| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valentina Basso, Máté D Döbrössy, Lachlan H Thompson, Deniz Kirik, Heidi R Fuller, Monte A Gate. State of the Art in Sub-Phenotyping Midbrain Dopamine Neurons. Biology. vol 13. issue 9. 2024-09-28. PMID:39336117. |
dopaminergic neurons in the ventral tegmental area (vta) and the substantia nigra pars compacta (snpc) comprise around 75% of all dopaminergic neurons in the human brain. |
2024-09-28 |
2024-10-01 |
human |
| Beatrice Zarrilli, Cecilia Giacomet, Francesca Cossa, Mauro Federici, Nicola Berretta, Nicola B Mercur. Functional efficacy of the MAO-B inhibitor safinamide in murine substantia nigra pars compacta dopaminergic neurons in vitro: A comparative study with tranylcypromine. Parkinsonism & related disorders. vol 128. 2024-09-26. PMID:39326285. |
functional efficacy of the mao-b inhibitor safinamide in murine substantia nigra pars compacta dopaminergic neurons in vitro: a comparative study with tranylcypromine. |
2024-09-26 |
2024-09-29 |
Not clear |
| Anoy Kumar Das, Subhas C Biswa. Cdc25A phosphatase is activated and mediates neuronal cell death by PUMA via pRb/E2F1 pathway in a model of Parkinson's disease. Biochimica et biophysica acta. Molecular cell research. 2024-09-21. PMID:39305937. |
parkinson's disease (pd) is a predominant movement disorder caused mainly due to selective loss of the dopaminergic neurons in the substantia nigra pars compacta of the mid brain. |
2024-09-21 |
2024-09-24 |
Not clear |
| Han Ting Guo, Zi Xin Lee, Kasthuri Bai Magalingam, Ammu Kutty Radhakrishnan, Saatheeyavaane Bhuvanendra. Carotenoids Modulate Antioxidant Pathways in In vitro Models of Parkinson's Disease: A Comprehensive Scoping Review. Neurochemistry international. 2024-09-18. PMID:39293662. |
pd is characterised by the accumulation of α-synuclein and progressive loss of dopaminergic neurons at the substantia nigra pars compacta. |
2024-09-18 |
2024-09-21 |
Not clear |
| Laura Patricia Perez-Abshana, Miguel Mendivil-Perez, Marlene Jimenez-Del-Rio, Carlos Velez-Pard. The GBA1 K198E Variant Is Associated with Suppression of Glucocerebrosidase Activity, Autophagy Impairment, Oxidative Stress, Mitochondrial Damage, and Apoptosis in Skin Fibroblasts. International journal of molecular sciences. vol 25. issue 17. 2024-09-14. PMID:39273169. |
parkinson's disease (pd) is a multifactorial, chronic, and progressive neurodegenerative disorder inducing movement alterations as a result of the loss of dopaminergic (daergic) neurons of the pars compacta in the substantia nigra and protein aggregates of alpha synuclein (α-syn). |
2024-09-14 |
2024-09-16 |
Not clear |
| Philippe-Antoine Beauséjour, Jean-Christophe Veilleux, Steven Condamine, Barbara S Zielinski, Réjean Dubu. Olfactory Projections to Locomotor Control Centers in the Sea Lamprey. International journal of molecular sciences. vol 25. issue 17. 2024-09-14. PMID:39273317. |
in the sea lamprey, anatomical evidence shows that olfactory inputs project to the posterior tuberculum (pt), a structure containing dopaminergic (da) neurons homologous to the mammalian ventral tegmental area and the substantia nigra pars compacta. |
2024-09-14 |
2024-09-16 |
Not clear |
| Malcolm C Harrison, Pin-Kuang La. Investigating the Mechanisms of Antibody Binding to Alpha-Synuclein for the Treatment of Parkinson's Disease. Molecular pharmaceutics. 2024-09-09. PMID:39251364. |
