| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoyun Ji, Haimeng Luo, Xianyan Li, Siwei Wang, Lijun Xia, Maojun Ni, Jingxia Wang, Chaorong Peng, Xiaoqing Wu, Rui Tan, Xiaobin Zhang, Hezhong Jian. Structural characterization, anti-aging activity and mechanisms investigation in vivo of a polysaccharide from Anthriscus sylvestris. International journal of biological macromolecules. 2024-09-05. PMID:39233161. |
moreover, ap reduced inflammation and downregulated aging genes p53 and p21 in hippocampus and liver tissues, enhanced the cholinergic system, and improved liver functions and lipid metabolism. |
2024-09-05 |
2024-09-08 |
mouse |
| Vibhav Varshney, Prachi Varshney, Abhishek Kumar, Ahsas Goyal, Debapriya Garabad. Nerolidol- Potential Therapeutic Agent for Various Neurological Disorders via its Antioxidative Property. Current pharmaceutical biotechnology. 2024-09-04. PMID:39229977. |
in alzheimer's disease, nerolidol shows neuroprotection by decreasing amyloid plaque formation, lipid peroxidation, cholinergic neuronal loss, locomotor dysfunction, neuroinflammation, and hippocampal damage via enhancing antioxidant expression. |
2024-09-04 |
2024-09-06 |
Not clear |
| Mohammed Zacky Ariffin, Si Yun Ng, Hamzah Nadia, Darrel Koh, Natasha Loh, Naomi Michiko, Sanjay Khann. Neurokinin1 - cholinergic receptor mechanisms in the medial Septum-Dorsal hippocampus axis mediates experimental neuropathic pain. Neurobiology of pain (Cambridge, Mass.). vol 16. 2024-09-03. PMID:39224764. |
the neurokinin-1 receptors (nk1rs) in the forebrain medial septum (ms) region are localized exclusively on cholinergic neurons that partly project to the hippocampus and the cingulate cortex (cg), regions implicated in nociception. |
2024-09-03 |
2024-09-05 |
rat |
| Mohammed Zacky Ariffin, Si Yun Ng, Hamzah Nadia, Darrel Koh, Natasha Loh, Naomi Michiko, Sanjay Khann. Neurokinin1 - cholinergic receptor mechanisms in the medial Septum-Dorsal hippocampus axis mediates experimental neuropathic pain. Neurobiology of pain (Cambridge, Mass.). vol 16. 2024-09-03. PMID:39224764. |
in the present study, we explored the hypothesis that neurotransmission at septal nk1r and hippocampal cholinergic mechanisms mediate experimental neuropathic pain in the rodent chronic constriction injury model (cci). |
2024-09-03 |
2024-09-05 |
rat |
| Jinquan Li, Yanjun Liu, Chuhui Yin, Yan Zeng, Yufei Me. Structural and functional remodeling of neural networks in β-amyloid driven hippocampal hyperactivity. Ageing research reviews. 2024-09-01. PMID:39218080. |
therefore, in this narrative review, we discuss the role of aβ-induced altered intrinsic neuronal properties as well as structural and functional remodeling of glutamatergic, gabaergic, cholinergic, noradrenergic, serotonergic circuits in hippocampal hyperactivity. |
2024-09-01 |
2024-09-04 |
Not clear |
| Lindsey Avery Fitzsimons, Mohammad Atif-Sheikh, Jayden Lovely, Madison Mueth, Makaela Rice, Kevin Kotredes, Gareth Howell, Benjamin J Harriso. CD2AP is Co-Expressed with Tropomyosin-Related Kinase A and Ras-Related Protein Rab-5A in Cholinergic Neurons of the Murine Basal Forebrain. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211110. |
basal forebrain cholinergic neurons project to the hippocampus and cortex, are critical for learning and memory, and are central to the pathogenesis of alzheimer's disease (ad). |
2024-08-30 |
2024-09-04 |
Not clear |
| Eric Fagerli, Charles W Jackson, Iris Escobar, Fernando J Ferrier, Efrain J Perez Lao, Isabel Saul, Jorge Gomez, Kunjan R Dave, Oliver Bracko, Miguel A Perez-Pinzo. Resveratrol Mitigates Cognitive Impairments and Cholinergic Cell Loss in the Medial Septum in a Mouse Model of Gradual Cerebral Hypoperfusion. Antioxidants (Basel, Switzerland). vol 13. issue 8. 2024-08-29. PMID:39199230. |
