All Relations between Lorcaserin and serotonin

Publication Sentence Publish Date Extraction Date Species
Jennifer B Faske, Meagan B Myers, Matthew Bryant, Xiaobo He, Florence McLellen, Todd Bourcier, Barbara L Parson. CarcSeq detection of lorcaserin-induced clonal expansion of Pik3ca H1047R mutants in rat mammary tissue. Toxicological sciences : an official journal of the Society of Toxicology. 2024-06-09. PMID:38851877. lorcaserin is a 5-hydroxytryptamine 2c (serotonin) receptor agonist and a non-genotoxic rat carcinogen, which induced mammary tumors in male and female rats in a two-year bioassay. 2024-06-09 2024-06-11 rat
David J McCann, Hegang H Chen, Eric G Devine, Shwe Gyaw, Tatiana Rame. Results of a randomized, double-blind, placebo-controlled trial of lorcaserin in cocaine use disorder. Drug and alcohol dependence. vol 255. 2024-01-01. PMID:38163425. the primary purpose of this study was to evaluate the ability of lorcaserin, a 5-hydroxytryptamine 2024-01-01 2024-01-05 Not clear
David R Maguir. Interactions between lorcaserin and opioids: Ventilation and food-versus-drug choice. Pharmacology, biochemistry, and behavior. 2023-11-11. PMID:37951365. lorcaserin, a selective serotonin 2c (5-ht 2023-11-11 2023-11-20 Not clear
Marianna Mazza, Georgios Demetrios Kotzalidis, Giuseppe Marano, Domenico De Berardis, Giovanni Martinotti, Enrico Romagnoli, Giuseppe Biondi-Zoccai, Antonio Abbate, Gabriele San. Lorcaserin: worthy of further insights? Results from recent research. CNS & neurological disorders drug targets. 2023-04-03. PMID:37005521. lorcaserin is a 3-benzazepine that binds 5-ht2c serotonin receptors in the hypothalamus, where it mediates lack of hunger and/or satiety, and in the ventral tegmental area, the site of origin of the mesolimbic and mesocortical dopaminergic projections, which mediate pleasure and reward. 2023-04-03 2023-08-14 Not clear
Tiffany Schwasinger-Schmidt, Sheldon H Preskor. Reverse Engineering Drugs: Lorcaserin as an Example. Advances in neurobiology. vol 30. 2023-03-17. PMID:36928851. lorcaserin was developed as a specific 5ht 2023-03-17 2023-08-14 Not clear
Joon Ho Moon, Chang-Myung Oh, Hail Ki. Serotonin in the regulation of systemic energy metabolism. Journal of diabetes investigation. 2022-06-28. PMID:35762288. a number of drugs that modulate central serotonin function (e.g., fenfluramine, sibutramine, and lorcaserin) were approved and used as anti-obesity drugs, but then later withdrawn due to adverse cardiovascular and carcinogenic effects. 2022-06-28 2023-08-14 Not clear
Nina M Beltran, Jeremiah Ramos, Antonio Landavazo, Bruce Blough, Katherine M Serafin. Eating a High Fat Diet Enhances Sensitivity of Rats to 5-HT FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555947. to test the hypothesis that eating a high fat diet enhances sensitivity of rats to 5-ht syndrome, male (n=16) and female (n=16) rats eating high fat (60% kcal from fat) or standard (17% kcal from fat) laboratory chow were tested once weekly with cumulative doses of 5-ht receptor agonists, including 8-oh-dpat (0.01-1.0 mg/kg, s.c.), lorcaserin (1.0-32.0 mg/kg, i.p.) 2022-05-13 2023-08-13 rat
Ken W Grasing, Kim Burnell, Alok D. Biphasic reward effects are characteristic of both lorcaserin and drugs of abuse: implications for treatment of substance use disorders. Behavioural pharmacology. 2022-03-24. PMID:35324488. lorcaserin is a modestly selective agonist for 2c serotonin receptors (5-ht2cr). 2022-03-24 2023-08-13 Not clear
Meir Bialer, Emilio Perucc. Lorcaserin for Dravet Syndrome: A Potential Advance Over Fenfluramine? CNS drugs. 2022-01-30. PMID:35094259. lorcaserin, a selective serotonin 5-ht 2022-01-30 2023-08-13 Not clear
Muhan Jing, Shanshan Wang, Ding Li, Zeyu Wang, Ziwen Li, Yichen Lu, Tong Sun, Chen Qiu, Fang Chen, Haijuan Yu, Wei Zhan. Lorcaserin Inhibit Glucose-Stimulated Insulin Secretion and Calcium Influx in Murine Pancreatic Islets. Frontiers in pharmacology. vol 12. 2021-11-23. PMID:34803706. lorcaserin is a serotonergic agonist specific to the 5-hydroxytryptamine 2c receptor (5-ht 2021-11-23 2023-08-13 Not clear
