| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philippe-Antoine Beauséjour, Jean-Christophe Veilleux, Steven Condamine, Barbara S Zielinski, Réjean Dubu. Olfactory Projections to Locomotor Control Centers in the Sea Lamprey. International journal of molecular sciences. vol 25. issue 17. 2024-09-14. PMID:39273317. |
in the sea lamprey, anatomical evidence shows that olfactory inputs project to the posterior tuberculum (pt), a structure containing dopaminergic (da) neurons homologous to the mammalian ventral tegmental area and the substantia nigra pars compacta. |
2024-09-14 |
2024-09-16 |
Not clear |
| Shijia Ma, Qianyi Ma, Songhui Hu, Xinlei Mo, Chenze Zhu, Xingxian Zhang, Zetao Jia, Lingjie Tang, Lei Jiang, Yihui Cui, Zhong Chen, Weiwei Hu, Xiangnan Zhan. Deletion of histamine H2 receptor in VTA dopaminergic neurons of mice induces behavior reminiscent of mania. Cell reports. vol 43. issue 9. 2024-09-12. PMID:39264811. |
here, we present mice lacking dopaminergic histamine h2 receptor (h2r) in the ventral tegmental area (vta) that exhibit a behavioral phenotype mirroring some of the symptoms of mania, including increased locomotor activity and reduced anxiety- and depression-like behavior. |
2024-09-12 |
2024-09-15 |
mouse |
| Natalia López-González Del Rey, Nagore Hernández-Pinedo, Megan Carrillo, María Del Cerro, Noelia Esteban-García, Inés Trigo-Damas, Mariana H G Monje, José L Lanciego, Carmen Cavada, José A Obeso, Javier Bles. Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson's disease model. NPJ Parkinson's disease. vol 10. issue 1. 2024-09-02. PMID:39223183. |
in the ventral tier of the snc (nigrosome), neurons rich in aldh1a1 and girk2 are intermingled, whereas calbindin is the marker that best identifies the most resilient neurons located in the dorsal tier and ventral tegmental area, recapitulating the well-defined dorsoventral axis of susceptibility to degeneration of dopaminergic neurons. |
2024-09-02 |
2024-09-05 |
mouse |
| Jordan E Elum, Eric R Szelenyi, Barbara Juarez, Alexandria D Murry, Grigory Loginov, Catalina A Zamorano, Pan Gao, Ginny Wu, Scott Ng-Evans, Joshua X Yee, Xiangmin Xu, Sam A Golden, Larry S Zweife. Distinct dynamics and intrinsic properties in ventral tegmental area populations mediate reward association and motivation. Cell reports. vol 43. issue 9. 2024-08-29. PMID:39207900. |
here, we compare the contribution of two primarily dopaminergic and largely non-overlapping vta subpopulations, all vta dopamine neurons and vta gabaergic neurons of the mouse midbrain, to these processes. |
2024-08-29 |
2024-09-04 |
mouse |
| L Galindo-Charles, C Reyes-Legorreta, J Garduño, E Galarraga, D Tapia, S Hernández-Lópe. The activation of D2-like dopamine receptors increases NMDA currents in the dorsal raphe serotonergic neurons. Neuroscience letters. 2024-08-11. PMID:39128818. |
the dorsal raphe nucleus (drn) receives dopaminergic inputs from the ventral tegmental area (vta). |
2024-08-11 |
2024-08-14 |
Not clear |
| Stefan M Brudzynski, Jeffrey S Burgdorf, Joseph R Moska. From emotional arousal to executive action. Role of the prefrontal cortex. Brain structure & function. 2024-08-03. PMID:39096390. |
the mesolimbic cholinergic system originates in the laterodorsal tegmental nucleus and the mesolimbic dopaminergic system in the ventral tegmental area. |
2024-08-03 |
2024-08-06 |
Not clear |
| Joanna Medina, Rose M De Guzman, Joanna L Workma. Prolactin mitigates chronic stress-induced maladaptive behaviors and physiology in ovariectomized female rats. Neuropharmacology. 2024-07-31. PMID:39084597. |
