| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Imogen Stockwell, Jake F Watson, Ingo H Grege. Tuning synaptic strength by regulation of AMPA glutamate receptor localization. BioEssays : news and reviews in molecular, cellular and developmental biology. 2024-05-02. PMID:38693811. |
tuning synaptic strength by regulation of ampa glutamate receptor localization. |
2024-05-02 |
2024-05-04 |
Not clear |
| Aaron J Barbour, Sarah Gourmaud, Eunjoo Lancaster, Xiaofan Li, David A Stewart, Keegan F Hoag, David J Irwin, Delia M Talos, Frances E Jense. Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer's disease and 5XFAD mice. Brain : a journal of neurology. 2024-04-25. PMID:38662500. |
post-mortem ad temporal cortical tissue from patients with or without seizure history were examined for changes in several markers of e:i balance, including levels of the inhibitory gabaa receptor, the sodium potassium chloride cotransporter 1 (nkcc1) and potassium chloride cotransporter 2 (kcc2), and the excitatory nmda and ampa type glutamate receptors. |
2024-04-25 |
2024-04-28 |
mouse |
| Aaron J Barbour, Sarah Gourmaud, Eunjoo Lancaster, Xiaofan Li, David A Stewart, Keegan F Hoag, David J Irwin, Delia M Talos, Frances E Jense. Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer's disease and 5XFAD mice. Brain : a journal of neurology. 2024-04-25. PMID:38662500. |
furthermore, seizure induction in prodromal 5xfad mice led to later dysregulation of nkcc1/kcc2 and a reduction in glua2 ampa glutamate receptor subunit expression, indicative of depolarizing gaba receptors and calcium permeable ampa receptors. |
2024-04-25 |
2024-04-28 |
mouse |
| Sanghyeon Lee, Jungho Kim, Hyun-Hee Ryu, Hanbyul Jang, DoEun Lee, Seungha Lee, Jae-Man Song, Yong-Seok Lee, Young Ho Su. SHP2 regulates GluA2 tyrosine phosphorylation required for AMPA receptor endocytosis and mGluR-LTD. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 18. 2024-04-24. PMID:38657042. |
during long-term depression (ltd), protein tyrosine phosphatases (ptps) dephosphorylate tyrosine residues in the c-terminal tail of ampa receptor glua2 subunit, which is essential for glua2 endocytosis and group i metabotropic glutamate receptor (mglur)-dependent ltd. |
2024-04-24 |
2024-04-28 |
Not clear |
| Adam J Carlton, Jing-Yi Jeng, Fiorella C Grandi, Francesca De Faveri, Ana E Amariutei, Lara De Tomasi, Andrew O'Connor, Stuart L Johnson, David N Furness, Steve D M Brown, Federico Ceriani, Michael R Bowl, Mirna Mustapha, Walter Marcott. BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing. Cell reports. vol 43. issue 4. 2024-04-02. PMID:38564333. |
here, we demonstrate that brain-specific angiogenesis inhibitor 1 (bai1) is required for the clustering of ampa receptors glur2-4 (glutamate receptors 2-4) at the psd. |
2024-04-02 |
2024-04-05 |
mouse |
| Nicholas Pintori, Alessandro Piva, Francesca Mottarlini, Fernando Castillo Díaz, Coralie Maggi, Lucia Caffino, Fabio Fumagalli, Cristiano Chiamuler. Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint. The European journal of neuroscience. 2024-02-20. PMID:38378276. |
we focused our investigation on the expression of nmda and ampa receptor subunits, their scaffolding proteins sap102 and sap97, vesicular and membrane glutamate transporters vglut1 and glt-1, and critical structural components such as proteins involved in morphology and function of glutamatergic synapses, psd95 and arc/arg3.1. |
2024-02-20 |
2024-02-23 |
rat |
| Kaspar Vogt, Ashwinikumar Kulkarni, Richa Pandey, Mantre Dehnad, Genevieve Konopka, Robert Green. Sleep need driven oscillation of glutamatergic synaptic phenotype. bioRxiv : the preprint server for biology. 2024-02-19. PMID:38370691. |
