| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiaxin Gao, Yi Li, Junyi Hou, Yirong Wan. Unveiling the depths of pelvic organ prolapse: From risk factors to therapeutic methods (Review). Experimental and therapeutic medicine. vol 29. issue 1. 2024-11-25. PMID:39582942. |
to address this gap and enhance researchers' understanding of pop, the present study reviewed the risk factors and molecular mechanisms of pop [including matrix metalloproteinases (mmps) and tissue inhibitors of mmps, transforming growth factor β, advanced glycation end products (ages)/receptor for age, phosphoinositide 3-kinase/protein kinase b, fibulin, lysyl oxidase-like 1, homeobox a11, collagen α-1 (xviii) chain, wnt signaling pathways and estrogen receptor α], as well as therapeutic approaches, such as lifestyle interventions, physical methods, pharmacotherapy, stem cell transplantation and surgical techniques. |
2024-11-25 |
2024-11-27 |
human |
| Y Yoshida, T Inubushi, M Yokoyama, P Nag, J I Sasaki, A Oka, T Murotani, R Kani, Y Shiraishi, H Kurosaka, Y Takahata, R Nishimura, S Imazato, P Papagerakis, T Yamashir. Slc26a2-mediated sulfate metabolism is significant for the tooth development. Disease models & mechanisms. 2024-11-07. PMID:39508796. |
ex vivo and in vitro studies further reveal dentin matrix hypoplasia, tooth root shortening, and downregulation of wnt signaling in slc26a2-deficient cells. |
2024-11-07 |
2024-11-16 |
mouse |
| Yinghua Chen, Adrienn Petho, Amudha Ganapathy, Anne Georg. DPP an extracellular matrix molecule induces Wnt5a mediated signaling to promote the differentiation of adult stem cells into odontogenic lineage. Scientific reports. vol 14. issue 1. 2024-10-31. PMID:39478025. |
dentin phosphophoryn (dpp) an extracellular matrix protein activates wnt signaling in dpscs (dental pulp stem cells). |
2024-10-31 |
2024-11-02 |
mouse |
| Prashanta Silwal, Allison M Nguyen-Thai, Peter G Alexander, Gwendolyn A Sowa, Nam V Vo, Joon Y Le. Cellular and Molecular Mechanisms of Hypertrophy of Ligamentum Flavum. Biomolecules. vol 14. issue 10. 2024-10-26. PMID:39456209. |
we also discuss in detail how several pathomechanisms such as fibrosis, proliferation and apoptosis, macrophage infiltration, and autophagy, in addition to several molecular pathways involving tgf-β1, mitogen-activated protein kinase (mapks), and nuclear factor-κb (nf-κb) signaling, pi3k/akt signaling, wnt signaling, micro-rnas, extracellular matrix proteins, reactive oxygen species (ros), etc. |
2024-10-26 |
2024-10-29 |
Not clear |
| Anil Kumar, Lekha Sah. Colorectal cancer cell dormancy: An insight into pathways. World journal of gastroenterology. vol 30. issue 33. 2024-10-01. PMID:39351431. |
additionally, erk/p38α/β/mapk pathways, akt signalling pathway, and extracellular matrix metalloproteinase inducer, along with some potential less explored pathways such as stat/p53 switch and canonical and non-canonical wnt and smad signalling, are also involved in promoting colorectal ccd. |
2024-10-01 |
2024-10-03 |
Not clear |
| Rajanya Ghosh, Samuel Herber. The role of YAP/TAZ mechanosignaling in trabecular meshwork and Schlemm's canal cell dysfunction. Vision research. vol 224. 2024-08-29. PMID:39208753. |
this focused review highlights the importance of yes-associated protein (yap)/transcriptional coactivator with pdz binding motif (taz) mechanosignaling in human trabecular meshwork and schlemm's canal cells in response to glaucoma-associated extracellular matrix stiffening and cyclic mechanical stretch, as well as biochemical pathway modulators (with signaling crosstalk) including transforming growth factor beta 2, glucocorticoids, wnt, lysophosphatidic acid, vascular endothelial growth factor, and oxidative stress. |
2024-08-29 |
