All Relations between Haloperidol and dopaminergic

Publication Sentence Publish Date Extraction Date Species
Foteini Xeni, Caterina Marangoni, Megan G Jackso. Validation of a non-food or water motivated effort-based foraging task as a measure of motivational state in male mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-06-19. PMID:38898205. acute dopaminergic modulation with haloperidol, amphetamine and methylphenidate, and two phenotypic models known to induce motivational deficits (healthy ageing and chronic administration of corticosterone) were used to validate this task. 2024-06-19 2024-06-22 mouse
Hend A Sabry, Mai M Zahr. Icariin Attenuates Dopaminergic Neural Loss in Haloperidol-Induced Parkinsonism in Rats via GSK-3β and Tyrosine Hydroxylase Regulation Mechanism. Journal of chemical neuroanatomy. 2023-12-31. PMID:38160784. in animal models, the administration of the dopaminergic d2 antagonist haloperidol (hp) affects the nigrostriatal pathway, inducing catalepsy, a state of immobility like pd, bradykinesia, and akinesia. 2023-12-31 2024-01-05 rat
Olusegun Adebayo Adeoluwa, Anthony Taghogho Eduviere, Gladys Onyinye Adeoluwa, Lily Oghenevovwero Otomewo, Funmilayo Racheal Adeniy. The monoaminergic pathways are involved in the antidepressant-like effect of quercetin. Naunyn-Schmiedeberg's archives of pharmacology. 2023-10-18. PMID:37851059. in addition, monoaminergic involvement was investigated by combining quercetin (100 mg/kg) with dopaminergic antagonists (haloperidol and sulpiride), adrenergic blockers (prazosin, propranolol and yohimbine), and serotonergic blockers/inhibitors (metergoline). 2023-10-18 2023-11-08 mouse
Karima Chakroun, Antonius Wiehler, Ben Wagner, David Mathar, Florian Ganzer, Thilo van Eimeren, Tobias Sommer, Jan Peter. Dopamine regulates decision thresholds in human reinforcement learning in males. Nature communications. vol 14. issue 1. 2023-09-04. PMID:37666865. here, we examine dopaminergic mechanisms underlying human reinforcement learning and action selection via a combined pharmacological neuroimaging approach in male human volunteers (n = 31, within-subjects; placebo, 150 mg of the dopamine precursor l-dopa, 2 mg of the d2 receptor antagonist haloperidol). 2023-09-04 2023-09-07 human
Laura Lopez-Cruz, Benjamin U Phillips, Jonathan M Hailwood, Lisa M Saksida, Christopher J Heath, Timothy J Busse. Refining the study of decision-making in animals: differential effects of d-amphetamine and haloperidol in a novel touchscreen-automated Rearing-Effort Discounting (RED) task and the Fixed-Ratio Effort Discounting (FRED) task. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-08-29. PMID:37644210. results from dopaminergic (haloperidol and d-amphetamine), behavioral (changes in the order of effort demand; fixed-ratio schedule in fred or response height in red), and dietary manipulations (reward devaluation by pre-feeding) were consistent with the presence of variables that may complicate interpretation of conventional decision-making tasks, and demonstrate how red appears to minimize such variables. 2023-08-29 2023-09-07 mouse
Emma Howell, Abigail Lancaster, Jordan Besh, Bea Richardson, Eileen Gomez, Sophia Harnew-Spradley, Chris Shelle. The dopamine receptor antagonist haloperidol disrupts behavioral responses of sea urchins and sea stars. The Journal of experimental biology. 2023-08-14. PMID:37578035. in many animals, dopaminergic systems play key roles in motivating and coordinating behavior and although the dopamine receptor antagonist haloperidol has been shown to inhibit the righting response of the sea urchin strongylocentrotus purpuratus, it is not known if this is specific to this behavior, in this species, or whether dopaminergic systems are needed in general for echinoderm behaviors. 2023-08-14 2023-08-16 Not clear
