| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Regoni, Letizia Zanetti, Martina Sevegnani, Chiara Domenicale, Stefano Magnabosco, Jyoti C Patel, Megan K Fernandes, Ryan M Feeley, Elena Monzani, Cecilia Mini, Stefano Comai, Laura Cherchi, Danilo De Gregorio, Isabella Soliman, Fabio Ruto, Laura Croci, Giacomo Consalez, Simona Rodighiero, Andrea Ciammola, Flavia Valtorta, Michele Morari, Giovanni Piccoli, Margaret E Rice, Jenny Sasson. Dopamine neuron dysfunction and loss in the PrknR275W mouse model of juvenile parkinsonism. Brain : a journal of neurology. 2024-10-01. PMID:39350737. |
we report here that prknr275w mice show early da neuron dysfunction, age-dependent loss of da neurons in the substantia nigra, decreased da content and stimulus-evoked da release in the striatum, and progressive motor impairment. |
2024-10-01 |
2024-10-03 |
mouse |
| Charles Ducrot, Gregory de Carvalho, Benoit Delignat-Lavaud, Constantin V L Delmas, Priyabrata Halder, Nicolas Giguère, Consiglia Pacelli, Sriparna Mukherjee, Marie-Josée Bourque, Martin Parent, LuLu Y Chen, Louis-Eric Trudea. Conditional deletion of neurexins dysregulates neurotransmission from dopamine neurons. eLife. vol 12. 2023-07-06. PMID:37409563. |
strikingly, electrophysiological recordings revealed an increase of gaba co-release from da neuron axons in the striatum of these mice. |
2023-07-06 |
2023-08-14 |
mouse |
| William Tanguay, Charles Ducrot, Nicolas Giguère, Marie-Josée Bourque, Louis-Eric Trudea. Neonatal 6-OHDA lesion of the SNc induces striatal compensatory sprouting from surviving SNc dopaminergic neurons without VTA contribution. The European journal of neuroscience. vol 54. issue 7. 2021-11-01. PMID:34470083. |
we find that at 10 and 90 days after the lesion, the axons of snc da neurons show massive compensatory sprouting, as revealed by the proportionally smaller decrease in tyrosine hydroxylase (th) in the striatum compared with the loss of snc da neuron cell bodies. |
2021-11-01 |
2023-08-13 |
mouse |
| Deirdre B Hoban, Shelby Shrigley, Bengt Mattsson, Ludivine S Breger, Ulla Jarl, Tiago Cardoso, Jenny Nelander Wahlestedt, Kelvin C Luk, Anders Björklund, Malin Parma. Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 26. 2020-09-01. PMID:32541058. |
this model gives rise to da neuron dysfunction and progressive loss of da neurons from the sn and terminals in the striatum, accompanied by extensive α-syn pathology and a prominent inflammatory response, making it an interesting and relevant model in which to examine long-term function and integrity of transplanted neurons in a pd-like brain. |
2020-09-01 |
2023-08-13 |
human |
| Zhao-Li Hu, Ting Sun, Ming Lu, Jian-Hua Ding, Ren-Hong Du, Gang H. Kir6.1/K-ATP channel on astrocytes protects against dopaminergic neurodegeneration in the MPTP mouse model of Parkinson's disease via promoting mitophagy. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31288070. |
here, we found that astrocytic kir6.1 ko mice showed more da neuron loss in substantia nigra compacta (snc), lower level of dopamine in the striatum, and more severe motor dysfunction than controls. |
2020-08-14 |
2023-08-13 |
mouse |
| Qi-Min Wang, Yu-Yu Xu, Shang Liu, Ze-Gang M. Isradipine attenuates MPTP-induced dopamine neuron degeneration by inhibiting up-regulation of L-type calcium channels and iron accumulation in the substantia nigra of mice. Oncotarget. vol 8. issue 29. 2018-04-23. PMID:28521299. |
we also found that isradipine prevented against mptp-induced da neuron depletion in the sn and partly restored the da content in the striatum. |
2018-04-23 |
2023-08-13 |
mouse |
| Tao Lu, Paul P Kim, Nigel H Greig, Yu Lu. Dopaminergic Neuron-Specific Deletion of p53 Gene Attenuates Methamphetamine Neurotoxicity. Neurotoxicity research. vol 32. issue 2. 2018-04-02. PMID:28342134. |