earlier observations have shown an overall increase in synaptic strength and number of cortical, glutamate, ampa receptor (ampar) synapses in response to sd that is recovered by sleep. |
2024-02-19 |
2024-02-21 |
Not clear |
| Naoya Atarashi, Misaki Morishita, Shinji Matsud. Activation of innate immune receptor TLR9 by mitochondrial DNA plays essential roles in the chemical long-term depression of hippocampal neurons. The Journal of biological chemistry. 2024-02-14. PMID:38354781. |
although long-term depression (ltd), a form of synaptic plasticity, is caused by the activity-dependent reduction of cell surface α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa)--type glutamate receptors (ampa receptors) at postsynaptic sites, its regulation by neuronal activity is not completely understood. |
2024-02-14 |
2024-02-17 |
Not clear |
| Michael D Hadler, Alexandra Tzilivaki, Dietmar Schmitz, Henrik Alle, Jörg R P Geige. Gamma oscillation plasticity is mediated via parvalbumin interneurons. Science advances. vol 10. issue 5. 2024-01-31. PMID:38295164. |
gamma potentiation obeys established rules of pvi plasticity, requiring calcium-permeable ampa receptors (cp-ampars) and metabotropic glutamate receptors (mglurs). |
2024-01-31 |
2024-02-03 |
Not clear |
| Priya P Shejul, Gaurav M Dosh. Glutamate Receptors and C-ABL Inhibitors: A New Therapeutic Approach for Parkinson's Disease. Central nervous system agents in medicinal chemistry. 2024-01-26. PMID:38273763. |
furthermore, the concepts of nmethyl- d-aspartate (nmda), α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (ampa) receptor, and glutamate receptors are discussed briefly. |
2024-01-26 |
2024-01-28 |
Not clear |
| Mohammad Qneibi, Sosana Bdir, Mohammad Bdair, Samia Ammar Aldwaik, Dana Sandouka, Maram Heeh, Tala Iyad Idai. AMPA receptor neurotransmission and therapeutic applications: A comprehensive review of their multifaceted modulation. European journal of medicinal chemistry. vol 266. 2024-01-18. PMID:38237342. |
ampa receptors, members of the ionotropic glutamate receptor family, allow rapid excitatory neurotransmission in the brain. |
2024-01-18 |
2024-01-21 |
Not clear |
| Jiahui Chen, Yinlong Li, QingZhen Yu, Jimmy S Patel, Xin Zhou, Kuo Zhang, Jian Rong, Chunyu Zhao, Ahmad F Chaudhary, Wei Zhang, Chunyang Bi, Zhendong Song, April T Davenport, Ahmed Haider, James B Daunais, Lee Collier, Hongjie Yuan, Steven Lian. Preclinical Evaluation of Azabenzimidazole-Based PET Radioligands for γ-8 Dependent Transmembrane AMPA Receptor Regulatory Protein Imaging. Chembiochem : a European journal of chemical biology. 2024-01-16. PMID:38227784. |
ampa glutamate receptors (ampars) play a pivotal role in excitatory neurotransmission, particularly in the hippocampus where the tarp γ-8 subunit is enriched and serves as a target for emerging anti-epileptic drugs. |
2024-01-16 |
2024-01-19 |
rat |
| Kyle A Brown, Todd D Goul. Targeting metaplasticity mechanisms to promote sustained antidepressant actions. Molecular psychiatry. 2024-01-04. PMID:38177353. |
specifically, while the initiating mechanisms of these therapies may differ (e.g., cell type-specificity, n-methyl-d-aspartate receptor (nmdar) subtype-selective inhibition vs activation, metabotropic glutamate receptor 2/3 antagonism, ampa receptor potentiation, 5-ht receptor-activating psychedelics, etc. |
2024-01-04 |
2024-01-07 |
Not clear |
| Mohammad Qneibi, Mohammed Hawash, Mehmet Gümüş, İrfan Çapan, Yusuf Sert, Sosana Bdir, İrfan Koca, Mohammad Bdai. Deciphering the Biophysical Properties of Ion Channel Gating Pores by Coumarin-Benzodiazepine Hybrid Derivatives: Selective AMPA Receptor Antagonists. Molecular neurobiology. 2023-12-17. PMID:38105408. |