Yasemin Baranoglu Kilinc, Ibrahim Ethem Torun, Erkan Kilin. D2 dopamine receptor-mediated mechanisms of dopaminergic system modulation in in vivo and in vitro experimental models of migraine. The European journal of neuroscience. 2023-08-04. PMID:37539658. dopaminergic agonist apomorphine, d2 receptor antagonists metoclopramide and haloperidol and 5-ht3 receptor antagonist ondansetron alone and together were tested in nitroglycerin-induced migraine model, in vivo. 2023-08-04 2023-08-14 rat
Yasemin Baranoglu Kilinc, Ibrahim Ethem Torun, Erkan Kilin. D2 dopamine receptor-mediated mechanisms of dopaminergic system modulation in in vivo and in vitro experimental models of migraine. The European journal of neuroscience. 2023-08-04. PMID:37539658. haloperidol with pure d2 receptor antagonism feature appears to be more effective than metoclopramide in reducing migraine-related parameters in dopaminergic activation- and/or ntg-induced migraine-like conditions. 2023-08-04 2023-08-14 rat
Solomon Umukoro, Abayomi Mayowa Ajayi, Benneth Ben-Azu, Adeleke Pual Ademola, Jacob Areelu, Chika Orji, Olajuwon Okuben. Jobelyn® improves motor dysfunctions induced by haloperidol in mice via neuroprotective mechanisms relating to modulation of cAMP response-element binding protein and mitogen-activated protein kinase. Metabolic brain disease. 2023-06-22. PMID:37347426. oxidative stress-evoked neuroinflammation has been implicated as the key neuropathological mechanism by which haloperidol induces loss of dopaminergic neurons and motor dysfunctions. 2023-06-22 2023-08-14 mouse
L G De la Casa, M A Cintado, G González-Tirado, L Cárce. Conditioned Catalepsy vs. Increase in Locomotor Activity Induced by Haloperidol. Neuroscience letters. 2023-03-11. PMID:36906082. previous research has revealed a high degree of complexity of the conditioned response that appears after associating a context with the effects of the dopaminergic antagonist haloperidol. 2023-03-11 2023-08-14 rat
Maciej M Jankowski, Bogna M Ignatowska-Jankowska, Wojciech Glac, Marek Wiergowski, Paulina Kazmierska-Grebowska, Artur H Swiergie. Intravenous haloperidol and cocaine alter the distribution of T CD3 Clinical and experimental pharmacology & physiology. 2023-02-21. PMID:36802086. the results suggest that blood lymphopenia which was induced by haloperidol and cocaine (except for nkt cells), is independent of d2-like dopaminergic activity and most likely results from the massive secretion of corticosterone. 2023-02-21 2023-08-14 rat
Isabelle Waku, Adriano E Reimer, Amanda R de Oliveir. Effects of Immediate Aversive Stimulation on Haloperidol-Induced Catalepsy in Rats. Frontiers in behavioral neuroscience. vol 16. 2022-04-28. PMID:35481243. in animal models, the administration of the dopaminergic d2 antagonist haloperidol affects the nigrostriatal pathway, inducing catalepsy, a state of immobility similar to parkinson's disease (pd) bradykinesia and akinesia. 2022-04-28 2023-08-13 rat
Snezana Kusljic, Maarten van den Buuse, Andrea Gogo. Reassessment of amphetamine- and phencyclidine-induced locomotor hyperactivity as a model of psychosis-like behavior in rats. Journal of integrative neuroscience. vol 21. issue 1. 2022-02-15. PMID:35164453. a total of 32 rats were pre-treated with antagonists affecting dopaminergic, noradrenergic and serotonergic transmission: haloperidol (0.05 mg/kg), prazosin (2 mg/kg) and ritanserin (1 mg/kg), respectively. 2022-02-15 2023-08-13 rat