whereas dat-p53ko mice demonstrated a consistently higher density of th fibers in striatum compared to wt mice at 10 days after ma exposure, da neuron counts within the substantia nigra pars compacta (snpc) were similar. |
2018-04-02 |
2023-08-13 |
mouse |
| Su-Ping Peng, Sjef Copra. Comparison of Human Primary with Human iPS Cell-Derived Dopaminergic Neuron Grafts in the Rat Model for Parkinson's Disease. Stem cell reviews and reports. vol 12. issue 1. 2016-12-13. PMID:26438376. |
the differences we observed in the efficacy to restore normal function between the 2 types of da neuron grafts could be ascribed to intrinsic properties of the ips cell-derived da neurons that critically affected survival and proper neurite extension in the striatum after implantation. |
2016-12-13 |
2023-08-13 |
human |
| Marta Esteves, Ana C Cristóvão, Tatiana Saraiva, Sandra M Rocha, Graça Baltazar, Lino Ferreira, Liliana Bernardin. Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson's disease. Frontiers in aging neuroscience. vol 7. 2015-03-23. PMID:25798108. |
the results showed that the ra-nps administration induced a significant reduction of da neuron loss in the substantia nigra (sn) as well as their neuronal fiber/axonal innervations in the striatum. |
2015-03-23 |
2023-08-13 |
mouse |
| Karolina Noworyta-Sokołowska, Anna Górska, Krystyna Gołembiowsk. LPS-induced oxidative stress and inflammatory reaction in the rat striatum. Pharmacological reports : PR. vol 65. issue 4. 2014-06-13. PMID:24145080. |
the aim of our study was to determine the appropriate dose and route of lps administration to study hydroxyl radical generation and extracellular level of dopamine (da), glutamate (glu) and adenosine (adn) in the rat striatum as markers of da neuron damage and glial cell activation. |
2014-06-13 |
2023-08-12 |
rat |
| Sang J Na, Anthony G DiLella, Edward V Lis, Keith Jones, David M Levine, David J Stone, J F Hes. Molecular profiling of a 6-hydroxydopamine model of Parkinson's disease. Neurochemical research. vol 35. issue 5. 2010-07-08. PMID:20169470. |
to improve the understanding of this model, gene expression changes in the substantia nigra, which contains the da neuron cell bodies, and the striatum, which contains the da neuron synaptic terminals, were examined using dna microarrays. |
2010-07-08 |
2023-08-12 |
rat |
| Xiao-Hong Lu, Sheila M Fleming, Bernhard Meurers, Larry C Ackerson, Farzad Mortazavi, Victor Lo, Daniela Hernandez, David Sulzer, George R Jackson, Nigel T Maidment, Marie-Francoise Chesselet, X William Yan. Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 7. 2009-04-16. PMID:19228951. |
stereological analyses reveal that the mutant mice develop age-dependent da neuron degeneration in substantia nigra accompanied by a significant loss of da neuron terminals in the striatum. |
2009-04-16 |
2023-08-12 |
mouse |
| Masaya Segaw. [Japanese originality, clinical symptoms to the causative gene 1 Segawa disease]. Rinsho shinkeigaku = Clinical neurology. vol 47. issue 11. 2008-04-04. PMID:18210786. |
the clinical course of this adult patient was correlated to the age variation of the activities of tyrosine hydroxylase (th) in the striatum and suggested non-progressive decrease of th at the terminal of the nigrostriatal da neuron. |
2008-04-04 |
2023-08-12 |
Not clear |
| Yuji Nagai, Shigeru Obayashi, Kiyoshi Ando, Motoki Inaji, Jun Maeda, Takashi Okauchi, Hiroshi Ito, Tetsuya Suhar. Progressive changes of pre- and post-synaptic dopaminergic biomarkers in conscious MPTP-treated cynomolgus monkeys measured by positron emission tomography. Synapse (New York, N.Y.). vol 61. issue 10. 2007-10-31. PMID:17598150. |
