| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Amrutha, Chandran S Abhinand, Shubham Sukerndeo Upadhyay, Ravishankar Parvaje, Thottethodi Subrahmanya Keshava Prasad, Prashant Kumar Mod. Network pharmacology and metabolomics analysis of Tinospora cordifolia reveals BACE1 and MAOB as potential therapeutic targets for neuroprotection in Alzheimer's disease. Scientific reports. vol 15. issue 1. 2025-03-08. PMID:40057579. |
pathway analysis highlighted the enrichment of camp, mtor, mapk, and pi3k-akt signaling pathways along with cholinergic, dopaminergic, serotonergic, glutamatergic synapse, and apoptosis. |
2025-03-08 |
2025-03-12 |
human |
| Paulina Borkowska, Małgorzata Kowalczyk, Aleksandra Zielińska, Karol Poskrobko, Magdalena B Rother, Monika Paul-Samojedny, Jan Kowalsk. NGF regulates survival and differentiation of umbilical mesenchymal stem/stromal cells into GABAergic, dopaminergic and cholinergic lineages. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2025-02-26. PMID:40010415. |
ngf regulates survival and differentiation of umbilical mesenchymal stem/stromal cells into gabaergic, dopaminergic and cholinergic lineages. |
2025-02-26 |
2025-03-01 |
Not clear |
| Paulina Borkowska, Małgorzata Kowalczyk, Aleksandra Zielińska, Karol Poskrobko, Magdalena B Rother, Monika Paul-Samojedny, Jan Kowalsk. NGF regulates survival and differentiation of umbilical mesenchymal stem/stromal cells into GABAergic, dopaminergic and cholinergic lineages. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2025-02-26. PMID:40010415. |
the study concluded that sustained overexpression of ngf: guides mesenchymal stem cells towards the neural pathway, facilitates the differentiation of modified mesenchymal stem cells into gabaergic, dopaminergic, and cholinergic neuron-like cells, suggests that gabaergic neurons' marker predominantly co-expresses with other neurons' markers, such as cholinergic or dopaminergic ones, increases survivability of modified mesenchymal stem cells in toxic conditions; the limitations of the study is that we merely know that cells have begun to express neurogenic markers, but in the absence of standards for mature neuronal markers, we do not yet know how far they have progressed as differentiating cells. |
2025-02-26 |
2025-03-01 |
Not clear |
| Junia Lara de Deus, Juliana Marino Maia, Renato Nery Soriano, Mateus R Amorim, Luiz G S Branc. Psychedelics in neuroinflammation: Mechanisms and therapeutic potential. Progress in neuro-psychopharmacology & biological psychiatry. 2025-02-01. PMID:39892847. |
beyond the serotonergic system, other neurotransmitter systems-including the glutamatergic, dopaminergic, noradrenergic, gamma-aminobutyric acid (gabaergic), and cholinergic systems-also play significant roles in mediating the effects of psychedelics. |
2025-02-01 |
2025-02-04 |
Not clear |
| Melody C Iacino, Elizabeth G Pitts, Amelia G Bonsib, Lacey L Sexton, Mark J Ferri. Long-term effects of adolescent versus adult nicotine self-administration on cholinergic modulation of dopamine in the nucleus accumbens core. Drug and alcohol dependence. vol 268. 2025-01-30. PMID:39881470. |
while dopaminergic reorganization is necessary for the transition into adulthood, how adolescent nicotine exposure affects cholinergic modulation of adult nac da dynamics is less understood. |
2025-01-30 |
2025-02-01 |
rat |
| Shenyu Zhai, Qiaoling Cui, David Wokosin, Linqing Sun, Tatiana Tkatch, Jill R Crittenden, Ann M Graybiel, D James Surmeie. State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson's disease. bioRxiv : the preprint server for biology. 2025-01-20. PMID:39829758. |
although triggered by levodopa, these rapid oscillations in spn properties depended on both dopaminergic and cholinergic signaling. |
