Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Szidónia Farkas, Adrienn Szabó, Bibiána Török, Csenge Sólyomvári, Csilla Lea Fazekas, Krisztina Bánrévi, Pedro Correia, Tiago Chaves, Dóra Zelen. Ovariectomy-induced hormone deprivation aggravates Aβ Frontiers in endocrinology. vol 13. 2022-10-28. PMID:36303870. |
despite no progression of dementia-like behavior after ovx, at the histological level, ovx aggravated the amyloid-β plaque deposition in the basolateral amygdala and induced early cholinergic neuronal fiber loss in the somatosensory cortex of the transgenic animals. |
2022-10-28 |
2023-08-14 |
mouse |
Kana Okada, Kouichi Hashimoto, Kazuto Kobayash. Cholinergic regulation of object recognition memory. Frontiers in behavioral neuroscience. vol 16. 2022-10-17. PMID:36248033. |
cholinergic projections from the nucleus basalis magnocellularis innervating the entire cortex are associated with recognition memory for object identification. |
2022-10-17 |
2023-08-14 |
human |
Dorottya Várkonyi, Bibiána Török, Eszter Sipos, Csilla Lea Fazekas, Krisztina Bánrévi, Pedro Correia, Tiago Chaves, Szidónia Farkas, Adrienn Szabó, Sergio Martínez-Bellver, Balázs Hangya, Dóra Zelen. Investigation of Anxiety- and Depressive-like Symptoms in 4- and 8-Month-Old Male Triple Transgenic Mouse Models of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142737. |
acetylcholinesterase histochemistry visualized cholinergic fibers in the cortex. |
2022-09-23 |
2023-08-14 |
mouse |
Shigeru Ogata, Yuta Miyamoto, Naoki Shigematsu, Shigeyuki Esumi, Takaichi Fukud. The tail of the mouse striatum contains a novel large type of GABAergic neuron incorporated in a unique disinhibitory pathway that relays auditory signals to subcortical nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-09-14. PMID:36104279. |
their somata were larger than cholinergic giant aspiny neurons, were located in a narrow space adjacent to the globus pallidus (gp), and extended long dendrites laterally toward the intermediate division (id) of the tri-laminar part of the ts, the region targeted by axons from the primary auditory cortex (a1). |
2022-09-14 |
2023-08-14 |
mouse |
Hao Yang, XiaoLi Yang, SiLu Yan, ZhongKui Su. Effect of acetylcholine deficiency on neural oscillation in a brainstem-thalamus-cortex neurocomputational model related with Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-09-02. PMID:36056083. |
this work constructs a comprehensive neural mass model for cholinergic neuropathogenesis that involves brainstem, thalamus and cortex, wherein how acetylcholine deficiency in ad affects neural oscillation of the model output is systematically explored from the perspective of neurocomputation. |
2022-09-02 |
2023-08-14 |
Not clear |
Hao Yang, XiaoLi Yang, SiLu Yan, ZhongKui Su. Effect of acetylcholine deficiency on neural oscillation in a brainstem-thalamus-cortex neurocomputational model related with Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-09-02. PMID:36056083. |
by decreasing synapse connectivity parameters in direct cholinergic pathway from brainstem to thalamus or in indirect glutamatergic synapse pathway from cortex to brainstem to mimic the pathological condition of reduced acetylcholine release in patients with ad, the property of neural oscillation in this model is numerically investigated by means of power spectrum in frequency domain and amplitude distribution in time domain. |
2022-09-02 |
2023-08-14 |
Not clear |
Manfred J Oswald, Yechao Han, Han Li, Samuel Marashli, Deniz Nouri Oglo, Bhavya Ojha, Paul V Naser, Zheng Gan, Rohini Kune. Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex. Nature communications. vol 13. issue 1. 2022-08-25. PMID:36008394. |
cholinergic basal forebrain nucleus of meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex. |
2022-08-25 |
2023-08-14 |
mouse |
Ariel A Batallán Burrowes, Olayemi Joseph Olajide, Isabella A Iasenza, Waqqas M Shams, Francis Carter, C Andrew Chapma. Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex. PloS one. vol 17. issue 8. 2022-08-08. PMID:35939438. |
ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex. |
2022-08-08 |
2023-08-14 |
rat |
Ariel A Batallán Burrowes, Olayemi Joseph Olajide, Isabella A Iasenza, Waqqas M Shams, Francis Carter, C Andrew Chapma. Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex. PloS one. vol 17. issue 8. 2022-08-08. PMID:35939438. |
estrogens are thought to contribute to cognitive function in part by promoting the function of basal forebrain cholinergic neurons that project to the hippocampus and cortical regions including the entorhinal cortex. |
2022-08-08 |
2023-08-14 |
rat |
Ariel A Batallán Burrowes, Olayemi Joseph Olajide, Isabella A Iasenza, Waqqas M Shams, Francis Carter, C Andrew Chapma. Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex. PloS one. vol 17. issue 8. 2022-08-08. PMID:35939438. |
reductions in estrogens may alter cognition by reducing the function of cholinergic inputs to both the hippocampus and entorhinal cortex. |
