| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anze Testen, Jonathan W VanRyzin, Tania J Bellinger, Ronald Kim, Han Wang, Matthew J Gastinger, Emily A Witt, Janay P Franklin, Haley A Vecchiarelli, Katherine Picard, Marie-Ève Tremblay, Kathryn J Reissne. Abstinence from cocaine self-administration promotes microglia pruning of astrocytes which drives cocaine-seeking behavior. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345569. |
here, we report that long-access cocaine self-administration followed by prolonged home cage abstinence results in decreased branching complexity of nucleus accumbens astrocytes, characterized by the loss of peripheral processes. |
2024-09-30 |
2024-10-02 |
Not clear |
| Sophia J Weber, Alex B Kawa, Madelyn M Beutler, Hayley M Kuhn, Alana L Moutier, Jonathan G Westlake, Lara M Koyshman, Cloe D Moreno, Amanda M Wunsch, Marina E Wol. Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-09-19. PMID:39300272. |
dopamine transmission at d1 and d2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. |
2024-09-19 |
2024-09-22 |
rat |
| Qiaowei Xie, Rohan Dasari, Mark D Namba, Lauren A Buck, Christine M Side, Kyewon Park, Joshua G Jackson, Jacqueline M Barke. Astrocytic Regulation of Cocaine Locomotor Sensitization in EcoHIV Infected Mice. bioRxiv : the preprint server for biology. 2024-09-16. PMID:39282274. |
this includes development of cocaine locomotor sensitization - or increased locomotor responses to the same doses of cocaine - which depends on nucleus accumbens (nac) neural plasticity. |
2024-09-16 |
2024-09-19 |
mouse |
| Shahid Nazir Wani, Amarjot Kaur Grewal, Heena Khan, Thakur Gurjeet Sing. Elucidating the molecular symphony: unweaving the transcriptional & epigenetic pathways underlying neuroplasticity in opioid dependence and withdrawal. Psychopharmacology. 2024-09-10. PMID:39254835. |
chronic cocaine usage leads to synchronized alterations in gene expression, causing modifications in the nucleus accumbens (nac), a vital part of the reward system of the brain. |
2024-09-10 |
2024-09-13 |
Not clear |
| Emily G Peck, Katherine M Holleran, Alyson M Curry, Kimberly M Holter, Paige M Estave, Jonathon P Sens, Jason L Locke, Olivia A Ortelli, Brianna E George, Monica H Dawes, Alyssa M West, Nancy J Alexander, Drew D Kiraly, Sean P Farris, Robert W Gould, Brian A McCool, Sara R Jone. Synaptogyrin-3 Prevents Cocaine Addiction and Dopamine Deficits. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211138. |
overexpression also enhanced nucleus accumbens dopamine signaling and prevented cocaine-induced deficits, suggesting a putative therapeutic role for synaptogyrin-3 in cocaine use disorder. |
2024-08-30 |
2024-09-04 |
rat |
| Daniel J Wood, Jessica L Huebschman, Dalia Martinez, Evgeny Tsvetkov, Kirsten Snyder, Raymond Tjhia, Jaswinder Kumar, Brandon W Hughes, Makoto Taniguchi, Laura N Smith, Christopher W Cowan, Rachel D Penro. The activity-regulated cytoskeleton-associated protein (Arc) functions in a cell type- and sex-specific manner in the adult nucleus accumbens to regulate non-contingent cocaine behaviors. Genes, brain, and behavior. vol 23. issue 4. 2024-08-21. PMID:39164860. |
the activity-regulated cytoskeleton-associated protein (arc) functions in a cell type- and sex-specific manner in the adult nucleus accumbens to regulate non-contingent cocaine behaviors. |
2024-08-21 |
2024-08-23 |
mouse |
