| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hye-Yeon Park, Ga Seul Lee, Jun Go, Young-Kyoung Ryu, Chul-Ho Lee, Jeong Hee Moon, Kyoung-Shim Ki. Angiotensin-converting enzyme inhibition prevents L-dopa-induced dyskinesia in a 6-OHDA-induced mouse model of Parkinson's disease. European journal of pharmacology. 2024-04-20. PMID:38642669. |
in addition, the astrocyte and microglial transcripts involving ccl2, c3, cd44, and iigp1 were reduced by co-treatment with acei and l-dopa in the 6-ohda-lesioned striatum. |
2024-04-20 |
2024-04-23 |
mouse |
| Ing Chee Wee, Alina Arulsamy, Frances Corrigan, Lyndsey Collins-Prain. Long-Term Impact of Diffuse Traumatic Brain Injury on Neuroinflammation and Catecholaminergic Signaling: Potential Relevance for Parkinson's Disease Risk. Molecules (Basel, Switzerland). vol 29. issue 7. 2024-04-13. PMID:38611750. |
at 12 months post-injury, astrocyte reactivity (gfap) and microglial levels (iba1) were assessed in the striatum (str), substantia nigra (sn), and prefrontal cortex (pfc) using immunohistochemistry. |
2024-04-13 |
2024-04-15 |
rat |
| Hoang Kieu Chi Ngo, Hoang Le, Samuel J Ayer, Grace F Crotty, Michael A Schwarzschild, Rachit Baksh. Short-term lipopolysaccharide treatment leads to astrocyte activation in LRRK2 G2019S knock-in mice without loss of dopaminergic neurons. Research square. 2024-04-02. PMID:38562908. |
lps treatment caused a greater increase in the activated astrocyte marker glial fibrillary acidic protein (gfap) in the striatum and substantia nigra of lrrk2 g2019s mice than in those of wt mice. |
2024-04-02 |
2024-04-04 |
mouse |
| Maurício Dos Santos Pereira, Gabriel Henrique Dias de Abreu, Leonardo Calaça Arruda Vanderlei, Rita Raisman-Vozari, Francisco Silveira Guimarães, Hui-Chen Lu, Patrick Pierre Michel, Elaine Del Be. 4'-fluorocannabidiol associated with capsazepine restrains L-DOPA-induced dyskinesia in hemiparkinsonian mice: Contribution of anti-inflammatory and anti-glutamatergic mechanisms. Neuropharmacology. 2024-03-30. PMID:38554815. |
both combination treatments efficiently reduced microglial and astrocyte activation in the dorsal striatum of dyskinetic mice. |
2024-03-30 |
2024-04-02 |
mouse |
| Vesna Sočan, Klemen Dolinar, Mojca Krža. Cortical and Striatal Astrocytes of Neonatal Rats Display Distinct Molecular and Pharmacological Characteristics of Dopamine Uptake. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255983. |
in the present study, experiments were conducted on primary astrocyte cultures from the striatum and cortex of neonatal rats. |
2024-01-23 |
2024-01-25 |
rat |
| Max Gentenaar, Fleur L Meulmeester, Ximaine R van der Burg, Anna T Hoekstra, Hazel Hunt, Jan Kroon, Willeke M C van Roon-Mom, Onno C Meije. Glucocorticoid receptor antagonist CORT113176 attenuates motor and neuropathological symptoms of Huntington's disease in R6/2 mice. Experimental neurology. 2024-01-12. PMID:38216109. |
it also restored hd-related parameters including astrocyte markers in both the dorsolateral striatum and the hippocampus, and microglia markers in the hippocampus. |
2024-01-12 |
2024-01-15 |
mouse |
| Chiara Cervetto, Guido Maura, Diego Guidolin, Sarah Amato, Cristina Ceccoli, Luigi F Agnati, Manuela Marcol. Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders. Neuropharmacology. 2023-06-15. PMID:37321323. |
a2a-d2 heteromers on striatal astrocytes and astrocyte processes are discussed as far as their potential relevance in the control of glutamatergic transmission in striatum is concerned, including potential roles in glutamatergic transmission dysregulation in pathological conditions including schizophrenia or the parkinson's disease. |
