| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyoungjune Pak, Lauri Nummenma. Brain dopamine receptor system is not altered in obesity: Bayesian and frequentist meta-analyses. Human brain mapping. 2023-11-11. PMID:37950852. |
feeding induces dopamine release in the striatum, and a dysfunction of the dopaminergic reward system can lead to overeating, and obesity. |
2023-11-11 |
2023-11-20 |
human |
| Patricia Alejandra Brand-Rubalcava, Aldo Rafael Tejeda-Mart\\xc3\\xadnez, Orfil Gonz\\xc3\\xa1lez-Reynoso, Angelica Yanet N\\xc3\\xa1poles-Medina, Ver\\xc3\\xb3nica Chaparro-Huerta, Mario Eduardo Flores-Sot. \\xce\\xb2-Caryophyllene decreases neuroinflammation and exerts neuroprotection of dopaminergic neurons in a model of hemiparkinsonism through inhibition of the NLRP3 inflammasome. Parkinsonism & related disorders. vol 117. 2023-11-04. PMID:37924806. |
parkinson's disease represents a neurodegenerative condition characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta (snpc), resulting in diminished dopamine levels in the striatum (str) and chronic neuroinflammation. |
2023-11-04 |
2023-11-08 |
Not clear |
| Hye Yun Kim, Jieun Lee, Hyun-Jin Kim, Byeong Eun Lee, Jaewook Jeong, Eun Jeong Cho, Hyun-Jun Jang, Kyeong Jin Shin, Min Ji Kim, Young Chan Chae, Seung Eun Lee, Kyungjae Myung, Ja-Hyun Baik, Pann-Ghill Suh, Jae-Ick Ki. PLC\\xce\\xb31 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III. Experimental & molecular medicine. 2023-11-01. PMID:37907739. |
we found that cell type-specific deletion of plc\xce\xb31 does not adversely affect the development and cellular morphology of midbrain dopamine neurons but does facilitate dopamine release from dopaminergic axon terminals in the striatum. |
2023-11-01 |
2023-11-08 |
mouse |
| Rafael Franco, Joan Serrano-Mar\\xc3\\xadn, Gemma Navarro, Rafael Rivas-Santisteba. The NADPH Link between the Renin Angiotensin System and the Antioxidant Mechanisms in Dopaminergic Neurons. Antioxidants (Basel, Switzerland). vol 12. issue 10. 2023-10-30. PMID:37891948. |
the production of ras peptides and the expression of several ras enzymes and receptors in dopaminergic neurons of the substantia nigra has raised expectations in the therapy of parkinson's disease, a neurodegenerative condition characterized by lack of dopamine in the striatum, the motor control region of the mammalian brain. |
2023-10-30 |
2023-11-08 |
Not clear |
| Sonia G Prieto, Maria Camila Almeida, Jo\\xc3\\xa3o C S Silva, Elaine Del-Bel, Marcela B Echeverr. Extrapyramidal Side Effects with Chronic Atypical Antipsychotic Can Be Predicted by Labeling Pattern of FosB and phosphoThr Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893051. |
extrapyramidal side effects with chronic atypical antipsychotic can be predicted by labeling pattern of fosb and phosphothr extrapyramidal side effects (eps) can be induced by neuroleptics that regulate the expression of transcription factor fosb and dopaminergic mediator darpp-32 in the striatum. |
2023-10-30 |
2023-11-08 |
mouse |
| Chang Li, Osama F Elabi, Tim Fieblinger, M Angela Cenc. Structural-functional properties of direct-pathway striatal neurons at early and chronic stages of dopamine denervation. The European journal of neuroscience. 2023-10-25. PMID:37876330. |
at both the time points studied (5 and 28\xe2\x80\x89days following 6-ohda lesion), there was a complete loss of dopaminergic fibres through the dorsolateral striatum. |
2023-10-25 |
2023-11-08 |
mouse |
| Shenyu Zhai, Qiaoling Cui, DeNard V Simmons, D James Surmeie. Distributed dopaminergic signaling in the basal ganglia and its relationship to motor disability in Parkinson's disease. Current opinion in neurobiology. vol 83. 2023-10-22. PMID:37866012. |
