| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zeliha Bayram, Esra Akcabag, Gul Ozbey, Cahit Nacitarhan, Sebahat Ozdem, Cengiz Turkay, Sadi S Ozde. THE effect of P2X7 receptor activation on functional responses of human left internal mammary artery. Naunyn-Schmiedeberg's archives of pharmacology. 2024-09-03. PMID:39225832. |
long-term (60 min) incubation with specific p2x7r agonist bz-atp caused significant reductions in relaxation responses of lima to atp and acetylcholine, which were reversed by selective p2x7r antagonists brilliant blue g or az11645373, whereas there were no changes in relaxation responses to endothelium-independent vasodilators isoprenaline, camp analog 8-br-camp, and nitric oxide donor sodium nitroprusside. |
2024-09-03 |
2024-09-05 |
human |
| Christian Ellermann, Jonas Brandt, Julian Wolfes, Kevin Willy, Felix K Wegner, Patrick Leitz, Philipp S Lange, Florian Reinke, Lars Eckardt, Gerrit Frommeye. Safe electrophysiologic profile of dexmedetomidine in different experimental arrhythmia models. Scientific reports. vol 11. issue 1. 2021-12-15. PMID:34907251. |
in the last group (n = 12), a combination of acetylcholine (1 µm) and isoproterenol (1 µm) was used to facilitate atrial fibrillation. |
2021-12-15 |
2023-08-13 |
rabbit |
| Shigeki Kiuchi, Akino Usami, Tae Shimoyama, Fuminori Otsuka, Shigeto Suzuki, Kageyoshi On. Generation of cardiomyocytes by atrioventricular node cells in long-term cultures. Biochemistry and biophysics reports. vol 26. 2021-09-24. PMID:34095551. |
stimulation of muscarinic receptors with acetylcholine induced a beating rate decrease which was blocked by atropine, and activation of adenylate cyclase activity with forskolin increased the beat rate, while stimulation of beta adrenoceptors by isoproterenol had no effect. |
2021-09-24 |
2023-08-13 |
Not clear |
| Yosra Doghri, Laurence Dubreil, Valérie Lalanne, Ophélie Hélissen, Romain Fleurisson, Chantal Thorin, Jean-Claude Desfontis, M Yassine Malle. Soluble guanylate cyclase chronic stimulation effects on cardiovascular reactivity in cafeteria diet-induced rat model of metabolic syndrome. European journal of pharmacology. vol 899. 2021-05-20. PMID:33691164. |
at the end of the feeding period, ex vivo cumulative concentration-response curves were performed on isolated perfused heart (isoproterenol (0.1 nm - 1 μm)) and thoracic aorta (phenylephrine (1 nm-10 μm), acetylcholine (1 nm-10 μm), and sodium nitroprusside (snp) (0.1 nm-0.1 μm)). |
2021-05-20 |
2023-08-13 |
rat |
| Christian Ellermann, André Mittelstedt, Julian Wolfes, Kevin Willy, Patrick Leitz, Florian Reinke, Lars Eckardt, Gerrit Frommeye. Action Potential Triangulation Explains Acute Proarrhythmic Effect of Aliskiren in a Whole-Heart Model of Atrial Fibrillation. Cardiovascular toxicology. vol 20. issue 1. 2020-10-13. PMID:31175534. |
to enhance atrial vulnerability, a combination of acetylcholine (ach) and isoproterenol (iso) was infused and significantly reduced atrial action potential duration (aapd |
2020-10-13 |
2023-08-13 |
rabbit |
| Algotsson, Nordberg, Winbla. Apolipoprotein E varepsilon4 allele has an impact on vascular reactivity in Alzheimer's disease. Archives of gerontology and geriatrics. vol 31. issue 3. 2019-11-20. PMID:11154777. |
three substances were iontophoresed into the skin: sodium nitroprusside (snp) delivered at the cathode, and acetylcholine chloride and isoprenaline sulphate delivered at the anode. |
2019-11-20 |
2023-08-12 |
Not clear |
| Donald E. Smith, Alan David Kaye, Chang J. Feng, Bin Kang, Philip J. Kadowitz, Bobby Dean Nossama. Comparative Effects of N(omega)-L-Nitro-L-Arginine Methyl Ester and N(omega)-L-Nitro-L-Arginine Benzyl Ester in the Mesenteric Circulation of the Rat. American journal of therapeutics. vol 3. issue 4. 2019-11-20. PMID:11862266. |