the pathophysiological hallmarks of pd are both degeneration of dopaminergic neurons in the substantia nigra pars compacta and the inclusion of misfolded α-synuclein (α-syn) aggregates known as lewy bodies. |
2024-09-09 |
2024-09-13 |
Not clear |
| Sarah Chevalier, Mélina Decourt, Maureen Francheteau, François Nicol, Anaïs Balbous, Pierre-Olivier Fernagut, Marianne Benoit-Maran. Alpha-synuclein-induced nigrostriatal degeneration and pramipexole treatment disrupt frontostriatal plasticity. NPJ Parkinson's disease. vol 10. issue 1. 2024-09-09. PMID:39251645. |
parkinson's disease is characterized by the degeneration of substantia nigra pars compacta (snc) dopaminergic neurons, leading to motor and cognitive symptoms. |
2024-09-09 |
2024-09-13 |
human |
| Ashini Singh, Suman Sinha, Niraj Kumar Sing. Dietary Natural Flavonoids: Intervention for MAO-B Against Parkinson's Disease. Chemical biology & drug design. vol 104. issue 3. 2024-09-03. PMID:39223743. |
the precise etiology of pd remains elusive, but recent research has shed light on potential factors, including the formation of α-synuclein aggregates, oxidative stress, neurotransmitter imbalances, and dopaminergic neurodegeneration in the substantia nigra pars compacta (snpc) region of the brain, culminating in motor symptoms such as bradykinesia, akinesia, tremors, and rigidity. |
2024-09-03 |
2024-09-05 |
Not clear |
| Hongyan Feng, Ning Tu, Ke Wang, Xiaowei Ma, Zhentao Zhang, Zhongchun Liu, Zhen Cheng, Lihong B. Neuromelanin-targeted 18 F-P3BZA PET/MR imaging of the substantia nigra in rhesus macaques. EJNMMI research. vol 14. issue 1. 2024-09-03. PMID:39225971. |
neuromelanin is mostly located in dopaminergic neurons in the substantia nigra (sn) pars compacta, and can be detected by magnetic resonance imaging (mri). |
2024-09-03 |
2024-09-05 |
Not clear |
| Juan García-Revilla, Rocío Ruiz, Ana M Espinosa-Oliva, Marti Santiago, Irene García-Domínguez, Lluís Camprubí-Ferrer, Sara Bachiller, Tomas Deierborg, Bertrand Joseph, Rocío M de Pablos, José A Rodríguez-Gómez, José Luis Vener. Dopaminergic neurons lacking Caspase-3 avoid apoptosis but undergo necrosis after MPTP treatment inducing a Galectin-3-dependent selective microglial phagocytic response. Cell death & disease. vol 15. issue 8. 2024-09-02. PMID:39223107. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (snpc). |
2024-09-02 |
2024-09-05 |
mouse |
| Natalia López-González Del Rey, Nagore Hernández-Pinedo, Megan Carrillo, María Del Cerro, Noelia Esteban-García, Inés Trigo-Damas, Mariana H G Monje, José L Lanciego, Carmen Cavada, José A Obeso, Javier Bles. Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson's disease model. NPJ Parkinson's disease. vol 10. issue 1. 2024-09-02. PMID:39223183. |
the differential vulnerability of dopaminergic neurons of the substantia nigra pars compacta (snc) is a critical and unresolved question in parkinson´s disease. |
2024-09-02 |
2024-09-05 |
mouse |
| Zhengyang Yao, Qian Jiao, Xixun Du, Fengju Jia, Xi Chen, Chunling Yan, Hong Jian. Ferroptosis in Parkinson's disease -- the iron-related degenerative disease. Ageing research reviews. 2024-09-01. PMID:39218077. |
parkinson's disease (pd) is a prevalent and advancing age-related neurodegenerative disorder, distinguished by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (snpc). |
2024-09-01 |
2024-09-04 |
Not clear |