it has been thought that loss of dopaminergic signaling in one basal ganglia region - the striatum - was solely responsible for the network pathophysiology causing pd motor symptoms. |
2023-10-22 |
2023-11-08 |
mouse |
| Lin Zhou, Rongjie Yang, Xinru Li, Nuo Dong, Boyu Zhu, Jingjing Wang, Xingyu Lin, Bin S. COF-Coated Microelectrode for Space-Confined Electrochemical Sensing of Dopamine in Parkinson's Disease Model Mouse Brain. Journal of the American Chemical Society. 2023-10-20. PMID:37859408. |
parkinson's disease (pd) is a progressive neurodegenerative disorder causing the loss of dopaminergic neurons in the substantia nigra and the drastic depletion of dopamine (da) in the striatum; thus, da can act as a marker for pd diagnosis and therapeutic evaluation. |
2023-10-20 |
2023-11-08 |
mouse |
| Pol Bech, Sylvain Crochet, Robin Dard, Parviz Ghaderi, Yanqi Liu, Meriam Malekzadeh, Carl C H Petersen, Mauro Pulin, Anthony Renard, Christos Sourmpi. Striatal Dopamine Signals and Reward Learning. Function (Oxford, England). vol 4. issue 6. 2023-10-16. PMID:37841525. |
here, we review evidence suggesting that midbrain dopaminergic neurons signal reward prediction error, driving synaptic plasticity in the striatum underlying learning. |
2023-10-16 |
2023-11-08 |
Not clear |
| Chun Cui, Yun Shi, Hui Hong, Yu Zhou, Chenmeng Qiao, Liping Zhao, Xuebing Jia, Weijiang Zhao, Yanqin She. 5-HT4 Receptor is Protective for MPTP-induced Parkinson's Disease Mice Via Altering Gastrointestinal Motility or Gut Microbiota. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-10-02. PMID:37782386. |
in addition, gr 125487 pretreatment exacerbated the loss of dopaminergic neurons probably by suppressing jak2/pka/creb signaling pathway and increased reactive glia and neuroinflammation in the striatum. |
2023-10-02 |
2023-10-07 |
mouse |
| Jingbo Wang, Sabitha Joseph, Siv Vingill, Ekrem Dere, Lars Tatenhorst, Anja Ronnenberg, Paul Lingor, Christian Preisinger, Hannelore Ehrenreich, J\\xc3\\xb6rg B Schulz, Judith Stegm\\xc3\\xbclle. Loss of the parkinsonism-associated protein FBXO7 in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects. Journal of neurochemistry. 2023-09-27. PMID:37753846. |
nex-cre;fbxo7fl/fl mice revealed an increase in striatal dopamine concentrations, changes in the glutamatergic, gabaergic and dopaminergic pathways, astrogliosis and microgliosis and little or no neuronal loss in the striatum. |
2023-09-27 |
2023-10-07 |
mouse |
| Shirley D Wenker, Mar\\xc3\\xada Isabel Farias, Victoria Gradaschi, Corina Garcia, Juan Beauquis, Mar\\xc3\\xada Celeste Leal, Carina Ferrari, Xianmin Zeng, Fernando J Pitoss. Microglia-secreted TNF-\\xce\\xb1 affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors. PloS one. vol 18. issue 9. 2023-09-26. PMID:37751438. |
we first observed that transplanted human dopaminergic precursors into the striatum of immunosuppressed rats elicited an early and sustained activation of astroglial and microglial cells after 15 days' post-transplant. |
2023-09-26 |
2023-10-07 |
human |
| Brittany Liebenow, Thomas Wilson, Benjamin Maas, Emily Aladnani, Rosalyn J Moran, Jason White, Terry Lohrenz, Ihtsham Ul Haq, Mustafa S Siddiqui, Adrian W Laxton, Stephen B Tatter, P Read Montague, Kenneth T Kishid. Sub-second Dopamine Signals during Risky Decision-Making in Patients with Impulse Control Disorder. bioRxiv : the preprint server for biology. 2023-09-25. PMID:37745618. |
prior research implicates changes in striatal function and heightened dopaminergic activity in the dorsal striatum of patients with icd. |
2023-09-25 |
2023-10-07 |
Not clear |