2024-09-04 |
human |
| Lütfiye Ozpak, Bakiye Göker Bağc. Neuroprotective effects of resveratrol through modulation of PI3K/Akt/GSK-3β pathway and metalloproteases. IUBMB life. 2024-08-19. PMID:39159067. |
network analysis shows the functional enrichment of 23 alzheimer-related go terms in the wnt signaling, proteolysis, and extracellular matrix organization pathways. |
2024-08-19 |
2024-08-22 |
Not clear |
| Zhenlie Chen, Wen Zhong, Ruiqing Zhang, Guigui Li, Yuanzhen Zhang, Ming Zhan. Down-regulation of PCBP2 Suppresses the Invasion and Migration of Trophoblasts via the WNT5A/ROR2 Pathway in Preeclampsia. Biology of reproduction. 2024-08-08. PMID:39115369. |
go and kegg analysis indicated that wnt signaling pathway and the related processes such as extracellular matrix remodeling and cell adhesion were among the most enriched pathways or processes. |
2024-08-08 |
2024-08-10 |
Not clear |
| Huizhen Wang, Jing Li, Kexun Yu, Yida Lu, Mengdi Ma, Yongxiang L. The cellular localization and oncogenic or tumor suppressive effects of angiomiotin-like protein 2 in tumor and normal cells. IUBMB life. 2024-05-08. PMID:38717123. |
moreover, overall analysis, gsea and roc curve analysis indicate that amotl2 exerts as an oncogenic protein in coad by modulating wnt pathway, participating in synthesis of collagen formation, and interacting with extracellular matrix receptor. |
2024-05-08 |
2024-05-27 |
human |
| David T Humphreys, Amy Lewis, Belen Pan-Castillo, Giulio Berti, Charles Mein, Eva Wozniak, Hannah Gordon, Radha Gadhok, Annamaria Minicozzi, Joanna ChinAleong, Roger Feakins, Eleni Giannoulatou, Louisa K James, Andrew J Stagg, James Oliver Lindsay, Andrew Silve. Single cell sequencing data identify distinct B cell and fibroblast populations in stricturing Crohn's disease. Journal of cellular and molecular medicine. vol 28. issue 9. 2024-04-30. PMID:38685679. |
go and kegg biological terms showed extracellular matrix and stricture organization associated with c12 and c9, and regulation of wnt pathway genes with c9. |
2024-04-30 |
2024-05-03 |
human |
| Shi Duan, Qing Yang, Fan Wu, Zhenyu Li, Wentao Hong, Mengxi Cao, Xinhua Chen, Xueping Zhong, Qingchun Zhou, Haobin Zha. Maternal methylosome protein 50 is essential for embryonic development in medaka Oryzias latipes. Journal of experimental zoology. Part A, Ecological and integrative physiology. 2024-04-24. PMID:38654580. |
the major interfered regulatory networks in the embryos losing maternal mep50 included dna replication and cell cycle regulation, ap-1 transcription factors such as jun and fos, the wnt pathway, rna processing, and the extracellular matrix. |
2024-04-24 |
2024-04-28 |
mouse |
| Chatvadee Kornsuthisopon, Nunthawan Nowwarote, Ajjima Chansaenroj, Suphalak Photichailert, Sunisa Rochanavibhata, Nuttha Klincumhom, Stephane Petit, Florent Dingli, Damarys Loew, Benjamin P J Fournier, Thanaphum Osathano. Human dental pulp stem cells derived extracellular matrix promotes mineralization via Hippo and Wnt pathways. Scientific reports. vol 14. issue 1. 2024-03-22. PMID:38514682. |
human dental pulp stem cells derived extracellular matrix promotes mineralization via hippo and wnt pathways. |
2024-03-22 |
2024-03-24 |
human |
| James Melros. Hippo cell signaling and HS-proteoglycans regulate tissue form and function, age-dependent maturation, extracellular matrix remodeling, and repair. American journal of physiology. Cell physiology. vol 326. issue 3. 2024-02-29. PMID:38223931. |
the primary cilium is a mechanosensory hub on neurons, utilized by yes associated protein (yap)-transcriptional coactivator with pdz-binding motif (taz) hippo, hh, wnt, transforming growth factor (tgf)-β/bone matrix protein (bmp) receptor tyrosine kinase cell signaling. |
2024-02-29 |
