| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chang Li, Osama F Elabi, Tim Fieblinger, M Angela Cenc. Structural-functional properties of direct-pathway striatal neurons at early and chronic stages of dopamine denervation. The European journal of neuroscience. 2023-10-25. PMID:37876330. |
using 6-hydroxydopamine (6-ohda) lesions of the medial forebrain bundle as a model, we set out to compare morphological and electrophysiological properties of spns at an early versus a chronic stage of dopaminergic degeneration. |
2023-10-25 |
2023-11-08 |
mouse |
| Cintia Klaudia Finszter, R\\xc3\\xb3bert Kemecsei, Gergely Zachar, Sophie Holtkamp, Diego Echevarr\\xc3\\xada, Istv\\xc3\\xa1n Adorj\\xc3\\xa1n, \\xc3\\x81gota \\xc3\\x81d\\xc3\\xa1m, Andr\\xc3\\xa1s Csilla. Early cellular and synaptic changes in dopaminoceptive forebrain regions of juvenile mice following gestational exposure to valproate. Frontiers in neuroanatomy. vol 17. 2023-08-21. PMID:37603782. |
the morpho-functional changes found in forebrain regions of vpa-exposed mice may signify dendritic and synaptic reorganization in dopaminergic target regions, with potential translational value to similar impairments in the pathogenesis of human asd. |
2023-08-21 |
2023-09-07 |
mouse |
| Amirah E-E Aly, Tao Sun, Yongzhi Zhang, Zejun Li, Margee Kyada, Qingxi Ma, Linas Padegimas, Ozge Sesenoglu-Laird, Mark J Cooper, Nathan J McDannold, Barbara L Waszcza. Focused ultrasound enhances transgene expression of intranasal hGDNF DNA nanoparticles in the sonicated brain regions. Journal of controlled release : official journal of the Controlled Release Society. 2023-05-01. PMID:37127076. |
additionally, fus with intranasal delivery increased transgene expression in the sonicated hemisphere by over 80%, altered cellular transfection patterns at the sonication sites, and improved penetration of plasmid nps into the brain parenchyma (with a 1-fold and 3-fold increase in proximity of transgene expression to neurons in the forebrain and midbrain respectively, and a 40% increase in proximity of transgene expression to dopaminergic neurons in the substantia nigra). |
2023-05-01 |
2023-08-14 |
Not clear |
| Micha\\xc5\\x82 Sobstyl, Angelika Stapi\\xc5\\x84ska-Synie. Deep brain stimulation of the medial forebrain bundle for treatment-resistant depression - a narrative literature review. Postepy psychiatrii neurologii. vol 30. issue 3. 2023-04-21. PMID:37082768. |
also, white matter bundles connecting different structures of the reward circuit have been studied clinically as targets for dbs, including the medial forebrain bundle (mfb) - a central component of the mesolimbic dopaminergic reward circuit. |
2023-04-21 |
2023-08-14 |
Not clear |
| L Sofia Gonzalez, Austen A Fisher, Shane P D'Souza, Evelin M Cotella, Richard A Lang, J Elliott Robinso. Ventral striatum dopamine release encodes unique properties of visual stimuli in mice. eLife. vol 12. 2023-04-17. PMID:37067979. |
in this circuitry, ascending dopaminergic projections from the ventral midbrain innervate targets throughout the limbic forebrain, such as the ventral striatum/nucleus accumbens (nac). |
2023-04-17 |
2023-08-14 |
mouse |
| Hellen Weinschutz Mendes, Uma Neelakantan, Yunqing Liu, Sarah E Fitzpatrick, Tianying Chen, Weimiao Wu, April Pruitt, David S Jin, Priyanka Jamadagni, Marina Carlson, Cheryl M Lacadie, Kristen D Enriquez, Ningshan Li, Dejian Zhao, Sundas Ijaz, Catalina Sakai, Christina Szi, Brendan Rooney, Marcus Ghosh, Ijeoma Nwabudike, Andrea Gorodezky, Sumedha Chowdhury, Meeraal Zaheer, Sarah McLaughlin, Joseph M Fernandez, Jia Wu, Jeffrey A Eilbott, Brent Vander Wyk, Jason Rihel, Xenophon Papademetris, Zuoheng Wang, Ellen J Hoffma. High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways. Cell reports. vol 42. issue 3. 2023-03-18. PMID:36933215. |
