| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yutaka Arahata, Takashi Kato, Kengo It. [Molecular imaging in Parkinson's disease]. Nihon rinsho. Japanese journal of clinical medicine. vol 65. issue 2. 2007-04-26. PMID:17302279. |
in terms of therapy of pd, functional images have provided some objective evidences for possible neuroprotective effect of dopamine agonists, survival of fetal dopaminergic tissue grafted into patient's putamen, an increase of dopamine release by bdnf focal infusion therapy, and functional modification by deep brain stimulation. |
2007-04-26 |
2023-08-12 |
Not clear |
| Hidehiko Takahashi, Tetsuya Suhar. [Molecular imaging of psychiatric disorders]. Nihon rinsho. Japanese journal of clinical medicine. vol 65. issue 2. 2007-04-26. PMID:17302281. |
since dopamine is an important molecule for pathophysiology of schizophrenia, we reviewed in vivo imaging studies focusing on dopaminergic transmission in schizophrenia. |
2007-04-26 |
2023-08-12 |
human |
| Eva Lindström, Sten Levande. Sertindole: efficacy and safety in schizophrenia. Expert opinion on pharmacotherapy. vol 7. issue 13. 2007-04-19. PMID:16925508. |
preclinical studies suggest that sertindole acts preferentially on limbic and cortical dopaminergic neurons and clinical trials have confirmed that sertindole is effective at a low dopamine d2 occupancy level. |
2007-04-19 |
2023-08-12 |
Not clear |
| Yasuomi Ouchi, Teiji Nakayama, Toshihiko Kanno, Etsuji Yoshikawa, Tomomi Shinke, Tatsuo Torizuk. In vivo presynaptic and postsynaptic striatal dopamine functions in idiopathic normal pressure hydrocephalus. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 27. issue 4. 2007-04-19. PMID:16926840. |
to investigate dopaminergic contribution to its pathophysiology, two aspects of the trans-synaptic dopamine functions in the striatal region in eight inph patients naïve to dopaminergic drugs were examined using positron emission tomography with a presynaptic marker [11c]cft ([11c]2-beta-carbomethoxy-3beta-(4-fluorophenyl) tropane) that binds to dopamine transporter and a postsynaptic marker [11c]raclopride that binds to d2 receptor. |
2007-04-19 |
2023-08-12 |
human |
| Anthony E Lan. The progression of Parkinson disease: a hypothesis. Neurology. vol 68. issue 12. 2007-04-16. PMID:17372132. |
it is proposed that once the snc is affected by the original pathobiological process (for example, protein aggregation), additional processes more specific to dopaminergic neurons are triggered (including sources of oxidative stress such as increased dopamine turnover, reduced levels of reduced glutathione, increased iron, and the presence of neuromelanin, as well as altered calcium homeostasis and excitotoxicity). |
2007-04-16 |
2023-08-12 |
Not clear |
| Jeffrey N Joyce, Mark J Milla. Dopamine D3 receptor agonists for protection and repair in Parkinson's disease. Current opinion in pharmacology. vol 7. issue 1. 2007-04-12. PMID:17174156. |
although the dopamine precursor, l-dopa, is effective in the short-term in relieving motor dysfunction, it does not stop the progressive disappearance of dopaminergic neurons, encouraging interest in alternative therapeutic strategies. |
2007-04-12 |
2023-08-12 |
Not clear |
| Jeffrey N Joyce, Mark J Milla. Dopamine D3 receptor agonists for protection and repair in Parkinson's disease. Current opinion in pharmacology. vol 7. issue 1. 2007-04-12. PMID:17174156. |
of particular interest, dopamine d3 receptors contribute to the beneficial influence of dopaminergic agonists for the protection and restoration of dopaminergic pathways in parkinson's disease. |
2007-04-12 |
2023-08-12 |
Not clear |
| Matthew P Mount, Arman Lira, David Grimes, Patrice D Smith, Sylvie Faucher, Ruth Slack, Hymie Anisman, Shawn Hayley, David S Par. Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 12. 2007-04-12. PMID:17376993. |
after this initial finding, we found that ifn-gamma-deficient mice displayed attenuated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced substantia nigra pars compacta dopaminergic cell loss along with reduced loss of striatal tyrosine hydroxylase and dopamine transporter fiber density. |
2007-04-12 |
2023-08-12 |
mouse |
| Júlia P Genro, Cristian Zeni, Guilherme V Polanczyk, Tatiana Roman, Luis A Rohde, Mara H Hut. A promoter polymorphism (-839 C > T) at the dopamine transporter gene is associated with attention deficit/hyperactivity disorder in Brazilian children. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 2. 2007-04-11. PMID:17044101. |
the dopamine transporter (dat) plays a key role in the regulation of dopaminergic neurotransmission and is also the major site of action for methylphenidate which is one of the main drugs used to treat attention deficit hyperactivity disorder (adhd). |
2007-04-11 |
2023-08-12 |
Not clear |
| Maria Del Zompo, Vincenzo De Luca, Giovanni Severino, Xingqun Ni, Stefania Mulas, Donatella Congiu, Maria Paola Piccardi, James L Kenned. Haplotype association study between DRD1 gene and bipolar type I affective disorder in two samples from Canada and Sardinia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 2. 2007-04-11. PMID:17066478. |
