Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Niels Okkels, Jacob Horsager, Miguel Labrador-Espinosa, Pernille L Kjeldsen, Malene F Damholdt, Janne Mortensen, Karsten Vestergård, Karoline Knudsen, Katrine B Andersen, Tatyana D Fedorova, Casper Skjærbæk, Hanne Gottrup, Allan K Hansen, Michel J Grothe, Per Borghamme. Severe cholinergic terminal loss in newly diagnosed dementia with Lewy bodies. Brain : a journal of neurology. 2023-06-06. PMID:37279796. |
by contrast, patients without dementia showed decreased cholinergic terminal binding in the cerebral cortex despite preserved basal forebrain volumes. |
2023-06-06 |
2023-08-14 |
human |
Kylee R Graham, Kara D Hayes, Sean K Meeha. Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning. Journal of visualized experiments : JoVE. issue 194. 2023-05-09. PMID:37154553. |
the extent of inhibition in the motor-evoked response reflects the magnitude of the afferent volley converging on the motor cortex and involves central gabaergic and cholinergic contributions. |
2023-05-09 |
2023-08-14 |
Not clear |
Mojtaba Nazari, Javad Karimi Abadchi, Milad Naghizadeh, Edgar J Bermudez-Contreras, Bruce L McNaughton, Masami Tatsuno, Majid H Mohajeran. Regional variation in cholinergic terminal activity determines the non-uniform occurrence of cortical slow waves during REM sleep in mice. Cell reports. vol 42. issue 5. 2023-05-01. PMID:37126447. |
the role of the cholinergic system in local desynchronization during rem sleep is also explored by calcium imaging of cholinergic activity within the cortex and analyzing structural data. |
2023-05-01 |
2023-08-14 |
mouse |
Lindsay Collins, John Francis, Brett Emanuel, David A McCormic. Cholinergic and noradrenergic axonal activity contains a behavioral-state signal that is coordinated across the dorsal cortex. eLife. vol 12. 2023-04-27. PMID:37102362. |
cholinergic and noradrenergic axonal activity contains a behavioral-state signal that is coordinated across the dorsal cortex. |
2023-04-27 |
2023-08-14 |
mouse |
Lindsay Collins, John Francis, Brett Emanuel, David A McCormic. Cholinergic and noradrenergic axonal activity contains a behavioral-state signal that is coordinated across the dorsal cortex. eLife. vol 12. 2023-04-27. PMID:37102362. |
in this study, we use mesoscale two-photon calcium imaging to examine spontaneous activity of cholinergic and noradrenergic axons in awake mice in order to determine the interaction between arousal/movement state transitions and neuromodulatory activity across the dorsal cortex at distances separated by up to 4 mm. |
2023-04-27 |
2023-08-14 |
mouse |
Lindsay Collins, John Francis, Brett Emanuel, David A McCormic. Cholinergic and noradrenergic axonal activity contains a behavioral-state signal that is coordinated across the dorsal cortex. eLife. vol 12. 2023-04-27. PMID:37102362. |
by monitoring the activity of cholinergic interneurons in the cortex we found that a subpopulation of these cells also exhibit state-dependent (arousal/movement) activity. |
2023-04-27 |
2023-08-14 |
mouse |
Adam J Granger, Karen Mao, Jessica L Saulnier, Morgan E Hines, Bernardo L Sabatin. Developmental regulation of GABAergic gene expression in forebrain cholinergic neurons. Frontiers in neural circuits. vol 17. 2023-04-10. PMID:37035505. |
the co-release of the functionally antagonistic neurotransmitters gaba and acetylcholine (ach) greatly expands the possible functional effects of cholinergic neurons and provides an additional exogenous source of inhibition to the cortex. |
2023-04-10 |
2023-08-14 |
mouse |
Fangchen Zhu, Sarah Elnozahy, Jennifer Lawlor, Kishore V Kuchibhotl. The cholinergic basal forebrain provides a parallel channel for state-dependent sensory signaling to auditory cortex. Nature neuroscience. 2023-03-27. PMID:36973512. |
the cholinergic basal forebrain provides a parallel channel for state-dependent sensory signaling to auditory cortex. |
2023-03-27 |
2023-08-14 |
Not clear |
Fangchen Zhu, Sarah Elnozahy, Jennifer Lawlor, Kishore V Kuchibhotl. The cholinergic basal forebrain provides a parallel channel for state-dependent sensory signaling to auditory cortex. Nature neuroscience. 2023-03-27. PMID:36973512. |
however, it remains unknown whether sensory cholinergic signals target the sensory cortex and how they relate to local functional topography. |
2023-03-27 |
2023-08-14 |
Not clear |
Fangchen Zhu, Sarah Elnozahy, Jennifer Lawlor, Kishore V Kuchibhotl. The cholinergic basal forebrain provides a parallel channel for state-dependent sensory signaling to auditory cortex. Nature neuroscience. 2023-03-27. PMID:36973512. |
finally, slow fluctuations in cholinergic activity modulated the fast, sensory-evoked signals in the same axons, suggesting that a multiplexed combination of fast and slow signals is projected from the cbf to the auditory cortex. |
2023-03-27 |
2023-08-14 |
Not clear |
Emma Sola, Paula Moyano, Andrea Flores, José Manuel García, Jimena García, María José Anadon, María Teresa Frejo, Adela Pelayo, Maria de la Cabeza Fernandez, Javier Del Pin. Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain. Chemico-biological interactions. 2023-03-03. PMID:36868496. |
