| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamad Rima, Yara Lattouf, Maroun Abi Younes, Erika Bullier, Pascal Legendre, Jean-Marie Mangin, Elim Hon. Dynamic regulation of the cholinergic system in the spinal central nervous system. Scientific reports. vol 10. issue 1. 2021-01-19. PMID:32948826. |
we found that protein and enzymatic activities of presynaptic cholinergic genes were also reduced in the rostral spinal cord. |
2021-01-19 |
2023-08-13 |
zebrafish |
| Mohamad Rima, Yara Lattouf, Maroun Abi Younes, Erika Bullier, Pascal Legendre, Jean-Marie Mangin, Elim Hon. Dynamic regulation of the cholinergic system in the spinal central nervous system. Scientific reports. vol 10. issue 1. 2021-01-19. PMID:32948826. |
our work demonstrating that cholinergic genes are initially expressed in the embryonic spinal cord, which is dynamically downregulated during development suggests that cholinergic signaling may play a pivotal role during the formation of intra-spinal locomotor circuit. |
2021-01-19 |
2023-08-13 |
zebrafish |
| Bernd Fritzsch, Karen L Elliot. Evolution and Development of the Inner Ear Efferent System: Transforming a Motor Neuron Population to Connect to the Most Unusual Motor Protein via Ancient Nicotinic Receptors. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:28484373. |
experimental transplantations mimicking this possible aspect of ear evolution showed that different motor neurons of the spinal cord or brainstem form cholinergic synapses on hair cells when ears replace somites or eyes. |
2020-10-01 |
2023-08-13 |
Not clear |
| Isobel T French, Kalai A Muthusam. A Review of the Pedunculopontine Nucleus in Parkinson's Disease. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:29755338. |
the human ppn is divided into two subnuclei, the pars compacta (ppnc) and pars dissipatus (ppnd), and constitutes both cholinergic and non-cholinergic neurons with afferent and efferent projections to the cerebral cortex, thalamus, basal ganglia (bg), cerebellum, and spinal cord. |
2020-10-01 |
2023-08-13 |
human |
| R Chinthu, T R Anju, C S Paulos. Cholinergic receptor alterations in the cerebral cortex of spinal cord injured rat. Biochemistry and biophysics reports. vol 10. 2020-09-30. PMID:29114569. |
spinal cord injury causes severe motor impairment and disturbances in cholinergic signalling can aggravate the situation. |
2020-09-30 |
2023-08-13 |
rat |
| R Chinthu, T R Anju, C S Paulos. Cholinergic receptor alterations in the cerebral cortex of spinal cord injured rat. Biochemistry and biophysics reports. vol 10. 2020-09-30. PMID:29114569. |
considering the impact of cortical cholinergic firing in locomotion, we focussed the study in understanding the cholinergic alterations in cerebral cortex during spinal cord injury. |
2020-09-30 |
2023-08-13 |
rat |
| R Chinthu, T R Anju, C S Paulos. Cholinergic receptor alterations in the cerebral cortex of spinal cord injured rat. Biochemistry and biophysics reports. vol 10. 2020-09-30. PMID:29114569. |
the gene expression of key enzymes in cholinergic pathway - acetylcholine esterase and choline acetyl transferase showed significant upregulation in the cerebral cortex of spinal cord injured group compared to control with the fold increase in expression of acetylcholine esterase prominently higher than cholineacetyl transferase. |
2020-09-30 |
2023-08-13 |
rat |
| R Chinthu, T R Anju, C S Paulos. Cholinergic receptor alterations in the cerebral cortex of spinal cord injured rat. Biochemistry and biophysics reports. vol 10. 2020-09-30. PMID:29114569. |
our data pin points the disturbances in cortical cholinergic function due to spinal cord injury; which can augment the locomotor deficits. |
2020-09-30 |
2023-08-13 |
rat |
| Daria Guseva, Igor Jakovcevski, Andrey Irintchev, Iryna Leshchyns'ka, Vladimir Sytnyk, Evgeni Ponimaskin, Melitta Schachne. Cell Adhesion Molecule Close Homolog of L1 (CHL1) Guides the Regrowth of Regenerating Motor Axons and Regulates Synaptic Coverage of Motor Neurons. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:29881335. |
while no differences in phenotypes were detectable in the femoral nerve, corresponding segments in the spinal cord were observed to differ in that inhibitory perisomatic innervation of motor neurons was increased in chl1-deficient mice, and numbers of perisomatic cholinergic synapses on motor neuronal somata were reduced. |
2020-09-30 |
2023-08-13 |
mouse |
| Kamil Grycz, Anna Głowacka, Benjun Ji, Julita Czarkowska-Bauch, Olga Gajewska-Woźniak, Małgorzata Sku. Early pre- and postsynaptic decrease in glutamatergic and cholinergic signaling after spinalization is not modified when stimulating proprioceptive input to the ankle extensor α-motoneurons: Anatomical and neurochemical study. PloS one. vol 14. issue 9. 2020-04-02. PMID:31557259. |
in rats with intact spinal cord 7-days of low-threshold proprioceptive stimulation of the tibial nerve enriched glutamatergic ia and cholinergic innervation of lateral gastrocnemius (lg) mns, suggesting usefulness of selective stimulation for restoration of inputs to extensor mns after sct. |
2020-04-02 |
2023-08-13 |
rat |