Lisa R Gerak, Charles P Franc. Effects of buprenorphine/lorcaserin mixtures on preference for heroin, cocaine, or saline over food using a concurrent choice procedure in rhesus monkeys. Drug and alcohol dependence. vol 227. 2021-10-21. PMID:34482043. treatment outcomes might be improved by combining buprenorphine with a second medication targeting substance use disorder (sud), such as lorcaserin, a serotonin 2021-10-21 2023-08-13 monkey
Erin J Campbell, Yvonne Bonomo, Adam Pastor, Lisa Collins, Amanda Norman, Peter Galettis, Janice Johnstone, Andrew J Lawrenc. The 5-HT Pharmacology research & perspectives. vol 9. issue 3. 2021-09-22. PMID:33929084. lorcaserin, a 5-ht 2021-09-22 2023-08-13 Not clear
b' Rayane I Tabbara, Zhaoxia Li, Paul J Fletcher, Anh D L\\xc3\\xa. The serotonin 2C receptor agonist lorcaserin, alone and in combination with the opioid receptor antagonist naltrexone, attenuates binge-like ethanol drinking. Addiction biology. vol 26. issue 5. 2021-09-10. PMID:33928736.' the serotonin 2c receptor agonist lorcaserin, alone and in combination with the opioid receptor antagonist naltrexone, attenuates binge-like ethanol drinking. 2021-09-10 2023-08-13 Not clear
b' Rayane I Tabbara, Zhaoxia Li, Paul J Fletcher, Anh D L\\xc3\\xa. The serotonin 2C receptor agonist lorcaserin, alone and in combination with the opioid receptor antagonist naltrexone, attenuates binge-like ethanol drinking. Addiction biology. vol 26. issue 5. 2021-09-10. PMID:33928736.' lorcaserin, a 5-ht 2021-09-10 2023-08-13 Not clear
Tanishka S Saraf, Daniel E Felsing, Jessica L Armstrong, Raymond G Booth, Clinton E Cana. Evaluation of lorcaserin as an anticonvulsant in juvenile Fmr1 knockout mice. Epilepsy research. vol 175. 2021-07-23. PMID:34130255. recent preclinical and clinical studies suggest that lorcaserin, a preferential serotonin 2c receptor (5-ht 2021-07-23 2023-08-13 mouse
Ekta Kapoor, Stephanie Faubion, Ryan T Hurt, Karen Fischer, Darrell Schroeder, Shawn Fokken, Ivana T Crogha. A selective serotonin receptor agonist for weight loss and management of menopausal vasomotor symptoms in overweight midlife women: a pilot study. Menopause (New York, N.Y.). vol 27. issue 11. 2021-04-27. PMID:33110038. a selective serotonin 2c (5-ht2c) receptor agonist, lorcaserin, which was previously approved by the food and drug administration for weight loss, has unreported observational evidence suggesting improvement in vms with its use. 2021-04-27 2023-08-13 Not clear
Salvador Sierra, Kumiko M Lippold, David L Stevens, Justin L Poklis, William L Dewey, Javier González-Maes. Adjunctive effect of the serotonin 5-HT Neuropharmacology. vol 167. 2021-04-23. PMID:31987863. lorcaserin is a serotonin 5-ht 2021-04-23 2023-08-13 Not clear
Philippe De Deurwaerdère, Marta Ramos, Rahul Bharatiya, Emilie Puginier, Abdeslam Chagraoui, Julien Manem, Eleonora Cuboni, Massimo Pierucci, Gabriele Deidda, Maurizio Casarrubea, Giuseppe Di Giovann. Lorcaserin bidirectionally regulates dopaminergic function site-dependently and disrupts dopamine brain area correlations in rats. Neuropharmacology. vol 166. 2021-04-02. PMID:31862271. lorcaserin, which is a selective agonist of serotonin2c receptors (5-ht 2021-04-02 2023-08-13 rat
Dattatraya V Wani, Santosh N Mokal. A Validated Stability-Indicating Liquid Chromatographic Method for the Determination of Lorcaserin and Related Impurities in DRUG Substance Supported by Quality by Design. Journal of chromatographic science. vol 58. issue 7. 2021-04-01. PMID:32642780. lorcaserin (lor) is selective and potent antiobesity drug that targets the activation of the serotonin 5ht2c receptor. 2021-04-01 2023-08-13 Not clear
Laura Brandt, Jermaine D Jones, Suky Martinez, Jeanne M Manubay, Shanthi Mogali, Tatiana Ramey, Frances R Levin, Sandra D Come. Effects of lorcaserin on oxycodone self-administration and subjective responses in participants with opioid use disorder. Drug and alcohol dependence. vol 208. 2021-01-18. PMID:31980285. lorcaserin, a high-affinity 5-ht 2021-01-18 2023-08-13 human