| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adam Brzezinski, Cesar I Menchaca, Shashikanth Gang. Phenobarbital use in pediatric perampanel overdose with coma, respiratory compromise. Toxicology reports. vol 13. 2024-12-05. PMID:39633963. |
perampanel (fycompa®) is a non-competitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) glutamate receptor antagonistic antiepileptic medication used to treat generalized seizure disorders. |
2024-12-05 |
2024-12-07 |
Not clear |
| Wallace B Thoreson, Thomas M Bartol, Nicholas H Conoan, Jeffrey S Diamon. Geometric tortuosity at invaginating rod synapses slows glutamate diffusion and shapes synaptic responses: insights from anatomically realistic Monte Carlo simulations. bioRxiv : the preprint server for biology. 2024-11-18. PMID:39554003. |
by comparing simulations with electrophysiological recordings, we modeled synaptic activation of eaat5 glutamate transporters in rods, ampa receptors on hc dendrites, and metabotropic glutamate receptors (mglur6) on rrbp dendrites. |
2024-11-18 |
2024-11-22 |
mouse |
| Olga Vladimirovna Nadei, Natalia Ivanovna Agalakov. AMPA and NMDA Receptors in Hippocampus of Rats with Fluoride-Induced Cognitive Decline. International journal of molecular sciences. vol 25. issue 21. 2024-11-09. PMID:39519348. |
this experimental study was performed to evaluate the alterations in the expression of a few subunits composing glutamate ampa (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and nmda (n-methyl-d-aspartate) receptors in the hippocampal cells of wistar rats in response to long-term fluoride (f |
2024-11-09 |
2024-11-17 |
rat |
| Yu-Chen Deng, Jen-Wei Liu, Hsiao-Chien Ting, Tzu-Chen Kuo, Chia-Hung Chiang, En-Yi Lin, Horng-Jyh Harn, Shinn-Zong Lin, Chia-Yu Chang, Tzyy-Wen Chio. n-Butylidenephthalide recovered calcium homeostasis to ameliorate neurodegeneration of motor neurons derived from amyotrophic lateral sclerosis iPSCs. PloS one. vol 19. issue 11. 2024-11-07. PMID:39509425. |
meanwhile, bp treatment effectively restored calcium ion channel function by reducing the expression of glutamate receptors including glutamate ionotropic receptor ampa type subunit 3 (glur3) and glutamate ionotropic receptor nmda type subunit 1 (nmdar1). |
2024-11-07 |
2024-11-16 |
human |
| Aya Matsui, Cathy Spangler, Johannes Elferich, Momoko Shiozaki, Nikki Jean, Xiaowei Zhao, Maozhen Qin, Haining Zhong, Zhiheng Yu, Eric Gouau. Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses. eLife. vol 13. 2024-11-04. PMID:39495821. |
at excitatory synapses, glutamate is the primary neurotransmitter and upon release from presynaptic vesicles, is detected by postsynaptic glutamate receptors, which include ionotropic ampa and nmda receptors. |
2024-11-04 |
2024-11-07 |
Not clear |
| Arseniy S Zhigulin, Mikhail Y Dron, Oleg I Barygin, Denis B Tikhono. The diversity of AMPA receptor inhibition mechanisms among amidine-containing compounds. Frontiers in pharmacology. vol 15. 2024-10-24. PMID:39444609. |
in this study, we examined the activity of these compounds and analyzed the mechanisms of action in relation to another important class of ionotropic glutamate receptors-calcium-permeable ampa receptors (cp-ampars) and calcium-impermeable ampa receptors (ci-ampars) - using the whole-cell patch-clamp method on isolated male wistar rat brain neurons. |
2024-10-24 |
2024-10-26 |
rat |
| Qingchen Gu. Quantitative analysis of the interaction between NMDA and AMPA receptors in glutamatergic synapses based on mathematical model. Neuroscience research. 2024-10-20. PMID:39427699. |
glutamate binds to both the nmda and ampa receptors. |
2024-10-20 |
2024-10-23 |
Not clear |
| Qingchen Gu. Quantitative analysis of the interaction between NMDA and AMPA receptors in glutamatergic synapses based on mathematical model. Neuroscience research. 2024-10-20. PMID:39427699. |
initially, i investigated whether there is competition between ampa receptors and n-methyl-d-aspartic acid (nmda) receptors for glutamate. |
2024-10-20 |
2024-10-23 |
Not clear |
| Qingchen Gu. Quantitative analysis of the interaction between NMDA and AMPA receptors in glutamatergic synapses based on mathematical model. Neuroscience research. 2024-10-20. PMID:39427699. |
if there is competition for glutamate between ampa receptors and nmda receptors, the number of activated nmda receptor channels will decrease. |
2024-10-20 |
2024-10-23 |
Not clear |
| Burcin Alacam, Seyma Nur Basarir, Ayca Tas Tuna, Onur Palabiyik, Huseyin Cakirogl. The Effect Of Amantadine On Recovery, Postoperative Cognitive Dysfunction And Pain After Propofol Anesthesia in Mice. Behavioural brain research. 2024-10-13. PMID:39396575. |
the pathogenesis involves glutamate toxicity, gaba receptor dysfunction, and alterations in nmda and ampa receptors. |
2024-10-13 |
2024-10-16 |
mouse |