whole-brain mapping identifies the forebrain and cerebellum as the most significant contributors to brain size differences, while regions involved in sensory-motor control, particularly dopaminergic regions, are associated with altered baseline brain activity. |
2023-03-18 |
2023-08-14 |
zebrafish |
| Sara El Idrissi, Nada Fath, Hind Ibork, Khalid Taghzouti, Meryem Alamy, Oualid Abbouss. Restraint Stress Exacerbates Apoptosis in a 6-OHDA Animal Model of Parkinson Disease. Neurotoxicity research. 2023-01-12. PMID:36633788. |
thus, in this study, we aimed to investigate the effect of subchronic restraint stress on striatal dopaminergic activity, iron, p53, caspase-3, and plasmatic acetylcholinesterase (ache) levels in male wistar rat model of pd induced by administration of 6-hydroxydopamine (6-ohda) in the medial forebrain bundle (mfb). |
2023-01-12 |
2023-08-14 |
rat |
| Daniel Rees, Amy L Beynon, Mariah J Lelos, Gaynor A Smith, Luke D Roberts, Lyndsey Phelps, Stephen B Dunnett, Alwena H Morgan, Rowan M Brown, Timothy Wells, Jeffrey S Davie. Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson's Disease. Cellular and molecular neurobiology. 2022-09-15. PMID:36107359. |
however, the potential protective effect of acyl-ghrelin on substantia nigra pars compacta (snpc) dopaminergic neurones and consequent behavioural correlates in the more widely used 6-hydroxydopamine (6-ohda) rat medial forebrain bundle (mfb) lesion model of pd are unknown. |
2022-09-15 |
2023-08-14 |
rat |
| Airi Yoshimoto, Yusuke Shibata, Mikuru Kudara, Yuji Ikegaya, Nobuyoshi Matsumot. Enhancement of motor cortical gamma oscillations and sniffing activity by medial forebrain bundle stimulation precedes locomotion. eNeuro. 2022-06-14. PMID:35701167. |
the medial forebrain bundle (mfb) is a white matter pathway that traverses through mesolimbic structures and includes dopaminergic neural fibers ascending from the ventral tegmental area. |
2022-06-14 |
2023-08-14 |
Not clear |
| S Ram\\xc3\\xadrez-Calero, J R Paula, E Otjacques, R Rosa, T Ravasi, C Schunte. Neuro-molecular characterization of fish cleaning interactions. Scientific reports. vol 12. issue 1. 2022-05-19. PMID:35589869. |
here we show, using transcriptomics, that most of the transcriptional response in both species was regulated in the hindbrain and forebrain regions and that the interacting behaviour responses of l. dimidiatus involved immediate early gene alteration, dopaminergic and glutamatergic pathways, the expression of neurohormones (such as isotocin) and steroids (e.g. |
2022-05-19 |
2023-08-13 |
Not clear |
| Alexandra Tallafuss, Sarah J Stednitz, Mae Voeun, Anastasia Levichev, Johannes Larsch, Judith Eisen, Philip Washbourn. Egr1 is necessary for forebrain dopaminergic signaling during social behavior. eNeuro. 2022-03-29. PMID:35346959. |
egr1 is necessary for forebrain dopaminergic signaling during social behavior. |
2022-03-29 |
2023-08-13 |
Not clear |
| Laszlo Peczely, Tamas Ollmann, Kristof Laszlo, Laszlo Lenard, Anthony A Grac. The D2-like dopamine receptor agonist quinpirole microinjected into the ventral pallidum dose-dependently inhibits the VTA and induces place aversion. The international journal of neuropsychopharmacology. 2022-03-29. PMID:35348731. |
the ventral pallidum (vp) is a dopaminoceptive forebrain structure regulating the ventral tegmental area (vta) dopaminergic population activity. |
2022-03-29 |
2023-08-13 |
rat |
| Markus Westphal, Paolo Panza, Edda Kastenhuber, Johanna Wehrle, Wolfgang Drieve. Wnt/\\xce\\xb2-catenin signaling promotes neurogenesis in the diencephalospinal dopaminergic system of embryonic zebrafish. Scientific reports. vol 12. issue 1. 2022-01-20. PMID:35046434. |
wnt/\xce\xb2-catenin signaling is important for mammalian midbrain dopaminergic neurogenesis, while little is known about its role in ventral forebrain dopaminergic development. |
2022-01-20 |
2023-08-13 |
zebrafish |
