| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong-Yuan Chu, Liqiang Chen, Hiba Douja Chehad. Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation. Research square. 2024-09-16. PMID:39281856. |
to begin to address these questions, we injected α-synuclein (αsyn) preformed fibrils (pffs) into the dorsolateral striatum of mice to seed αsyn pathology in the cortical cortex and induce degeneration of midbrain dopaminergic neurons. |
2024-09-16 |
2024-09-19 |
mouse |
| M A Elfoul. Improved Mathematical Models of Parkinson's Disease with Hopf Bifurcation and Huntington's Disease with Chaos. Acta biotheoretica. vol 72. issue 3. 2024-09-02. PMID:39223402. |
the direct pathway can increase the time delay in the dopaminergic pathway, which significantly increases the activity of the motor cortex. |
2024-09-02 |
2024-09-05 |
Not clear |
| Bartosz Dawidowski, Barbara Olejniczak, Katarzyna Groblińska, Magdalena Knapińska, Urszula Kozicka, Michał Krasiński, Anna Kułak, Grzegorz Grelecki, Zuzanna Czaplińska, Oliwia Piotrowska, Klaudia Kościelecka, Piotr Podwalski, Anna Michalczyk, Jerzy Samochowie. The rs4354668 polymorphism in the SLC1A2 gene for the EAAT2 glutamate transporter is associated with an increased risk of harmful drug use - an exploratory study on a university student population. Psychiatria polska. vol 58. issue 3. 2024-09-01. PMID:39217423. |
dopaminergic projections of the reward system receive glutaminergic projections from cortex. |
2024-09-01 |
2024-09-04 |
Not clear |
| Carina R Oehrn, Stephanie Cernera, Lauren H Hammer, Maria Shcherbakova, Jiaang Yao, Amelia Hahn, Sarah Wang, Jill L Ostrem, Simon Little, Philip A Star. Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial. Nature medicine. 2024-08-19. PMID:39160351. |
we identified stimulation-entrained gamma oscillations in the subthalamic nucleus or motor cortex as optimal markers of high versus low dopaminergic states and their associated residual motor signs in all four patients. |
2024-08-19 |
2024-08-22 |
Not clear |
| Liqiang Chen, Hiba Douja Chehade, Hong-Yuan Ch. Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation. bioRxiv : the preprint server for biology. 2024-08-02. PMID:39091827. |
to begin to address these questions, we injected α-synuclein (αsyn) preformed fibrils (pffs) into the dorsolateral striatum of mice to seed αsyn pathology in the cortical cortex and induce degeneration of midbrain dopaminergic neurons. |
2024-08-02 |
2024-08-05 |
mouse |
| Richard M Köhler, Thomas S Binns, Timon Merk, Guanyu Zhu, Zixiao Yin, Baotian Zhao, Meera Chikermane, Jojo Vanhoecke, Johannes L Busch, Jeroen G V Habets, Katharina Faust, Gerd-Helge Schneider, Alessia Cavallo, Stefan Haufe, Jianguo Zhang, Andrea A Kühn, John-Dylan Haynes, Wolf-Julian Neuman. Dopamine and deep brain stimulation accelerate the neural dynamics of volitional action in Parkinson's disease. Brain : a journal of neurology. 2024-07-02. PMID:38954651. |
combined sensorimotor cortex electrocorticography (ecog) and subthalamic local field potential (lfp) recordings were performed off therapy (n = 22), on dopaminergic medication (n = 18) and on subthalamic deep brain stimulation (n = 8). |
2024-07-02 |
2024-07-06 |
human |
| Tousif Jamal, Xuan Yan, Angelica da Silva Lantyer, Judith G Ter Horst, Tansu Celike. Experience-dependent regulation of dopaminergic signaling in the somatosensory cortex. Progress in neurobiology. 2024-06-04. PMID:38834131. |
experience-dependent regulation of dopaminergic signaling in the somatosensory cortex. |
2024-06-04 |
2024-06-07 |
human |
