concomitant loss of striatal dopamine, may induce compensatory changes in the expression of target derived gdnf, but not its receptor system. |
2006-09-12 |
2023-08-12 |
human |
| Yulia Y Tyurina, Alexander A Kapralov, Jianfei Jiang, Grigory G Borisenko, Alla I Potapovich, Andrey Sorokin, Patrick M Kochanek, Steven H Graham, Nina F Schor, Valerian E Kaga. Oxidation and cytotoxicity of 6-OHDA are mediated by reactive intermediates of COX-2 overexpressed in PC12 cells. Brain research. vol 1093. issue 1. 2006-09-12. PMID:16712820. |
parkinson's disease is characterized by a progressive loss of dopaminergic neurons, likely associated with dysregulation of oxidation of catechols, such as dopamine (da) and 6-hydroxydopamine (6-ohda), and resulting in oxidative stress. |
2006-09-12 |
2023-08-12 |
Not clear |
| S Nudmamud-Thanoi, S Thanoi, P Sobho. Increase of glutamate/N-methyl-D-aspartate receptor immunodensity in the dentate gyrus of rats following pseudoephedrine administration. Neurotoxicology. vol 27. issue 4. 2006-09-08. PMID:16542726. |
changes of dopamine function can induce malfunction of glutamatergic system because there are well-documented interactions between glutamate/n-methyl-d-aspartate (nmda) receptors and dopaminergic system. |
2006-09-08 |
2023-08-12 |
rat |
| I Schwienbacher, H-U Schnitzler, R F Westbrook, R Richardson, M Fend. Carbachol injections into the nucleus accumbens disrupt acquisition and expression of fear-potentiated startle and freezing in rats. Neuroscience. vol 140. issue 3. 2006-09-08. PMID:16581194. |
this was not due to altered dopaminergic activity as we have also found that intra-nucleus accumbens infusions of the dopamine agonist amphetamine do not affect either the acquisition or the expression of conditioned fear. |
2006-09-08 |
2023-08-12 |
rat |
| Krystyna Ossowska, Jadwiga Wardas, Katarzyna Kuter, Przemysław Nowak, Joanna Dabrowska, Aleksandra Bortel, Łukasz Labus, Adam Kwieciński, Anna Krygowska-Wajs, Stainsław Wolfart. Influence of paraquat on dopaminergic transporter in the rat brain. Pharmacological reports : PR. vol 57. issue 3. 2006-09-07. PMID:15985715. |
selective toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), a parkinsonism inducing compound, is well known to be related to an uptake of its active metabolite mpp+ into dopaminergic neurons by dopamine transporter (dat). |
2006-09-07 |
2023-08-12 |
rat |
| Krystyna Ossowska, Jadwiga Wardas, Katarzyna Kuter, Przemysław Nowak, Joanna Dabrowska, Aleksandra Bortel, Łukasz Labus, Adam Kwieciński, Anna Krygowska-Wajs, Stainsław Wolfart. Influence of paraquat on dopaminergic transporter in the rat brain. Pharmacological reports : PR. vol 57. issue 3. 2006-09-07. PMID:15985715. |
the present study seems to suggest that systemic paraquat administration affects striatal dat and dopamine metabolism in the nigrostriatal neurons in rats which may be crucial for its neurotoxic effects on dopaminergic neurons. |
2006-09-07 |
2023-08-12 |
rat |
| Juan A Flores, Beatriz Galan-Rodriguez, Susana Ramiro-Fuentes, Emilio Fernandez-Espej. Role for dopamine neurons of the rostral linear nucleus and periaqueductal gray in the rewarding and sensitizing properties of heroin. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 7. 2006-09-05. PMID:16292327. |
the objectives were to study the morphological characteristics of the dopamine network of the rli/pag region, and to discern its role on rewarding and sensitizing effects of heroin in rats, following dopamine depletion or local injection of dopaminergic antagonists. |
2006-09-05 |
2023-08-12 |
rat |
| Pablo Brumovsky, Marcelo J Villar, Tomas Hökfel. Tyrosine hydroxylase is expressed in a subpopulation of small dorsal root ganglion neurons in the adult mouse. Experimental neurology. vol 200. issue 1. 2006-09-05. PMID:16516890. |
the fact that neither aadc nor the dopamine transporter could be visualized suggests of non-dopaminergic transmitter phenotype, but the levels of these two dopaminergic markers may be too low to be detected with the present methodology. |
2006-09-05 |
2023-08-12 |
mouse |
| Annette Møller Dall, Jens Zimme. Development of DARPP-32-positive parts of fetal pig ganglionic eminence and ventral mesencephalon in organotypic slice co-cultures. Experimental neurology. vol 200. issue 1. 2006-09-05. PMID:16529743. |
this was used (a) to study the developmental expression of the striatal marker protein, dopamine and adenosine 3,5-monophosphate regulated phospho-protein (darpp-32) in the two parts and (b) to compare innervations of the two parts by tyrosine hydroxylase (th)-positive, dopaminergic fibers from co-cultured slices of the ventral mesencephalon. |