| Meng Ji, Shi-Qin Niu, He-Yin Mi, Peng Jiang, Yue L. Vinpocetine improves dyskinesia in Parkinson's disease rats by reducing oxidative stress and activating the Wnt/\\xce\\xb2-catenin signaling pathway. Chemical biology & drug design. 2023-09-25. PMID:37749299. |
besides, h&e staining was applied to observe the changes of dopaminergic neurons in the striatum. |
2023-09-25 |
2023-10-07 |
rat |
| Yan Geng, Xinyi Long, Yuting Zhang, Yupeng Wang, Guoxing You, Wenjie Guo, Gaoming Zhuang, Yuanyuan Zhang, Xiao Cheng, Zhengqiang Yuan, Jie Za. FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA. Journal of translational medicine. vol 21. issue 1. 2023-09-22. PMID:37737187. |
parkinson's disease (pd), characterized by the progressive loss of dopaminergic neurons in the substantia nigra and striatum of brain, seriously threatens human health, and is still lack of effective treatment. |
2023-09-22 |
2023-10-07 |
human |
| Emily K DiMarco, Renata Sadibolova, Angela Jiang, Brittany Liebenow, Rachel E Jones, Ihtsham U Haq, Mustafa S Siddiqui, Devin B Terhune, Kenneth T Kishid. Time perception reflects individual differences in motor and non-motor symptoms of Parkinson's disease. Parkinsonism & related disorders. vol 114. 2023-09-04. PMID:37595329. |
notably, dopaminergic signaling in the striatum has been shown to play a critical role in the perception of time. |
2023-09-04 |
2023-09-07 |
Not clear |
| Louisa A Christie, Nicola L Brice, Anna Rowland, Louise Dickson, Rishi Anand, Martin Teall, Kevin J Doyle, Lakshminarayana Narayana, Christine Mitchell, Jenna R M Harvey, Victoria Mulligan, Lee A Dawson, Stephanie J Cragg, Mark Carlton, Roland W B\\xc3\\xbcrl. Discovery of Journal of medicinal chemistry. 2023-08-31. PMID:37651656. |
discovery of nicotinic acetylcholine receptor (nachr) \xce\xb16 subunit rna expression is relatively restricted to midbrain regions and is located presynaptically on dopaminergic neurons projecting to the striatum. |
2023-08-31 |
2023-09-07 |
Not clear |
| Peter van Ruitenbeek, Luisa Franzen, Natasha Leigh Mason, Peter Stiers, Johannes G Ramaeker. Methylphenidate as a treatment option for substance use disorder: a transdiagnostic perspective. Frontiers in psychiatry. vol 14. 2023-08-21. PMID:37599874. |
both disorders are characterized by maladaptive goal-directed behavior, impaired cognitive control, hyperactive phasic dopaminergic neurotransmission in the striatum, prefrontal hypoactivation, and reduced frontal cortex gray matter volume/density. |
2023-08-21 |
2023-09-07 |
Not clear |
| Miguel A Zamora-Ursulo, Job Perez-Becerra, Luis A Tellez, Nadia Saderi, Luis Carrillo-Rei. Reversal of pathological motor behavior in a model of Parkinson's disease by striatal dopamine uncaging. PloS one. vol 18. issue 8. 2023-08-20. PMID:37594935. |
we conclude that optical delivery of dopamine in the striatum resembles the motor effects induced by systemic injection of dopaminergic agonists in unilateral dopamine-depleted mice. |
2023-08-20 |
2023-09-07 |
mouse |
| V\\xc3\\xa9ronique Coizet, Racha Al Tannir, Arnaud Pautrat, Paul G Overto. Separation of Channels Subserving Approach and Avoidance/Escape at the Level of the Basal Ganglia and Related Brainstem Structures. Current neuropharmacology. 2023-08-18. PMID:37594168. |
in this review, we describe how brainstem structures also project to the main input structures of the basal ganglia, namely the striatum, the subthalamic nucleus and midbrain dopaminergic neurons, in the context of approach and avoidance (including escape from threat), two fundamental, mutually exclusive behavioral choices in an animal's repertoire in which the brainstem is strongly involved. |
2023-08-18 |
2023-09-07 |
Not clear |