| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Regoni, Flavia Valtorta, Jenny Sasson. Dopaminergic neuronal death via necroptosis in Parkinson's disease: A review of the literature. The European journal of neuroscience. 2023-09-05. PMID:37667848. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive dysfunction and loss of dopaminergic neurons of the substantia nigra pars compacta (snc). |
2023-09-05 |
2023-09-07 |
human |
| Yongyi Li, Mingwei Zhu, Wen-Xiong Chen, Jing Luo, Xin Li, Yangyang Cao, Meng Zheng, Shanshan Ma, Zhilan Xiao, Yani Zhang, Linyan Jiang, Xiumin Wang, Ting Tan, Xia Li, Qian Gong, Xiaoli Xiong, Jun Wang, Mingxi Tang, Mingtao Li, Ya-Ping Tan. A novel mutation in intron 1 of Wnt1 causes developmental loss of dopaminergic neurons in midbrain and ASD-like behaviors in rats. Molecular psychiatry. 2023-09-01. PMID:37658228. |
moreover, in the substantia nigra compacta (snpc) and the ventral tegmental area (vta) of mutant rats, dopaminergic (daergic) neurons were dramatically lost, together with a comparable decrease in striatal daergic fibers. |
2023-09-01 |
2023-09-07 |
rat |
| Tali Fishman-Jacob, Moussa B H Youdi. A sporadic Parkinson's disease model via silencing of the ubiquitin-proteasome/E3 ligase component,\\xc2\\xa0SKP1A. Journal of neural transmission (Vienna, Austria : 1996). 2023-08-29. PMID:37644186. |
our and other's laboratory microarray-derived transcriptomic studies in human pd substantia nigra pars compacta (snpc) samples have opened an avenue to concentrate on potential gene intersections or cross-talks along the dopaminergic (daergic) neurodegenerative cascade in sporadic pd (spd). |
2023-08-29 |
2023-09-07 |
mouse |
| Chandra Kanta Bhusal, Daniel Ejim Uti, Dattatreya Mukherjee, Taha Alqahtani, Saud Alqahtani, Arghya Bhattacharya, Shopnil Akas. Unveiling Nature's potential: Promising natural compounds in Parkinson's disease management. Parkinsonism & related disorders. 2023-08-26. PMID:37633805. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. |
2023-08-26 |
2023-09-07 |
Not clear |
| Linlin Wang, Qing Dan, Bingxuan Xu, Yun Chen, Tingting Zhen. Research progress on gas signal molecular therapy for Parkinson's disease. Open life sciences. vol 18. issue 1. 2023-08-17. PMID:37588999. |
among the pathological manifestations is the progressive degeneration of the nigrostriatal dopaminergic pathway, leading to massive loss of neurons in the substantia nigra pars compacta and dopamine (da) depletion. |
2023-08-17 |
2023-09-07 |
Not clear |
| Aishwarya Mary Johnson, Sara Jose, Abdul Rasheed Palakkott, Farheen Badrealam Khan, Nanthini Jayabalan, Jaleel Kizhakkayil, Shamma Abdulla Ali AlNaqbi, Mark Gh Scott, Mohammed Akli Ayoub, Richard Gordon, Hariharan Saminatha. Pharmacological Inhibition of PTEN Rescues Dopaminergic Neurons by Attenuating Apoptotic and Neuroinflammatory Signaling Events. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-08-17. PMID:37589761. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the selective degeneration of dopaminergic neurons in the substantia nigra pars compacta resulting in an irreversible and a debilitating motor dysfunction. |
2023-08-17 |
2023-09-07 |
Not clear |
| Satinder Kaur, Abhishek Sehrawat, Sarabjit Singh Mastana, Ramesh Kandimalla, Pushpender Kumar Sharma, Gurjit Kaur Bhatti, Jasvinder Singh Bhatt. Targeting calcium homeostasis and impaired inter-organelle crosstalk as a potential therapeutic approach in Parkinson's disease. Life sciences. 2023-08-04. PMID:37541578. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to motor symptoms such as tremors, rigidity, and bradykinesia. |
2023-08-04 |
2023-08-14 |
Not clear |
