| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elemer Szabad. Three paradoxes related to the mode of action of pramipexole: The path from D2/D3 dopamine receptor stimulation to modification of dopamine-modulated functions. Journal of psychopharmacology (Oxford, England). 2024-07-23. PMID:39041250. |
the functions considered are modulated by midbrain dopaminergic nuclei: locomotion - substantia nigra pars compacta (snc), reinforcement/motivation - ventral tegmental area (vta), sympathetic activity (as reflected in pupil function) - vta; arousal - ventral periaqueductal grey (vpag), with contributions from vta and snc. |
2024-07-23 |
2024-07-25 |
Not clear |
| Taylor Russo, Markus Riesslan. Lipid accumulation drives cellular senescence in dopaminergic neurons. Aging. vol undefined. 2024-07-21. PMID:39033779. |
parkinson's disease (pd) is an age-related movement disorder caused by the loss of dopaminergic (da) neurons of the substantia nigra pars compacta (snpc) of the midbrain, however, the underlying cause(s) of this da neuron loss in pd is unknown and there are currently no effective treatment options to prevent or slow neuronal loss or the progression of related symptoms. |
2024-07-21 |
2024-07-24 |
Not clear |
| Roshan Lal, Aditi Singh, Shivam Watts, Kanwaljit Chopr. Experimental models of Parkinson's disease: Challenges and Opportunities. European journal of pharmacology. 2024-07-19. PMID:39029778. |
parkinson's disease (pd) is a widespread neurodegenerative disorder occurs due to the degradation of dopaminergic neurons present in the substantia nigra pars compacta (snpc). |
2024-07-19 |
2024-07-22 |
mouse |
| Zhihao Lin, Changzhou Ying, Xiaoli Si, Naijia Xue, Yi Liu, Ran Zheng, Ying Chen, Jiali Pu, Baorong Zhan. NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation. Neural regeneration research. 2024-07-12. PMID:38993139. |
parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra compacta. |
2024-07-12 |
2024-07-14 |
Not clear |
| Ao Wang, Guangshang Zhong, Mengjiao Ying, Zhuling Fang, Ying Chen, Haojie Wang, Chunjing Wang, Changqing Liu, Yu Gu. Inhibition of NLRP3 inflammasome ameliorates LPS-induced neuroinflammatory injury in mice via PINK1/Parkin pathway. Neuropharmacology. 2024-07-07. PMID:38972372. |
parkinson's disease (pd) is characterized by the severe loss of dopaminergic neurons in the substantia nigra pars compacta, leading to motor dysfunction. |
2024-07-07 |
2024-07-11 |
mouse |
| Fatema Currim, Reeya Tanwar, Josephine M Brown-Leung, Neha Paranjape, Jennifer Liu, Laurie H Sanders, Jonathan A Doorn, Jason R Canno. Selective dopaminergic neurotoxicity modulated by inherent cell-type specific neurobiology. Neurotoxicology. 2024-07-04. PMID:38964509. |
hallmark features of pd pathology are the formation of lewy bodies in neuromelanin-containing dopaminergic neurons of the substantia nigra pars compacta (snpc), and the subsequent irreversible death of these neurons. |
2024-07-04 |
2024-07-11 |
Not clear |
| Md Reyaz Alam, Vaishali Dobhal, Shamsher Sing. Neuroprotective potential of solanesol against tramadol induced zebrafish model of Parkinson's disease: insights from neurobehavioral, molecular, and neurochemical evidence. Drug and chemical toxicology. 2024-06-28. PMID:38938099. |
parkinson's disease (pd) is a prevalent neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (snpc) and subsequent depletion of dopamine in the striatum. |
2024-06-28 |
2024-06-30 |
human |
| Vidhi Bhatt, Halak Shukla, Anand Krishna Tiwar. Parkinson's Disease and Mitotherapy-Based Approaches towards α-Synucleinopathies. Journal of integrative neuroscience. vol 23. issue 6. 2024-06-28. PMID:38940084. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain and the formation of intracellular protein aggregates known as lewy bodies, of which a major component is the protein α-synuclein. |
2024-06-28 |
2024-06-30 |
Not clear |
| Sandeep Sathyanandan Nair, Srinivasa Chakravarth. A Computational Model of Deep Brain Stimulation for Parkinson's Disease Tremor and Bradykinesia. Brain sciences. vol 14. issue 6. 2024-06-27. PMID:38928620. |
the loss of dopaminergic neurons in the substantia nigra pars compacta (snc) leads to an array of dysfunctions in the functioning of the basal ganglia (bg) circuitry that manifests into pd. |
2024-06-27 |
2024-06-29 |
Not clear |
| Hayato Itoh, Masahiro Oda, Shinji Saiki, Koji Kamagata, Wataru Sako, Kei-Ichi Ishikawa, Nobutaka Hattori, Shigeki Aoki, Kensaku Mor. Preliminary study of substantia nigra analysis by tensorial feature extraction. International journal of computer assisted radiology and surgery. 2024-06-27. PMID:38935246. |
since one of the characteristics of pd is the progressive loss of dopaminergic neurons in the substantia nigra pars compacta, we propose a feature extraction method for analysing the differences in the substantia nigra between pd and non-pd patients. |
2024-06-27 |
2024-06-29 |
Not clear |
