| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antonio Del Casale, Martina Nicole Modesti, Giovanna Gentile, Cecilia Guariglia, Stefano Ferracuti, Maurizio Simmaco, Marina Borr. Is the Hedgehog Pathway Involved in the Pathophysiology of Schizophrenia? A Systematic Review of Current Evidence of Neural Molecular Correlates and Perspectives on Drug Development. Current issues in molecular biology. vol 46. issue 6. 2024-06-26. PMID:38920990. |
the hh pathway is crucial in the development of midbrain dopaminergic neurons, neuroplasticity mechanisms, regulating astrocyte phenotype and function, brain-derived neurotrophic factor expression, brain glutamatergic neural transmission, and responses to antipsychotics. |
2024-06-26 |
2024-06-29 |
human |
| Edgardo Torres-Carmona, Shinichiro Nakajima, Yusuke Iwata, Fumihiko Ueno, Cristiana Stefan, Jianmeng Song, Ali Abdolizadeh, Michel Teruki Koizumi, Yasaman Kambari, Aron Amaev, Sri Mahavir Agarwal, Wanna Mar, Vincenzo de Luca, Gary Remington, Philip Gerretsen, Ariel Graff-Guerrer. Clozapine treatment and astrocyte activity in treatment resistant schizophrenia: A proton magnetic resonance spectroscopy study. Schizophrenia research. vol 270. 2024-06-23. PMID:38909486. |
however, in vitro evidence suggests clozapine may mitigate glutamatergic dysregulations observed in trs, by modulating astrocyte activity in clzr+, but not clzr-. |
2024-06-23 |
2024-06-26 |
human |
| Liang Zhao, Hui Ling Qu, Yan Zhang, Xin Wu, Qian Xin Ji, Zhuo Zhang, Dan L. ZL006 mitigates anxiety-like behaviors induced by closed head injury through modulation of the neural circuit from the medial prefrontal cortex to amygdala. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 6. 2024-06-08. PMID:38850218. |
moreover, in the context of attenuating anxiety-like behaviors through zl006 treatment, we observe a reduction in closed head injury-induced astrocyte engulfment, which may correlate with the observed decrease in dendritic spine density of medial prefrontal cortex glutamatergic neurons. |
2024-06-08 |
2024-06-11 |
Not clear |
| Roberta De Ceglia, Andrea Volterr. Vesicular Glutamate Transporters in Astrocytes as Potential New Therapeutic Targets: Astrocyte-targeted Viral Vectors Expressing Inhibitory Nanobodies. Chimia. vol 76. issue 12. 2023-12-09. PMID:38069799. |
therefore, targeting astrocyte glutamate release is a promising new therapeutic strategy in hyper-glutamatergic brain conditions, as it does not directly block glutamatergic neurotransmission. |
2023-12-09 |
2023-12-17 |
Not clear |
| Adriana Fernanda K Vizuete, Fernanda Fróes, Marina Seady, Fernanda Hansen, Rodrigo Ligabue-Braun, Carlos-Alberto Gonçalves, Diogo O Souz. A Mechanism of Action of Metformin in the Brain: Prevention of Methylglyoxal-Induced Glutamatergic Impairment in Acute Hippocampal Slices. Molecular neurobiology. 2023-11-18. PMID:37980327. |
the drug also improved astrocyte function, particularly with regard to the glutamatergic system, increasing glutamate uptake. |
2023-11-18 |
2023-11-20 |
Not clear |
| Cam Ha Tran, Robert Renden, Adam Institoris, Kushal Sharm. Modulatory Effects of Noradrenergic and Serotonergic Signaling Pathway on Neurovascular Coupling. Research square. 2023-07-28. PMID:37502946. |
although the critical role of glutamatergic signaling in this process has been extensively investigated, the impact of behavioral state, and the release of behavior-associated neurotransmitters, such as norepinephrine and serotonin, on astrocyte ca2+ dynamics and functional hyperemia have received less attention. |
2023-07-28 |
2023-08-14 |
mouse |
