| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Martínez, Alexis Caballero, Rodrigo Ramírez, Emiliano Perez-Sanchez, Esperanza Quevedo, Diana Salvador-Garcí. Chemical Reactivity Parameters to Analyze Psychedelics: How Do We Explain the Potency of the Drugs? ACS omega. vol 9. issue 38. 2024-09-30. PMID:39346816. |
these compounds are serotonergic psychedelics; that is, they are serotonin agonists. |
2024-09-30 |
2024-10-02 |
Not clear |
| Geoffrey B Varty, Clinton E Canal, Tina A Mueller, Joshua A Hartsel, Richa Tyagi, Ken Avery, Michael E Morgan, Amy C Reichelt, Pradip Pathare, Erik Stang, Michael G Palfreyman, Alex Nivorozhki. Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT Journal of medicinal chemistry. 2024-04-09. PMID:38593423. |
synthesis and structure-activity relationships of 2,5-dimethoxy-4-substituted phenethylamines and the discovery of cyb210010: a potent, orally bioavailable and long-acting serotonin 5-ht structure-activity studies of 4-substituted-2,5-dimethoxyphenethylamines led to the discovery of 2,5-dimethoxy-4-thiotrifluoromethylphenethylamines, including cyb210010, a potent and long-acting serotonin 5-ht |
2024-04-09 |
2024-04-12 |
Not clear |
| Pol Puigseslloses, Núria Nadal-Gratacós, Gabriel Ketsela, Nicola Weiss, Xavier Berzosa, Roger Estrada-Tejedor, Mohammad Nazmul Islam, Marion Holy, Marco Niello, David Pubill, Jordi Camarasa, Elena Escubedo, Harald H Sitte, Raúl López-Arna. Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties. Molecular psychiatry. 2024-03-15. PMID:38486047. |
in fact, tryptamines that produced a higher hypothermic response, mediated by 5-ht1ar, tended to exhibit a lower hallucinogenic effect, highlighting the opposite role of both 5-ht receptors. |
2024-03-15 |
2024-03-17 |
mouse |
| Ahmed Bada. Serotonin syndrome: An often-neglected medical emergency. Journal of family & community medicine. vol 31. issue 1. 2024-02-26. PMID:38406216. |
some of the common classes of drugs that can contribute to the development of ss include selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, stimulants (e.g., amphetamines and cocaine), lithium, opioids, drugs used for recreational purposes like ecstasy methylenedioxymethamphetamine (mdma), and some herbal supplements (e.g., st. john's wort). |
2024-02-26 |
2024-02-28 |
Not clear |
| Breno A Soares, Thirumal Yempala, Darío Martínez-Afani, Williams Acevedo-Fuentes, José Brea, María Isabel Loza, Marta Cimadevila, Bruce K Cassel. Effect of Bulky ACS chemical neuroscience. 2024-01-19. PMID:38241462. |
effect of bulky the introduction of arylmethyl substituents on the amine nitrogen atom of phenethylamines and tryptamines often results in profound increases in their affinity and functional activity at 5-ht |
2024-01-19 |
2024-01-22 |
Not clear |
| Ralph Gradisch, Katharina Schlögl, Erika Lazzarin, Marco Niello, Julian Maier, Felix P Mayer, Leticia Alves da Silva, Sophie M C Skopec, Randy D Blakely, Harald H Sitte, Marko D Mihovilovic, Thomas Stockne. Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors. Nature communications. vol 15. issue 1. 2024-01-09. PMID:38195746. |
in contrast, illicit drugs of abuse like amphetamines reverse sert directionality, causing serotonin efflux. |
2024-01-09 |
2024-01-13 |
human |
| Alexander M Sherwood, Elise K Burkhartzmeyer, Samuel E Williamson, Michael H Baumann, Grant C Glatfelte. Psychedelic-like Activity of Norpsilocin Analogues. ACS chemical neuroscience. 2024-01-08. PMID:38189238. |