2025-01-20 |
2025-01-23 |
mouse |
| Hui Li, Jinyu Chen, Chenyin Dong, Xiaoxia Chen, Yulun Gu, Yongqi Jiang, Jingwen Cui, Haibo Che. Behavioral and molecular neurotoxicity of thermally degraded polystyrene in Caenorhabditis elegans. Journal of hazardous materials. vol 487. 2025-01-19. PMID:39827801. |
in transgenic nematodes, t-ps exposure significantly impacted fluorescence intensity and the percentage of worms exhibiting neurodegeneration in serotonergic, cholinergic, dopaminergic, and γ-aminobutyric acid (gaba) neurons. |
2025-01-19 |
2025-01-23 |
caenorhabditis_elegans |
| Maximiliano Abarca, Humberto Pizarro, M Leonor Bustamante, Gustav Rohde, Marcelo Arancibi. Genetic and neurobiological aspects of psychosis in major neurocognitive disorder. Medwave. vol 25. issue 1. 2025-01-08. PMID:39772397. |
on the other hand, alterations of the cholinergic, serotonergic, dopaminergic, and gabaergic neurotransmitter systems and the excitatory-inhibitory balance have been described in dementia. |
2025-01-08 |
2025-01-13 |
Not clear |
| Judy Cheng, Ellen T Koch, Daniel Ramandi, James P Mackay, Timothy P O'Leary, William Rees-Jones, Lynn A Raymon. Synaptic modulation of glutamate in striatum of the YAC128 mouse model of Huntington disease. Neurobiology of disease. 2024-12-24. PMID:39716682. |
d2 receptors are also expressed on glutamatergic cortical terminals, cholinergic interneurons, and dopaminergic terminals from substantia nigra where they suppress release of glutamate, acetylcholine and dopamine, respectively, and these cell types may contribute to early striatal dysfunction in hd. |
2024-12-24 |
2024-12-26 |
mouse |
| Sungwoo Kang, Seun Jeon, Yeoju Kim, Su-Hee Jeon, Minsun Choi, Young-Gun Lee, Mijin Yun, Byoung Seok Y. White matter hyperintensities and cholinergic degeneration as Lewy body disease. Annals of clinical and translational neurology. 2024-12-10. PMID:39654300. |
although basal forebrain (bf) cholinergic degeneration and white matter hyperintensities (wmhs) are important in neurodegeneration in alzheimer's disease (ad) and dementia with lewy bodies (dlb), their relationships with dopaminergic degeneration and clinical manifestations remain unclear. |
2024-12-10 |
2024-12-12 |
Not clear |
| O S Okoh, J K Akintunde, A J Akamo, Ubong Akpa. Thymoquinone inhibits Neuroinflammatory mediators and vasoconstriction injury via NF-κB dependent NeuN/GFAP/Ki-67 in hypertensive Dams and F1 male pups on exposure to a mixture of Bisphenol-A analogues. Toxicology and applied pharmacology. 2024-11-22. PMID:39577800. |
dysregulation of cholinergic, dopaminergic and adenosinergic enzymes in addition to decreased nitric oxide levels were also associated with mbfs toxicity. |
2024-11-22 |
2024-11-25 |
rat |
| V Witzig, R Pjontek, S K H Tan, J B Schulz, F Holtbern. Modulating the cholinergic system-Novel targets for deep brain stimulation in Parkinson's disease. Journal of neurochemistry. 2024-11-18. PMID:39556446. |
thus, there is a growing interest in bolstering the cholinergic tone by dbs of cholinergic targets such as the pedunculopontine nucleus (ppn) and nucleus basalis of meynert (nbm), aiming to alleviate these debilitating symptoms resistant to traditional treatment strategies targeting the dopaminergic network. |
2024-11-18 |
2024-11-22 |
Not clear |
| Pascal Grumbach, Jan Kasper, Joerg F Hipp, Anna Forsyth, Sofie L Valk, Suresh Muthukumaraswamy, Simon B Eickhoff, Leonhard Schilbach, Juergen Dukar. Local activity alterations in autism spectrum disorder correlate with neurotransmitter properties and ketamine induced brain changes. medRxiv : the preprint server for health sciences. 2024-11-06. PMID:39502665. |
these lcor alterations negatively co-localized with dopaminergic (d1, d2, dat), glutamatergic (nmda, mglur5), gabaergic (gabaa) and cholinergic neurotransmission (vacht). |