however, prolactin treatment reduced basal cort concentrations and increased dopaminergic cells in the ventral tegmental area. |
2024-07-31 |
2024-08-03 |
rat |
| Jana M Zielinski, Marco Reisert, Bastian E A Sajonz, Shi Jia Teo, Annette Thierauf-Emberger, Johanna Wessolleck, Maximilian Frosch, Björn Spittau, Jochen Leupold, Máté D Döbrössy, Volker A Coene. In Search for a Pathogenesis of Major Depression and Suicide-A Joint Investigation of Dopamine and Fiber Tract Anatomy Focusing on the Human Ventral Mesencephalic Tegmentum: Description of a Workflow. Brain sciences. vol 14. issue 7. 2024-07-27. PMID:39061463. |
the stimulation region (ventral tegmental area, vta), supported by experimental data, points to the role of dopaminergic (da) transmission in disease pathology. |
2024-07-27 |
2024-07-29 |
human |
| Elemer Szabad. Three paradoxes related to the mode of action of pramipexole: The path from D2/D3 dopamine receptor stimulation to modification of dopamine-modulated functions. Journal of psychopharmacology (Oxford, England). 2024-07-23. PMID:39041250. |
the functions considered are modulated by midbrain dopaminergic nuclei: locomotion - substantia nigra pars compacta (snc), reinforcement/motivation - ventral tegmental area (vta), sympathetic activity (as reflected in pupil function) - vta; arousal - ventral periaqueductal grey (vpag), with contributions from vta and snc. |
2024-07-23 |
2024-07-25 |
Not clear |
| Ming Li, Xue-Ke Yang, Jian Yang, Tong-Xia Li, Chi Cui, Xiang Peng, Jie Lei, Kun Ren, Jie Ming, Pei Zhang, Bo Tia. Ketamine ameliorates post-traumatic social avoidance by erasing the traumatic memory encoded in VTA-innervated BLA engram cells. Neuron. 2024-07-20. PMID:39032491. |
furthermore, activation or inhibition of dopaminergic projections from the ventral tegmental area to the bla effectively mimics or blocks the therapeutic effect of re-exposure with ketamine and is dopamine d2 receptor dependent. |
2024-07-20 |
2024-07-24 |
mouse |
| Lei Jia, Jieting Yin, Tielong Liu, Wenqiang Qi, Tongyu Du, Quntao Li, Ketao Ma, Junqiang Si, Jiangwen Yin, Yan L. Activation of Ventral Tegmental Area Dopaminergic Neurons Projecting to the Parabrachial Nucleus Promotes Emergence from Propofol Anesthesia in Male Rats. Neurochemical research. vol 49. issue 8. 2024-07-09. PMID:38814359. |
however, whether dopaminergic (da) projections from the vta to the pbn play a role in mediating the effects of general anesthesia is unclear. |
2024-07-09 |
2024-07-12 |
rat |
| Agnieszka Boroń, Aleksandra Suchanecka, Krzysztof Chmielowiec, Jolanta Chmielowiec, Jolanta Masiak, Grzegorz Trybek, Aleksandra Strońska-Pluta, Monika Rychel, Anna Grzywac. Analysis of the International journal of molecular sciences. vol 25. issue 12. 2024-06-27. PMID:38928154. |
a surge in bdnf levels in the ventral tegmental area (the region from which the dopaminergic neurons of the mesocorticolimbic dopamine system originate and extend to the dorsolateral and ventromedial striatum) triggers a state of reward similar to that produced by opiates in animal studies. |
2024-06-27 |
2024-06-29 |
Not clear |
| Tiziano Balzano, Natalia López-González Del Rey, Noelia Esteban-García, Alejandro Reinares-Sebastián, José A Pineda-Pardo, Inés Trigo-Damas, José A Obeso, Javier Bles. Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates. NPJ Parkinson's disease. vol 10. issue 1. 2024-06-19. PMID:38886348. |
dopaminergic neurons in the ventral tier of the substantia nigra pars compacta (snc) degenerate prominently in parkinson's disease (pd), while those in the dorsal tier and ventral tegmental area are relatively spared. |
2024-06-19 |
2024-06-21 |
monkey |