| B Frias, A A Phillips, J W Squair, A H X Lee, I Laher, A V Krassiouko. Reduced colonic smooth muscle cholinergic responsiveness is associated with impaired bowel motility after chronic experimental high-level spinal cord injury. Autonomic neuroscience : basic & clinical. vol 216. 2020-03-10. PMID:30196037. |
reduced colonic smooth muscle cholinergic responsiveness is associated with impaired bowel motility after chronic experimental high-level spinal cord injury. |
2020-03-10 |
2023-08-13 |
Not clear |
| Chunling Liu, Hui Liu, Hongjun Jin, Xuyi Yue, Zonghua Luo, Zhude T. Cholinergic imbalance in lumbar spinal cord of a rat model of multiple sclerosis. Journal of neuroimmunology. vol 318. 2019-09-30. PMID:29397207. |
cholinergic imbalance in lumbar spinal cord of a rat model of multiple sclerosis. |
2019-09-30 |
2023-08-13 |
rat |
| Angelika Więckowska, Olga Gajewska-Woźniak, Anna Głowacka, Benjun Ji, Kamil Grycz, Julita Czarkowska-Bauch, Małgorzata Sku. Spinalization and locomotor training differentially affect muscarinic acetylcholine receptor type 2 abutting on α-motoneurons innervating the ankle extensor and flexor muscles. Journal of neurochemistry. vol 147. issue 3. 2019-09-27. PMID:30102779. |
complete thoracic spinal cord transection (sct) impairs excitatory cholinergic inputs to ankle extensor (soleus; sol) but not to flexor (tibialis anterior; ta) α-motoneurons (mns) modifiable by locomotor training applied post-transection. |
2019-09-27 |
2023-08-13 |
Not clear |
| Guillaume Osterstock, Barbara Le Bras, Kalaimakan Hervé Arulkandarajah, Hervé Le Corronc, Antonny Czarnecki, Christine Mouffle, Erika Bullier, Pascal Legendre, Jean-Marie Mangi. Axoglial synapses are formed onto pioneer oligodendrocyte precursor cells at the onset of spinal cord gliogenesis. Glia. vol 66. issue 8. 2019-07-18. PMID:29603384. |
in the embryonic spinal cord, neuro-epithelial precursors in the pmn domain cease generating cholinergic motor neurons (mns) to produce opcs when the first synapses are formed in the ventral-lateral marginal zone. |
2019-07-18 |
2023-08-13 |
Not clear |
| Guillaume Osterstock, Barbara Le Bras, Kalaimakan Hervé Arulkandarajah, Hervé Le Corronc, Antonny Czarnecki, Christine Mouffle, Erika Bullier, Pascal Legendre, Jean-Marie Mangi. Axoglial synapses are formed onto pioneer oligodendrocyte precursor cells at the onset of spinal cord gliogenesis. Glia. vol 66. issue 8. 2019-07-18. PMID:29603384. |
our results demonstrate that opcs are contacted by functional synapses as soon as they emerge from their precursor domain and that embryonic spinal cord colonization by opcs can be regulated by cholinergic signaling acting onto these axoglial synapses. |
2019-07-18 |
2023-08-13 |
Not clear |
| Mélissa Sourioux, Sandrine S Bertrand, Jean-René Cazalet. Cholinergic-mediated coordination of rhythmic sympathetic and motor activities in the newborn rat spinal cord. PLoS biology. vol 16. issue 7. 2019-05-06. PMID:29985914. |
using an in vitro spinal cord preparation from newborn rat, we demonstrate that the specific activation of muscarinic cholinergic receptors (machrs) (with oxotremorine) triggers a slow burst rhythm in thoracic spinal segments, thereby revealing a rhythmogenic capability in this cord region. |
2019-05-06 |
2023-08-13 |
rat |
| Maria Bertuzzi, Konstantinos Ampatzi. Spinal cholinergic interneurons differentially control motoneuron excitability and alter the locomotor network operational range. Scientific reports. vol 8. issue 1. 2018-12-17. PMID:29386582. |
here, we show that cholinergic interneurons are present in the zebrafish spinal cord and differentially control the excitability of distinct classes of motoneurons (slow, intermediate and fast) in a muscarinic dependent manner. |
2018-12-17 |
2023-08-13 |
zebrafish |
| Vedangana Saini, Gabriele Loers, Gurcharan Kaur, Melitta Schachner, Igor Jakovcevsk. Impact of neural cell adhesion molecule deletion on regeneration after mouse spinal cord injury. The European journal of neuroscience. vol 44. issue 1. 2017-12-22. PMID:27178448. |
worse locomotor function was associated with decreased monoaminergic and cholinergic innervation of the spinal cord caudal to the injury site and decreased axonal regrowth/sprouting at the site of injury. |
2017-12-22 |
2023-08-13 |
mouse |
| Kathleen B G Huber, Victor V Uteshev, James R Paul. Targeting the Cholinergic System for Neuroprotection and/or Enhancement of Functional Recovery Following Neurotrauma. Current pharmaceutical design. vol 22. issue 14. 2017-11-16. PMID:26818862. |
the purpose of this review is to summarize the models used for preclinical neurotrauma research, provide a brief overview of previous failed clinical trials in head and spinal cord injury, and finally, to review involvement of the cholinergic system and discuss implications for future research. |
2017-11-16 |
2023-08-13 |
Not clear |
| Renzo Mancuso, Xavier Navarr. Sigma-1 Receptor in Motoneuron Disease. Advances in experimental medicine and biology. vol 964. 2017-09-26. PMID:28315275. |
the sigma-1 receptor is highly expressed in motoneurons of the spinal cord, particularly enriched in the endoplasmic reticulum (er) at postsynaptic cisternae of cholinergic c-terminals. |
2017-09-26 |
2023-08-13 |
mouse |