| Masaki Oya, Kiwamu Matsuoka, Manabu Kubota, Junya Fujino, Shisei Tei, Keisuke Takahata, Kenji Tagai, Yasuharu Yamamoto, Hitoshi Shimada, Chie Seki, Takashi Itahashi, Yuta Y Aoki, Haruhisa Ohta, Ryu-Ichiro Hashimoto, Genichi Sugihara, Takayuki Obata, Ming-Rong Zhang, Tetsuya Suhara, Motoaki Nakamura, Nobumasa Kato, Yuhei Takado, Hidehiko Takahashi, Makoto Higuch. Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468523. |
the amplified glutamate signals may arise from enhanced glutamatergic circuits, which can be affected by astrocyte activation and suppressive signaling of dopamine neurotransmission. |
2023-07-19 |
2023-08-14 |
Not clear |
| Chiara Cervetto, Guido Maura, Diego Guidolin, Sarah Amato, Cristina Ceccoli, Luigi F Agnati, Manuela Marcol. Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders. Neuropharmacology. 2023-06-15. PMID:37321323. |
a2a-d2 heteromers on striatal astrocytes and astrocyte processes are discussed as far as their potential relevance in the control of glutamatergic transmission in striatum is concerned, including potential roles in glutamatergic transmission dysregulation in pathological conditions including schizophrenia or the parkinson's disease. |
2023-06-15 |
2023-08-14 |
Not clear |
| Courtney Clyburn, Kaitlin E Carson, Caleb R Smith, R Alberto Travagli, Kirsteen N Brownin. Brainstem astrocytes control homeostatic regulation of caloric intake. The Journal of physiology. 2023-01-25. PMID:36696965. |
astrocyte regulation of glutamatergic transmission to dmv neurons appears to involve release of the gliotransmitters glutamate and atp. |
2023-01-25 |
2023-08-14 |
Not clear |
| Jonas Blixt, Yutong Song, Michael Wanecek, Eli Gunnarso. EPO has multiple positive effects on astrocytes in an experimental model of ischemia. Brain research. 2022-12-22. PMID:36549360. |
we have previously shown that epo has short-term effects on astrocyte glutamatergic signalling in vitro and that administration of epo after experimental tbi decreases early cytotoxic brain edema and preserves structural and functional properties of the blood-brain barrier. |
2022-12-22 |
2023-08-14 |
Not clear |
| Xueqin Wang, Zan Xu, Fangli Zhao, Kuanhung J Lin, Joshua B Foster, Tianqi Xiao, Nydia Kung, Candice C Askwith, John P Bruno, Valentina Valentini, Kevin J Hodgetts, Chien-Liang Glenn Li. Restoring tripartite glutamatergic synapses: A potential therapy for mood and cognitive deficits in Gulf War illness. Neurobiology of stress. vol 13. 2021-05-14. PMID:33344696. |
they exhibited the following pathological changes in hippocampi: elevated extracellular glutamate levels, impaired glutamatergic synapses, astrocyte atrophy, loss of interneurons, and decreased neurogenesis. |
2021-05-14 |
2023-08-13 |
mouse |
| Neus Fullana, Júlia Gasull-Camós, Mireia Tarrés-Gatius, Anna Castañé, Analía Bortolozzi, Francesc Artiga. Astrocyte control of glutamatergic activity: Downstream effects on serotonergic function and emotional behavior. Neuropharmacology. vol 166. 2021-04-02. PMID:32045742. |
astrocyte control of glutamatergic activity: downstream effects on serotonergic function and emotional behavior. |
2021-04-02 |
2023-08-13 |
mouse |
| Patrick D Parker, Pratyush Suryavanshi, Marcello Melone, Punam A Sawant-Pokam, Katelyn M Reinhart, Dan Kaufmann, Jeremy J Theriot, Arianna Pugliese, Fiorenzo Conti, C William Shuttleworth, Daniela Pietrobon, K C Brenna. Non-canonical glutamate signaling in a genetic model of migraine with aura. Neuron. vol 109. issue 4. 2021-03-10. PMID:33321071. |
glutamatergic plumes overlapped anatomically with a reduced density of glt-1a-positive astrocyte processes and were mimicked in wild-type animals by inhibiting glutamate clearance. |
2021-03-10 |
2023-08-13 |
mouse |
| Julien Genty, Milène Tetsi Nomigni, Fernand Anton, Ulrike Hanesc. The combination of postnatal maternal separation and social stress in young adulthood does not lead to enhanced inflammatory pain sensitivity and depression-related behavior in rats. PloS one. vol 13. issue 8. 2019-02-08. PMID:30142161. |