| Can-Tang Zhang, Deng-Li Qin, Xia-Yin Cao, Jia-Shuo Kan, Xin-Xing Huang, Dian-Shuai Gao, Jin Ga. Dephosphorylation of Six2Y129 protects tyrosine hydroxylase-positive cells in SNpc by regulating TEA domain 1 expression. iScience. vol 26. issue 7. 2023-08-03. PMID:37534182. |
parkinson's disease (pd) is a neurodegenerative disease characterized by selective loss of dopaminergic (da) neurons in the substantia nigra pars compacta (snpc). |
2023-08-03 |
2023-08-14 |
Not clear |
| Honoka Fujimori, Takuya Ohba, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Har. The Involvement of Progranulin for \\xce\\xb1-Synuclein Reduction through Autolysosome Formation. Biological & pharmaceutical bulletin. vol 46. issue 8. 2023-08-02. PMID:37532554. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by motor symptoms and neuropathological features, such as loss of dopaminergic neurons in the substantia nigra pars compacta and accumulation of alpha-synuclein (\xce\xb1-syn). |
2023-08-02 |
2023-08-14 |
mouse |
| Avika Chopra, Tiago Fleming Outeir. Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies. Brain : a journal of neurology. 2023-08-01. PMID:37526295. |
parkinson's disease is clinically known for the loss of dopaminergic neurons in the substantia nigra pars compacta and accumulation of intraneuronal cytoplasmic inclusions rich in alpha-synuclein called 'lewy bodies' and 'lewy neurites'. |
2023-08-01 |
2023-08-14 |
Not clear |
| Zhongting Zhao, Zheng Li, Fangning Du, Yixin Wang, Yue Wu, Kah-Leong Lim, Lin Li, Naidi Yang, Changmin Yu, Chengwu Zhan. Linking Heat Shock Protein 70 and Parkin in Parkinson's Disease. Molecular neurobiology. 2023-08-01. PMID:37526897. |
parkinson's disease (pd) is a neurodegenerative disease that affects millions of elderly people worldwide and is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (snpc). |
2023-08-01 |
2023-08-14 |
Not clear |
| M\\xc3\\xa1t\\xc3\\xa9 Feh\\xc3\\xa9r, Zsombor M\\xc3\\xa1rton, \\xc3\\x81kos Szab\\xc3\\xb3, J\\xc3\\xa1nos Kocsa, Vikt\\xc3\\xb3ria Kormos, \\xc3\\x81gnes Hunyady, L\\xc3\\xa1szl\\xc3\\xb3 \\xc3\\x81kos Kov\\xc3\\xa1cs, Bal\\xc3\\xa1zs Ujv\\xc3\\xa1ri, Gergely Berta, J\\xc3\\xb3zsef Farkas, N\\xc3\\xb3ra F\\xc3\\xbcredi, Tam\\xc3\\xa1s Gaszner, Bence Pytel, D\\xc3\\xb3ra Regl\\xc5\\x91di, Bal\\xc3\\xa1zs Gaszne. Downregulation of PACAP and the PAC1 Receptor in the Basal Ganglia, Substantia Nigra and Centrally Projecting Edinger-Westphal Nucleus in the Rotenone model of Parkinson's Disease. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511603. |
reduced dopaminergic cell count in the substantia nigra pars compacta (snpc) diminished the dopaminergic fiber density in the caudate-putamen (cpu) and decreased the peptidergic cell count in the centrally projecting edinger-westphal nucleus (ewcp), supporting the efficacy of rotenone treatment. |
2023-07-29 |
2023-08-14 |
rat |
| Qin Li, Shuai Li, Jiankang Fang, Chao Yang, Xia Zhao, Qing Wang, Wenshu Zhou, Wenhua Zhen. Artemisinin Confers Neuroprotection against 6-OHDA-Induced Neuronal Injury In Vitro and In Vivo through Activation of the ERK1/2 Pathway. Molecules (Basel, Switzerland). vol 28. issue 14. 2023-07-29. PMID:37513399. |
parkinson's disease (pd) is an age-related, progressive neurodegenerative disease characterized by the gradual and massive loss of dopaminergic neurons in the substantia nigra pars compacta (snc). |
2023-07-29 |
2023-08-14 |
Not clear |
| Taylor Russo, Benjamin Kolisnyk, Aswathy Bs, Tae Wan Kim, Jacqueline Martin, Jonathan Plessis-Belair, Jason Ni, Jordan A Pearson, Emily J Park, Roger B Sher, Lorenz Studer, Markus Riesslan. The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37503189. |
