| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zuzana Bacova, Tomas Havranek, Denisa Mihalj, Veronika Borbelyova, Kristina Kostrubanicova, Michaela Kramarova, Daniela Ostatnikova, Jan Bako. Reduced Neurite Arborization in Primary Dopaminergic Neurons in Autism-Like Shank3B-Deficient Mice. Molecular neurobiology. 2024-12-09. PMID:39654001. |
therefore, we aimed to investigate whether shank3 deficiency (shank3b) leads to changes in the morphology of primary neuronal cell cultures from dopaminergic brain regions of neonatal mouse pups and whether it results in alterations in synaptic proteins in dopaminergic nerve pathway projection areas (striatum, frontal cortex). |
2024-12-09 |
2024-12-12 |
mouse |
| Zuzana Bacova, Tomas Havranek, Denisa Mihalj, Veronika Borbelyova, Kristina Kostrubanicova, Michaela Kramarova, Daniela Ostatnikova, Jan Bako. Reduced Neurite Arborization in Primary Dopaminergic Neurons in Autism-Like Shank3B-Deficient Mice. Molecular neurobiology. 2024-12-09. PMID:39654001. |
significantly reduced neurite outgrowth was observed in primary dopaminergic neurons from the midbrain and striatum of shank3-deficient compared to wt mice. |
2024-12-09 |
2024-12-12 |
mouse |
| Zuzana Bacova, Tomas Havranek, Denisa Mihalj, Veronika Borbelyova, Kristina Kostrubanicova, Michaela Kramarova, Daniela Ostatnikova, Jan Bako. Reduced Neurite Arborization in Primary Dopaminergic Neurons in Autism-Like Shank3B-Deficient Mice. Molecular neurobiology. 2024-12-09. PMID:39654001. |
no changes in the gene expression of synaptic proteins were observed in the striatum and frontal cortex of shank3-deficient mice, but an altered gene expression profile of dopaminergic receptors was found. |
2024-12-09 |
2024-12-12 |
mouse |
| Lorenzo Sansalone, Rebekah C Evans, Emily Twedell, Renshu Zhang, Zayd M Khali. Corticonigral projections recruit substantia nigra pars lateralis dopaminergic neurons for auditory threat memories. bioRxiv : the preprint server for biology. 2024-11-22. PMID:39574768. |
dopaminergic neurons (dans) in the lateral substantia nigra project to the tail of striatum (ts), which is involved in threat conditioning. |
2024-11-22 |
2024-11-24 |
Not clear |
| Fang Wang, Xuanzhuo Liu, Mingyi Chen, Xiaoxin Xu, Ying Yang, Qiuhong Xu, Huili Zhu, Anding Xu, Mahmoud A Pouladi, Xiaohong X. Neuroprotective Role of CHCHD2 in Parkinson's Disease: Insights into the GPX4-Related Ferroptosis Pathway. Free radical biology & medicine. 2024-11-20. PMID:39566750. |
additionally, chchd2 overexpression ameliorated motor function impairment, reduced α-synuclein levels, and mitigated dopaminergic (da) neuron loss in the substantia nigra and striatum of pd mice. |
2024-11-20 |
2024-11-23 |
mouse |
| Emilio Fernández-Espejo, Fernando Rodríguez de Fonsec. Association of Hemispheric Asymmetry of Dopamine-Transporter Binding with Risk of Parkinsonian Depression. Movement disorders clinical practice. 2024-11-20. PMID:39564715. |
a direct role in pd depression for loss of dopaminergic terminals and dopamine-transporter (dat) expression in the striatum is revealed by many studies. |
2024-11-20 |
2024-11-23 |
Not clear |
| Tomohiko Yoshizawa, Makoto Funahash. Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice. Neuroscience research. 2024-11-09. PMID:39515479. |
the striatum consists of two anatomically and neurochemically distinct compartments, striosomes and the matrix, which receive dopaminergic inputs from the midbrain and exhibit distinct dopamine release dynamics in acute brain slices. |