| Daniel J Wood, Jessica L Huebschman, Dalia Martinez, Evgeny Tsvetkov, Kirsten Snyder, Raymond Tjhia, Jaswinder Kumar, Brandon W Hughes, Makoto Taniguchi, Laura N Smith, Christopher W Cowan, Rachel D Penro. The activity-regulated cytoskeleton-associated protein (Arc) functions in a cell type- and sex-specific manner in the adult nucleus accumbens to regulate non-contingent cocaine behaviors. Genes, brain, and behavior. vol 23. issue 4. 2024-08-21. PMID:39164860. |
in rodents, the activity-regulated cytoskeleton-associated protein (arc) can regulate glutamatergic synaptic transmission, and cocaine regulates arc expression and subcellular localization in multiple brain regions, including the nucleus accumbens (nac)-a brain region linked to cud-related behavior. |
2024-08-21 |
2024-08-23 |
mouse |
| Janay P Franklin, Anze Testen, Piotr A Mieczkowski, Austin Hepperla, Gogce Crynen, Jeremy M Simon, Jonathan D Wood, Eden V Harder, Tania J Bellinger, Emily A Witt, N LaShae Powell, Kathryn J Reissne. Investigating cocaine- and abstinence-induced effects on astrocyte gene expression in the nucleus accumbens. bioRxiv : the preprint server for biology. 2024-08-16. PMID:39149305. |
astrocytes are structurally altered following exposure to drugs of abuse; specifically, astrocytes within the nucleus accumbens (nac) exhibit significantly decreased surface area, volume, and synaptic colocalization after operant self-administration of cocaine and extinction or protracted abstinence (45 days). |
2024-08-16 |
2024-08-18 |
rat |
| Kelsey E Lucerne, Calista R Dean, Aya Osman, Katherine R Meckel, Yesha A Dave, Ava L Shipman, Dannis R Cazarez, Flurin Cathomas, Rebecca S Hofford, Drew D Kiral. Colony-stimulating factor 2 (CSF2) as a gut microbiome dependent immune factor that alters molecular and behavioral responses to cocaine in male mice. Brain, behavior, and immunity. 2024-08-04. PMID:39098439. |
on a molecular level, we find that peripheral injections of csf2 alter the transcriptional response to both acute and repeated cocaine in the nucleus accumbens. |
2024-08-04 |
2024-08-07 |
mouse |
| Freddyson J Martínez-Rivera, Yun Young Yim, Arthur Godino, Angélica Minier-Toribio, Solange Tofani, Leanne M Holt, Angélica Torres-Berrío, Rita Futamura, Caleb J Browne, Tamara Markovic, Peter J Hamilton, Rachael L Neve, Eric J Nestle. Cell-Type-Specific Regulation of Cocaine Reward by the E2F3a Transcription Factor in Nucleus Accumbens. bioRxiv : the preprint server for biology. 2024-07-19. PMID:39026727. |
cell-type-specific regulation of cocaine reward by the e2f3a transcription factor in nucleus accumbens. |
2024-07-19 |
2024-07-21 |
mouse |
| Sophia J Weber, Alex B Kawa, Alana L Moutier, Madelyn M Beutler, Lara M Koyshman, Cloe D Moreno, Jonathan G Westlake, Amanda M Wunsch, Marina E Wol. Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. bioRxiv : the preprint server for biology. 2024-07-09. PMID:38979157. |
dopamine transmission at d1 and d2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. |
2024-07-09 |
2024-07-12 |
rat |
| Young-Jung Kim, Su Jeong Choi, Sa-Ik Hong, Jung-Cheol Park, Youyoung Lee, Shi-Xun Ma, Kwang-Hyun Hur, Young Lee, Kyeong-Man Kim, Hyung Kyu Kim, Hee Young Kim, Seok-Yong Lee, Se-Young Choi, Choon-Gon Jan. The ion channel TRPA1 is a modulator of the cocaine reward circuit in the nucleus accumbens. Molecular psychiatry. 2024-05-31. PMID:38822069. |
the ion channel trpa1 is a modulator of the cocaine reward circuit in the nucleus accumbens. |
2024-05-31 |
2024-06-02 |
mouse |
