| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chang Li, Osama F Elabi, Tim Fieblinger, M Angela Cenc. Structural-functional properties of direct-pathway striatal neurons at early and chronic stages of dopamine denervation. The European journal of neuroscience. 2023-10-25. PMID:37876330. |
using 6-hydroxydopamine (6-ohda) lesions of the medial forebrain bundle as a model, we set out to compare morphological and electrophysiological properties of spns at an early versus a chronic stage of dopaminergic degeneration. |
2023-10-25 |
2023-11-08 |
mouse |
| Micha\\xc5\\x82 Sobstyl, Angelika Stapi\\xc5\\x84ska-Synie. Deep brain stimulation of the medial forebrain bundle for treatment-resistant depression - a narrative literature review. Postepy psychiatrii neurologii. vol 30. issue 3. 2023-04-21. PMID:37082768. |
also, white matter bundles connecting different structures of the reward circuit have been studied clinically as targets for dbs, including the medial forebrain bundle (mfb) - a central component of the mesolimbic dopaminergic reward circuit. |
2023-04-21 |
2023-08-14 |
Not clear |
| Sara El Idrissi, Nada Fath, Hind Ibork, Khalid Taghzouti, Meryem Alamy, Oualid Abbouss. Restraint Stress Exacerbates Apoptosis in a 6-OHDA Animal Model of Parkinson Disease. Neurotoxicity research. 2023-01-12. PMID:36633788. |
thus, in this study, we aimed to investigate the effect of subchronic restraint stress on striatal dopaminergic activity, iron, p53, caspase-3, and plasmatic acetylcholinesterase (ache) levels in male wistar rat model of pd induced by administration of 6-hydroxydopamine (6-ohda) in the medial forebrain bundle (mfb). |
2023-01-12 |
2023-08-14 |
rat |
| Daniel Rees, Amy L Beynon, Mariah J Lelos, Gaynor A Smith, Luke D Roberts, Lyndsey Phelps, Stephen B Dunnett, Alwena H Morgan, Rowan M Brown, Timothy Wells, Jeffrey S Davie. Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson's Disease. Cellular and molecular neurobiology. 2022-09-15. PMID:36107359. |
however, the potential protective effect of acyl-ghrelin on substantia nigra pars compacta (snpc) dopaminergic neurones and consequent behavioural correlates in the more widely used 6-hydroxydopamine (6-ohda) rat medial forebrain bundle (mfb) lesion model of pd are unknown. |
2022-09-15 |
2023-08-14 |
rat |
| Airi Yoshimoto, Yusuke Shibata, Mikuru Kudara, Yuji Ikegaya, Nobuyoshi Matsumot. Enhancement of motor cortical gamma oscillations and sniffing activity by medial forebrain bundle stimulation precedes locomotion. eNeuro. 2022-06-14. PMID:35701167. |
the medial forebrain bundle (mfb) is a white matter pathway that traverses through mesolimbic structures and includes dopaminergic neural fibers ascending from the ventral tegmental area. |
2022-06-14 |
2023-08-14 |
Not clear |
| Rayanne Poletti Guimar\\xc3\\xa3es, Danilo Leandro Ribeiro, Keila Bariotto Dos Santos, L\\xc3\\xadvea Dornela Godoy, Mirella Rosine Corr\\xc3\\xaaa, Fernando Eduardo Padovan-Net. The 6-hydroxydopamine Rat Model of Parkinson's Disease. Journal of visualized experiments : JoVE. issue 176. 2021-11-15. PMID:34779439. |
the infusion of the neurotoxin, 6-hydroxydopamine (6-ohda), into a medial forebrain bundle (mfb) of rats reproduces the severe destruction of dopaminergic neurons and simulates pd symptoms. |
2021-11-15 |
2023-08-13 |
human |
| Ingrid Morales, Ricardo Puertas-Avenda\\xc3\\xb1o, Alberto Sanchez, Adrian Perez-Barreto, Clara Rodriguez-Sabate, Manuel Rodrigue. Astrocytes and retrograde degeneration of nigrostriatal dopaminergic neurons in Parkinson's disease: removing axonal debris. Translational neurodegeneration. vol 10. issue 1. 2021-11-06. PMID:34727977. |