comparative effects of the nitric oxide (no) synthase inhibitors, n(omega)-l-nitro-l-arginine methyl ester, and n(omega)-l-nitro-l-arginine benzyl ester on baseline arterial tone and on vasodilator responses to acetylcholine, isoproterenol, prostaglandin e(1), histamine, and nitroglycerin were investigated in the isolated mesenteric vascular bed of the rat. |
2019-11-20 |
2023-08-12 |
rat |
| Donald E. Smith, Alan David Kaye, Chang J. Feng, Bin Kang, Philip J. Kadowitz, Bobby Dean Nossama. Comparative Effects of N(omega)-L-Nitro-L-Arginine Methyl Ester and N(omega)-L-Nitro-L-Arginine Benzyl Ester in the Mesenteric Circulation of the Rat. American journal of therapeutics. vol 3. issue 4. 2019-11-20. PMID:11862266. |
under constant-flow conditions, intra-arterial (ia) injections of acetylcholine (100 ng--1 &mgr;g), isoproterenol (100 ng--1 &mgr;g), prostaglandin e(1) (0.3--3 &mgr;g), histamine (300 ng--3 &mgr;g), and nitroglycerin (100 ng--1 &mgr;g) caused dose-related decreases in mesenteric arterial perfusion pressure and decreases in systemic arterial pressure. |
2019-11-20 |
2023-08-12 |
rat |
| Donald E. Smith, Alan David Kaye, Chang J. Feng, Bin Kang, Philip J. Kadowitz, Bobby Dean Nossama. Comparative Effects of N(omega)-L-Nitro-L-Arginine Methyl Ester and N(omega)-L-Nitro-L-Arginine Benzyl Ester in the Mesenteric Circulation of the Rat. American journal of therapeutics. vol 3. issue 4. 2019-11-20. PMID:11862266. |
following administration of the no synthase inhibitors, n(omega)-l-nitro-l-arginine methyl ester or n(omega)-l-nitro-l-arginine benzyl ester, mesenteric vascular resistance, and systemic arterial pressure were increased and mesenteric vasodilator responses to acetylcholine were significantly decreased, whereas n(omega)-l-nitro-l-arginine methyl ester and n(omega)-nitro-l-arginine benzyl ester did not significantly decrease vasodilator responses to nitroglycerin, histamine, isoproterenol, or prostaglandin e(1). |
2019-11-20 |
2023-08-12 |
rat |
| Lei Li, Hiroshi Hasegawa, Niro Inaba, Wataru Yoshioka, Dennis Chang, JianXun Liu, Kimiyoshi Ichid. Diet-induced hyperhomocysteinemia impairs vasodilation in 5/6-nephrectomized rats. Amino acids. vol 50. issue 10. 2018-11-05. PMID:30062489. |
we show that in 5/6-nephrectomized rats, a model of chronic kidney disease, a methionine-rich diet for 8 weeks induces moderate hyperhomocysteinemia, exacerbates hypertension, and attenuates the vascular response to acetylcholine, sodium nitroprusside, 8-bromo-cgmp, and isoprenaline. |
2018-11-05 |
2023-08-13 |
rat |
| Hicla S Moreira, Geórgia A Lima-Leal, Juliana Santos-Rocha, Leonardo Gomes-Pereira, Gloria P Duarte, Fabiano E Xavie. Phosphodiesterase-3 inhibitor cilostazol reverses endothelial dysfunction with ageing in rat mesenteric resistance arteries. European journal of pharmacology. vol 822. 2018-08-20. PMID:29355555. |
using eight-week cilostazol-treated (100mg/kg/day) or untreated 72-week-old wistar rats, we evaluate the relaxation to acetylcholine, sodium nitroprusside (snp), forskolin and isoproterenol and the noradrenaline-induced contraction in mra. |
2018-08-20 |
2023-08-13 |
rat |
| Gerrit Frommeyer, André Mittelstedt, Julian Wolfes, Christian Ellermann, Simon Kochhäuser, Patrick Leitz, Dirk G Dechering, Lars Eckard. The anti-influenza drug oseltamivir reduces atrial fibrillation in an experimental whole-heart model. Naunyn-Schmiedeberg's archives of pharmacology. vol 390. issue 11. 2018-07-13. PMID:28780600. |
subsequently, a combination of acetylcholine (1 μm) and isoproterenol (1 μm) was administered to increase af occurrence. |
2018-07-13 |
2023-08-13 |
rabbit |
| Ling-Zong Hong, Keh-Feng Huang, Siu-Wan Hung, Li-Te Ku. Chronic fluoxetine treatment enhances sympathetic activities associated with abnormality of baroreflex function in conscious normal rats. European journal of pharmacology. vol 811. 2018-05-30. PMID:28629735. |
vascular responsiveness to acetylcholine, phenylephrine and sodium nitroprusside, and cardiac responsiveness to isoproterenol were determined after ganglionic blockade. |
2018-05-30 |
2023-08-13 |
rat |