2023-06-15 |
2023-08-14 |
Not clear |
| Sarah Amato, Monica Averna, Diego Guidolin, Cristina Ceccoli, Elena Gatta, Simona Candiani, Marco Pedrazzi, Michela Capraro, Guido Maura, Luigi F Agnati, Chiara Cervetto, Manuela Marcol. Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902106. |
in purified astrocyte processes from adult rat striatum, we assessed otr and dopamine d2 receptor expression by confocal analysis. |
2023-03-11 |
2023-08-14 |
rat |
| Rafael Teixeira Ribeiro, Andrey Vinícios Soares Carvalho, Rafael Palavro, Luz Elena Durán-Carabali, Ângela Beatris Zemniaçak, Alexandre Umpierrez Amaral, Carlos Alexandre Netto, Moacir Wajne. L-2-Hydroxyglutaric Acid Administration to Neonatal Rats Elicits Marked Neurochemical Alterations and Long-Term Neurobehavioral Disabilities Mediated by Oxidative Stress. Neurotoxicity research. 2022-12-29. PMID:36580261. |
l-2-hg also decreased the content of neun, mbp, and cnpase, and increased s100b, gfap, and iba1 in the cerebral cortex and striatum at postnatal days 15 and 75, implying long-standing neuronal loss, demyelination, astrocyte reactivity, and increased inflammatory response, respectively. |
2022-12-29 |
2023-08-14 |
rat |
| D N Voronkov, A V Stavrovskaya, A S Guschina, A S Olshansky, O S Lebedeva, A V Eremeev, M A Lagarkov. Morphological Characterization of Astrocytes in a Xenograft of Human iPSCDerived Neural Precursor Cells. Acta naturae. vol 14. issue 3. 2022-11-09. PMID:36348713. |
in the experiment performed, human ipsc-derived neural progenitors transplanted into a rat striatum produced a mixed neuron and astrocyte population in vivo by the sixth month after transplantation. |
2022-11-09 |
2023-08-14 |
human |
| Weizhao Chen, Qiongping Zheng, Qiaoying Huang, Shanshan Ma, Mingtao L. Repressing PTBP1 fails to convert reactive astrocytes to dopaminergic neurons in a 6-hydroxydopamine mouse model of Parkinson's disease. eLife. vol 11. 2022-05-10. PMID:35535997. |
however, it is unclear whether repressing polypyrimidine tract binding protein 1 (ptbp1) could efficiently convert astrocyte to dans in the substantia nigra and striatum. |
2022-05-10 |
2023-08-13 |
mouse |
| Jing Zhang, Bohao Sun, Jifeng Yang, Zhuo Chen, Zhengzheng Li, Nan Zhang, Hongzhi Li, Luxi She. Comparison of the effect of rotenone and 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine on inducing chronic Parkinson's disease in mouse models. Molecular medicine reports. vol 25. issue 3. 2022-01-18. PMID:35039876. |
in the mptp group, the loss of dopaminergic (da) neurons in the substantia nigra (sn) pars compacta, the reduction of the tyrosine hydroxylase content in the sn and striatum and the astrocyte proliferation and microglial activation in the sn were more significant compared with the rotenone group. |
2022-01-18 |
2023-08-13 |
mouse |
| Adam J Lundquist, Tyler J Gallagher, Giselle M Petzinger, Michael W Jakowe. Exogenous l-lactate promotes astrocyte plasticity but is not sufficient for enhancing striatal synaptogenesis or motor behavior in mice. Journal of neuroscience research. vol 99. issue 5. 2021-11-18. PMID:33629362. |
similar to our previous report demonstrating exercise-induced changes in astrocytic structure within the striatum, l-lactate administration to healthy mice led to increased astrocyte morphological complexity as well as astrocyte-specific neurotrophic expression within the striatum. |
2021-11-18 |
2023-08-13 |
mouse |
