| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erwin Lauwers, Dirk Bequé, Koen Van Laere, Johan Nuyts, Guy Bormans, Luc Mortelmans, Cindy Casteels, Linda Vercammen, Olivier Bockstael, Bart Nuttin, Zeger Debyser, Veerle Baekeland. Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression. Neurobiology of aging. vol 28. issue 2. 2007-01-09. PMID:16423428. |
there was a strong correlation between the reduction of dopaminergic neurons in the substantia nigra and the reduction of dopamine transporter binding in the striatum. |
2007-01-09 |
2023-08-12 |
rat |
| Roya Tehranian, Susana E Montoya, Amber D Van Laar, Teresa G Hastings, Ruth G Pere. Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells. Journal of neurochemistry. vol 99. issue 4. 2007-01-09. PMID:16981894. |
because dopamine neurons are invariably compromised during pathogenesis in pd, we have been exploring the functions of alpha-synuclein with particular relevance to dopaminergic neuronal cells. |
2007-01-09 |
2023-08-12 |
Not clear |
| Manuchair Ebadi, Holly Brown-Borg, Jun Ren, Sushil Sharma, Shaik Shavali, Hesham El ReFaey, Edward C Carlso. Therapeutic efficacy of selegiline in neurodegenerative disorders and neurological diseases. Current drug targets. vol 7. issue 11. 2007-01-04. PMID:17100591. |
selegiline inhibits the activity of monoamine oxidase b, enhances the release of dopamine, blocks the uptake of dopamine, acts as a calmodulin antagonist, and enhances the level of cyclic amp, which in turn protects dopaminergic neurons. |
2007-01-04 |
2023-08-12 |
rat |
| Stephen H Reaney, Louisa C Johnston, William J Langston, Donato A Di Mont. Comparison of the neurotoxic effects of proteasomal inhibitors in primary mesencephalic cultures. Experimental neurology. vol 202. issue 2. 2007-01-03. PMID:16920101. |
preincubation of cultures with alpha-methyl-p-tyrosine, an inhibitor of dopamine synthesis, reduced dopamine concentration by 65% but failed to significantly change lactacystin- and mg-132-induced damage to dopaminergic neurons. |
2007-01-03 |
2023-08-12 |
rat |
| Rachel L Dennis, William M Muir, Heng-Wei Chen. Effects of raclopride on aggression and stress in diversely selected chicken lines. Behavioural brain research. vol 175. issue 1. 2007-01-03. PMID:16978715. |
the dopamine (d2) receptor, an integral part of the dopaminergic system, was hypothesized to be a key contributory factor of the stress response. |
2007-01-03 |
2023-08-12 |
chicken |
| Dan J Stein, Timothy K Newman, Jonathan Savitz, Rajkumar Ramesa. Warriors versus worriers: the role of COMT gene variants. CNS spectrums. vol 11. issue 10. 2006-12-27. PMID:17008817. |
under conditions of increased dopamine release (eg, stress), individuals with val158 alleles may have improved dopaminergic transmission and better performance, while individuals with met158 alleles may have less efficient neurotransmission and worse performance. |
2006-12-27 |
2023-08-12 |
Not clear |
| Cindy Casteels, Peter Vermaelen, Johan Nuyts, Annemie Van Der Linden, Veerle Baekelandt, Luc Mortelmans, Guy Bormans, Koen Van Laer. Construction and evaluation of multitracer small-animal PET probabilistic atlases for voxel-based functional mapping of the rat brain. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 47. issue 11. 2006-12-26. PMID:17079820. |
we have mapped metabolic ((18)f-fdg), dopamine transporter (dat) (2'-(18)f-fluoroethyl(1r-2-exo-3-exe)-8-methyl-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]-octane-2-carboxylate [(18)f-fect]), and dopaminergic d(2) receptor ((11)c-raclopride) small-animal pet data onto a 3-dimensional t2-weighted mri rat brain template oriented according to the rat brain paxinos atlas. |
2006-12-26 |
2023-08-12 |
rat |
| Teri L Wolf, Joan Kotun, James H Meador-Woodruf. Plasma copper, iron, ceruloplasmin and ferroxidase activity in schizophrenia. Schizophrenia research. vol 86. issue 1-3. 2006-12-20. PMID:16842975. |
it has been proposed that copper, as a component of several enzymes linked to dopamine synthesis, may play a role in schizophrenia by exacerbating or perpetuating dopaminergic dysregulation. |
2006-12-20 |
2023-08-12 |
Not clear |
| Roger Kurlan, Irene Hegeman Richard, Cheryl Deele. Medication tolerance and augmentation in restless legs syndrome: the need for drug class rotation. Journal of general internal medicine. vol 21. issue 12. 2006-12-20. PMID:17105517. |
the medications used most commonly to treat rls include dopaminergic drugs (levodopa, dopamine agonists), benzodiazepines, and narcotic analgesics. |
2006-12-20 |
2023-08-12 |
Not clear |
| Samir N P Kelada, Harvey Checkoway, Sharon L R Kardia, Christopher S Carlson, Paola Costa-Mallen, David L Eaton, Jordan Firestone, Karen M Powers, Phillip D Swanson, Gary M Franklin, W T Longstreth, Terri-Smith Weller, Zahra Afsharinejad, Lucio G Cost. 5' and 3' region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's disease risk: a hypothesis-generating study. Human molecular genetics. vol 15. issue 20. 2006-12-18. PMID:16963468. |
the dopamine transporter gene (slc6a3) is a candidate gene for parkinson's disease (pd) on the basis of its critical role in dopaminergic neurotransmission. |
2006-12-18 |
2023-08-12 |
human |