despite these deficits, no hippocampal pathology was observed; however, cholinergic cell loss in the medial septum was significantly increased after gbccas. |
2024-08-29 |
2024-09-01 |
mouse |
| Vanessa Valéria Miron, Charles Elias Assmann, Vitor Bastianello Mostardeiro, Marcylene Vieira da Silveira, Priscila Marquezan Copetti, Bianca Fagan Bissacotti, Adriel Antonio Schirmann, Milagros Fanny Vera Castro, Jessié Martins Gutierres, Marilda da Cruz Fernandes, Fernanda Tibolla Viero, Vera Maria Morsch, Maria Rosa Chitolina Schetinger, Andréia Machado Cardos. Neuroprotective effect of long-term resistance physical exercise against memory damage elicited by a lipopolysaccharide-induced neuroinflammation model in male rats. Journal of neuroscience research. vol 102. issue 8. 2024-08-19. PMID:39158105. |
the cholinergic system, oxidative stress, and histochemical parameters were analyzed in the cerebral cortex and hippocampus, and memory tests were also performed. |
2024-08-19 |
2024-08-21 |
rat |
| Leslie Doucette, Victoria Turnbill, Katherine Carlin, Andrew Cavanagh, Benjamin Sollinger, Nazli Kuter, Debra L Flock, Shenandoah Robinson, Raul Chavez-Valdez, Lauren Jantzie, Lee J Martin, Frances J Northingto. Neocortical cholinergic pathology after neonatal brain injury is increased by Alzheimer's disease-related genes in mice. Neurobiology of disease. 2024-08-07. PMID:39111704. |
cortical and hippocampal cholinergic axonal and in pathology and aβ plaques, identified by immunohistochemistry for choline acetyltransferase (chat) and 6e10 antibody respectively, were counted at p210. |
2024-08-07 |
2024-08-10 |
mouse |
| Nicole L Reitz, Polliana T Nunes, Lisa M Savag. Adolescent alcohol exposure alters age-related progression of behavioral and neurotrophic dysfunction in the TgF344-AD model in a sex-specific manner. bioRxiv : the preprint server for biology. 2024-08-02. PMID:39091885. |
both alcohol-related brain damage (abrd) and ad result in cholinergic dysfunction, reductions in hippocampal neurogenesis, and the emergence of hippocampal-dependent cognitive impairments. |
2024-08-02 |
2024-08-05 |
rat |
| Rahmi Lee, Gayeon Kim, Seonil Ki. Co-activation of selective nicotinic acetylcholine receptor subtypes is required to reverse hippocampal network dysfunction and prevent fear memory loss in Alzheimer's disease. bioRxiv : the preprint server for biology. 2024-07-19. PMID:39026693. |
here, we discover that α7- and α4β2-nachrs predominantly control the nicotinic cholinergic signaling and neuronal activity in hippocampal parvalbumin-positive (pv+) and somatostatin-positive (sst+) inhibitory interneurons, respectively. |
2024-07-19 |
2024-07-21 |
mouse |
| Xinyu Zou, Qian Tang, Ryota Ojiro, Shunsuke Ozawa, Momoka Shobudani, Yuri Sakamaki, Yuri Ebizuka, Meilan Jin, Toshinori Yoshida, Makoto Shibutan. Increased spontaneous activity and progressive suppression of adult neurogenesis in the hippocampus of rat offspring after maternal exposure to imidacloprid. Chemico-biological interactions. 2024-07-13. PMID:39002876. |
these results suggest that imi persistently affected cholinergic signaling, induced neuroinflammation and oxidative stress during exposure, and increased sensitivity to oxidative stress after exposure in the hippocampus, causing hyperactivity and progressive suppression of neurogenesis in adulthood. |
2024-07-13 |
2024-07-16 |
rat |
| Reham L Younis, Rehab M El-Gohary, Asmaa A Ghalwash, Islam Ibrahim Hegab, Maram M Ghabrial, Azza M Aboshanady, Raghad A Mostafa, Alaa H Abd El-Azeem, Eman E Farghal, Asmaa A E Belal, Haidy Khatta. Luteolin Mitigates D-Galactose-Induced Brain Ageing in Rats: SIRT1-Mediated Neuroprotection. Neurochemical research. 2024-07-10. PMID:38987448. |
all groups were subjected to behavioural, cholinergic function, and hippocampal mitochondrial respiration assessments. |
