| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nataliya V Yaglova, Sergey S Obernikhin, Svetlana V Nazimova, Dibakhan A Tsomartova, Ekaterina P Timokhina, Valentin V Yaglov, Elina S Tsomartova, Elizaveta V Chereshneva, Marina Y Ivanova, Tatiana A Lomanovskay. Postnatal Exposure to the Endocrine Disruptor Dichlorodiphenyltrichloroethane Affects Adrenomedullary Chromaffin Cell Physiology and Alters the Balance of Mechanisms Underlying Cell Renewal. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338771. |
the ddt-exposed rats exhibited normal growth of the adrenal medulla but significantly decreased tyrosine hydroxylase production by chromaffin cells during postnatal period. |
2024-02-10 |
2024-02-12 |
rat |
| N V Yaglova, S S Obernikhin, D A Tsomartova, V V Yaglov, S V Nazimova, E P Timokhina, E S Tsomartov. Mechanisms of Suppression of Epinephrine Production in Rats by Low-Dose Developmental Exposure to DDT. Bulletin of experimental biology and medicine. 2022-05-26. PMID:35618967. |
it was found that the main mechanisms of disruptive action of ddt leading to a decrease in epinephrine secretion into systemic circulation are a decrease in the growth rate of the adrenal medulla, a decrease in the number of mitochondria in adrenal cells, especially under the outer cytoplasmic membrane, destructive changes in mitochondria, and a progressive decrease in the synthesis of tyrosine hydroxylase. |
2022-05-26 |
2023-08-13 |
rat |
| N V Yaglova, S S Obernikhin, D A Tsomartova, V V Yaglov, S V Nazimova, E P Timokhina, E S Tsomartov. Mechanisms of Suppression of Epinephrine Production in Rats by Low-Dose Developmental Exposure to DDT. Bulletin of experimental biology and medicine. 2022-05-26. PMID:35618967. |
the decrease in the number of mitochondria and suppression tyrosine hydroxylase synthesis in adrenal cells predominate during the pubertal period, while slowdown of the growth of the adrenal medulla and progressive decrease in the synthesis of tyrosine hydroxylase seem to be the most evident mechanisms after puberty. |
2022-05-26 |
2023-08-13 |
rat |
| Andrej Tillinger, Boris Mrave. Vagotomy Affects Lipopolysaccharide-Induced Changes of Urocortin 2 Gene Expression in the Brain and on the Periphery. Neurochemical research. vol 46. issue 2. 2021-08-09. PMID:33170479. |
in addition, lps administration induced a significant increase in the gene expression of tyrosine hydroxylase (th) and phenylethanolamine n-methyltransferase (pnmt) in the adrenal medulla. |
2021-08-09 |
2023-08-13 |
rat |
| N V Yaglova, E P Timokhina, V V Yaglov, S S Obernikhin, S V Nazimova, D A Tsomartov. Changes in Histophysiology of the Adrenal Medulla in Rats after Prenatal and Postnatal Exposure to Endocrine Disruptor DDT. Bulletin of experimental biology and medicine. vol 169. issue 3. 2021-06-07. PMID:32748142. |
it was found that exposure to ddt during the prenatal and postnatal ontogeny decelerated the development of the adrenal medulla and reduced the synthesis of tyrosine hydroxylase, the rate-liming enzyme of catecholamine synthesis, in chromaffin cells, which led to a decrease in epinephrine secretion into the blood. |
2021-06-07 |
2023-08-13 |
rat |
| Maíra Schuchter Ferreira, Sheila Cristina Potente Dutra Luquetti, Poliana Guiomar de Almeida Brasiel, Kacia Mateus, Alice Helena de Souza Paulino, Mayara Medeiros de Freitas Carvalho, Ana Eliza Andreazzi, Aline Silva de Aguia. Maternal soy protein isolate diet during lactation programs deleterious effects on hepatic lipid metabolism, atherogenic indices, and function of adrenal in adult rat offspring. Journal of developmental origins of health and disease. 2021-05-12. PMID:33975670. |