neuroinflammation accelerates the cell degeneration and may be critical for the transition between the slow physiological and the rapid pathological degeneration of da cells, particularly when it activates microglial cells of the medial forebrain bundle near dopaminergic axons. |
2021-11-06 |
2023-08-13 |
Not clear |
| Owen M Peters, Alexandra Weiss, Jake Metterville, Lina Song, Robert Logan, Gaynor A Smith, Michael A Schwarzschild, Christian Mueller, Robert H Brown, Marc Freema. Genetic diversity of axon degenerative mechanisms in models of Parkinson's disease. Neurobiology of disease. vol 155. 2021-09-03. PMID:33892050. |
in sarm1 deficient mice, we observed a significant delay in the degeneration of severed dopaminergic axons distal to a 6-ohda lesion of the medial forebrain bundle (mfb) in the nigrostriatal tract, and an accompanying rescue of morphological, biochemical and behavioural phenotypes. |
2021-09-03 |
2023-08-13 |
mouse |
| Katarzyna Z Kuter, \\xc5\\x81ukasz Olech, Urszula G\\xc5\\x82owacka, Martyna Paleczn. Increased Beta-Hydroxybutyrate Level Is Not Sufficient for the Neuroprotective Effect of Long-Term Ketogenic Diet in an Animal Model of Early Parkinson's Disease. Exploration of Brain and Liver Energy Metabolism Markers. International journal of molecular sciences. vol 22. issue 14. 2021-07-30. PMID:34299176. |
a progressive, selective dopaminergic medium size lesion was induced by 6-ohda injection into the medial forebrain bundle. |
2021-07-30 |
2023-08-13 |
human |
| M\\xc3\\xa1t\\xc3\\xa9 D D\\xc3\\xb6br\\xc3\\xb6ssy, Chockalingam Ramanathan, Danesh Ashouri Vajari, Yixin Tong, Thomas Schlaepfer, Volker A Coene. Neuromodulation in Psychiatric disorders: Experimental and Clinical evidence for reward and motivation network Deep Brain Stimulation: Focus on the medial forebrain bundle. The European journal of neuroscience. vol 53. issue 1. 2021-06-28. PMID:32931064. |
as one of the hypotheses is that depression engenders changes in the reward and motivational networks, the review looks at how stimulation of the medial forebrain bundle impacts the dopaminergic system. |
2021-06-28 |
2023-08-13 |
Not clear |
| Stephanie Thiele, Arnd S\\xc3\\xb6rensen, Jasmin Weis, Friederike Braun, Philipp T Meyer, Volker A Coenen, M\\xc3\\xa1t\\xc3\\xa9 D D\\xc3\\xb6br\\xc3\\xb6ss. Deep Brain Stimulation of the Medial Forebrain Bundle in a Rodent Model of Depression: Exploring Dopaminergic Mechanisms with Raclopride and Micro-PET. Stereotactic and functional neurosurgery. vol 98. issue 1. 2021-05-17. PMID:31982883. |
deep brain stimulation of the medial forebrain bundle in a rodent model of depression: exploring dopaminergic mechanisms with raclopride and micro-pet. |
2021-05-17 |
2023-08-13 |
Not clear |
| Sini K Koski, Sakari Leino, Pertti Panula, Saara Rannanp\\xc3\\xa4\\xc3\\xa4, Outi Salmine. Genetic lack of histamine upregulates dopamine neurotransmission and alters rotational behavior but not levodopa-induced dyskinesia in a mouse model of Parkinson's disease. Neuroscience letters. vol 729. 2021-05-14. PMID:32224226. |
dopaminergic lesions were induced in histidine decarboxylase knockout and wildtype mice by 6-hydroxydopamine injections into the medial forebrain bundle. |
2021-05-14 |
2023-08-13 |
mouse |
| Ke Chen, Roberto Vincis, Alfredo Fontanin. Disruption of Cortical Dopaminergic Modulation Impairs Preparatory Activity and Delays Licking Initiation. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 4. 2020-06-02. PMID:30721984. |
we first demonstrate licking deficits and concurrent alterations of spiking activity in alm of head-fixed mice with unilateral depletion of dopaminergic neurons (i.e., mice injected with 6-ohda into the medial forebrain bundle). |
2020-06-02 |
2023-08-13 |
mouse |
