All Relations between Fenfluramine and serotonergic

Publication Sentence Publish Date Extraction Date Species
Elaine C Wirrell, Lieven Lagae, Ingrid E Scheffer, J Helen Cross, Nicola Specchio, Adam Strzelczy. Practical considerations for the use of fenfluramine to manage patients with Dravet syndrome or Lennox-Gastaut syndrome in clinical practice. Epilepsia open. 2024-07-04. PMID:38962968. fenfluramine (ffa), an antiseizure medication (asm) with serotonergic and sigma-1 receptor activity, is used to manage patients with developmental and epileptic encephalopathies (dees). 2024-07-04 2024-07-10 Not clear
Margaret R MacLean, Barry Fanburg, Nicolas Hill, Howard M Lazarus, Thomas F Pack, Michelle Palacios, Krishna C Penumatsa, Stephen A Wrin. Serotonin and Pulmonary Hypertension; Sex and Drugs and ROCK and Rho. Comprehensive Physiology. vol 12. issue 4. 2022-08-29. PMID:36036567. the "serotonin hypothesis of pulmonary hypertension" arose when serotonin was associated with pah induced by diet pills such as fenfluramine, aminorex, and chlorphentermine; these act as indirect serotonergic agonists causing the release of serotonin from platelets and cells through the sert. 2022-08-29 2023-08-14 Not clear
Maria Gogou, J Helen Cros. Fenfluramine as antiseizure medication for epilepsy. Developmental medicine and child neurology. vol 63. issue 8. 2021-10-11. PMID:33565102. fenfluramine hydrochloride has classically been described as acting pharmacologically through a serotonergic mechanism. 2021-10-11 2023-08-13 zebrafish
Parthena Martin, Peter A M de Witte, Tangui Maurice, Arnold Gammaitoni, Gail Farfel, Bradley Gale. Fenfluramine acts as a positive modulator of sigma-1 receptors. Epilepsy & behavior : E&B. vol 105. 2020-12-29. PMID:32169824. adjunctive fenfluramine hydrochloride, classically described as acting pharmacologically through a serotonergic mechanism, has demonstrated a unique and robust clinical response profile with regard to its magnitude, consistency, and durability of effect on seizure activity in patients with pharmacoresistant dravet syndrome. 2020-12-29 2023-08-13 Not clear
Tilman Polste. Individualized treatment approaches: Fenfluramine, a novel antiepileptic medication for the treatment of seizures in Dravet syndrome. Epilepsy & behavior : E&B. vol 91. 2020-06-16. PMID:30269941. fenfluramine, an amphetamine derivative, was initially developed as an appetite suppressant with a serotonergic mechanism of action. 2020-06-16 2023-08-13 zebrafish
C A Shively, M B Fontenot, J R Kapla. Social status, behavior, and central serotonergic responsivity in female cynomolgus monkeys. American journal of primatology. vol 37. issue 4. 2020-01-15. PMID:31936955. the early follicular phase of the menstrual cycle was determined based on the occurrence of menses, and the prolactin response to acute administration of fenfluramine hcl during the early follicular phase was used as a measure of net brain serotonergic responsivity. 2020-01-15 2023-08-13 human
Steiner, Yatham, Coote, Wilkins, Lepag. Serotonergic dysfunction in women with pure premenstrual dysphoric disorder: is the fenfluramine challenge test still relevant? Psychiatry research. vol 87. issue 2-3. 2019-11-20. PMID:10579544. serotonergic dysfunction in women with pure premenstrual dysphoric disorder: is the fenfluramine challenge test still relevant? 2019-11-20 2023-08-12 Not clear
C. Sánche. Effect of serotonergic drugs on footshock-induced ultrasonic vocalization in adult male rats. Behavioural pharmacology. vol 4. issue 3. 2019-11-20. PMID:11224195. the effects of 5-ht(1a) receptor agonists with different intrinsic activities and the role of other 5-ht(1) receptor subtypes, and of 5-ht(2) and 5-ht(3) receptors, in mediation of ultrasonic vocalization were studied, as were the effects of increasing serotonergic activity by administration of the 5-ht releaser fenfluramine or the 5-ht precursor 1-5 htp. 2019-11-20 2023-08-12 rat
Michael E. Newman, Baruch Shapira, Bernard Lere. Evaluation of central serotonergic function in affective and related disorders by the fenfluramine challenge test: a critical review. The international journal of neuropsychopharmacology. vol 1. issue 1. 2019-11-20. PMID:11281946. evaluation of central serotonergic function in affective and related disorders by the fenfluramine challenge test: a critical review. 2019-11-20 2023-08-12 human
Michael E. Newman, Baruch Shapira, Bernard Lere. Evaluation of central serotonergic function in affective and related disorders by the fenfluramine challenge test: a critical review. The international journal of neuropsychopharmacology. vol 1. issue 1. 2019-11-20. PMID:11281946. plasma prolactin levels following oral administration of the serotonin (5-ht) releasing agent, fenfluramine hydrochloride, have been extensively used to evaluate central serotonergic function in affective and related disorders. 2019-11-20 2023-08-12 human