despite the finding that stress conditions differentially affected different players of glutamatergic transmission, astrocyte activity and ngf expression, our biochemical results could not readily be related to the behavioral observations, precluding a congruent conclusion. |
2019-02-08 |
2023-08-13 |
rat |
| Fabiana Galland, Elisa Negri, Carollina Da Ré, Fernanda Fróes, Liliane Strapazzon, Maria Cristina Guerra, Lucas Silva Tortorelli, Carlos-Alberto Gonçalves, Marina Concli Leit. Hyperammonemia compromises glutamate metabolism and reduces BDNF in the rat hippocampus. Neurotoxicology. vol 62. 2018-05-30. PMID:28506823. |
hyperammonemia directly impaired astrocyte function, inducing a decrease in glutamate uptake and in the activity of glutamine synthetase, in turn altering the glutamine-glutamate cycle, glutamatergic neurotransmission and ammonia detoxification itself. |
2018-05-30 |
2023-08-13 |
rat |
| Zhi Zhang, Bassam Bassam, Ajit G Thomas, Monica Williams, Jinhuan Liu, Elizabeth Nance, Camilo Rojas, Barbara S Slusher, Sujatha Kanna. Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain. Neurobiology of disease. vol 94. 2018-02-27. PMID:27326668. |
astrocyte dysfunction and excessive activation of glutamatergic systems have been implicated in a number of neurologic disorders, including periventricular leukomalacia (pvl) and cerebral palsy (cp). |
2018-02-27 |
2023-08-13 |
rabbit |
| Tudor Puiu, Anson E Kairys, Lynne Pauer, Tobias Schmidt-Wilcke, Eric Ichesco, Johnson P Hampson, Vitaly Napadow, Daniel J Clauw, Richard E Harri. Association of Alterations in Gray Matter Volume With Reduced Evoked-Pain Connectivity Following Short-Term Administration of Pregabalin in Patients With Fibromyalgia. Arthritis & rheumatology (Hoboken, N.J.). vol 68. issue 6. 2017-07-07. PMID:26816332. |
preclinical studies indicate that pgb may down-regulate brain glutamate release while also inhibiting astrocyte induction of glutamatergic synapse formation, and recent clinical findings support the notion that pgb modulates glutamatergic activity and functional brain connectivity in order to produce analgesia. |
2017-07-07 |
2023-08-13 |
Not clear |
| Maurizio De Pittà, Nicolas Brune. Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study. Neural plasticity. vol 2016. 2016-12-30. PMID:27195153. |
glutamatergic gliotransmission, that is, the release of glutamate from perisynaptic astrocyte processes in an activity-dependent manner, has emerged as a potentially crucial signaling pathway for regulation of synaptic plasticity, yet its modes of expression and function in vivo remain unclear. |
2016-12-30 |
2023-08-13 |
Not clear |
| Elizabeth Hanson, Niels Christian Danbolt, Chris G Dull. Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust. Neurobiology of disease. vol 89. 2016-12-13. PMID:26875663. |
taken together, our results demonstrate that the maturation of astrocyte membrane resistance, local distribution of glutamate transporters, and glutamatergic input to the cortex are altered in the fl model, but that single-cell astrocytic glutamate uptake is robust. |
2016-12-13 |
2023-08-13 |
human |
| Catherine S John, Elizabeth I Sypek, William A Carlezon, Bruce M Cohen, Dost Öngür, Anita J Bechthol. Blockade of the GLT-1 Transporter in the Central Nucleus of the Amygdala Induces both Anxiety and Depressive-Like Symptoms. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 7. 2016-01-25. PMID:25586634. |
depression has been associated with abnormalities in glutamatergic neurotransmission and decreased astrocyte number in limbic areas. |
2016-01-25 |
2023-08-13 |
rat |