| Kaveh M Koochesfahani, Raúl de la Fuente-Fernández, Vesna Sossi, Michael Schulzer, Lakshmi N Yatham, Thomas J Ruth, Stephan Blinder, A Jon Stoess. Oral methylphenidate fails to elicit significant changes in extracellular putaminal dopamine levels in Parkinson's disease patients: positron emission tomographic studies. Movement disorders : official journal of the Movement Disorder Society. vol 21. issue 7. 2006-12-15. PMID:16570297. |
failure of oral mp to alter extracellular da levels in putamen could result from degeneration of presynaptic dopaminergic terminals, with consequent severe reductions in the levels of endogenous da and dopamine transporter in pd subjects. |
2006-12-15 |
2023-08-12 |
human |
| Megumi Nakamura, Masaki Yamada, Takako Ohsawa, Hiraku Morisawa, Tsutomu Nishine, Osamu Nishimura, Tosifusa Tod. Phosphoproteomic profiling of human SH-SY5Y neuroblastoma cells during response to 6-hydroxydopamine-induced oxidative stress. Biochimica et biophysica acta. vol 1763. issue 9. 2006-12-15. PMID:16949164. |
dopaminergic neurons are known to be vulnerable to age-related neuronal disorders due to reactive oxygen species (ros) generated during dopamine metabolism. |
2006-12-15 |
2023-08-12 |
human |
| Kimberly A Badanich, Kristopher J Adler, Cheryl L Kirstei. Adolescents differ from adults in cocaine conditioned place preference and cocaine-induced dopamine in the nucleus accumbens septi. European journal of pharmacology. vol 550. issue 1-3. 2006-12-15. PMID:17011546. |
to address whether age-related differences in cocaine place preferences were related to differences in the mesolimbic dopaminergic system, we measured extracellular dopamine levels in the nucleus accumbens septi of pnd 35, pnd 45 and pnd 60 rats via quantitative microdialysis under transient conditions. |
2006-12-15 |
2023-08-12 |
rat |
| Toshiyuki Kawasaki, Kotaro Ishihara, Yukio Ago, Shigeo Nakamura, Soichi Itoh, Akemichi Baba, Toshio Matsud. Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum. European journal of pharmacology. vol 542. issue 1-3. 2006-12-14. PMID:16784740. |
methamphetamine treatment (4 mg/kg, s.c. x 4 with 2 h intervals) showed striatal dopaminergic degeneration as observed by decreases in dopamine levels and tyrosine hydroxylase immunoreactivity in the striatum. |
2006-12-14 |
2023-08-12 |
mouse |
| Marco Sarchiapone, Vladimir Carli, Giovanni Camardese, Chiara Cuomo, Daniela Di Giuda, Maria-Lucia Calcagni, C Focacci, Sergio De Risi. Dopamine transporter binding in depressed patients with anhedonia. Psychiatry research. vol 147. issue 2-3. 2006-12-07. PMID:16952448. |
the dopamine transporter (dat) is a predominantly presynaptic receptor that may play a critical role in the pathophysiology of dopaminergic transmission. |
2006-12-07 |
2023-08-12 |
human |
| Paolo S D'Aquila, Francesca Panin, Maria Paola Castelli, Gino Serr. Dopamine D3 receptor antisense oligodeoxynucleotide potentiates imipramine-induced dopaminergic behavioural supersensitivity. Behavioural pharmacology. vol 17. issue 2. 2006-12-06. PMID:16495718. |
dopamine d3 receptor antisense oligodeoxynucleotide potentiates imipramine-induced dopaminergic behavioural supersensitivity. |
2006-12-06 |
2023-08-12 |
human |
| Paolo S D'Aquila, Francesca Panin, Maria Paola Castelli, Gino Serr. Dopamine D3 receptor antisense oligodeoxynucleotide potentiates imipramine-induced dopaminergic behavioural supersensitivity. Behavioural pharmacology. vol 17. issue 2. 2006-12-06. PMID:16495718. |
the results show that a treatment previously shown to reduce the synthesis of dopamine d3 receptors, rather than resulting in an inhibitory effect, potentiated the ability of imipramine to induce dopaminergic motor supersensitivity. |
2006-12-06 |
2023-08-12 |
human |
| Paolo S D'Aquila, Francesca Panin, Maria Paola Castelli, Gino Serr. Dopamine D3 receptor antisense oligodeoxynucleotide potentiates imipramine-induced dopaminergic behavioural supersensitivity. Behavioural pharmacology. vol 17. issue 2. 2006-12-06. PMID:16495718. |
the present results suggest that increased dopamine d3 receptor expression following antidepressant treatments is not involved in the mechanism of dopaminergic supersensitivity, and are consistent with evidence supporting an inhibitory role for dopamine d3 receptors in motor activity, both in normal and in sensitized subjects. |
2006-12-06 |
2023-08-12 |
human |
| Samuel D Gale, David J Perke. Physiological properties of zebra finch ventral tegmental area and substantia nigra pars compacta neurons. Journal of neurophysiology. vol 96. issue 5. 2006-12-06. PMID:16870835. |
homologous dopaminergic cell groups in songbirds project anatomically in a manner that may allow dopamine to influence song learning or song production. |
2006-12-06 |
2023-08-12 |
Not clear |
| Samuel D Gale, David J Perke. Physiological properties of zebra finch ventral tegmental area and substantia nigra pars compacta neurons. Journal of neurophysiology. vol 96. issue 5. 2006-12-06. PMID:16870835. |
our results show that zebra finch dopaminergic neurons possess physiological properties very similar to those of mammalian dopaminergic neurons, including broad action potentials, calcium- and apamin-sensitive membrane-potential oscillations underlying pacemaker firing, powerful spike-frequency adaptation, and autoinhibition via d2 dopamine receptors. |
2006-12-06 |
2023-08-12 |
Not clear |