the pre-synaptic biomarkers of da neuron in the striatum decreased [11c]pe2i binding and [beta-11c]dopa uptake in an mptp dose-dependent manner. |
2007-10-31 |
2023-08-12 |
monkey |
| Asuka Morizane, Jun Takahashi, Mizuya Shinoyama, Makoto Ideguchi, Yasushi Takagi, Hitoshi Fukuda, Masaomi Koyanagi, Yoshiki Sasai, Nobuo Hashimot. Generation of graftable dopaminergic neuron progenitors from mouse ES cells by a combination of coculture and neurosphere methods. Journal of neuroscience research. vol 83. issue 6. 2006-07-13. PMID:16493682. |
transplantation of conditioned medium-treated day 4 spheres, which contained da neuron progenitors, into the mouse striatum resulted in the generation of a significant number of graft-derived da neurons. |
2006-07-13 |
2023-08-12 |
mouse |
| Chih C Chao, Cheng H Chiang, Yun L Ma, Eminy H Y Le. Molecular mechanism of the neurotrophic effect of GDNF on DA neurons: role of protein kinase CK2. Neurobiology of aging. vol 27. issue 1. 2006-02-14. PMID:16298246. |
on the other hand, the da neuron toxin 1-methyl-4-phenylpyridinium iodide (mpp+) markedly decreased the number of th-positive neurons and th protein level in the sn, decreased da level in the striatum and impaired rotarod performance in rats. |
2006-02-14 |
2023-08-12 |
rat |
| Sylvia Navailles, Philippe De Deurwaerdère, Grégory Porras, Umberto Spampinat. In vivo evidence that 5-HT2C receptor antagonist but not agonist modulates cocaine-induced dopamine outflow in the rat nucleus accumbens and striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 2. 2004-04-27. PMID:14560323. |
the obtained results provide evidence that 5-ht(2c) receptors exert similar effects in both the nac and the striatum, and they modulate da exocytosis also when its increase occurs independently from an increase in da neuron impulse activity. |
2004-04-27 |
2023-08-12 |
rat |
| Sylvia Navailles, Philippe De Deurwaerdère, Grégory Porras, Umberto Spampinat. In vivo evidence that 5-HT2C receptor antagonist but not agonist modulates cocaine-induced dopamine outflow in the rat nucleus accumbens and striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 2. 2004-04-27. PMID:14560323. |
in the present study, using in vivo microdialysis in the nucleus accumbens (nac) and the striatum of halothane-anesthetized rats, we addressed this hypothesis by assessing the ability of 5-ht(2c) agents to modulate the increase in da outflow induced by haloperidol and cocaine, of which the effects on da outflow are associated or not with an increase in da neuron firing, respectively. |
2004-04-27 |
2023-08-12 |
rat |
| C E Sortwell, T J Collier, J R Slade. Co-grafted embryonic striatum increases the survival of grafted embryonic dopamine neurons. The Journal of comparative neurology. vol 399. issue 4. 1998-11-13. PMID:9741481. |
to enhance the current therapeutic benefit of dopamine (da) neuron grafts in parkinson's disease, strategies must be developed that increase both da neuron survival and fiber outgrowth into the denervated striatum. |
1998-11-13 |
2023-08-12 |
rat |
| Y P Tang, Y L Ma, C C Chao, K Y Chen, E H Le. Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments. Journal of neuroscience research. vol 53. issue 5. 1998-10-29. PMID:9726430. |
furthermore, among several da neuron protective and/or therapeutic agents examined, both intrastriatal injections of (-)-deprenyl (1.25 microg and 2.5 microg) and melatonin (30 microg, 60 microg, and 120 microg) significantly enhanced gdnf mrna expression in the striatum, whereas the same concentrations of (-)-deprenyl did not affect monoamine oxidase b (maob) activity, although it increased glutathione peroxidase (gpx) and/or superoxide dismutase (sod) activities. |
1998-10-29 |
2023-08-12 |
Not clear |