| Jyoti Mishra, Vaishali Walecha, Tuithung Sophronea, Ankit Singh, Saurabh Agrawal, Pratibha Mehta Luthr. BBPT attenuated 6-OHDA-induced toxicity by modulating oxidative stress, apoptotic, and inflammatory proteins in primary neurons and rat models of Parkinson's Disease. Neurotoxicology. 2024-08-31. PMID:39216605. |
parkinson's disease (pd) results from the degeneration of dopaminergic neurons in substantia nigra pars compacta (snpc). |
2024-08-31 |
2024-09-04 |
rat |
| Ashutosh Pareek, Runjhun Singhal, Aaushi Pareek, Terisha Ghazi, Devesh U Kapoor, Yashumati Ratan, Arun Kumar Singh, Vivek Jain, Anil A Chuturgoo. Retinoic acid in Parkinson's disease: Molecular insights, therapeutic advances, and future prospects. Life sciences. 2024-08-24. PMID:39181315. |
parkinson's disease (pd) is a common and progressively worsening neurodegenerative disorder characterized by abnormal protein homeostasis and the degeneration of dopaminergic neurons, particularly in the substantia nigra pars compacta. |
2024-08-24 |
2024-08-28 |
Not clear |
| Mohamed J Saadh, Faris Anad Muhammad, Anamika Singh, Mohammed Ahmed Mustafa, Rafil Adnan Hussein Al Zuhairi, Pallavi Ghildiyal, Ghassan Hashim, Fahad Alsaikhan, Shayan Khalilollah, Reza Akhavan-Sigar. MicroRNAs Modulating Neuroinflammation in Parkinson's disease. Inflammation. 2024-08-20. PMID:39162871. |
presence of α-synuclein-containing aggregates in the substantia nigra pars compacta (snpc) and loss of dopaminergic (da) neurons are among the characteristic of pd. |
2024-08-20 |
2024-08-22 |
Not clear |
| Xiaowei Sun, Rou Gu, Jie Ba. Differentiation and regulation of CD4 Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-08-17. PMID:39153043. |
differentiation and regulation of cd4 parkinson's disease (pd) is the second most common neurodegenerative disease, and its hallmark pathological features are the loss of dopaminergic (da) neurons in the midbrain substantia nigra pars compacta (snpc) and the accumulation of alpha-synuclein (α-syn). |
2024-08-17 |
2024-08-20 |
Not clear |
| Jiyeon Na, Hye Guk Ryu, Haeun Park, Hyeonwoo Park, Eunmin Lee, Younwoo Nam, Hyerynn Kim, Sang-Min Jang, Do-Yeon Kim, Sangjune Ki. FoxO1 Alleviates the Mitochondrial ROS Levels Induced by α-Synuclein Preformed Fibrils in BV-2 Microglial Cells. Inflammation. 2024-08-15. PMID:39145787. |
parkinson's disease (pd) is a complex neurodegenerative disorder marked by the gradual deterioration of dopaminergic neurons, especially in the substantia nigra pars compacta (snc). |
2024-08-15 |
2024-08-17 |
cat |
| Gabriella M Mazzotta, Carmela Cont. Alpha Synuclein Toxicity and Non-Motor Parkinson's. Cells. vol 13. issue 15. 2024-08-09. PMID:39120295. |
the main neuropathological features of pd are the loss of dopaminergic neurons in the substantia nigra pars compacta (snpc) and the presence of alpha synuclein (αsyn)-rich lewy bodies both manifesting with classical motor signs. |
2024-08-09 |
2024-08-12 |
Not clear |
| Simone Steinbach, Mariana Molina, Lea T Grinberg, Luisa Aring, Annika Guntermann, Katrin Marcus, Helmut Heinsen, Renata E Paraizo Leite, Caroline Ma. Don't die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra? PloS one. vol 19. issue 7. 2024-08-01. PMID:39089320. |
a hallmark of parkinson's disease is the specific degeneration of dopaminergic neurons in the substantia nigra pars compacta. |
2024-08-01 |
2024-08-05 |
human |