| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christina A Brezing, Mohammad Sibai, C Jean Choi, Souparno Mitra, John J Mariani, Nasir Naqvi, Amy L Mahony, Daniel Brooks, Martina Pavlicova, Frances R Levi. Open Label Pilot of Lorcaserin (a serotonin 2C-receptor agonist) for Cannabis Use Disorder. Journal of substance use. vol 29. issue 4. 2024-07-18. PMID:39021751. |
open label pilot of lorcaserin (a serotonin 2c-receptor agonist) for cannabis use disorder. |
2024-07-18 |
2024-07-20 |
human |
| Jennifer B Faske, Meagan B Myers, Matthew Bryant, Xiaobo He, Florence McLellen, Todd Bourcier, Barbara L Parson. CarcSeq detection of lorcaserin-induced clonal expansion of Pik3ca H1047R mutants in rat mammary tissue. Toxicological sciences : an official journal of the Society of Toxicology. 2024-06-09. PMID:38851877. |
lorcaserin is a 5-hydroxytryptamine 2c (serotonin) receptor agonist and a non-genotoxic rat carcinogen, which induced mammary tumors in male and female rats in a two-year bioassay. |
2024-06-09 |
2024-06-11 |
rat |
| David J McCann, Hegang H Chen, Eric G Devine, Shwe Gyaw, Tatiana Rame. Results of a randomized, double-blind, placebo-controlled trial of lorcaserin in cocaine use disorder. Drug and alcohol dependence. vol 255. 2024-01-01. PMID:38163425. |
the primary purpose of this study was to evaluate the ability of lorcaserin, a 5-hydroxytryptamine |
2024-01-01 |
2024-01-05 |
Not clear |
| David R Maguir. Interactions between lorcaserin and opioids: Ventilation and food-versus-drug choice. Pharmacology, biochemistry, and behavior. 2023-11-11. PMID:37951365. |
lorcaserin, a selective serotonin 2c (5-ht |
2023-11-11 |
2023-11-20 |
Not clear |
| Marianna Mazza, Georgios Demetrios Kotzalidis, Giuseppe Marano, Domenico De Berardis, Giovanni Martinotti, Enrico Romagnoli, Giuseppe Biondi-Zoccai, Antonio Abbate, Gabriele San. Lorcaserin: worthy of further insights? Results from recent research. CNS & neurological disorders drug targets. 2023-04-03. PMID:37005521. |
lorcaserin is a 3-benzazepine that binds 5-ht2c serotonin receptors in the hypothalamus, where it mediates lack of hunger and/or satiety, and in the ventral tegmental area, the site of origin of the mesolimbic and mesocortical dopaminergic projections, which mediate pleasure and reward. |
2023-04-03 |
2023-08-14 |
Not clear |
| Tiffany Schwasinger-Schmidt, Sheldon H Preskor. Reverse Engineering Drugs: Lorcaserin as an Example. Advances in neurobiology. vol 30. 2023-03-17. PMID:36928851. |
lorcaserin was developed as a specific 5ht |
2023-03-17 |
2023-08-14 |
Not clear |
| Joon Ho Moon, Chang-Myung Oh, Hail Ki. Serotonin in the regulation of systemic energy metabolism. Journal of diabetes investigation. 2022-06-28. PMID:35762288. |
a number of drugs that modulate central serotonin function (e.g., fenfluramine, sibutramine, and lorcaserin) were approved and used as anti-obesity drugs, but then later withdrawn due to adverse cardiovascular and carcinogenic effects. |
2022-06-28 |
2023-08-14 |
Not clear |
| Nina M Beltran, Jeremiah Ramos, Antonio Landavazo, Bruce Blough, Katherine M Serafin. Eating a High Fat Diet Enhances Sensitivity of Rats to 5-HT FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555947. |
to test the hypothesis that eating a high fat diet enhances sensitivity of rats to 5-ht syndrome, male (n=16) and female (n=16) rats eating high fat (60% kcal from fat) or standard (17% kcal from fat) laboratory chow were tested once weekly with cumulative doses of 5-ht receptor agonists, including 8-oh-dpat (0.01-1.0 mg/kg, s.c.), lorcaserin (1.0-32.0 mg/kg, i.p.) |
2022-05-13 |
2023-08-13 |
rat |
| Ken W Grasing, Kim Burnell, Alok D. Biphasic reward effects are characteristic of both lorcaserin and drugs of abuse: implications for treatment of substance use disorders. Behavioural pharmacology. 2022-03-24. PMID:35324488. |
lorcaserin is a modestly selective agonist for 2c serotonin receptors (5-ht2cr). |
2022-03-24 |
2023-08-13 |
Not clear |
| Meir Bialer, Emilio Perucc. Lorcaserin for Dravet Syndrome: A Potential Advance Over Fenfluramine? CNS drugs. 2022-01-30. PMID:35094259. |
lorcaserin, a selective serotonin 5-ht |
2022-01-30 |
2023-08-13 |
Not clear |