| Mohammad Qneibi, Sosana Bdir, Mohammad Bdair, Samia Ammar Aldwaik, Maram Heeh, Dana Sandouka, Tala Idai. Exploring the role of AMPA receptor auxiliary proteins in synaptic functions and diseases. The FEBS journal. 2024-10-11. PMID:39394632. |
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) ionotropic glutamate receptors (ampars) mediate rapid excitatory synaptic transmission in the mammalian brain, primarily driven by the neurotransmitter glutamate. |
2024-10-11 |
2024-10-14 |
Not clear |
| Sara Faccidomo, Vallari R Eastman, Taruni S Santanam, Katarina S Swaim, Seth M Taylor, Clyde W Hodg. Sex Differences in Home-Cage Ethanol Drinking and Operant Self-Administration in C57BL/6J Mice but Equivalent Regulation by Glutamate AMPAR Activity. bioRxiv : the preprint server for biology. 2024-10-10. PMID:39386480. |
this study aims to elucidate sabv in ethanol (etoh) consumption by evaluating its reinforcing effects and regulation by glutamate ampa receptor activity in male and female mice. |
2024-10-10 |
2024-10-12 |
mouse |
| Misaki Morishita, Shinji Matsud. SARM1 is essential for NMDA receptor-dependent endocytosis of AMPA receptors in hippocampal neurons. Neuroscience research. 2024-09-30. PMID:39349221. |
ltd is caused by an activity-dependent decrease in cell surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa)-type glutamate receptors (ampa receptors) at the postsynaptic sites. |
2024-09-30 |
2024-10-03 |
Not clear |
| Sara Faccidomo, Briana L Saunders, Ashley M May, Vallari R Eastman, Michelle Kim, Seth M Taylor, Jessica L Hoffman, Zoé A McElligott, Clyde W Hodg. Operant alcohol self-administration targets GluA2-containing AMPAR expression and synaptic activity in the nucleus accumbens in a manner that drives the reinforcing properties of the drug. bioRxiv : the preprint server for biology. 2024-09-24. PMID:39314444. |
ethanol alters the expression of glutamate ampa receptor (ampar) subunits in reward-related brain regions, but the extent to which this molecular effect regulates ethanol's reinforcing properties is unclear. |
2024-09-24 |
2024-09-26 |
Not clear |
| Leonor Mirand. Antidepressant and anxiolytic effects of activating 5HT2A receptors in the anterior cingulate cortex and the theoretical mechanisms underlying them - A scoping review of available literature. Brain research. 2024-09-09. PMID:39251056. |
this is possibly due to a complex interplay with glutamate and gamma-butyric acid neurotransmission, particularly 5ht2a activation enhances α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptor signalling, thus altering the ratio of ampa to n-methyl-d-aspartate (nmda) activity in the acc, which can dismantle previously established neuronal connections and aid the formation of new ones, an effect that may be beneficial for fear extinction and reversal learning. |
2024-09-09 |
2024-09-13 |
Not clear |
| Junwen Chen, Ming Zhang, Ziyi Shen, Ming Tang, Yumei Zeng, Dazhang Bai, Peilin Zhao, Guohui Jian. Low-dose diazepam improves cognitive function in APP/PS1 mouse models: Involvement of AMPA receptors. Brain research. 2024-08-30. PMID:39214326. |
mechanistic investigations revealed that dzp exerted its neuroprotective effects and reduced aβ deposition by modulating glua1 (glutamate ampa receptor subunit) to influence synaptic function. |
2024-08-30 |
2024-09-04 |
mouse |
| Dirk Trauner, Philipp Leipppe, Prashant Donthamsetti, Tongil Ko, Cherise Stanley, Ehud Isacof. Cell-Specific Optical Control of AMPA Glutamate Receptors with a Photoswitchable Tethered Antagonist. Angewandte Chemie (International ed. in English). 2024-08-27. PMID:39189798. |
cell-specific optical control of ampa glutamate receptors with a photoswitchable tethered antagonist. |
2024-08-27 |
2024-08-30 |
Not clear |
| Jennifer M Walters, Hayden A Noblet, Hee Jung Chun. An emerging role of STriatal-enriched protein tyrosine phosphatase in hyperexcitability-associated brain disorders. Neurobiology of disease. 2024-08-19. PMID:39159894. |
importantly, step dephosphorylates nmda and ampa receptors, two major glutamate receptors that mediate fast excitatory synaptic transmission. |
2024-08-19 |
2024-08-22 |
mouse |
| Josip Ivica, Nejc Kejzar, Hinze Ho, Imogen Stockwell, Viktor Kuchtiak, Alexander M Scrutton, Terunaga Nakagawa, Ingo H Grege. Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nature structural & molecular biology. 2024-08-13. PMID:39138332. |
ampa glutamate receptors (ampars) are ion channel tetramers that mediate the majority of fast excitatory synaptic transmission. |
2024-08-13 |
2024-08-16 |
mouse |
| Liqin Wang, Mengfan Xu, Qing Zhang, Geng-Lin L. Amitriptyline protects afferent synapses in the cochlea against excitotoxic trauma in vitro. The FEBS journal. 2024-08-11. PMID:39128014. |
in this study, we simulated excitotoxic trauma by incubating kainic acid, a non-desensitizing agonist for ampa type glutamate receptors on cultured cochleae. |
2024-08-11 |
2024-08-14 |
Not clear |