| Tousif Jamal, Xuan Yan, Angelica da Silva Lantyer, Judith G Ter Horst, Tansu Celike. Experience-dependent regulation of dopaminergic signaling in the somatosensory cortex. Progress in neurobiology. 2024-06-04. PMID:38834131. |
here, by manipu- lating sensory experience using bilateral single-row whisker deprivation, we demonstrated that gene transcription in the dopaminergic signal- ing pathway (dsp) undergoes experience-dependent plasticity in both granular and supragranular layers of the primary somatosensory (barrel) cortex (s1). |
2024-06-04 |
2024-06-07 |
human |
| Tousif Jamal, Xuan Yan, Angelica da Silva Lantyer, Judith G Ter Horst, Tansu Celike. Experience-dependent regulation of dopaminergic signaling in the somatosensory cortex. Progress in neurobiology. 2024-06-04. PMID:38834131. |
these findings suggest that the dopaminergic drive originating from midbrain dopaminergic neurons, targeting the sensory cortex, is subject to experience-dependent regulation and might create a regulatory feed- back loop for modulating sensory processing. |
2024-06-04 |
2024-06-07 |
human |
| Utkarsh Tripathi, Idan Rosh, Ran Ben Ezer, Ritu Nayak, Yara Hussein, Ashwani Choudhary, Jose Djamus, Andreea Manole, Henry Houlden, Fred H Gage, Shani Ster. Upregulated ECM genes and increased synaptic activity in Parkinson's human DA neurons with PINK1/ PRKN mutations. NPJ Parkinson's disease. vol 10. issue 1. 2024-05-21. PMID:38762512. |
primary symptoms of pd arise with the loss of dopaminergic (da) neurons in the substantia nigra pars compacta, but pd also affects the hippocampus and cortex, usually in its later stage. |
2024-05-21 |
2024-05-27 |
human |
| Aggeliki Dimopoulou, Vasiliki Panagiotakopoulou, Theodora Mourtzi, Ilias Kazanis, Fevronia Angelato. Alpha-synuclein pathology in the "weaver" mouse, a genetic model of dopaminergic denervation. microPublication biology. vol 2024. 2024-03-29. PMID:38550606. |
our results revealed increased serine 129 phosphorylation in the midbrain, striatum, and cortex at a phase of established dopaminergic degeneration on postnatal day 100. |
2024-03-29 |
2024-03-31 |
mouse |
| Julia Elmers, Lorenza S Colzato, Focke Ziemssen, Tjalf Ziemssen, Christian Best. Optical coherence tomography as a potential surrogate marker of dopaminergic modulation across the life span. Ageing research reviews. 2024-03-22. PMID:38518921. |
the retina has been considered a "window to the brain" and shares similar innervation by the dopaminergic system with the cortex in terms of an unequal distribution of d1 and d2 receptors. |
2024-03-22 |
2024-03-25 |
Not clear |
| Maria João Nunes, Andreia Neves Carvalho, Alexandra I Rosa, Paula A Videira, Maria João Gama, Elsa Rodrigues, Margarida Castro-Calda. Altered expression of Sialyl Lewis X in experimental models of Parkinson's disease. Journal of molecular medicine (Berlin, Germany). 2024-01-10. PMID:38197965. |
importantly, our results show that mptp triggers the presentation of more proteins decorated with slex in mouse cortex and striatum in a time-dependent manner, as well as increased mrna expression of its rate-limiting enzyme fucosyltransferase 7. slex is expressed in neurons, including dopaminergic neurons, and microglia. |
2024-01-10 |
2024-01-13 |
mouse |
| Daniel Reumann, Christian Krauditsch, Maria Novatchkova, Edoardo Sozzi, Sakurako Nagumo Wong, Michael Zabolocki, Marthe Priouret, Balint Doleschall, Kaja I Ritzau-Reid, Marielle Piber, Ilaria Morassut, Charles Fieseler, Alessandro Fiorenzano, Molly M Stevens, Manuel Zimmer, Cedric Bardy, Malin Parmar, Jürgen A Knoblic. In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain-striatum-cortex assembloids. Nature methods. 2023-12-05. PMID:38052989. |