primary metabolites of mushroom tryptamines, psilocybin and baeocystin (i.e., psilocin and norpsilocin), exhibit potent agonist activity at the serotonin 2a receptor (5-ht |
2024-01-08 |
2024-01-10 |
Not clear |
| Jason Wallach, Andrew B Cao, Maggie M Calkins, Andrew J Heim, Janelle K Lanham, Emma M Bonniwell, Joseph J Hennessey, Hailey A Bock, Emilie I Anderson, Alexander M Sherwood, Hamilton Morris, Robbin de Klein, Adam K Klein, Bruna Cuccurazzu, James Gamrat, Tilka Fannana, Randy Zauhar, Adam L Halberstadt, John D McCorv. Identification of 5-HT Nature communications. vol 14. issue 1. 2023-12-15. PMID:38102107. |
identification of 5-ht serotonergic psychedelics possess considerable therapeutic potential. |
2023-12-15 |
2023-12-18 |
Not clear |
| Uriel Heresco-Levy, Bernard Lere. Synergistic psychedelic - NMDAR modulator treatment for neuropsychiatric disorders. Molecular psychiatry. 2023-11-09. PMID:37945694. |
serotonergic psychedelics enhance neuroplasticity via serotonin 2 a receptors (5ht2ar) activation and complex serotonergic-glutamatergic interactions involving the ionotropic glutamate receptors, tropomyosin receptor kinase b (trkb) and the mammalian target of rapamycin (mtor). |
2023-11-09 |
2023-11-20 |
Not clear |
| Lindsay P Cameron, Joseph Benetatos, Vern Lewis, Emma M Bonniwell, Alaina M Jaster, Rafael Moliner, Eero Castrén, John D McCorvy, Mikael Palner, Argel Aguilar-Valle. Beyond the 5-HT The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 43. issue 45. 2023-11-08. PMID:37940583. |
beyond the 5-ht serotonergic psychedelics, such as psilocybin and lsd, have garnered significant attention in recent years for their potential therapeutic effects and unique mechanisms of action. |
2023-11-08 |
2023-11-20 |
Not clear |
| Raly James Perez Custodio, Darlene Mae Ortiz, Hyun Jun Lee, Leandro Val Sayson, Mikyung Kim, Yong Sup Lee, Kyeong-Man Kim, Jae Hoon Cheong, Hee Jin Ki. Serotonin 2C receptors are also important in head-twitch responses in male mice. Psychopharmacology. 2023-10-26. PMID:37882810. |
serotonergic psychedelics exert their effects via their high affinity for serotonin (5-ht) receptors, particularly through activating 5-ht2a receptors (5-ht2ar), employing the frontal cortex-dependent head-twitch response (htr). |
2023-10-26 |
2023-11-08 |
mouse |
| Pablo Mallaroni, Natasha L Mason, Lilian Kloft, Johannes T Reckweg, Kim van Oorsouw, Johannes G Ramaeker. Cortical structural differences following repeated ayahuasca use hold molecular signatures. Frontiers in neuroscience. vol 17. 2023-10-24. PMID:37869513. |
serotonergic psychedelics such as ayahuasca are reported to promote both structural and functional neural plasticity via partial 5-ht |
2023-10-24 |
2023-11-08 |
Not clear |
| Rika Takaba, Daisuke Ibi, Keisuke Yoshida, Eri Hosomi, Ririna Kawase, Hiroko Kitagawa, Hirotaka Goto, Mizuki Achiwa, Kento Mizutani, Kyosuke Maede, Javier González-Maeso, Shinji Kitagaki, Masayuki Hiramats. Ethopharmacological evaluation of antidepressant-like effect of serotonergic psychedelics in C57BL/6J male mice. Naunyn-Schmiedeberg's archives of pharmacology. 2023-10-24. PMID:37874338. |
serotonergic psychedelics such as psilocybin, lysergic acid diethylamide, and doi exert a hallucinatory effect through serotonin 5-ht |
2023-10-24 |
2023-11-08 |