2024-11-09 |
2024-11-17 |
mouse |
| Saeed Kayhanian, Roger A Barke. Dopamine Cell-Based Replacement Therapies. Cold Spring Harbor perspectives in medicine. 2024-11-05. PMID:39500633. |
parkinson's disease (pd) is a common disorder that has, as part of its core pathology, the loss of the nigral dopaminergic nerve cells that project to the striatum. |
2024-11-05 |
2024-11-08 |
human |
| Jin-Sun Park, Yea-Hyun Leem, Do-Yeon Kim, Jae-Min Park, Seong-Eun Kim, Hee-Sun Ki. Neuroprotective and anti-inflammatory effects of the RIPK3 inhibitor GSK872 in an MPTP-induced mouse model of Parkinson's disease. Neurochemistry international. 2024-11-04. PMID:39491747. |
gsk872 rescued mptp-induced motor impairment and inhibited tyrosine hydroxylase-positive dopaminergic cell death in the sn and striatum. |
2024-11-04 |
2024-11-06 |
mouse |
| Wisberty J Gordián-Vélez, Kevin D Browne, Jonathan H Galarraga, Dimple Chouhan, John E Duda, Rodrigo A España, H Isaac Chen, Jason A Burdick, D Kacy Culle. Dopaminergic Axon Tracts Within a Hyaluronic Acid Hydrogel Encasement to Restore the Nigrostriatal Pathway. Advanced healthcare materials. 2024-11-04. PMID:39494983. |
parkinson's disease is characterized by motor deficits emerging from insufficient dopamine in the striatum after degeneration of dopaminergic neurons and their long-projecting axons comprising the nigrostriatal pathway. |
2024-11-04 |
2024-11-06 |
rat |
| Ziyao Liu, Shijun Xiang, Bei Chen, Jian Li, Dingcheng Zhu, Hongjuan Xu, Shuo H. Parkinson Disease -Targeted Nanocapsules for Synergistic Treatment: Combining Dopamine Replacement and Neuroinflammation Mitigation. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-10-21. PMID:39431293. |
da supplementation significantly enhanced dopaminergic signaling, increasing da levels 1.8- and 3.5-fold in the striatum and substantia nigra, respectively. |
2024-10-21 |
2024-10-23 |
mouse |
| Anna Nelke, Silvia García-López, Javier R Caso, Marta P Pereir. The therapeutic use of clonal neural stem cells in experimental Parkinson´s disease. Stem cell research & therapy. vol 15. issue 1. 2024-10-10. PMID:39385216. |
parkinson´s disease (pd), the second most common neurodegenerative disease in the world, is characterized by the death or impairment of dopaminergic neurons (dan) in the substantia nigra pars compacta and dopamine depletion in the striatum. |
2024-10-10 |
2024-10-12 |
mouse |
| Zijiao Tian, Yixin Zhang, Jing Xu, Qianwen Yang, Die Hu, Jing Feng, Cong Ga. Primary cilia in Parkinson's disease: summative roles in signaling pathways, genes, defective mitochondrial function, and substantia nigra dopaminergic neurons. Frontiers in aging neuroscience. vol 16. 2024-10-05. PMID:39364348. |
parkinson's disease (pd), a neurodegenerative disease that progresses over time, is primarily caused by a gradual degradation of the dopaminergic pathway in the striatum nigra, which results in a large loss of neurons in the substantia nigra compact (snpc) and a depletion of dopamine (da). |
2024-10-05 |
2024-10-07 |
Not clear |
| Wen Cheng, Kexin Fang, Xiaorong Ouyang, Lingjing Jin, Yunping Song, Bin Y. Vagus nerve stimulation with a small total charge transfer improves motor behavior and reduces neuroinflammation in a mouse model of Parkinson's disease. Neurochemistry international. vol 180. 2024-10-04. PMID:39362497. |
our results suggest that vns improved behavioral performance in rod rotation, open field tests and pole-climbing tests in pd mice, accompanied by a decrease in the loss of dopaminergic neurons in the sn and increased th expression in the striatum. |
