| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anze Testen, Jonathan W VanRyzin, Tania J Bellinger, Ronald Kim, Han Wang, Matthew J Gastinger, Emily A Witt, Janay P Franklin, Haley A Vecchiarelli, Katherine Picard, Marie-Ève Tremblay, Kathryn J Reissne. Abstinence from cocaine self-administration promotes microglia pruning of astrocytes which drives cocaine-seeking behavior. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345569. |
abstinence from cocaine self-administration promotes microglia pruning of astrocytes which drives cocaine-seeking behavior. |
2024-09-30 |
2024-10-02 |
Not clear |
| Anze Testen, Jonathan W VanRyzin, Tania J Bellinger, Ronald Kim, Han Wang, Matthew J Gastinger, Emily A Witt, Janay P Franklin, Haley A Vecchiarelli, Katherine Picard, Marie-Ève Tremblay, Kathryn J Reissne. Abstinence from cocaine self-administration promotes microglia pruning of astrocytes which drives cocaine-seeking behavior. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345569. |
collectively, these results provide evidence for microglia pruning of accumbens astrocytes across cocaine abstinence which mediates cocaine craving. |
2024-09-30 |
2024-10-02 |
Not clear |
| B Celia Cui, Marina Aksenova, Aliaksandra Sikirzhytskaya, Diana Odhiambo, Elizaveta Korunova, Vitali Sikirzhytski, Hao Ji, Diego Altomare, Eugenia Broude, Norma Frizzell, Rosemarie Booze, Michael D Wyatt, Michael Shtutma. Suppression of HIV-TAT and cocaine-induced neurotoxicity and inflammation by cell penetrable itaconate esters. Journal of neurovirology. 2024-06-17. PMID:38884890. |
when primary cortical cultures exposed to tat and cocaine were treated with 4oi, microglial cell number increased and the morphological altercations induced by tat and cocaine were reversed. |
2024-06-17 |
2024-06-19 |
Not clear |
| Jian Ye, Shuang-Qi Gao, Zi-Cun Liu, Xi Chen, Jin-Gang He, Zhuang-Li H. The HMGB1-RAGE axis in nucleus accumbens facilitates cocaine-induced conditioned place preference via modulating microglial activation. Brain and behavior. vol 14. issue 3. 2024-03-07. PMID:38450910. |
however, whether the secretion of hmgb1 acts on microglia or contributes to cocaine addiction is largely unknown. |
2024-03-07 |
2024-03-09 |
Not clear |
| Oualid Abboussi, Zmarak Ahmad Khan, Hind Ibork, Simo S Zulu, William Daniels, Khalid Taghzouti, Tim G Hale. CB2 agonist mitigates cocaine-induced reinstatement of place preference and modulates the inflammatory response in mice. Behavioural pharmacology. 2023-12-12. PMID:38085651. |
chronic exposure to cocaine is known to have profound effects on the brain, leading to the dysregulation of inflammatory signalling pathways, the activation of microglia, and the manifestation of cognitive and motivational behavioural impairments. |
2023-12-12 |
2023-12-17 |
mouse |
| Ingrid Reverte, Claudia Marchetti, Sara Pezza, Soami F Zenoni, Giorgia Scaringi, Laura Ferrucci, Ginevra D'Ottavio, Annabella Pignataro, Diego Andolina, Marcello Raspa, Ferdinando Scavizzi, Marco Venniro, Leslie A Ramsey, Cornelius Gross, Daniele Caprioli, Davide Ragozzin. Microglia-mediated calcium-permeable AMPAR accumulation in the nucleus accumbens drives hyperlocomotion during cocaine withdrawal. Brain, behavior, and immunity. 2023-11-15. PMID:37967660. |
we depleted microglia using plx5622-supplemented diet during cocaine withdrawal, and after the place preference test, we measured dendritic spine density and the presence of cp-ampar in the nac shell. |
2023-11-15 |
2023-11-20 |
Not clear |
| Ingrid Reverte, Claudia Marchetti, Sara Pezza, Soami F Zenoni, Giorgia Scaringi, Laura Ferrucci, Ginevra D'Ottavio, Annabella Pignataro, Diego Andolina, Marcello Raspa, Ferdinando Scavizzi, Marco Venniro, Leslie A Ramsey, Cornelius Gross, Daniele Caprioli, Davide Ragozzin. Microglia-mediated calcium-permeable AMPAR accumulation in the nucleus accumbens drives hyperlocomotion during cocaine withdrawal. Brain, behavior, and immunity. 2023-11-15. PMID:37967660. |