2006-09-05 |
2023-08-12 |
Not clear |
| Christophe Wersinger, Milan Rusnak, Anita Sidh. Modulation of the trafficking of the human serotonin transporter by human alpha-synuclein. The European journal of neuroscience. vol 24. issue 1. 2006-09-05. PMID:16882008. |
alpha-synuclein (alpha-syn), a protein primarily localized in the presynaptic compartment of neurons, is known to regulate dopaminergic neurotransmission by negatively modulating dopamine transporter activity and regulating its trafficking to or away from the cell surface. |
2006-09-05 |
2023-08-12 |
human |
| Thomas Siessmeier, Thorsten Kienast, Jana Wrase, Jennifer Lynne Larsen, Dieter F Braus, Michael N Smolka, Hans Georg Buchholz, Mathias Schreckenberger, Frank Rösch, Paul Cumming, Karl Mann, Peter Bartenstein, Andreas Hein. Net influx of plasma 6-[18F]fluoro-L-DOPA (FDOPA) to the ventral striatum correlates with prefrontal processing of affective stimuli. The European journal of neuroscience. vol 24. issue 1. 2006-09-05. PMID:16882026. |
the observed correlation between dopamine synthesis capacity in the dorsal striatum and bold signal changes in the dorsolateral prefrontal cortex suggests dopaminergic modulation of processing of emotional stimuli in brain areas associated with motor planning and executive behaviour control. |
2006-09-05 |
2023-08-12 |
human |
| Sang Eun Kim, Insop Shim, June-Key Chung, Myung Chul Le. Effect of ginseng saponins on enhanced dopaminergic transmission and locomotor hyperactivity induced by nicotine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 8. 2006-08-31. PMID:16251992. |
in an attempt to investigate whether the effect of ginseng saponins is through their inhibitory action on the enhanced dopaminergic transmission by psychomotor stimulants, we examined the effects of ginseng total saponin (gts) presynaptically on nicotine-induced dopamine (da) release in the striatum of freely moving rats using in vivo microdialysis technique and postsynaptically on the in vitro and in vivo binding of [3h]raclopride to da d2 receptors. |
2006-08-31 |
2023-08-12 |
rat |
| Kristi S Rau, Elisabeth Birdsall, Trent J Volz, James A Riordan, Anthony J Baucum, Brian P Adair, Rebecca Bitter, James W Gibb, Glen R Hanson, Annette E Fleckenstei. Methamphetamine administration reduces hippocampal vesicular monoamine transporter-2 uptake. The Journal of pharmacology and experimental therapeutics. vol 318. issue 2. 2006-08-31. PMID:16687477. |
repeated high-dose injections of methamphetamine (meth) rapidly decrease dopamine uptake by the vesicular monoamine transporter-2 (vmat-2) associated with dopaminergic nerve terminals, as assessed in nonmembrane-associated vesicles purified from striata of treated rats. |
2006-08-31 |
2023-08-12 |
rat |
| Zhe Cheng, Yong-Mei Zhong, Xiong-Li Yan. Expression of the dopamine transporter in rat and bullfrog retinas. Neuroreport. vol 17. issue 8. 2006-08-31. PMID:16708013. |
in both species, the dopamine transporter was strongly expressed in somata and processes of all dopaminergic amacrine cells. |
2006-08-31 |
2023-08-12 |
rat |
| Zhe Cheng, Yong-Mei Zhong, Xiong-Li Yan. Expression of the dopamine transporter in rat and bullfrog retinas. Neuroreport. vol 17. issue 8. 2006-08-31. PMID:16708013. |
in rat dopaminergic interplexiform cells, dopamine transporter immunoreactivity was also observed on the ascending processes terminating in the outer plexiform layer. |
2006-08-31 |
2023-08-12 |
rat |
| Fumihiko Nishimura, Hayato Toriumi, Shigeaki Ishizaka, Toshisuke Sakaki, Masahide Yoshikaw. Use of differentiating embryonic stem cells in the Parkinsonian mouse model. Methods in molecular biology (Clifton, N.J.). vol 329. 2006-08-25. PMID:16846012. |
progressive loss of dopaminergic neurons in the substantia nigra pars compacta and the following reduction in striatal dopamine cause parkinson's disease (pd). |
2006-08-25 |
2023-08-12 |
mouse |
| Christoph Scherfler, Clemens Decristofor. Small animal imaging using a conventional gamma camera exemplified in studies on the striatal dopaminergic system. Nuclear medicine review. Central & Eastern Europe. vol 9. issue 1. 2006-08-21. PMID:16791797. |
to bypass limitations arising from high acquisition costs and dependence on an in-house cyclotron unit inevitably associated with pet, a conventional gamma camera has been equipped with a pinhole collimator and used to visualize striatal pre- and post-synaptic dopaminergic function in rats measured by the dopamine transporter ligand [123i]beta-cit and the dopamine d2/dopamine d3 receptor ligand [123i]ibzm. |
2006-08-21 |
2023-08-12 |
human |