Floyd R Sallee, Nandagopal S Vrindavanam, Hong Liu, Gopalan Sethuraman, Lauren Sin. Fenfluramine challenge in anxious children. Human psychopharmacology. vol 15. issue 8. 2019-11-20. PMID:12404615. the study objective was to determine if serotonergic challenge with oral racemic fenfluramine would differentiate between childhood anxiety disorders in comparison to normal controls. 2019-11-20 2023-08-12 human
Iliyan Ivanov, Janine Flory, Jeffrey H Newcorn, Jeffrey M Halperi. Childhood serotonergic function and early adult outcomes in youth with ADHD: A 15-year follow-up study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 12. 2019-06-12. PMID:30454909. we used logistic regression to assess whether serotonergic measures in childhood assessed via prolactin and cortisol responses to a fenfluramine challenge, would selectively predict the development of aspd in early adulthood. 2019-06-12 2023-08-13 human
A Faron-Górecka, M Kuśmider, K Szafran-Pilch, M Kolasa, D Żurawek, P Gruca, M Papp, J Solich, P Pabian, M Dziedzicka-Wasylewsk. Basal prolactin levels in rat plasma correlates with response to antidepressant treatment in animal model of depression. Neuroscience letters. vol 647. 2017-10-06. PMID:28336340. many studies have focused on the response to antidepressant treatment (especially related to the serotonergic system) using the fenfluramine test (prf), however some data suggest lack of correlation between prf and prediction of clinical response to ads. 2017-10-06 2023-08-13 rat
Jill S Carmody, Nadia N Ahmad, Sriram Machineni, Scott Lajoie, Lee M Kapla. Weight Loss After RYGB Is Independent of and Complementary to Serotonin 2C Receptor Signaling in Male Mice. Endocrinology. vol 156. issue 9. 2015-11-17. PMID:26066076. consistent with this hypothesis, wild-type rygb-treated mice lost additional weight after the administration of the serotonergic drugs fenfluramine and meta-chlorophenylpiperazine but not the nonserotonergic agent topiramate. 2015-11-17 2023-08-13 mouse
L M Neckers, L Bertilsson, E Cost. The action of fenfluramine andp-chloramphetamine on serotonergic mechanisms: A comparative study in rat brain nuclei. Neurochemical research. vol 1. issue 1. 2013-11-26. PMID:24271241. the action of fenfluramine andp-chloramphetamine on serotonergic mechanisms: a comparative study in rat brain nuclei. 2013-11-26 2023-08-12 rat
L M Neckers, L Bertilsson, E Cost. The action of fenfluramine andp-chloramphetamine on serotonergic mechanisms: A comparative study in rat brain nuclei. Neurochemical research. vol 1. issue 1. 2013-11-26. PMID:24271241. other reports have shown that a single injection of fenfluramine or pca causes cytopathological changes in a serotonergic midbrain nucleus which was termed b9 by dahlstrom and fuxe (1). 2013-11-26 2023-08-12 rat
L M Neckers, L Bertilsson, E Cost. The action of fenfluramine andp-chloramphetamine on serotonergic mechanisms: A comparative study in rat brain nuclei. Neurochemical research. vol 1. issue 1. 2013-11-26. PMID:24271241. probably the decrease of tryptophan hydroxylase elicited by pca in b9 is due to retrograde degeneration; the intensity and duration of the biochemical lesion elicited by fenfluramine and pca in serotonergic terminals are a factor in determining the extent of the biochemical lesion in serotonergic cell bodies. 2013-11-26 2023-08-12 rat
Donatella Marazziti, Stefano Baroni, Gino Giannaccini, Laura Betti, Gabriele Massimetti, Claudia Carmassi, Mario Catena-Dell'Oss. A link between oxytocin and serotonin in humans: supporting evidence from peripheral markers. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 8. 2013-01-16. PMID:22297159. further, the administration of fenfluramine, a serotonergic agonist, to healthy subjects increases plasma ot levels. 2013-01-16 2023-08-12 human
J E Grice, J Jackson, P J Penfold, R V Jackso. Adrenocorticotropin hyperresponsiveness in myotonic dystrophy following oral fenfluramine administration. Journal of neuroendocrinology. vol 3. issue 1. 2012-10-02. PMID:19215449. fenfluramine activates central serotonergic and/or noradrenergic pathways initiating secretion of corticotropin-releasing hormone and possibly arginine vasopressin. 2012-10-02 2023-08-12 Not clear
Humberto Corrêa, Marco Aurélio Romano-Silva, Fabrice Duval, Ana Carolina Campi-Azevedo, Vivtor Lima, Jean-Paul Mache. Research on serotonin and suicidal behavior: neuroendocrine and molecular approaches. Dialogues in clinical neuroscience. vol 4. issue 4. 2012-09-10. PMID:22034390. we carried out two studies to test the hypothesis that altered central serotonergic function, as assessed by lower prolactin (prl) response to fenfluramine (d-fen), is more closely associated with suicidal behavior than a particular psychiatric diagnosis. 2012-09-10 2023-08-12 Not clear