| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José da Silva, Lariza Oliveira de Souza, Maria Paula Arakaki Severo, Sarah Luize Camargo Rodrigues, Patrícia Molz, Patrícia Schonhofen, Alice Laschuk Herlinger, Nadja Schröde. Effects of the AMPAR Antagonist, Perampanel, on Cognitive Function in Rats Exposed to Neonatal Iron Overload. Molecular neurobiology. 2024-05-02. PMID:38696064. |
drugs that block glutamatergic receptor eligibly mitigate neurotoxicity; among them is perampanel (per), a reversible ampa receptor (ampar) antagonist. |
2024-05-02 |
2024-05-04 |
rat |
| Seung Hyun Roh, Hadassah Mendez-Vazquez, Matheus F Sathler, Michael J Doolittle, Anastasiya Zaytseva, Hannah Brown, Morgan Sainsbury, Seonil Ki. Prenatal exposure to valproic acid reduces synaptic δ-catenin levels and disrupts ultrasonic vocalization in neonates. Neuropharmacology. 2024-04-26. PMID:38657945. |
prenatal vpa exposure significantly reduced synaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptor levels and postsynaptic density 95 (psd95) in the brain of mouse pups, indicating dysfunctions in glutamatergic synaptic transmission. |
2024-04-26 |
2024-04-28 |
mouse |
| Sarah C Simmons, William J Flerlage, Ludovic D Langlois, Ryan D Shepard, Christopher Bouslog, Emily H Thomas, Kaitlyn M Gouty, Jennifer L Sanderson, Shawn Gouty, Brian M Cox, Mark L Dell'Acqua, Fereshteh S Nugen. AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula. Communications biology. vol 7. issue 1. 2024-03-21. PMID:38509283. |
using whole cell patch clamp recordings in lhb of male wildtype and Δpka knockin mice (with deficiency in akap-anchoring of pka), here we show that the genetic disruption of pka anchoring to akap150 significantly reduces ampa receptor-mediated glutamatergic transmission and prevents the induction of presynaptic endocannabinoid-mediated long-term depression in lhb neurons. |
2024-03-21 |
2024-03-23 |
mouse |
| Maria Italia, Michela Salvadè, Filippo La Greca, Elisa Zianni, Silvia Pelucchi, Alessio Spinola, Elena Ferrari, Silvana Archetti, Antonella Alberici, Alberto Benussi, Eino Solje, Annakaisa Haapasalo, Dorit Hoffmann, Kasper Katisko, Johanna Krüger, Roberta Facchinetti, Caterina Scuderi, Alessandro Padovani, Monica DiLuca, Diego Scheggia, Barbara Borroni, Fabrizio Gardon. Anti-GluA3 autoantibodies define a new sub-population of frontotemporal lobar degeneration patients with distinct neuropathological features. Brain, behavior, and immunity. 2024-03-14. PMID:38485064. |
of note, anti-glua3 higgs-mediated alterations were rescued in the animal model by enhancing glutamatergic neurotransmission with a positive allosteric modulator of ampa receptors. |
2024-03-14 |
2024-03-17 |
mouse |
| Nicholas R Mill, Richard H Ogoe, Nazanin Valibeigi, Diyi Chen, Carmen L Kimbal, Stanley J Yoon, Shaunak Ganju, Josue A Perdomo, Anjali Sardana, Daniel G McHail, Diego A Gonzalez, Theodore C Duma. Positive modulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors differentially alters spatial learning and memory in juvenile rats younger and older than three weeks. Behavioural pharmacology. vol 35. issue 2-3. 2024-03-07. PMID:38451022. |
previously, we discovered that developmental modifications to hippocampal glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptors in juvenile rats was related to more mature spontaneous alternation behavior in a symmetrical y-maze. |
2024-03-07 |
2024-03-09 |
rat |
| Sabhya Rana, Firoj Alom, Robert C Martinez, David D Fuller, Aaron D Mickl. Acute ampakines increase voiding function and coordination in a rat model of SCI. eLife. vol 12. 2024-03-07. PMID:38451184. |
glutamatergic signaling via ampa receptors is fundamentally important to the neural circuits controlling bladder voiding. |
2024-03-07 |
2024-03-09 |
rat |
| Sabhya Rana, Firoj Alom, Robert C Martinez, David D Fuller, Aaron D Mickl. Acute ampakines increase voiding function and coordination in a rat model of SCI. eLife. vol 12. 2024-03-07. PMID:38451184. |
ampakines are positive allosteric modulators of ampa receptors that can enhance the function of glutamatergic neural circuits after sci. |