the primary objective of this investigation was to identify specific ampa receptor antagonists, namely 2,3-benzodiazepines, that function as negative allosteric modulators (nams) at distinct locations apart from the glutamate recognition site. |
2023-12-17 |
2023-12-21 |
Not clear |
| Pierre Francotte, Yasmin Bay, Eric Goffin, Thomas Colson, Cindy Lesenfants, Jerzy Dorosz, Saara Laulumaa, Pierre Fraikin, Pascal de Tullio, Caroline Beaufour, Iuliana Botez, Darryl S Pickering, Karla Frydenvang, Laurence Danober, Anders Skov Kristensen, Jette Sandholm Kastrup, Bernard Pirott. Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators. European journal of medicinal chemistry. vol 264. 2023-12-15. PMID:38101041. |
finally, compound 32 was selected for co-crystallization with the glua2-lbd (l504y,n775s) and glutamate to examine the binding mode of thienothiadiazine dioxides within the allosteric binding site of the ampa receptor. |
2023-12-15 |
2023-12-18 |
mouse |
| Marina N Vukolova, Laura Y Yen, Margarita I Khmyz, Alexander I Sobolevsky, Maria V Yelshanskay. Parkinson's disease, epilepsy, and amyotrophic lateral sclerosis-emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors. Frontiers in cell and developmental biology. vol 11. 2023-11-30. PMID:38033869. |
parkinson's disease, epilepsy, and amyotrophic lateral sclerosis-emerging role of ampa and kainate subtypes of ionotropic glutamate receptors. |
2023-11-30 |
2023-12-10 |
Not clear |
| Jean-Philippe Guilloux, Thi Mai Loan Nguyen, Alain M Gardie. [Ketamine: a neuropsychotropic drug with an innovative mechanism of action]. Biologie aujourd'hui. vol 217. issue 3-4. 2023-11-29. PMID:38018940. |
advances in knowledge of the consequences of r-nmda blockade allowed to specify the underlying mechanisms involving the activation of ampa glutamate receptors, which triggers a cascade of intracellular events dependent on the mechanistic target of rapamycin, brain-derived neurotrophic factor, and synaptic protein synthesis facilitating synaptic plasticity (number of dendritic spines, synaptogenesis). |
2023-11-29 |
2023-12-07 |
Not clear |
| Krisztina Takács-Lovász, Timea Aczél, Éva Borbély, Éva Szőke, Lilla Czuni, Péter Urbán, Attila Gyenesei, Zsuzsanna Helyes, József Kun, Kata Bölcske. Hemokinin-1 induces transcriptomic alterations in pain-related signaling processes in rat primary sensory neurons independent of NK1 tachykinin receptor activation. Frontiers in molecular neuroscience. vol 16. 2023-11-15. PMID:37965042. |
acid-sensing ion channel 1; 3 (asic1,3), n-methyl-d-aspartate (nmda) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) glutamate receptors decreased, myelin production and maintenance related genes (mbp, pmp2, myef2, mpz) and gndf changed by hk-1 treatment. |
2023-11-15 |
2023-11-20 |
rat |
| Paul G Morris, Allan E Herbiso. Mechanism of arcuate kisspeptin neuron synchronization in acute brain slices from female mice. Endocrinology. 2023-11-08. PMID:37936337. |
analysis of both spontaneous synchronizations and those driven by high frequency stimulation of individual arnkiss neurons revealed that the network exhibits semi-random emergent excitation dependent upon glutamate signaling through ampa receptors. |
2023-11-08 |
2023-11-20 |
mouse |
| Paul G Morris, Allan E Herbiso. Mechanism of arcuate kisspeptin neuron synchronization in acute brain slices from female mice. Endocrinology. 2023-11-08. PMID:37936337. |
these observations indicate that a very similar ampa receptor-dependent mechanism underlies arnkiss neuron synchronizations in the female mouse supporting the "glutamate two-transition" model for kisspeptin neuron synchronization. |
2023-11-08 |
2023-11-20 |
mouse |