| Jamie C Moffa, India N Bland, Jessica R Tooley, Vani Kalyanaraman, Monique Heitmeier, Meaghan C Creed, Bryan A Copit. Cell specific single viral vector CRISPR/Cas9 editing and genetically encoded tool delivery in the central and peripheral nervous systems. eNeuro. 2024-06-13. PMID:38871457. |
we tested these tools in multiple brain regions and cell types, including gabaergic neurons in the nucleus accumbens, glutamatergic neurons projecting from the ventral pallidum to the lateral habenula, dopaminergic neurons in the ventral tegmental area, and proprioceptive neurons in the periphery. |
2024-06-13 |
2024-06-16 |
mouse |
| Kathleen F Vincent, Edlyn R Zhang, Angel J Cho, Risako Kato-Miyabe, Olivia G Mallari, Olivia A Moody, David P Obert, Gwi H Park, Ken Sol. Electrical stimulation of the ventral tegmental area restores consciousness from sevoflurane-, dexmedetomidine-, and fentanyl-induced unconsciousness in rats. Brain stimulation. 2024-05-31. PMID:38821397. |
dopaminergic neurons in the ventral tegmental area (vta) are crucially involved in regulating arousal, making them a potential target for reversing general anesthesia. |
2024-05-31 |
2024-06-02 |
rat |
| Rohan V Bhimani, Lily Rzepecki, Jinwoo Park, Elizabeth G Mietlicki-Baas. Ventral tegmental area amylin receptor activation differentially modulates mesolimbic dopamine signaling in response to fat versus sugar. eNeuro. 2024-05-28. PMID:38806231. |
amylin receptor activation in the ventral tegmental area (vta), a key dopaminergic nucleus in the mesolimbic reward system, has a potent ability to suppress intake of palatable fat and sugar solutions. |
2024-05-28 |
2024-06-03 |
rat |
| C Duncan Spencer, Persephone A Miller, Jesukhogie G Williams-Ikhenoba, Ralitsa G Nikolova, Melissa J Che. Regulation of the mouse ventral tegmental area by melanin-concentrating hormone. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-05-28. PMID:38806249. |
we recently showed that mch suppresses dopamine release in the nucleus accumbens, which principally receives dopaminergic projections from the ventral tegmental area (vta), but the mechanisms underlying mch-regulated dopamine release are not clearly defined. |
2024-05-28 |
2024-06-03 |
mouse |
| C Duncan Spencer, Persephone A Miller, Jesukhogie G Williams-Ikhenoba, Ralitsa G Nikolova, Melissa J Che. Regulation of the mouse ventral tegmental area by melanin-concentrating hormone. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-05-28. PMID:38806249. |
mchr1 expression is widespread and includes dopaminergic vta cells. |
2024-05-28 |
2024-06-03 |
mouse |
| Suelen L Boschen, Julian Seethaler, Shaohua Wang, Wendy D Lujan, Jodi L Silvernail, Rickey E Carter, Su-Youne Chang, J Luis Luja. Midbrain dopaminergic degeneration differentially modulates primary motor cortex activity and motor behavior in hemi-parkinsonian rats. Research square. 2024-05-27. PMID:38798359. |
the modulation of m1 neuronal activity by dopaminergic inputs, particularly from the ventral tegmental area (vta) and substantia nigra pars compacta (snc), plays a crucial role in pd pathophysiology. |
2024-05-27 |
2024-05-31 |
rat |
| Yusuke Fujioka, Kaori Kawai, Kuniyuki Endo, Minaka Ishibashi, Nobuyuki Iwade, Dilina Tuerde, Kozo Kaibuchi, Takayuki Yamashita, Akihiro Yamanaka, Masahisa Katsuno, Hirohisa Watanabe, Gen Sobue, Shinsuke Ishigak. Stress-impaired reward pathway promotes distinct feeding behavior patterns. Frontiers in neuroscience. vol 18. 2024-05-24. PMID:38784098. |
moreover, inhibition of dopaminergic activity in the ventral tegmental area that projects into the nacc shell caused similar feeding pattern aberrations. |
2024-05-24 |
2024-05-27 |
mouse |