| Muhan Jing, Shanshan Wang, Ding Li, Zeyu Wang, Ziwen Li, Yichen Lu, Tong Sun, Chen Qiu, Fang Chen, Haijuan Yu, Wei Zhan. Lorcaserin Inhibit Glucose-Stimulated Insulin Secretion and Calcium Influx in Murine Pancreatic Islets. Frontiers in pharmacology. vol 12. 2021-11-23. PMID:34803706. |
lorcaserin is a serotonergic agonist specific to the 5-hydroxytryptamine 2c receptor (5-ht |
2021-11-23 |
2023-08-13 |
Not clear |
| Lisa R Gerak, Charles P Franc. Effects of buprenorphine/lorcaserin mixtures on preference for heroin, cocaine, or saline over food using a concurrent choice procedure in rhesus monkeys. Drug and alcohol dependence. vol 227. 2021-10-21. PMID:34482043. |
treatment outcomes might be improved by combining buprenorphine with a second medication targeting substance use disorder (sud), such as lorcaserin, a serotonin |
2021-10-21 |
2023-08-13 |
monkey |
| Erin J Campbell, Yvonne Bonomo, Adam Pastor, Lisa Collins, Amanda Norman, Peter Galettis, Janice Johnstone, Andrew J Lawrenc. The 5-HT Pharmacology research & perspectives. vol 9. issue 3. 2021-09-22. PMID:33929084. |
lorcaserin, a 5-ht |
2021-09-22 |
2023-08-13 |
Not clear |
| b' Rayane I Tabbara, Zhaoxia Li, Paul J Fletcher, Anh D L\\xc3\\xa. The serotonin 2C receptor agonist lorcaserin, alone and in combination with the opioid receptor antagonist naltrexone, attenuates binge-like ethanol drinking. Addiction biology. vol 26. issue 5. 2021-09-10. PMID:33928736.' |
the serotonin 2c receptor agonist lorcaserin, alone and in combination with the opioid receptor antagonist naltrexone, attenuates binge-like ethanol drinking. |
2021-09-10 |
2023-08-13 |
Not clear |
| b' Rayane I Tabbara, Zhaoxia Li, Paul J Fletcher, Anh D L\\xc3\\xa. The serotonin 2C receptor agonist lorcaserin, alone and in combination with the opioid receptor antagonist naltrexone, attenuates binge-like ethanol drinking. Addiction biology. vol 26. issue 5. 2021-09-10. PMID:33928736.' |
lorcaserin, a 5-ht |
2021-09-10 |
2023-08-13 |
Not clear |
| Tanishka S Saraf, Daniel E Felsing, Jessica L Armstrong, Raymond G Booth, Clinton E Cana. Evaluation of lorcaserin as an anticonvulsant in juvenile Fmr1 knockout mice. Epilepsy research. vol 175. 2021-07-23. PMID:34130255. |
recent preclinical and clinical studies suggest that lorcaserin, a preferential serotonin 2c receptor (5-ht |
2021-07-23 |
2023-08-13 |
mouse |
| Ekta Kapoor, Stephanie Faubion, Ryan T Hurt, Karen Fischer, Darrell Schroeder, Shawn Fokken, Ivana T Crogha. A selective serotonin receptor agonist for weight loss and management of menopausal vasomotor symptoms in overweight midlife women: a pilot study. Menopause (New York, N.Y.). vol 27. issue 11. 2021-04-27. PMID:33110038. |
a selective serotonin 2c (5-ht2c) receptor agonist, lorcaserin, which was previously approved by the food and drug administration for weight loss, has unreported observational evidence suggesting improvement in vms with its use. |
2021-04-27 |
2023-08-13 |
Not clear |
| Salvador Sierra, Kumiko M Lippold, David L Stevens, Justin L Poklis, William L Dewey, Javier González-Maes. Adjunctive effect of the serotonin 5-HT Neuropharmacology. vol 167. 2021-04-23. PMID:31987863. |
lorcaserin is a serotonin 5-ht |
2021-04-23 |
2023-08-13 |
Not clear |
| Philippe De Deurwaerdère, Marta Ramos, Rahul Bharatiya, Emilie Puginier, Abdeslam Chagraoui, Julien Manem, Eleonora Cuboni, Massimo Pierucci, Gabriele Deidda, Maurizio Casarrubea, Giuseppe Di Giovann. Lorcaserin bidirectionally regulates dopaminergic function site-dependently and disrupts dopamine brain area correlations in rats. Neuropharmacology. vol 166. 2021-04-02. PMID:31862271. |
lorcaserin, which is a selective agonist of serotonin2c receptors (5-ht |
2021-04-02 |
2023-08-13 |
rat |
| Dattatraya V Wani, Santosh N Mokal. A Validated Stability-Indicating Liquid Chromatographic Method for the Determination of Lorcaserin and Related Impurities in DRUG Substance Supported by Quality by Design. Journal of chromatographic science. vol 58. issue 7. 2021-04-01. PMID:32642780. |
lorcaserin (lor) is selective and potent antiobesity drug that targets the activation of the serotonin 5ht2c receptor. |
2021-04-01 |
2023-08-13 |
Not clear |