2022-08-08 |
2023-08-14 |
rat |
Ariel A Batallán Burrowes, Olayemi Joseph Olajide, Isabella A Iasenza, Waqqas M Shams, Francis Carter, C Andrew Chapma. Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex. PloS one. vol 17. issue 8. 2022-08-08. PMID:35939438. |
in the present study, we assessed the effects of ovariectomy on proteins associated with cholinergic synapses in the entorhinal cortex. |
2022-08-08 |
2023-08-14 |
rat |
Ariel A Batallán Burrowes, Olayemi Joseph Olajide, Isabella A Iasenza, Waqqas M Shams, Francis Carter, C Andrew Chapma. Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex. PloS one. vol 17. issue 8. 2022-08-08. PMID:35939438. |
the reduced modulatory effect of eserine is consistent with the observed changes in cholinergic proteins, and suggests that reductions in 17β-estradiol following ovariectomy lead to impaired cholinergic function within the entorhinal cortex. |
2022-08-08 |
2023-08-14 |
rat |
Chiara Orciani, Helene Hall, Rowan Pentz, Morgan K Foret, Sonia Do Carmo, A Claudio Cuell. Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis. Journal of neurochemistry. 2022-08-03. PMID:35921478. |
basal forebrain cholinergic neurons (bfcns) represent the main source of cholinergic innervation to the cortex and hippocampus and degenerate early in alzheimer's disease (ad) progression. |
2022-08-03 |
2023-08-14 |
rat |
Chiara Orciani, Helene Hall, Rowan Pentz, Morgan K Foret, Sonia Do Carmo, A Claudio Cuell. Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis. Journal of neurochemistry. 2022-08-03. PMID:35921478. |
to address our hypothesis, we immunolesioned the nucleus basalis (nb), a basal forebrain cholinergic nuclei projecting mainly to the cortex, by bilateral stereotaxic injection of 192-igg-saporin (the cytotoxin saporin binds p75ntr receptors expressed exclusively by bfcns) in 2.5-month-old wistar rats. |
2022-08-03 |
2023-08-14 |
rat |
P Yamini, R S Ray, Sonal Yadav, Jatinder Dhaliwal, Manisha Yadav, Kanthi Kiran Kondepudi, Kanwaljit Chopr. α7nAChR activation protects against oxidative stress, neuroinflammation and central insulin resistance in ICV-STZ induced sporadic Alzheimer's disease. Pharmacology, biochemistry, and behavior. 2022-05-09. PMID:35533773. |
oxido-nitrosative stress (gsh, mda and nitrite) and cholinergic activity (acetylcholine esterase and choline acetyltransferase) were estimated in the cortex and hippocampus through biochemical methods. |
2022-05-09 |
2023-08-13 |
mouse |
P Yamini, R S Ray, Sonal Yadav, Jatinder Dhaliwal, Manisha Yadav, Kanthi Kiran Kondepudi, Kanwaljit Chopr. α7nAChR activation protects against oxidative stress, neuroinflammation and central insulin resistance in ICV-STZ induced sporadic Alzheimer's disease. Pharmacology, biochemistry, and behavior. 2022-05-09. PMID:35533773. |
moreover, gts-21 treatment significantly decreased oxido-nitrosative stress, inflammatory markers and cholinergic dysfunction in cortex and hippocampus. |
2022-05-09 |
2023-08-13 |
mouse |
Ying Xia, Eamonn Eeles, Jurgen Fripp, Donna Pinsker, Paul Thomas, Melissa Latter, Vincent Doré, Amir Fazlollahi, Pierrick Bourgeat, Victor L Villemagne, Elizabeth J Coulson, Stephen Ros. Reduced cortical cholinergic innervation measured using [ NeuroImage. Clinical. vol 34. 2022-03-28. PMID:35344804. |
reduced cortical cholinergic innervation measured using [ dysfunction of the cholinergic basal forebrain (bf) neurotransmitter system, including cholinergic axon denervation of the cortex, plays an important role in cognitive decline and dementia. |
2022-03-28 |
2023-08-13 |
Not clear |
Xavier Caubit, Paolo Gubellini, Pierre L Roubertoux, Michèle Carlier, Jordan Molitor, Dorian Chabbert, Mehdi Metwaly, Pascal Salin, Ahmed Fatmi, Yasmine Belaidouni, Lucie Brosse, Lydia Kerkerian-Le Goff, Laurent Fasan. Targeted Tshz3 deletion in corticostriatal circuit components segregates core autistic behaviors. Translational psychiatry. vol 12. issue 1. 2022-03-16. PMID:35292625. |
in the cerebral cortex, tshz3 is expressed in cpns and in a proportion of gabaergic interneurons, but not in cholinergic interneurons or glial cells. |
2022-03-16 |
2023-08-13 |
mouse |
Roger L Albin, Sygrid van der Zee, Teus van Laar, Martin Sarter, Cindy Lustig, Martijn L T M Muller, Nicolaas I Bohne. Cholinergic systems, attentional-motor integration, and cognitive control in Parkinson's disease. Progress in brain research. vol 269. issue 1. 2022-03-06. PMID:35248201. |
thalamic and entorhinal cortex cholinergic deficits may impair multi-sensory integration. |
2022-03-06 |
2023-08-13 |
human |
Ke Xiang, Yin Liu, Li Su. Motoric Cognitive Risk Syndrome: Symptoms, Pathology, Diagnosis, and Recovery. Frontiers in aging neuroscience. vol 13. 2022-02-21. PMID:35185512. |
the pathological basis of mcr relates with the frontal lacunar infarcts, white matter hyperintensity (wmh), gray matter atrophy in the pre-motor and pre-frontal cortex, abnormal cholinergic functioning, inflammatory responses, and genetic factors. |
2022-02-21 |
2023-08-13 |
Not clear |