| Xiaoqian Zhang, Wei Chen, Yi Wu, Weiqi Zeng, Yuhao Yuan, Chi Cheng, Xiaoman Yang, Jialing Wang, Xiaomei Yang, Yu Xu, Hao Lei, Xuebing Cao, Yan X. Histological Correlates of Neuroanatomical Changes in a Rat Model of Levodopa-Induced Dyskinesia Based on Voxel-Based Morphometry. Frontiers in aging neuroscience. vol 13. 2021-11-17. PMID:34776935. |
taken together, our findings suggest that striatal volume changes in lid rats involve astrocyte activation, enrichment of synaptic ultrastructure and signaling proteins in the ipsilateral striatum. |
2021-11-17 |
2023-08-13 |
rat |
| L C Fernandes, A G Santos, T B Sampaio, Sms Sborgi, Rds Prediger, M M Ferro, Gcn Franco, L Lipinski, E Miyosh. Exposure to paraquat associated with periodontal disease causes motor damage and neurochemical changes in rats. Human & experimental toxicology. vol 40. issue 1. 2021-09-02. PMID:32748713. |
moreover, only the combination of periodontal disease and paraquat exposure induced the loss of dopaminergic neurons and astrocyte activation in the striatum. |
2021-09-02 |
2023-08-13 |
rat |
| Awatef Esshili, Marie-Pierre Manitz, Nadja Freund, Georg Jucke. Induction of inducible nitric oxide synthase expression in activated microglia and astrocytes following pre- and postnatal immune challenge in an animal model of schizophrenia. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 35. 2021-08-10. PMID:32439226. |
at postnatal day 30 (pnd0), the animals were sacrificed and the hippocampus, corpus callosum, striatum, cortex, fimbria and ventricle were immunostained for iba-1, a microglial marker, glial fibrillary acidic protein (gfap), an astrocyte marker, and inos, an activation marker for no. |
2021-08-10 |
2023-08-13 |
mouse |
| Yun Fan, Mei-Chuan Chou, Yen-Chin Liu, Ching-Kuan Liu, Chu-Huang Chen, Shiou-Lan Che. Intermittent Hypoxia Activates N-Methyl-D-Aspartate Receptors to Induce Anxiety Behaviors in a Mouse Model of Sleep-Associated Apnea. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33660202. |
increased glutamate n-methyl-d-aspartate (nmda) receptor subunits 2b (glun2b) and phosphorylated-erk1/2 were seen in the mpfc, striatum, and hippocampus of ih mice, but no significant microglial and astrocyte activation was found in these brain areas. |
2021-07-06 |
2023-08-13 |
mouse |
| Zhuang-Yao D Wei, Ashok K Shett. Treating Parkinson's disease by astrocyte reprogramming: Progress and challenges. Science advances. vol 7. issue 26. 2021-07-02. PMID:34162545. |
such in vivo astrocyte reprogramming in the mouse model of pd has successfully added new dopaminergic neurons to the substantia nigra and increased dopamine levels associated with axonal projections into the striatum. |
2021-07-02 |
2023-08-13 |
mouse |
| Young-Kyoung Ryu, Hye-Yeon Park, Jun Go, In-Bok Lee, Young-Keun Choi, Chul-Ho Lee, Kyoung-Shim Ki. β‑Lapachone ameliorates L‑DOPA‑induced dyskinesia in a 6‑OHDA‑induced mouse model of Parkinson's disease. Molecular medicine reports. vol 23. issue 3. 2021-05-04. PMID:33495840. |
in addition, astrocyte activation was markedly suppressed by β‑lapachone‑cotreatment with l‑dopa in the striatum and substantia nigra of the unilateral 6‑ohda model. |
2021-05-04 |
2023-08-13 |
mouse |
| Qianqian Liu, Shaozhi Zhang, Dashuai Zhu, Xinyu Tang, Yongzhe Che, Xizeng Fen. The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson's disease in mice. Behavioural brain research. vol 379. 2021-04-30. PMID:31697983. |
furthermore, act001 abolished mptp-induced α-synuclein overexpression, astrocyte activation and interleukin-1β (il-1β) production in the substantia nigra and striatum of the mouse brain. |
2021-04-30 |
2023-08-13 |
mouse |