| Vittorio Calabrese, Naomi Osakabe, Foziya Khan, Uwe Wenzel, Sergio Modafferi, Lidia Nicolosi, Tilman Fritsch, Ursula M Jacob, Ali S Abdelhameed, Luay Rasha. Frankincense: A neuronutrient to approach Parkinson's disease treatment. Open medicine (Warsaw, Poland). vol 19. issue 1. 2024-06-24. PMID:38911256. |
parkinson's disease (pd), characterized by tremor, slowness of movement, stiffness, and poor balance, is due to a significant loss of dopaminergic neurons in the substantia nigra pars compacta and dopaminergic nerve terminals in the striatum with deficit of dopamine. |
2024-06-24 |
2024-06-26 |
Not clear |
| Tiziano Balzano, Natalia López-González Del Rey, Noelia Esteban-García, Alejandro Reinares-Sebastián, José A Pineda-Pardo, Inés Trigo-Damas, José A Obeso, Javier Bles. Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates. NPJ Parkinson's disease. vol 10. issue 1. 2024-06-19. PMID:38886348. |
dopaminergic neurons in the ventral tier of the substantia nigra pars compacta (snc) degenerate prominently in parkinson's disease (pd), while those in the dorsal tier and ventral tegmental area are relatively spared. |
2024-06-19 |
2024-06-21 |
monkey |
| Patrick Oluwole Abolarin, Abdulbasit Amin, Abdulrazaq Bidemi Nafiu, Olalekan Michael Ogundele, Bamidele Victor Owoyel. Optimization of Parkinson's disease therapy with plant extracts and nutrition's evolving roles. IBRO neuroscience reports. vol 17. 2024-06-14. PMID:38872839. |
parkinson's disease (pd) is a neurodegenerative disease characterized by death of dopaminergic neurons in the substantia nigra pars compacta (snpc). |
2024-06-14 |
2024-06-16 |
Not clear |
| Jane E Manganaro, Katy Emanuel, Benjamin G Lamberty, Joseph W George, Kelly L Stauc. Pink1/Parkin deficiency alters circulating lymphocyte populations and increases platelet-T cell aggregates in rats. Research square. 2024-06-10. PMID:38854001. |
parkinson's disease (pd) is the most common progressive neurodegenerative movement disorder and results from the selective loss of dopaminergic neurons in the substantia nigra pars compacta. |
2024-06-10 |
2024-06-14 |
rat |
| Jiayu Chen, Qinghao Meng, Yuruo Zhang, Yue Liang, Jianhua Ding, Xian Xia, Gang H. TrueTH: A user-friendly deep learning approach for robust dopaminergic neuron detection. Neuroscience letters. 2024-06-10. PMID:38857698. |
parkinson's disease (pd) entails the progressive loss of dopaminergic (da) neurons in the substantia nigra pars compacta (snc), leading to movement-related impairments. |
2024-06-10 |
2024-06-14 |
Not clear |
| Demetra Ballardin, Leila Makrini-Maleville, Alexander Seper, Emmanuel Valjent, Heike Rebhol. 5-HT4R agonism reduces L-DOPA-induced dyskinesia via striatopallidal neurons in unilaterally 6-OHDA lesioned mice. Neurobiology of disease. 2024-06-09. PMID:38852753. |
parkinson's disease is caused by a selective vulnerability and cell loss of dopaminergic neurons of the substantia nigra pars compacta and, consequently, striatal dopamine depletion. |
2024-06-09 |
2024-06-14 |
mouse |
| Diana A Quintero-Espinosa, Marlene Jimenez-Del-Rio, Carlos Velez-Pard. LRRK2 Kinase Inhibitor PF-06447475 Protects Drosophila melanogaster against Paraquat-Induced Locomotor Impairment, Life Span Reduction, and Oxidative Stress. Neurochemical research. 2024-06-07. PMID:38847910. |
parkinson's disease (pd) is a complex multifactorial progressive neurodegenerative disease characterized by locomotor alteration due to the specific deterioration of dopaminergic (daergic) neurons in the substantia nigra pars compacta (snpc). |
2024-06-07 |
2024-06-10 |
human |
| Ozge Akyazı, Dılara Korkmaz, Sule Coskun Cevhe. Experimental Parkinson Models and Green Chemistry Approach. Behavioural brain research. 2024-06-06. PMID:38844056. |
motor findings in parkinson's occur as a result of the degeneration of dopaminergic neurons starting in the substantia nigra pars compacta and ending in the putamen and caudate nucleus. |
2024-06-06 |
2024-06-10 |
Not clear |
| Yangjing Lv, Miaoliang Fan, Jiayan He, Xiaoxin Song, Jianan Guo, Bianbian Gao, Jingqi Zhang, Changjun Zhang, YuanYuan Xi. Discovery of novel benzimidazole derivatives as selective and reversible monoamine oxidase B inhibitors for Parkinson's disease treatment. European journal of medicinal chemistry. vol 274. 2024-06-05. PMID:38838545. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. |
2024-06-05 |
2024-06-08 |
human |
| Tania Arora, Gaurav Sharma, Vikash Prashar, Randeep Singh, Arti Sharma, Harish Changotra, Jyoti Parkas. Mechanistic Evaluation of miRNAs and Their Targeted Genes in the Pathogenesis and Therapeutics of Parkinson's Disease. Molecular neurobiology. 2024-06-01. PMID:38823001. |
pd is mainly caused by the demolition of the primary dopamine neurotransmitter secretory cells and dopaminergic or dopamine secretory neurons in the substantia nigra pars compacta of the midbrain, which are majorly responsible for motor functions. |
2024-06-01 |
2024-06-03 |
Not clear |