| Ling-Zong Hong, Keh-Feng Huang, Siu-Wan Hung, Li-Te Ku. Chronic fluoxetine treatment enhances sympathetic activities associated with abnormality of baroreflex function in conscious normal rats. European journal of pharmacology. vol 811. 2018-05-30. PMID:28629735. |
chronic fluoxetine also diminished cardiac and vascular responsiveness to isoproterenol and acetylcholine, respectively. |
2018-05-30 |
2023-08-13 |
rat |
| Renato Filogonio, William Joyce, Tobias Wan. Nitrergic cardiovascular regulation in the African lungfish, Protopterus aethiopicus. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 207. 2017-08-04. PMID:28216392. |
to better understand the physiological relevance of no on cardiovascular regulation in this transitory group, we measured vascular reactivity to muscarinic agonist acetylcholine, α- and β-adrenergic agonists (phenylephrine and isoproterenol, respectively), or the no donor, sodium nitroprusside (snp) on four vessel segments-efferent branchial arteries, gill artery, ductus arteriosus and pulmonary artery-from the african lungfish, protopterus aethiopicus. |
2017-08-04 |
2023-08-13 |
Not clear |
| Renato Filogonio, William Joyce, Tobias Wan. Nitrergic cardiovascular regulation in the African lungfish, Protopterus aethiopicus. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 207. 2017-08-04. PMID:28216392. |
isoproterenol caused vasodilation, whereas acetylcholine and phenylephrine vasoconstricted all vessel segments. |
2017-08-04 |
2023-08-13 |
Not clear |
| Zhifeng He, Changzheng Sun, Yi Xu, Dezhi Chen. Reduction of atrial fibrillation by Tanshinone IIA in chronic heart failure. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 84. 2017-02-13. PMID:27847200. |
infusion of acetylcholine (1μm) and isoproterenol (1μm) led to af in all failing hearts and in 11 sham hearts. |
2017-02-13 |
2023-08-13 |
Not clear |
| Takayuki Matsumoto, Makoto Ando, Shun Watanabe, Maika Iguchi, Mako Nagata, Shota Kobayashi, Kumiko Taguchi, Tsuneo Kobayash. Tunicamycin-Induced Alterations in the Vasorelaxant Response in Organ-Cultured Superior Mesenteric Arteries of Rats. Biological & pharmaceutical bulletin. vol 39. issue 9. 2017-02-06. PMID:27582328. |
thus, we investigated the effect of tunicamycin on relaxations induced by various vasorelaxant agents, including acetylcholine (ach; endothelium-dependent vasodilator), sodium nitroprusside (snp; endothelium-independent vasodilator), isoprenaline (iso; beta-adrenoceptor agonist), forskolin (fsk; adenylyl cyclase activator), and cromakalim [atp-sensitive k(+) (katp) channel activator] in organ-cultured superior mesenteric arteries of rats, which are treated with either a vehicle [dimethyl sulfoxide (dmso)] or tunicamycin (20 µg/ml for 22-24 h). |
2017-02-06 |
2023-08-13 |
rat |
| P Castellanos, R Godine. Autonomic nervous system regulation of the sinoatrial cell depolarization rate: Unifying computational models. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2015. 2016-11-07. PMID:26736196. |
these modifications were enough to successfully reproduce the heart rate experimental recordings under acetylcholine (ach) or norepinephrine (ne) for independent stimulation: ach 10 nm stimulation showed a 21.54% action potential shift compared with the 20% reported for experimental recordings; isoprenaline 1 μm, also displayed a depolarization increased rate of 29.3%, compared with the experimental data of 28.2%. |
2016-11-07 |
2023-08-13 |
rabbit |
| Bjarke Jensen, Magnus Elfwing, Ruth M Elsey, Tobias Wang, Dane A Crossle. Coronary blood flow in the anesthetized American alligator (Alligator mississippiensis). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 191. 2016-09-12. PMID:26436857. |
here, we investigated the systemic and coronary arterial responses of five anesthetized juvenile american alligators (alligator mississippiensis) to hypoxia, acetylcholine, adenosine, sodium nitroprusside, isoproterenol, and phenylephrine. |
2016-09-12 |
2023-08-13 |
Not clear |