based on the dopaminergic hypothesis, the dopamine d(1) receptor gene (drd1) is considered to be a good candidate gene involved in the susceptibility of bipolar disorder (bp). |
2007-04-11 |
2023-08-12 |
human |
| S J O'Dell, N B Gross, A N Fricks, B D Casiano, T B Nguyen, J F Marshal. Running wheel exercise enhances recovery from nigrostriatal dopamine injury without inducing neuroprotection. Neuroscience. vol 144. issue 3. 2007-04-11. PMID:17157992. |
forced use of the forelimb contralateral to a unilateral injection of the dopaminergic neurotoxin 6-hydroxydopamine can promote recovery of motor function in that limb and can significantly decrease damage to dopamine terminals. |
2007-04-11 |
2023-08-12 |
rat |
| S J O'Dell, N B Gross, A N Fricks, B D Casiano, T B Nguyen, J F Marshal. Running wheel exercise enhances recovery from nigrostriatal dopamine injury without inducing neuroprotection. Neuroscience. vol 144. issue 3. 2007-04-11. PMID:17157992. |
after killing, dopaminergic damage was assessed by both quantifying 3 beta-(4-iodophenyl)tropan-2 beta-carboxylic acid methyl ester ([(125)i]rti-55) binding to striatal dopamine transporters and counting tyrosine hydroxylase-positive cells in the substantia nigra. |
2007-04-11 |
2023-08-12 |
rat |
| Erica L Unger, Tessy Paul, Laura E Murray-Kolb, Barbara Felt, Byron C Jones, John L Bear. Early iron deficiency alters sensorimotor development and brain monoamines in rats. The Journal of nutrition. vol 137. issue 1. 2007-04-10. PMID:17182811. |
only g15 iron deficient rats had greater dopaminergic activity than controls as indicated by increased tyrosine hydroxylase levels, phosphorylated tyrosine hydroxylase levels, and cellular dopamine in prefrontal cortex and striatum at p15. |
2007-04-10 |
2023-08-12 |
human |
| Hong Qu Yan, Xiecheng Ma, Xiangbai Chen, Youming Li, Lifang Shao, C Edward Dixo. Delayed increase of tyrosine hydroxylase expression in rat nigrostriatal system after traumatic brain injury. Brain research. vol 1134. issue 1. 2007-04-05. PMID:17196177. |
tyrosine hydroxylase (th) is the key enzyme for synthesizing dopamine (da) in dopaminergic neurons and its terminals. |
2007-04-05 |
2023-08-12 |
rat |
| Yasuko Kitao, Yuzuru Imai, Kentaro Ozawa, Ayane Kataoka, Toshio Ikeda, Mariko Soda, Kazuhiko Nakimawa, Hiroshi Kiyama, David M Stern, Osamu Hori, Kazumasa Wakamatsu, Shosuke Ito, Shigeyoshi Itohara, Ryosuke Takahashi, Satoshi Ogaw. Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. Human molecular genetics. vol 16. issue 1. 2007-04-03. PMID:17116640. |
pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. |
2007-04-03 |
2023-08-12 |
mouse |
| Y Naidu, K Ray Chaudhur. Transdermal rotigotine: a new non-ergot dopamine agonist for the treatment of Parkinson's disease. Expert opinion on drug delivery. vol 4. issue 2. 2007-04-03. PMID:17335409. |
studies in animal models and humans suggest that continuous dopaminergic stimulation could be achieved by the infusions of different dopamine agonists or levodopa, and may significantly reduce the risk of dyskinesias associated with treatment strategies utilising pulsatile treatment options. |
2007-04-03 |
2023-08-12 |
Not clear |
| Randy L Hunter, Natasa Dragicevic, Kristen Seifert, Dong Young Choi, Mei Liu, Hyoung-Chun Kim, Wayne A Cass, Patrick G Sullivan, Guoying Bin. Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system. Journal of neurochemistry. vol 100. issue 5. 2007-04-02. PMID:17254027. |
inflammation, mitochondrial dysfunction, oxidative stress, decreased dopamine, and nigral dopaminergic neuronal loss were observed post-lps. |
2007-04-02 |
2023-08-12 |
rat |
| Randy L Hunter, Natasa Dragicevic, Kristen Seifert, Dong Young Choi, Mei Liu, Hyoung-Chun Kim, Wayne A Cass, Patrick G Sullivan, Guoying Bin. Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system. Journal of neurochemistry. vol 100. issue 5. 2007-04-02. PMID:17254027. |
pioglitazone also attenuated oxidative stress and partially restored striatal dopamine as well as demonstrated dopaminergic neuroprotection and reduced nigral microglial activation. |
2007-04-02 |
2023-08-12 |
rat |
| Timothy M Fountaine, Richard Wade-Martin. RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport. Journal of neuroscience research. vol 85. issue 2. 2007-03-29. PMID:17131421. |
rna interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from mpp(+) toxicity and reduces dopamine transport. |
2007-03-29 |
2023-08-12 |
human |
| Diane Stephenson, Andres Ramirez, Jill Long, Nestor Barrezueta, Eva Hajos-Korcsok, Curt Matherne, Dan Gallagher, Anne Ryan, Ricardo Ochoa, Frank Menniti, James Ya. Quantification of MPTP-induced dopaminergic neurodegeneration in the mouse substantia nigra by laser capture microdissection. Journal of neuroscience methods. vol 159. issue 2. 2007-03-27. PMID:16949674. |
thus, this method provides a quantitative means to measure dopamine neuron toxicity in the substantia nigra and, as such has potential application in evaluating regimens that may be neuroprotective or neurorestorative for dopaminergic neurons. |
2007-03-27 |
2023-08-12 |
mouse |