2024-10-04 |
2024-10-07 |
mouse |
| Nicolas Prudon, Lucía Cordero-Espinoza, Myriam Abarkan, Basile Gurchenkov, Chloé Morel, Marilyn Lepleux, Valérie De Luca, Maxime Lartigue, Hélène Cabanas, Nadège Pujol, Loanne Milvoy, Pauline Morand, Fabien Moncaubeig, Hélène Wurtz, Léa Poinçot, Maëlle De Marco, Agathe Jonckeau, Justine Pletenka, Elisa Luquet, Andrea Sovera, Jérôme Hardoüin, Inês Januario Neves, Anaïs Machado-Hitau, Kathleen Schmit, Lucie Piouceau, Solenn Guilbert, Lucie Manache-Alberici, Michaël Lanero Fidalgo, Guillaume Dabée, Thibault Dufourd, Jens Schroeder, Kévin Alessandri, Erwan Bezard, Emilie Faggiani, Maxime Feyeu. Bioreactor-produced iPSCs-derived dopaminergic neuron-containing neural microtissues innervate and normalize rotational bias in a dose-dependent manner in a Parkinson rat model. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-10-01. PMID:39353832. |
the survival of the cells was confirmed by post-mortem histological analysis, characterised by the presence of human dopaminergic neurons projecting into the host striatum. |
2024-10-01 |
2024-10-05 |
human |
| Mariangela Scarduzio, Karen L Eskow Jaunarajs, David G Standaer. Striatal cholinergic transmission in an inducible transgenic mouse model of paroxysmal non-kinesiogenic dyskinesia. Neurobiology of disease. 2024-09-29. PMID:39343248. |
altered interaction between striatonigral dopaminergic (da) inputs and local acetylcholine (ach) in striatum has long been hypothesized to play a central role in the pathophysiology of dystonia and dyskinesia. |
2024-09-29 |
2024-10-02 |
mouse |
| Dishank Patel, Ritu Soni, Jigna Sha. Decoding the Role of Nuclear Sirtuins in Parkinson's Pathogenesis. ACS chemical neuroscience. 2024-09-27. PMID:39331405. |
parkinson's disease (pd) is the second most prevailing degenerative disease that deals with dopaminergic neuronal loss and deficiency of dopamine in snpc and striatum. |
2024-09-27 |
2024-09-29 |
Not clear |
| Tae-Young Ha, Jae-Bong Kim, Yeji Kim, Sang Myun Park, Keun-A Chan. GPR40 agonist ameliorates neurodegeneration and motor impairment by regulating NLRP3 inflammasome in Parkinson's disease animal models. Pharmacological research. 2024-09-23. PMID:39313081. |
in 6-ohda-induced pd model mice, tug469 treatment improved motor impairment, preserved dopaminergic fibers and cell bodies in the striatum (st) or sn, and attenuated 6-ohda-induced microgliosis and astrogliosis in the brain. |
2024-09-23 |
2024-09-26 |
mouse |
| Hong-Yuan Chu, Liqiang Chen, Hiba Douja Chehad. Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation. Research square. 2024-09-16. PMID:39281856. |
to begin to address these questions, we injected α-synuclein (αsyn) preformed fibrils (pffs) into the dorsolateral striatum of mice to seed αsyn pathology in the cortical cortex and induce degeneration of midbrain dopaminergic neurons. |
2024-09-16 |
2024-09-19 |
mouse |
| A C Martel, P Apicell. Insights into the interaction between time and reward prediction on the activity of striatal tonically active neurons: A pilot study in rhesus monkeys. Physiological reports. vol 12. issue 17. 2024-09-09. PMID:39245818. |
prior studies have documented the role of the striatum and its dopaminergic input in time processing, but the contribution of local striatal cholinergic innervation has not been specifically investigated. |
2024-09-09 |
2024-09-11 |
monkey |