2024-11-06 |
2024-11-08 |
human |
| Huize Pang, Xiaolu Li, Ziyang Yu, Hongmei Yu, Shuting Bu, Juzhou Wang, Mengwan Zhao, Yu Liu, Yueluan Jiang, Guoguang Fa. Disentangling gray matter atrophy and its neurotransmitter architecture in drug-naïve Parkinson's disease: an atlas-based correlation analysis. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 10. 2024-10-18. PMID:39420471. |
cognitively impaired parkinson's disease patients showed gray matter atrophy in the left middle temporal atrophy, which is associated with serotoninergic, dopaminergic, cholinergic, and glutamatergic receptors (fdr-p < 0.05). |
2024-10-18 |
2024-10-20 |
Not clear |
| Congying Luo, Qiong Zhang, Dinghui Wang, Han Xie, Shukai Zheng, Wenlong Huang, Yanhong Huang, Xiaoling Shi, Kusheng W. Tri-iso-butyl phosphate (TiBP) exposure induces neurotoxicity by triggering oxidative stress accompanied by neurotransmitter system disruptions and apoptosis in zebrafish larvae. Environmental pollution (Barking, Essex : 1987). 2024-10-18. PMID:39424049. |
in summary, our study indicates that oxidative stress is a pivotal molecular event in the neurotoxicity induced by tibp, implicating the disruption of the gabaergic, dopaminergic, and cholinergic systems, as well as triggering apoptosis. |
2024-10-18 |
2024-10-21 |
zebrafish |
| Fanni F Geibl, Martin T Henrich, Zhong Xie, Enrico Zampese, Jun Ueda, Tatiana Tkatch, David L Wokosin, Elena Nasiri, Constantin A Grotmann, Valina L Dawson, Ted M Dawson, Navdeep S Chandel, Wolfgang H Oertel, D James Surmeie. α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson's disease. Molecular neurodegeneration. vol 19. issue 1. 2024-10-09. PMID:39379975. |
to test this hypothesis, genetic and physiological methods were used to monitor mitochondrial function in substantia nigra pars compacta (snc) dopaminergic and pedunculopontine nucleus (ppn) cholinergic neurons after stereotaxic injection of asyn pre-formed fibrils (pffs) into the mouse brain. |
2024-10-09 |
2024-10-11 |
mouse |
| Melissa Hernández-Frausto, Carmen Viva. Entorhinal cortex-hippocampal circuit connectivity in health and disease. Frontiers in human neuroscience. vol 18. 2024-10-07. PMID:39372192. |
recent evidence shows that both ec and hc receive inputs from dopaminergic, cholinergic, and noradrenergic projections that modulate the mnemonic processes linked to the encoding and consolidation of memories. |
2024-10-07 |
2024-10-09 |
Not clear |
| Mariana Duhne, Ali Mohebi, Kyoungjun Kim, Lilian Pelattini, Joshua D Berk. A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 41. 2024-10-04. PMID:39365823. |
a mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors. |
2024-10-04 |
2024-10-07 |
rat |
| Michael Aschner, Anatoly V Skalny, Rongzhu Lu, Airton C Martins, Aristidis Tsatsakis, Sergey A Miroshnikov, Abel Santamaria, Alexey A Tinko. Molecular mechanisms of zinc oxide nanoparticles neurotoxicity. Chemico-biological interactions. 2024-09-15. PMID:39278458. |
znonps exposure is associated with altered cholinergic, dopaminergic, serotoninergic, as well as glutamatergic and γ-aminobutyric acid (gaba)-ergic neurotransmission, thus contributing to impaired neuronal signal transduction. |
2024-09-15 |
2024-09-18 |
human |
| A C Martel, P Apicell. Insights into the interaction between time and reward prediction on the activity of striatal tonically active neurons: A pilot study in rhesus monkeys. Physiological reports. vol 12. issue 17. 2024-09-09. PMID:39245818. |
prior studies have documented the role of the striatum and its dopaminergic input in time processing, but the contribution of local striatal cholinergic innervation has not been specifically investigated. |
2024-09-09 |
2024-09-11 |
monkey |