Annuska C Berz, Markus Wöhr, Rainer K W Schwartin. Response Calls Evoked by Playback of Natural 50-kHz Ultrasonic Vocalizations in Rats. Frontiers in behavioral neuroscience. vol 15. 2022-01-31. PMID:35095442. we compared different rat stocks, namely wistar (wi) and sprague-dawley (sd) and investigated the pharmacological treatment with the dopaminergic d2 receptor antagonist haloperidol. 2022-01-31 2023-08-13 rat
Tuane Bazanella Sampaio, Filipe Neimaier Bilheri, Gilson Rogério Zeni, Cristina Wayne Nogueir. Dopaminergic system contribution to the antidepressant-like effect of 3-phenyl-4-(phenylseleno) isoquinoline in mice. Behavioural brain research. vol 386. 2021-08-24. PMID:32184159. lastly, the contribution of dopaminergic system in the psi antidepressant-like effect was demonstrated by using dopamine receptors antagonists, sch23390, haloperidol and sulpiride. 2021-08-24 2023-08-13 mouse
Darlene Mae Ortiz, Raly James Perez Custodio, Arvie Abiero, Chrislean Jun Botanas, Leandro Val Sayson, Mikyung Kim, Hyun Jun Lee, Hee Jin Kim, Youngdo Jeong, Sulmin Yoon, Yong Sup Lee, Jae Hoon Cheon. The dopaminergic alterations induced by 4-F-PCP and 4-Keto-PCP may enhance their drug-induced rewarding and reinforcing effects: Implications for abuse. Addiction biology. vol 26. issue 4. 2021-08-16. PMID:33135332. dopamine (da) receptor antagonists (sch23390 and haloperidol) were administered during cpp to evaluate the involvement of the mesolimbic dopaminergic system. 2021-08-16 2023-08-13 Not clear
Christian Ole Wächtler, Karima Chakroun, Mareike Clos, Janine Bayer, Nora Hennies, Jean Martin Beaulieu, Tobias Somme. Region-specific effects of acute haloperidol in the human midbrain, striatum and cortex. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 35. 2021-08-10. PMID:32439227. in the current study we systematically tested this hypothesis by parametrically increasing haloperidol levels (placebo, 2 and 3 mg) in healthy volunteers and measuring brain activity in the three major dopaminergic pathways. 2021-08-10 2023-08-13 human
Bárbara Nunes Krum, Airton C Martins, Libânia Queirós, Beatriz Ferrer, Ginger L Milne, Félix Alexandre Antunes Soares, Roselei Fachinetto, Michael Aschne. Haloperidol Interactions with the dop-3 Receptor in Caenorhabditis elegans. Molecular neurobiology. vol 58. issue 1. 2021-08-04. PMID:32935232. here, we evaluated the possible involvement of dopaminergic receptors in the onset of these alterations followed by haloperidol exposure. 2021-08-04 2023-08-13 caenorhabditis_elegans
Bárbara Nunes Krum, Airton C Martins, Libânia Queirós, Beatriz Ferrer, Ginger L Milne, Félix Alexandre Antunes Soares, Roselei Fachinetto, Michael Aschne. Haloperidol Interactions with the dop-3 Receptor in Caenorhabditis elegans. Molecular neurobiology. vol 58. issue 1. 2021-08-04. PMID:32935232. haloperidol also decreased da levels, but it did not alter neither dop-1, dop-2, and dop-3 gene expression, nor cep dopaminergic neurons' morphology. 2021-08-04 2023-08-13 caenorhabditis_elegans
Graziela Vieira, Juliana Cavalli, Elaine C D Gonçalves, Saulo F P Braga, Rafaela S Ferreira, Adair R S Santos, Maíra Cola, Nádia R B Raposo, Raffaele Capasso, Rafael C Dutr. Antidepressant-Like Effect of Terpineol in an Inflammatory Model of Depression: Involvement of the Cannabinoid System and D2 Dopamine Receptor. Biomolecules. vol 10. issue 5. 2021-04-02. PMID:32443870. moreover, terpineol showed an antidepressant-like effect in the preventive treatment that was blocked by a nonselective dopaminergic receptor antagonist (haloperidol), a selective dopamine d2 receptor antagonist (sulpiride), a selective cb1 cannabinoid receptor antagonist/inverse agonist (am281), and a potent and selective cb2 cannabinoid receptor inverse agonist (am630), but it was not blocked by a nonselective adenosine receptor antagonist (caffeine) or a β-adrenoceptor antagonist (propranolol). 2021-04-02 2023-08-13 Not clear