2024-03-03 |
human |
| Jie Li, Junqin Zhang, Zhaoping Chu, Hua Han, Yuan Zhan. FZD3 regulates the viability, apoptosis, and extracellular matrix degradation of vaginal wall fibroblasts in pelvic organ prolapse via the Wnt signaling pathway. Journal of biochemical and molecular toxicology. vol 38. issue 2. 2024-02-13. PMID:38348712. |
fzd3 regulates the viability, apoptosis, and extracellular matrix degradation of vaginal wall fibroblasts in pelvic organ prolapse via the wnt signaling pathway. |
2024-02-13 |
2024-02-15 |
Not clear |
| Li Sun, Meifang Zheng, Yanhang Gao, David R Brigstock, Runping Ga. Retinoic acid signaling pathway in pancreatic stellate cells: Insight into the anti-fibrotic effect and mechanism. European journal of pharmacology. 2024-02-03. PMID:38309676. |
in vitro studies have shown that ra induces psc deactivation which reduces extracellular matrix production through multiple modes of action, such as inhibiting tβrⅡ, pdgfrβ, β-catenin and wnt production, downregulating erk1/2 and jnk phosphorylation and suppressing active tgf-β1 release. |
2024-02-03 |
2024-02-06 |
mouse |
| Xingwei Wu, Shengnan Wang, Chenci Wang, Chengwei Wu, Zhiyong Zha. Bioinformatics analysis identifies coagulation factor II receptor as a potential biomarker in stomach adenocarcinoma. Scientific reports. vol 14. issue 1. 2024-01-30. PMID:38291086. |
kegg analysis indicated associations to extracellular matrix (ecm) receptor interactions, neuroactive ligand-receptor interactions, the phosphoinositide-3-kinase-protein kinase b/akt (pi3k-akt) signaling pathway, the wnt signaling pathway and the transforming growth factor-beta (tgf-β) signaling pathway. |
2024-01-30 |
2024-02-02 |
human |
| Stacy A Semevolos, Elizabeth A Marchan. Comparison of differential protein expression of the marginal transitional zone in neonatal and weanling-aged foals. Tissue & cell. vol 87. 2024-01-10. PMID:38199048. |
several families of proteins with known roles in cartilage and bone development are investigated, including matrix molecules, members of the wnt signaling family, apoptotic factors and paracrine cell signaling molecules. |
2024-01-10 |
2024-01-13 |
Not clear |
| Shanzhen Peng, Mingzhu Guo, Cheng Wu, Jinsong Liu, Bin Zou, Yuanyuan Chen, Yingchun Su, Lei Shi, Shiyong Zhu, Shujuan Xu, Dianlei Guo, Rong Ju, Lai Wei, Yanhong Wei, Chunqiao Li. Age and light damage influence Fzd5 regulation of ocular growth-related genes. Experimental eye research. 2023-12-28. PMID:38154732. |
further bioinformatical analysis indicated that these genes are extracellular matrix (ecm)-related; and meanwhile an altered wnt signaling was detected. |
2023-12-28 |
2023-12-31 |
mouse |
| Huan Deng, Yao Wang, Yue Yin, Jun Shu, Junwei Zhang, Xuedong Shu, Fang Wu, Jing H. Effects of matrix viscoelasticity on cell-matrix interaction, actin cytoskeleton organization, and apoptosis of osteosarcoma MG-63 cells. Journal of materials chemistry. B. 2023-12-11. PMID:38079114. |
besides the upregulation of mapk, ras, rap1 and pi3k-akt pathways commonly involved in mechanotransduction, the upregulation of the wnt pathway and inhibited endoplasmic reticulum stress-mediated apoptosis were observed for the viscous matrix with a low loss modulus. |
2023-12-11 |
2023-12-17 |
Not clear |
| Hannah Reich, Cathy Savage-Dun. Signaling Circuits and the Apical Extracellular Matrix In Aging: Connections Identified in the Nematode American journal of physiology. Cell physiology. 2023-09-18. PMID:37721005. |
signaling circuits and the apical extracellular matrix in aging: connections identified in the nematode numerous conserved signaling pathways play critical roles in aging, including insulin, tgf-β, wnt, and autophagy pathways. |
2023-09-18 |
2023-10-07 |
Not clear |