mouse |
| Isadora Rocha De Abreu, Allison Barkdull, James R Munoz, Robert P Smith, Travis J A Craddoc. A molecular analysis of substituted phenylethylamines as potential microtubule targeting agents through in silico methods and in vitro microtubule-polymerization activity. Scientific reports. vol 13. issue 1. 2023-09-01. PMID:37658096. |
synthetic phenethylamines can have psychoactive and hallucinogenic effects due to their high affinity with the 5-ht |
2023-09-01 |
2023-09-07 |
Not clear |
| Jason Wallach, Andrew B Cao, Maggie M Calkins, Andrew J Heim, Janelle K Lanham, Emma M Bonniwell, Joseph J Hennessey, Hailey A Bock, Emilie I Anderson, Alexander M Sherwood, Hamilton Morris, Robbin de Klein, Adam K Klein, Bruna Cuccurazzu, James Gamrat, Tilka Fannana, Randy Zauhar, Adam L Halberstadt, John D McCorv. Identification of 5-HT bioRxiv : the preprint server for biology. 2023-08-14. PMID:37577474. |
identification of 5-ht serotonergic psychedelics possess considerable therapeutic potential. |
2023-08-14 |
2023-08-16 |
Not clear |
| Barbara G Ferri, Cintia O de Novais, Raquel S Bonani, Wellington A de Barros, Ângelo de Fátima, Fabiana C Vilela, Alexandre Giusti-Paiv. Psychoactive substances 25H-NBOMe and 25H-NBOH induce antidepressant-like behavior in male rats. European journal of pharmacology. 2023-07-21. PMID:37479015. |
ring-substituted phenethylamines are believed to induce psychedelic effects primarily by interacting with 5-hydroxytryptamine 2 (5-ht2a) receptors in the brain. |
2023-07-21 |
2023-08-14 |
rat |
| Eline Pottie, Christian B M Poulie, Icaro A Simon, Kasper Harpsøe, Laura D'Andrea, Igor V Komarov, David E Gloriam, Anders A Jensen, Jesper L Kristensen, Christophe P Stov. Structure-Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT ACS chemical neuroscience. 2023-07-20. PMID:37474114. |
structure-activity assessment and in-depth analysis of biased agonism in a set of phenylalkylamine 5-ht serotonergic psychedelics are described to have activation of the serotonin 2a receptor (5-ht |
2023-07-20 |
2023-08-14 |
Not clear |
| Rika Takaba, Daisuke Ibi, Keisuke Yoshida, Eri Hosomi, Ririna Kawase, Hiroko Kitagawa, Hirotaka Goto, Mizuki Achiwa, Kento Mizutani, Kyosuke Maede, Javier González-Maeso, Shinji Kitagaki, Masayuki Hiramats. Ethopharmacological evaluation of antidepressant-like effect of serotonergic psychedelics in C57BL/6J male mice. Research square. 2023-07-18. PMID:37461593. |
serotonergic psychedelics such as psilocybin, lysergic acid diethylamide, and doi exert a hallucinatory effect through serotonin 5-ht 2a receptor (5-ht2a) activation. |
2023-07-18 |
2023-08-14 |
mouse |
| Larissa Marcely Gomes Cassiano, Marina da Silva Oliveira, Wellington Alves de Barros, Ângelo de Fátima, Roney Santos Coimbr. Neurotoxic effects of hallucinogenic drugs 25H-NBOMe and 25H-NBOH in organotypic hippocampal cultures. Heliyon. vol 9. issue 7. 2023-07-15. PMID:37449113. |
nbomes and nbohs are psychoactive drugs derived from phenethylamines and have hallucinogenic effects due to their strong agonism to serotonin 5-ht |
2023-07-15 |
2023-08-14 |
Not clear |
| You-Peng Fu, Yun Wan. Amphetamines abuse and depression: Focus on TRPC channels. Experimental neurology. 2023-03-30. PMID:36996966. |
amphetamines abuse can damage dopaminergic and serotonin neurons and cause neuroinflammation and neurotoxicity. |
2023-03-30 |
2023-08-14 |
Not clear |