2024-03-07 |
2024-03-09 |
rat |
| Nicholas Pintori, Alessandro Piva, Francesca Mottarlini, Fernando Castillo Díaz, Coralie Maggi, Lucia Caffino, Fabio Fumagalli, Cristiano Chiamuler. Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint. The European journal of neuroscience. 2024-02-20. PMID:38378276. |
we focused our investigation on the expression of nmda and ampa receptor subunits, their scaffolding proteins sap102 and sap97, vesicular and membrane glutamate transporters vglut1 and glt-1, and critical structural components such as proteins involved in morphology and function of glutamatergic synapses, psd95 and arc/arg3.1. |
2024-02-20 |
2024-02-23 |
rat |
| Xiaona Wang, Yaodong Zhang, Shuying Luo, Ke Zhao, Chao Gao, Daoqi Mei, Yongtao Duan, Shunan H. Restoration of nNOS Expression Rescues Autistic-Like Phenotypes Through Normalization of AMPA Receptor-Mediated Neurotransmission. Molecular neurobiology. 2024-02-08. PMID:38329681. |
whole-cell patch-clamp recordings demonstrated that restoration of nnos had a significant enhancing effect on ampa receptor-mediated excitatory glutamatergic synaptic neurotransmission, which was inhibited by disturbing the interaction between narp and glua4 in acutely dissociated bla slices. |
2024-02-08 |
2024-02-10 |
mouse |
| Maria Hrickova, Petra Amchova, Jana Ruda-Kucerov. The effect of CNQX on self-administration: present in nicotine, absent in methamphetamine model. Frontiers in behavioral neuroscience. vol 17. 2024-01-22. PMID:38249125. |
our research aimed to evaluate the effects of cnqx, an antagonist that targets ampa and kainate glutamatergic receptors while also exhibiting affinity for the nmda receptor, especially by modulating its glycine site. |
2024-01-22 |
2024-01-24 |
rat |
| Nadia Perveen, Faleh Alqahtani, Waseem Ashraf, Muhammad Fawad Rasool, Syed Muhammad Muneeb Anjum, Iram Kaukab, Tanveer Ahmad, Saleh A Alqarni, Imran Imra. Perampanel increases seizure threshold in pentylenetetrazole-kindled mice and improves behavioral dysfunctions by modifying mRNA expression levels of BDNF/TrkB and inflammatory markers. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 32. issue 1. 2024-01-16. PMID:38226351. |
perampanel (per), a novel 3rd-generation antiseizure drug that modulates altered post-synaptic glutamatergic storming by selectively inhibiting ampa receptors, is recently approved to treat intractable forms of seizures. |
2024-01-16 |
2024-01-18 |
mouse |
| Milan D Valyear, Alexa Brown, Ghislaine Deyab, Franz R Villaruel, Soraya Lahlou, Nina Caporicci-Dinucci, Nadia Chaudhr. Augmenting glutamatergic, but not dopaminergic, activity in the nucleus accumbens shell disrupts responding to a discrete alcohol cue in an alcohol context. The European journal of neuroscience. 2024-01-08. PMID:38185906. |
when conditioned cs responding was tested by presenting the cs without alcohol, we found that augmenting glutamatergic activity in the nucleus accumbens (nac) shell by microinfusing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) reduced responding to an alcohol cs in an alcohol, but not neutral, context. |
2024-01-08 |
2024-01-10 |
rat |
| Seung Hyun Roh, Hadassah Mendez-Vazquez, Matheus F Sathler, Michael J Doolittle, Anastasiya Zaytseva, Hannah Brown, Morgan Sainsbury, Seonil Ki. Prenatal exposure to valproic acid reduces synaptic δ-catenin levels and disrupts ultrasonic vocalization in neonates. bioRxiv : the preprint server for biology. 2024-01-03. PMID:38168404. |
prenatal vpa exposure significantly reduced synaptic ampa receptor levels and postsynaptic density 95 (psd95) in the brain of mouse pups, indicating dysfunctions in glutamatergic synaptic transmission. |
2024-01-03 |
2024-01-06 |
mouse |
| Uwemedimo G Udoh, John R Bruno, Paige O Osborn, Kara G Prat. Serotonin strengthens a developing glutamatergic synapse through a PI3K-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-01-03. PMID:38169457. |
it is well established that, during neural circuit development, glutamatergic synapses become strengthened via nmda receptor (nmdar)-dependent up-regulation of ampa receptor (ampar)-mediated currents. |