idiopathic parkinson's disease (pd) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, which is associated with neuroinflammation and reactive gliosis. |
2023-07-28 |
2023-08-14 |
mouse |
| Tao Pan, Qi Xiao, Hui-Jie Fan, Lei Xu, Shao-Chen Qin, Li-Xia Yang, Xiao-Ming Jin, Bao-Guo Xiao, Bo Zhang, Cun-Gen Ma, Zhi Cha. Wuzi Yanzong Pill relieves MPTP-induced motor dysfunction and neuron loss by inhibiting NLRP3 inflammasome-mediated neuroinflammation. Metabolic brain disease. 2023-07-20. PMID:37470879. |
parkinson disease (pd) is an age-related neurodegenerative disease, which is associated with the loss of dopaminergic neurons (da neurons) in the substantia nigra pars compacta (snpc), and neuroinflammation may lead to the occurrence of pd. |
2023-07-20 |
2023-08-14 |
mouse |
| Haoran Peng, Siyuan Chen, Shaopu Wu, Xiaoxue Shi, Jianjun Ma, Hongqi Yang, Xue L. Alpha-synuclein in skin as a high-quality biomarker for Parkinson's disease. Journal of the neurological sciences. vol 451. 2023-07-16. PMID:37454572. |
parkinson's disease (pd), the most common neurological motor system disorder, which characterised by the irreversible loss of dopaminergic neurones in the substantia nigra pars compacta, and leads to the deficiency of dopamine in the striatum. |
2023-07-16 |
2023-08-14 |
human |
| Dalila Ciceri, Lierni Gregorio-Zabala, Xabier Llama-Pino, Beg\\xc3\\xbcm Kurt, Jon Olano-Bringas, Patricia Villegas-Zafra, Nora Bengoa-Vergnior. Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model. Journal of visualized experiments : JoVE. issue 196. 2023-07-10. PMID:37427919. |
this method allows one to report that substantia nigra pars compacta dopaminergic neurons harboring ps129 lesions show mitochondrial fragmentation (as suggested by their reduced aspect ratio, ar) compared to their healthy neighboring neurons in a pre-formed fibril intracranial injection parkinson model. |
2023-07-10 |
2023-08-14 |
Not clear |
| Zeynep Bengisu Kaya, Elif Karakoc, Pamela J McLean, Esen Saka, Pergin Atill. Post-inflammatory administration of FASEB bioAdvances. vol 5. issue 7. 2023-07-07. PMID:37415931. |
neuropathological hallmarks of pd include the loss of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of lewy bodies that contain a variety of proteins and lipids including alpha-synuclein (\xce\xb1-syn). |
2023-07-07 |
2023-08-14 |
Not clear |
| Xu Cao, Zhong-Rui Du, Xin Liu, Xiong Wang, Chong Li, Sai-Nan Zhou, Jia-Rui Liu, Ping-Yi Xu, Jun-Li Ye, Qing Zhao, Fang Zhao, Ka-Hing Wong, Xiao-Li Don. Low and high doses of oral maslinic acid protect against Parkinson's disease via distinct gut microbiota-related mechanisms. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-07. PMID:37418977. |
the present study found both low and high dose ma treatment significantly prevented dopaminergic neuronal loss in a classical chronic pd mouse model by ameliorating motor functions and improving tyrosine hydroxylase expressions in the substantia nigra pars compacta (snpc) and increasing dopamine and its metabolite homovanillic acid levels in the striatum. |
2023-07-07 |
2023-08-14 |
mouse |
| Francisco Jos\\xc3\\xa9 Sanz, Guillermo Mart\\xc3\\xadnez-Carri\\xc3\\xb3n, Cristina Solana-Manrique, Nuria Parici. Evaluation of type 1 diabetes mellitus as a risk factor of Parkinson's disease in a Drosophila model. Journal of experimental zoology. Part A, Ecological and integrative physiology. 2023-06-29. PMID:37381093. |
parkinson's disease (pd) is the most common neurodegenerative motor disorder caused by the selective loss of dopaminergic (da) neurons in the substantia nigra pars compacta. |
2023-06-29 |
2023-08-14 |
drosophila_melanogaster |