| Jonas A Hosp, V A Coenen, M Rijntjes, K Egger, H Urbach, C Weiller, M Reiser. Ventral tegmental area connections to motor and sensory cortical fields in humans. Brain structure & function. vol 224. issue 8. 2020-02-24. PMID:31440906. |
using a dti-based global tractography approach, we recently characterized the superolateral branch of the medial forebrain bundle (slmfb), a prominent pathway providing dopaminergic (and other transmitters) innervation for the pre-frontal cortex (coenen et al., neuroimage clin 18:770-783, 2018). |
2020-02-24 |
2023-08-13 |
Not clear |
| Sakari Leino, Sini K Koski, Raisa H\\xc3\\xa4nninen, Tuukka Tapanainen, Saara Rannanp\\xc3\\xa4\\xc3\\xa4, Outi Salmine. Attenuated dopaminergic neurodegeneration and motor dysfunction in hemiparkinsonian mice lacking the \\xce\\xb15 nicotinic acetylcholine receptor subunit. Neuropharmacology. vol 138. 2019-02-13. PMID:29940207. |
unilateral dopaminergic lesions were induced in wild-type and \xce\xb15-ko mice by 6-hydroxydopamine injections into the striatum or the medial forebrain bundle. |
2019-02-13 |
2023-08-13 |
mouse |
| Mei Liu, Adam D Bachstetter, Wayne A Cass, Jonathan Lifshitz, Guoying Bin. Pioglitazone Attenuates Neuroinflammation and Promotes Dopaminergic Neuronal Survival in the Nigrostriatal System of Rats after Diffuse Brain Injury. Journal of neurotrauma. vol 34. issue 2. 2018-01-12. PMID:27142118. |
dopaminergic axonal damage and microglial activation were revealed using immunohistochemistry in the medial forebrain bundle at 1 day post-injury. |
2018-01-12 |
2023-08-13 |
rat |
| Yuan Yao, Chen Huang, Ping Gu, Tieqiao We. Combined MSC-Secreted Factors and Neural Stem Cell Transplantation Promote Functional Recovery of PD Rats. Cell transplantation. vol 25. issue 6. 2017-03-06. PMID:26607204. |
the cm-nscs were able to differentiate into dopaminergic neurons in the ventral tegmental area (vta) and medial forebrain bundle (mfb), and migrated around the lesion site. |
2017-03-06 |
2023-08-13 |
rat |
| Sunghee E Park, Kang-Il Song, Jun-Kyo F Suh, Inchan You. Characteristics of the neuronal firing patterns in the subthalamic nucleus with graded dopaminergic cell loss in the nigrostriatal pathway. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2015. 2016-09-30. PMID:26736802. |
unilateral graded dopaminergic cell loss in the substantia nigra pars compacta was achieved by injecting different concentrations of 6-hydroxydopamine (6-ohda) in the right medial forebrain bundle. |
2016-09-30 |
2023-08-13 |
mouse |
| L L Furlanetti, V A Coenen, M D D\\xc3\\xb6br\\xc3\\xb6ss. Ventral tegmental area dopaminergic lesion-induced depressive phenotype in the rat is reversed by deep brain stimulation of the medial forebrain bundle. Behavioural brain research. vol 299. 2016-09-27. PMID:26657994. |
ventral tegmental area dopaminergic lesion-induced depressive phenotype in the rat is reversed by deep brain stimulation of the medial forebrain bundle. |
2016-09-27 |
2023-08-13 |
rat |
| Luciano L Furlanetti, Joacir Graciolli Cordeiro, Karina Kohn Cordeiro, Joanna A Garc\\xc3\\xada, Christian Winkler, Guilherme A Lepski, Volker A Coenen, Guido Nikkhah, M\\xc3\\xa1t\\xc3\\xa9 D D\\xc3\\xb6br\\xc3\\xb6ss. Continuous High-Frequency Stimulation of the Subthalamic Nucleus Improves Cell Survival and Functional Recovery Following Dopaminergic Cell Transplantation in Rodents. Neurorehabilitation and neural repair. vol 29. issue 10. 2016-07-21. PMID:25857428. |
the current experiment evaluated the potential synergy between neuromodulation and grafting by studying the effect of continuous stn-hfs on the survival, integration, and functional efficacy of ventral mesencephalic dopaminergic precursors transplanted into a unilateral 6-hydroxydopamine medial forebrain bundle lesioned rodent pd model. |
2016-07-21 |
2023-08-13 |
Not clear |