our results suggest that microglia are necessary for the synaptic adaptations in nac synapses during cocaine withdrawal and therefore represent a promising therapeutic target for relapse prevention. |
2023-11-15 |
2023-11-20 |
Not clear |
| Yan Cheng, Rachael Elizabeth Dempsey, Soheil Kazemi Roodsari, Dorela D Shuboni-Mulligan, Olivier George, Larry D Sanford, Ming-Lei Gu. Cocaine Regulates NLRP3 Inflammasome Activity and CRF Signaling in a Region- and Sex-Dependent Manner in Rat Brain. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509440. |
cocaine, one of the most abused drugs worldwide, is capable of activating microglia in vitro and in vivo. |
2023-07-29 |
2023-08-14 |
mouse |
| Yan Cheng, Rachael Elizabeth Dempsey, Soheil Kazemi Roodsari, Dorela D Shuboni-Mulligan, Olivier George, Larry D Sanford, Ming-Lei Gu. Cocaine Regulates NLRP3 Inflammasome Activity and CRF Signaling in a Region- and Sex-Dependent Manner in Rat Brain. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509440. |
previous work showed that cocaine activates microglia in a region-specific manner in the brains of self-administered mice. |
2023-07-29 |
2023-08-14 |
mouse |
| Yan Cheng, Rachael Elizabeth Dempsey, Soheil Kazemi Roodsari, Dorela D Shuboni-Mulligan, Olivier George, Larry D Sanford, Ming-Lei Gu. Cocaine Regulates NLRP3 Inflammasome Activity and CRF Signaling in a Region- and Sex-Dependent Manner in Rat Brain. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509440. |
to further characterize the effects of cocaine on microglia and neuroimmune signaling in vivo, we utilized the brains from both sexes of outbred rats with cocaine self-administration to explore the activation status of microglia, nod-, lrr-, and pyrin domain-containing protein 3 (nlrp3) inflammasome activity, corticotropin-releasing factor (crf) signaling, and nf-κb levels in the striatum and hippocampus (hp). |
2023-07-29 |
2023-08-14 |
mouse |
| Seema Singh, Annadurai Thangaraj, Ernest T Chivero, Ming-Lei Guo, Palsamy Periyasamy, Shilpa Buc. Role of Dysregulated Autophagy in HIV Tat, Cocaine, and cART Mediated NLRP3 Activation in Microglia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-05-06. PMID:37148425. |
role of dysregulated autophagy in hiv tat, cocaine, and cart mediated nlrp3 activation in microglia. |
2023-05-06 |
2023-08-14 |
mouse |
| Seema Singh, Annadurai Thangaraj, Ernest T Chivero, Ming-Lei Guo, Palsamy Periyasamy, Shilpa Buc. Role of Dysregulated Autophagy in HIV Tat, Cocaine, and cART Mediated NLRP3 Activation in Microglia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-05-06. PMID:37148425. |
our results demonstrated that exposure of mouse primary microglia (mpms) to these agents-hiv tat (25 ng/ml), cocaine (1 μm), and cart (1 μm each) resulted in upregulation of autophagy markers: beclin1, lc3b-ii, and sqstm1 with impaired lysosomal functioning involving increased lysosomal ph, decreased lamp2 and cathepsin d, ultimately leading to dysregulated autophagy. |
2023-05-06 |
2023-08-14 |
mouse |
| Palsamy Periyasamy, Annadurai Thangaraj, Muthukumar Kannan, Abiola Oladapo, Shilpa Buc. The Epigenetic Role of miR-124 in HIV-1 Tat- and Cocaine-Mediated Microglial Activation. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499350. |
we also found the increased expression of proinflammatory cytokines such as il1β, il6 and tnf in the mouse primary microglia exposed to hiv-1 tat and cocaine correlated with microglial activation. |
2022-12-11 |
2023-08-14 |
mouse |
| Palsamy Periyasamy, Annadurai Thangaraj, Muthukumar Kannan, Abiola Oladapo, Shilpa Buc. The Epigenetic Role of miR-124 in HIV-1 Tat- and Cocaine-Mediated Microglial Activation. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499350. |