2024-07-10 |
2024-07-13 |
rat |
| L Stan Leung, Ravnoor Singh Gill, Bixia Shen, Liangwei Ch. Cholinergic and behavior-dependent beta and gamma waves are coupled between olfactory bulb and hippocampus. Hippocampus. 2024-07-01. PMID:38949057. |
cholinergic and behavior-dependent beta and gamma waves are coupled between olfactory bulb and hippocampus. |
2024-07-01 |
2024-07-03 |
rat |
| Ga-Young Choi, In-Seo Lee, Eunyoung Moon, Hyosung Choi, A Reum Je, Ji-Ho Park, Hee-Seok Kweo. Ameliorative effect of vanillic acid against scopolamine-induced learning and memory impairment in rat via attenuation of oxidative stress and dysfunctional synaptic plasticity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-28. PMID:38941895. |
the study's findings suggest that va has a neuroprotective effect on scop-induced learning and memory impairment linked to the hippocampal cholinergic system, oxidative damage, and synaptic plasticity. |
2024-06-28 |
2024-07-01 |
rat |
| Edmund T Rolls, Alessandro Treve. A theory of hippocampal function: new developments. Progress in neurobiology. 2024-06-04. PMID:38834132. |
key new computational developments include the capacity of the ca3 attractor network for storing whole charts of space; how the correlations inherent in self-organizing continuous spatial representations impact the storage capacity; how the ca3 network can combine continuous spatial and discrete object and reward representations; the roles of the rewards that reach the hippocampus in the later consolidation into long-term memory in part via cholinergic pathways from the orbitofrontal cortex; and new ways of analysing neocortical information storage using potts networks. |
2024-06-04 |
2024-06-07 |
human |
| YeZi Li, XiaoLi Yang, SiLu Yan, ZhongKui Su. Complexity decline of hippocampal CA1 circuit model due to cholinergic deficiency associated with Alzheimer's disease. Cognitive neurodynamics. vol 18. issue 3. 2024-06-03. PMID:38826656. |
a hallmark of alzheimer's disease (ad) is cholinergic system dysfunction, directly affecting the hippocampal neurons. |
2024-06-03 |
2024-06-05 |
Not clear |
| Michelle L Kloc, Gregory L Holmes, Jeremy M Barr. Sex differences in cholinergic signaling affect functional outcomes for theta-gamma coordination in hippocampal subcircuits following experimental febrile status epilepticus. Epilepsia. 2024-05-23. PMID:38780490. |
sex differences in cholinergic signaling affect functional outcomes for theta-gamma coordination in hippocampal subcircuits following experimental febrile status epilepticus. |
2024-05-23 |
2024-05-27 |
rat |
| Michelle L Kloc, Gregory L Holmes, Jeremy M Barr. Sex differences in cholinergic signaling affect functional outcomes for theta-gamma coordination in hippocampal subcircuits following experimental febrile status epilepticus. Epilepsia. 2024-05-23. PMID:38780490. |
cholinergic signaling is essential for the generation of hippocampal oscillations, and supplementation of cholinergic precursors prior to status epilepticus in immature male rats prevents subsequent memory deficits. |
2024-05-23 |
2024-05-27 |
rat |
| Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zho. Study on the role and mechanism of Tan IIA in Alzheimer's disease based on CREB-BDNF-TrkB pathway. Neuroscience letters. 2024-04-14. PMID:38616003. |
these data suggest that tan iia may upregulate the expression of the creb-bdnf-trkb signaling pathway in the hippocampus of brain tissue, produce anti-neuroinflammatory, antioxidant stress, inhibit neuronal apoptosis effects, and improve cholinergic neurotransmitter disorder induced by stz, reduce the neuronal damage and learning and memory impairment caused by stz in rats, and improve the cognitive function of rats. |
2024-04-14 |
2024-04-17 |
rat |