2024-01-03 |
2024-01-06 |
xenopus_laevis |
| S C Simmons, W J Flerlage, L D Langlois, R D Shepard, C Bouslog, E H Thomas, K M Gouty, J L Sanderson, S Gouty, B M Cox, M L Dell'Acqua, F S Nugen. AKAP150-anchored PKA regulation of synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the lateral habenula. bioRxiv : the preprint server for biology. 2023-12-18. PMID:38106086. |
using whole cell patch clamp recordings in lhb of male wildtype (wt) and Δpka knockin mice (with deficiency in akap-anchoring of pka), we found that the genetic disruption of pka anchoring to akap150 significantly reduced ampa receptor (ampar)-mediated glutamatergic transmission and prevented the induction of presynaptic endocannabinoid (ecb)-mediated long-term depression (ltd) in lhb neurons. |
2023-12-18 |
2023-12-21 |
mouse |
| Ya-Yang Wu, Cheng-Hong Zeng, Kun-Yi Cai, Chao Zheng, Meng-Ya Wang, Huan-Huan Zhan. A glutamatergic pathway between the medial habenula and the rostral ventrolateral medulla may regulate cardiovascular function in a rat model of post-traumatic stress disorder. The Chinese journal of physiology. vol 66. issue 5. 2023-11-06. PMID:37929343. |
these findings suggest that there may be a glutamatergic pathway connection between mhb and rvlm and that this pathway may be involved in the regulation of cardiovascular function in the ptsd model rats, by acting on nmda and ampa receptors in the rvlm. |
2023-11-06 |
2023-11-08 |
rat |
| Aurelie Joly-Amado, Neel Kulkarni, Kevin R Nas. Reelin Signaling in Neurodevelopmental Disorders and Neurodegenerative Diseases. Brain sciences. vol 13. issue 10. 2023-10-30. PMID:37891846. |
reelin's signaling potentiates glutamatergic and gabaergic neurotransmission, induces synaptic maturation, and increases ampa and nmda receptor subunits' expression and activity. |
2023-10-30 |
2023-11-08 |
Not clear |
| Amanda M Perozzo, Jochen Schwenk, Aichurok Kamalova, Terunaga Nakagawa, Bernd Fakler, Derek Bowi. GSG1L-containing AMPA receptor complexes are defined by their spatiotemporal expression, native interactome and allosteric sites. Nature communications. vol 14. issue 1. 2023-10-26. PMID:37884493. |
transmembrane ampa receptor regulatory proteins (tarps) and germ cell-specific gene 1-like protein (gsg1l) are claudin-type ampa receptor (ampar) auxiliary subunits that profoundly regulate glutamatergic synapse strength and plasticity. |
2023-10-26 |
2023-11-08 |
Not clear |
| Kuniko Kusama-Eguchi, Yuki Tokui, Ai Minoura, Yuta Yanai, Dai Hirose, Megumi Furukawa, Yasuhiro Kosuge, Motofumi Miura, Emika Ohkoshi, Mitsuko Makino, Kimino Minagawa, Keiichi Matsuzaki, Yoshio Ogawa, Kazuko Watanabe, Ayumi Ohsak. 2(3H)-Dihydrofranolactone metabolites from Pleosporales sp. NUH322 as anti-amyotrophic lateral sclerosis drugs. Journal of natural medicines. 2023-10-07. PMID:37804412. |
nuh322 culture media, and their protective activity against the excitotoxicity of β-n-oxalyl-l-α,β-diaminopropionic acid (odap), an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa)-type glutamatergic agonist, was evaluated under low mitochondrial glutathione levels induced by ethacrynic acid (ea) and low sulfur amino acids using our developed odap-ea assay. |
2023-10-07 |
2023-10-15 |
mouse |
| Gustavo Almeida Carvalho, Raphaela Almeida Chiareli, João Francisco Cordeiro Pedrazzi, Danyelle Silva-Amaral, André Luís Batista da Rocha, Onésia Cristina Oliveira-Lima, Luciano Morais Lião, Elaine Maria de Souza-Fagundes, Stefan Schildknecht, Marcel Leist, Elaine Aparecida Del-Bel, Renato Santiago Gomez, Alexander Birbrair, Ricardo Menegatti, Mauro Cunha Xavier Pint. Novel Proline Transporter Inhibitor (LQFM215) Presents Antipsychotic Effect in Ketamine Model of Schizophrenia. Neurochemical research. 2023-09-08. PMID:37684384. |
it has been observed that the expression of the proline transporter (prot) in the central nervous system (cns) is associated with glutamatergic neurotransmission, as l-proline has the capacity to activate and modulate ampa and nmda receptors. |
2023-09-08 |
2023-10-07 |
human |