basal forebrain (bf) cholinergic neurons innervate the cortex and hippocampus, regulating cognition. |
2023-03-03 |
2023-08-14 |
rat |
Taylor Jefferson, Haram R Kim, Marco Martin. Impaired muscarinic modulation of the rat prelimbic cortex in neuropathic pain is sexually dimorphic and associated with cold allodynia. Frontiers in cellular neuroscience. vol 17. 2023-02-27. PMID:36846207. |
cholinergic modulation of the brain cortex is critical for cognitive processes, and altered cholinergic modulation of the prefrontal cortex is emerging as an important mechanism of neuropathic pain. |
2023-02-27 |
2023-08-14 |
rat |
Taylor Jefferson, Haram R Kim, Marco Martin. Impaired muscarinic modulation of the rat prelimbic cortex in neuropathic pain is sexually dimorphic and associated with cold allodynia. Frontiers in cellular neuroscience. vol 17. 2023-02-27. PMID:36846207. |
here we investigated potential sex differences in cholinergic modulation of layer five commissural pyramidal neurons of the rat prelimbic cortex in control conditions and in the sni model of neuropathic pain. |
2023-02-27 |
2023-08-14 |
rat |
Yutong Wu, Sheng Hu, Yi Wang, Ting Dong, Hongli Wu, Anqin Wang, Chuanfu Li, Hongxing Ka. Altered microstructural pattern of the cortex and basal forebrain cholinergic system in wilson's disease: an automated fiber quantification tractography study. Brain imaging and behavior. 2023-01-23. PMID:36690883. |
altered microstructural pattern of the cortex and basal forebrain cholinergic system in wilson's disease: an automated fiber quantification tractography study. |
2023-01-23 |
2023-08-14 |
human |
Yutong Wu, Sheng Hu, Yi Wang, Ting Dong, Hongli Wu, Anqin Wang, Chuanfu Li, Hongxing Ka. Altered microstructural pattern of the cortex and basal forebrain cholinergic system in wilson's disease: an automated fiber quantification tractography study. Brain imaging and behavior. 2023-01-23. PMID:36690883. |
basal forebrain (bf) cholinergic projection neurons form a highly extensive input to the cortex. |
2023-01-23 |
2023-08-14 |
human |
Yutong Wu, Sheng Hu, Yi Wang, Ting Dong, Hongli Wu, Anqin Wang, Chuanfu Li, Hongxing Ka. Altered microstructural pattern of the cortex and basal forebrain cholinergic system in wilson's disease: an automated fiber quantification tractography study. Brain imaging and behavior. 2023-01-23. PMID:36690883. |
failure of bf cholinergic circuits is responsible for the cognitive impairment associated with wilson's disease (wd), but whether and how the microstructural changes in fiber projections between the bf and cerebral cortex influence prospective memory (pm) remain poorly understood. |
2023-01-23 |
2023-08-14 |
human |
Yutong Wu, Sheng Hu, Yi Wang, Ting Dong, Hongli Wu, Anqin Wang, Chuanfu Li, Hongxing Ka. Altered microstructural pattern of the cortex and basal forebrain cholinergic system in wilson's disease: an automated fiber quantification tractography study. Brain imaging and behavior. 2023-01-23. PMID:36690883. |
our study highlights that the performance of projections between cholinergic input and output areas-the cerebral cortex and bf-may serve as neural biomarkers of pm and disease prognosis. |
2023-01-23 |
2023-08-14 |
human |
Sarah C Tryon, Joshua X Bratsch-Prince, James W Warren, Grace C Jones, Alexander J McDonald, David D Mot. Differential regulation of prelimbic and thalamic transmission to the basolateral amygdala by acetylcholine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-12-19. PMID:36535767. |
to better understand these effects of acetylcholine, we have used electrophysiology and optogenetics in male and female mouse brain slices to examine cholinergic regulation of afferent bla input from cortex and midline thalamic nuclei (mtn). |
2022-12-19 |
2023-08-14 |
mouse |
b' Paulo C\\xc3\\xa9zar Prado, Jos\\xc3\\xa9lia Alencar Lima, Lidilhone Hamerski, Magdalena Nascimento Renn\\xc3\\xb. Natural Products with BACE1 and GSK3\\xce\\xb2 Inhibitory Activity. Mini reviews in medicinal chemistry. 2022-11-22. PMID:36411570.' |
alzheimer's disease (ad) is a neurodegenerative, progressive, and fatal disorder characterized by marked atrophy of the cerebral cortex and loss of basal forebrain cholinergic neurons. |
2022-11-22 |
2023-08-14 |
Not clear |
Andrea Flores, Paula Moyano, Emma Sola, José Manuel García, Jimena García, María José Anadon, María Teresa Frejo, Maria Victoria Naval, Maria de la Cabeza Fernadez, Javier Del Pin. Single and repeated bisphenol A treatment induces ROS, Aβ and hyperphosphorylated-tau accumulation, and insulin pathways disruption, through HDAC2 and PTP1B overexpression, leading to SN56 cholinergic apoptotic cell death. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 170. 2022-11-14. PMID:36374790. |
cortex and hippocampus neuronal networks control cognitive functions, which are innervated by basal forebrain cholinergic neurons (bfcn), and their neurodegeneration induces cognitive dysfunctions. |
2022-11-14 |
2023-08-14 |
Not clear |