| Thomas Lissek, Andry Andrianarivelo, Estefani Saint-Jour, Marie-Charlotte Allichon, Hanke Gwendolyn Bauersachs, Merie Nassar, Charlotte Piette, Priit Pruunsild, Yan-Wei Tan, Benoit Forget, Nicolas Heck, Jocelyne Caboche, Laurent Venance, Peter Vanhoutte, Hilmar Badin. Npas4 regulates medium spiny neuron physiology and gates cocaine-induced hyperlocomotion. EMBO reports. vol 22. issue 12. 2021-12-06. PMID:34661342. |
npas4 is induced by synaptic stimuli that cause calcium influx, but not dopaminergic or pka-stimulating input, in mouse medium spiny neurons and human ipsc-derived forebrain organoids. |
2021-12-06 |
2023-08-13 |
mouse |
| Rayanne Poletti Guimar\\xc3\\xa3es, Danilo Leandro Ribeiro, Keila Bariotto Dos Santos, L\\xc3\\xadvea Dornela Godoy, Mirella Rosine Corr\\xc3\\xaaa, Fernando Eduardo Padovan-Net. The 6-hydroxydopamine Rat Model of Parkinson's Disease. Journal of visualized experiments : JoVE. issue 176. 2021-11-15. PMID:34779439. |
the infusion of the neurotoxin, 6-hydroxydopamine (6-ohda), into a medial forebrain bundle (mfb) of rats reproduces the severe destruction of dopaminergic neurons and simulates pd symptoms. |
2021-11-15 |
2023-08-13 |
human |
| Kaya von Eugen, Sepideh Tabrik, Onur G\\xc3\\xbcnt\\xc3\\xbcrk\\xc3\\xbcn, Felix Str\\xc3\\xb6cken. A comparative analysis of the dopaminergic innervation of the executive caudal nidopallium in pigeon, chicken, zebra finch, and carrion crow. The Journal of comparative neurology. vol 528. issue 17. 2021-11-11. PMID:32020608. |
in both carrion crow and zebra finch, we identified four different subareas of high dopaminergic innervation that span the entire caudal forebrain. |
2021-11-11 |
2023-08-13 |
chicken |
| Jonathan T Perelmuter, Kelsey N Hom, Robert A Mohr, Lina Demis, Spencer Kim, Alena Chernenko, Miky Timothy, Mollie A Middleton, Joseph A Sisneros, Paul M Forlan. Testosterone Treatment Mimics Seasonal Downregulation of Dopamine Innervation in the Auditory System of Female Midshipman Fish. Integrative and comparative biology. vol 61. issue 1. 2021-11-09. PMID:33974077. |
t-treatment also reduced th-ir fibers in the forebrain dopaminergic cell group that projects to the inner ear, and likely to the auditory hindbrain. |
2021-11-09 |
2023-08-13 |
Not clear |
| Ingrid Morales, Ricardo Puertas-Avenda\\xc3\\xb1o, Alberto Sanchez, Adrian Perez-Barreto, Clara Rodriguez-Sabate, Manuel Rodrigue. Astrocytes and retrograde degeneration of nigrostriatal dopaminergic neurons in Parkinson's disease: removing axonal debris. Translational neurodegeneration. vol 10. issue 1. 2021-11-06. PMID:34727977. |
neuroinflammation accelerates the cell degeneration and may be critical for the transition between the slow physiological and the rapid pathological degeneration of da cells, particularly when it activates microglial cells of the medial forebrain bundle near dopaminergic axons. |
2021-11-06 |
2023-08-13 |
Not clear |
| Owen M Peters, Alexandra Weiss, Jake Metterville, Lina Song, Robert Logan, Gaynor A Smith, Michael A Schwarzschild, Christian Mueller, Robert H Brown, Marc Freema. Genetic diversity of axon degenerative mechanisms in models of Parkinson's disease. Neurobiology of disease. vol 155. 2021-09-03. PMID:33892050. |
in sarm1 deficient mice, we observed a significant delay in the degeneration of severed dopaminergic axons distal to a 6-ohda lesion of the medial forebrain bundle (mfb) in the nigrostriatal tract, and an accompanying rescue of morphological, biochemical and behavioural phenotypes. |
2021-09-03 |
2023-08-13 |
mouse |
| Katarzyna Z Kuter, \\xc5\\x81ukasz Olech, Urszula G\\xc5\\x82owacka, Martyna Paleczn. Increased Beta-Hydroxybutyrate Level Is Not Sufficient for the Neuroprotective Effect of Long-Term Ketogenic Diet in an Animal Model of Early Parkinson's Disease. Exploration of Brain and Liver Energy Metabolism Markers. International journal of molecular sciences. vol 22. issue 14. 2021-07-30. PMID:34299176. |
a progressive, selective dopaminergic medium size lesion was induced by 6-ohda injection into the medial forebrain bundle. |
2021-07-30 |
2023-08-13 |
human |