| Bo W Sortman, Samantha Rakela, Sarah Paprotna, Berk Cerci, Brandon L Warre. Nucleus accumbens neuronal ensembles vary with cocaine reinforcement in male and female rats. Addiction biology. vol 29. issue 5. 2024-05-07. PMID:38711205. |
nucleus accumbens neuronal ensembles vary with cocaine reinforcement in male and female rats. |
2024-05-07 |
2024-05-27 |
rat |
| Bo W Sortman, Samantha Rakela, Sarah Paprotna, Berk Cerci, Brandon L Warre. Nucleus accumbens neuronal ensembles vary with cocaine reinforcement in male and female rats. Addiction biology. vol 29. issue 5. 2024-05-07. PMID:38711205. |
neuronal ensembles in the medial prefrontal cortex mediate cocaine self-administration via projections to the nucleus accumbens. |
2024-05-07 |
2024-05-27 |
rat |
| Mark D Namba, Qiaowei Xie, Kyewon Park, Joshua G Jackson, Jacqueline M Barke. EcoHIV Infection Modulates the Effects of Cocaine Exposure Pattern and Abstinence on Cocaine Seeking and Neuroimmune Protein Expression in Male Mice. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659915. |
analysis of corticolimbic cx3cl1-cx3cr1 and glutamate receptor expression revealed alterations in medial prefrontal cortex (mpfc) cx3cl1 and nucleus accumbens (nac) glun2a receptors that correlated with cocaine seeking following daily cocaine exposure. |
2024-04-25 |
2024-04-28 |
mouse |
| Freddyson J Martínez-Rivera, Leanne M Holt, Angélica Minier-Toribio, Molly Estill, Szu-Ying Yeh, Solange Tofani, Rita Futamura, Caleb J Browne, Philipp Mews, Li Shen, Eric J Nestle. Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559084. |
transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens. |
2024-04-01 |
2024-04-04 |
rat |
| Freddyson J Martínez-Rivera, Leanne M Holt, Angélica Minier-Toribio, Molly Estill, Szu-Ying Yeh, Solange Tofani, Rita Futamura, Caleb J Browne, Philipp Mews, Li Shen, Eric J Nestle. Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559084. |
cocaine use disorder (cud) exemplifies this phenomenon in which neurobiological modifications hijack brain reward regions such as the nucleus accumbens (nac) to manifest craving and withdrawal-like symptoms. |
2024-04-01 |
2024-04-04 |
rat |
| Henrique Nunes Pereira Oliva, Tiago Paiva Prudente, Eric J Nunes, Kelly P Cosgrove, Rajiv Radhakrishnan, Marc N Potenza, Gustavo A Angarit. Substance use and spine density: a systematic review and meta-analysis of preclinical studies. Molecular psychiatry. 2024-04-01. PMID:38561468. |
amphetamine, cocaine, and nicotine increased spine density in the nucleus accumbens. |
2024-04-01 |
2024-04-04 |
human |
| Jian Ye, Shuang-Qi Gao, Zi-Cun Liu, Xi Chen, Jin-Gang He, Zhuang-Li H. The HMGB1-RAGE axis in nucleus accumbens facilitates cocaine-induced conditioned place preference via modulating microglial activation. Brain and behavior. vol 14. issue 3. 2024-03-07. PMID:38450910. |
cocaine exposure also induces a release of high mobility group box-1 (hmgb1) from neurons into the extracellular space in the nucleus accumbens (nac). |
2024-03-07 |
2024-03-09 |
Not clear |
| Melinda Hersey, Maddalena Mereu, Claire S Jones, Mattingly K Bartole, Andy Y Chen, Jianjing Cao, Takato Hiranita, Lauren E Chun, Jessica P Lopez, Jonathan L Katz, Amy Hauck Newman, Gianluigi Tand. Dual DAT and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats. The European journal of neuroscience. 2024-03-06. PMID:38444104. |
dual dat and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats. |
2024-03-06 |
2024-03-08 |
rat |