ventral midbrain dopaminergic neurons project to the striatum as well as the cortex and are involved in movement control and reward-related cognition. |
2023-12-05 |
2023-12-10 |
human |
| Daniel Reumann, Christian Krauditsch, Maria Novatchkova, Edoardo Sozzi, Sakurako Nagumo Wong, Michael Zabolocki, Marthe Priouret, Balint Doleschall, Kaja I Ritzau-Reid, Marielle Piber, Ilaria Morassut, Charles Fieseler, Alessandro Fiorenzano, Molly M Stevens, Manuel Zimmer, Cedric Bardy, Malin Parmar, Jürgen A Knoblic. In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain-striatum-cortex assembloids. Nature methods. 2023-12-05. PMID:38052989. |
here, we have developed a human in vitro model that recapitulates key aspects of dopaminergic innervation of the striatum and cortex. |
2023-12-05 |
2023-12-10 |
human |
| Heidi Kleven, Ingvild E Bjerke, Francisco Clascá, Henk J Groenewegen, Jan G Bjaalie, Trygve B Leergaar. Waxholm Space atlas of the rat brain: a 3D atlas supporting data analysis and integration. Nature methods. 2023-10-02. PMID:37783883. |
it provides a detailed map of the cerebral cortex, hippocampal region, striatopallidal areas, midbrain dopaminergic system, thalamic cell groups, the auditory system and main fiber tracts. |
2023-10-02 |
2023-10-07 |
rat |
| Sibylle Frase, Julius Steddin, Enya Paschen, Maximilian Lenz, Pasquale Conforti, Carola A Haas, Andreas Vlachos, Christian Schachtrup, Jonas A Hos. Dense dopaminergic innervation of the peri-infarct cortex despite dopaminergic cell loss after a pure motor-cortical stroke in rats. Journal of neurochemistry. 2023-09-22. PMID:37735852. |
dense dopaminergic innervation of the peri-infarct cortex despite dopaminergic cell loss after a pure motor-cortical stroke in rats. |
2023-09-22 |
2023-10-07 |
rat |
| Olivia K Swanson, Priscilla E Yevoo, David Richard, Arianna Maffe. Altered Thalamocortical Signaling in a Mouse Model of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-08-01. PMID:37527923. |
our results demonstrate that loss of midbrain dopaminergic neurons alters thalamocortical activation of m1 in both male and female mice, and provide novel insights into circuit mechanisms for motor cortex dysfunction in a mouse model of pd. |
2023-08-01 |
2023-08-14 |
mouse |
| Sharafuddin Khairuddin, Wei Ling Lim, Luca Aquili, Ka Chun Tsui, Anna Chung-Kwan Tse, Shehani Jayalath, Ruhani Varma, Trevor Sharp, Abdelhamid Benazzouz, Harry Steinbusch, Arjan Blokland, Yasin Temel, Lee Wei Li. Prelimbic Cortical Stimulation Induces Antidepressant-like Responses through Dopaminergic-Dependent and -Independent Mechanisms. Cells. vol 12. issue 11. 2023-06-11. PMID:37296570. |
given that dopaminergic neurotransmission has been found to be disrupted in depression, we investigated the dopamine(da)-dependent mechanism of the antidepressant-like effects of hfs of the prelimbic cortex (hfs prl). |
2023-06-11 |
2023-08-14 |
rat |
| Sarah Barker, Bindu D Paul, Andrew A Piepe. Increased Risk of Aging-Related Neurodegenerative Disease after Traumatic Brain Injury. Biomedicines. vol 11. issue 4. 2023-05-16. PMID:37189772. |
disease-specific mechanistic links with tbi that are reviewed include tar dna binding protein 43 and motor cortex lesions in als and ftd; alpha-synuclein, dopaminergic cell death, and synergistic toxin exposure in pd; and brain insulin resistance, amyloid beta pathology, and tau pathology in ad. |
2023-05-16 |
2023-08-14 |
Not clear |