overall, our findings demonstrate that the exposure of mouse primary microglia to both hiv-1 tat and cocaine could result in intensified microglial activation via the promoter dna hypermethylation of mir-124, leading to the exacerbated release of proinflammatory cytokines, ultimately culminating in neuroinflammation. |
2022-12-11 |
2023-08-14 |
mouse |
| Soheil Kazemi Roodsari, Yan Cheng, Kirstin M Reed, Laurie L Wellman, Larry D Sanford, Woong-Ki Kim, Ming-Lei Gu. Sleep Disturbance Alters Cocaine-Induced Locomotor Activity: Involvement of Striatal Neuroimmune and Dopamine Signaling. Biomedicines. vol 10. issue 5. 2022-05-28. PMID:35625897. |
meanwhile, sf modulated the effects of cocaine on neuroimmune signaling in the striatum and in ex vivo isolated microglia. |
2022-05-28 |
2023-08-13 |
mouse |
| María Paula Avalos, Andrea Susana Guzmán, Daiana Rigoni, Ezequiel Axel Gorostiza, Marianela Adela Sanchez, Bethania Mongi-Bragato, Constanza García-Keller, Eduardo Marcelo Perassi, Miriam Beatriz Virgolini, Javier María Peralta Ramos, Pablo Iribarren, Gastón Diego Calfa, Flavia Andrea Bollati, Liliana Marina Cancel. Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia. Brain, behavior, and immunity. 2022-01-22. PMID:35065197. |
minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia. |
2022-01-22 |
2023-08-13 |
rat |
| María Paula Avalos, Andrea Susana Guzmán, Daiana Rigoni, Ezequiel Axel Gorostiza, Marianela Adela Sanchez, Bethania Mongi-Bragato, Constanza García-Keller, Eduardo Marcelo Perassi, Miriam Beatriz Virgolini, Javier María Peralta Ramos, Pablo Iribarren, Gastón Diego Calfa, Flavia Andrea Bollati, Liliana Marina Cancel. Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia. Brain, behavior, and immunity. 2022-01-22. PMID:35065197. |
by using minocycline, a potent inhibitor of microglia activation with anti-inflammatory properties, we determined whether microglia could aid chronic restraint stress (crs)-induced glutamate homeostasis disruption in the nacore, underpinning stress-induced cocaine self-administration. |
2022-01-22 |
2023-08-13 |
rat |
| María Paula Avalos, Andrea Susana Guzmán, Daiana Rigoni, Ezequiel Axel Gorostiza, Marianela Adela Sanchez, Bethania Mongi-Bragato, Constanza García-Keller, Eduardo Marcelo Perassi, Miriam Beatriz Virgolini, Javier María Peralta Ramos, Pablo Iribarren, Gastón Diego Calfa, Flavia Andrea Bollati, Liliana Marina Cancel. Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia. Brain, behavior, and immunity. 2022-01-22. PMID:35065197. |
these alterations were strongly related to the crs-induced reactive microglia and increased tnf-α mrna and protein expression, since by administering minocycline, the impaired glutamate homeostasis and the facilitation of cocaine self-administration were prevented. |
2022-01-22 |
2023-08-13 |
rat |
| María Paula Avalos, Andrea Susana Guzmán, Daiana Rigoni, Ezequiel Axel Gorostiza, Marianela Adela Sanchez, Bethania Mongi-Bragato, Constanza García-Keller, Eduardo Marcelo Perassi, Miriam Beatriz Virgolini, Javier María Peralta Ramos, Pablo Iribarren, Gastón Diego Calfa, Flavia Andrea Bollati, Liliana Marina Cancel. Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia. Brain, behavior, and immunity. 2022-01-22. PMID:35065197. |
a role of microglia is proposed for the development of glutamatergic mechanisms underpinning stress-induced vulnerability to cocaine addiction. |
2022-01-22 |
2023-08-13 |
rat |
| Ernest T Chivero, Annadurai Thangaraj, Ashutosh Tripathi, Palsamy Periyasamy, Ming-Lei Guo, Shilpa Buc. NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and Neuroinflammation. Molecular neurobiology. vol 58. issue 5. 2021-11-18. PMID:33417223. |
we examined activation of the nlrp3 pathway in microglia exposed to cocaine, followed by validation in mice administered either cocaine or saline for 7 days, with or without pretreatment with the nlrp3 inhibitor, mcc950, and in postmortem cortical brain tissues of chronic cocaine-dependent humans. |
2021-11-18 |
2023-08-13 |
mouse |