in addition, we found a decrease in catecholamines in the adrenal medulla and an increase in caffeine-stimulated secretion, but tyrosine hydroxylase expression remained constant. |
2021-05-12 |
2023-08-13 |
rat |
| Ramin Ekhteiari Salmas, Serdar Durdagi, Mehmet Fuat Gulhan, Merve Duruyurek, Huda I Abdullah, Zeliha Selamogl. The effects of pollen, propolis, and caffeic acid phenethyl ester on tyrosine hydroxylase activity and total RNA levels in hypertensive rats caused by nitric oxide synthase inhibition: experimental, docking and molecular dynamic studies. Journal of biomolecular structure & dynamics. vol 36. issue 3. 2019-01-09. PMID:28132600. |
the objective of the present study was to evaluate the effects of propolis, pollen, and caffeic acid phenethyl ester (cape) on tyrosine hydroxylase (th) activity and total rna levels of nω-nitro-l-arginine methyl ester (l-name) inhibition of nitric oxide synthase in the heart, adrenal medulla, and hypothalamus of hypertensive male sprague dawley rats. |
2019-01-09 |
2023-08-13 |
rat |
| Lin Kooi Ong, Scott Page, Gabrielle D Briggs, Liying Guan, Matthew D Dun, Nicole M Verrills, Peter R Dunkley, Phillip W Dickso. Peripheral Lipopolysaccharide Challenge Induces Long-Term Changes in Tyrosine Hydroxylase Regulation in the Adrenal Medulla. Journal of cellular biochemistry. vol 118. issue 8. 2017-11-02. PMID:27958651. |
peripheral lipopolysaccharide challenge induces long-term changes in tyrosine hydroxylase regulation in the adrenal medulla. |
2017-11-02 |
2023-08-13 |
Not clear |
| Lin Kooi Ong, Scott Page, Gabrielle D Briggs, Liying Guan, Matthew D Dun, Nicole M Verrills, Peter R Dunkley, Phillip W Dickso. Peripheral Lipopolysaccharide Challenge Induces Long-Term Changes in Tyrosine Hydroxylase Regulation in the Adrenal Medulla. Journal of cellular biochemistry. vol 118. issue 8. 2017-11-02. PMID:27958651. |
the effect of immune activation by lipopolysaccharide (lps) on the regulation of tyrosine hydroxylase (th) in the adrenal medulla in vivo was determined between 1 day and 6 months after lps injection. |
2017-11-02 |
2023-08-13 |
Not clear |
| Alexandra E Soto-Piña, Cynthia Franklin, C S Sheela Rani, Helmut Gottlieb, Carmen Hinojosa-Laborde, Randy Stron. A Novel Model of Dexamethasone-Induced Hypertension: Use in Investigating the Role of Tyrosine Hydroxylase. The Journal of pharmacology and experimental therapeutics. vol 358. issue 3. 2017-05-26. PMID:27405316. |
to evaluate the involvement of tyrosine hydroxylase (th), the rate-limiting step in catecholamine biosynthesis, we treated rats with the th inhibitor, α-methyl-para-tyrosine (α-mpt), for 3 days prior to administration of dex and assessed th mrna and protein expression by quantitative real-time polymerase chain reaction and western blot in the adrenal medulla. |
2017-05-26 |
2023-08-13 |
human |
| A Vavřínová, M Behuliak, J Zich. The importance of the selection of appropriate reference genes for gene expression profiling in adrenal medulla or sympathetic ganglia of spontaneously hypertensive rat. Physiological research. vol 65. issue 3. 2017-03-30. PMID:27070752. |
for example, tyrosine hydroxylase (th) gene was underexpressed in adrenal medulla of adult shr using the appropriate reference gene but unchanged after the standardization to the least stable reference gene. |
2017-03-30 |
2023-08-13 |
rat |
| Wing Hei Chan, David G Gonsalvez, Heather M Young, E Michelle Southard-Smith, Kylie N Cane, Colin R Anderso. Differences in CART expression and cell cycle behavior discriminate sympathetic neuroblast from chromaffin cell lineages in mouse sympathoadrenal cells. Developmental neurobiology. vol 76. issue 2. 2016-09-29. PMID:25989220. |
the noradrenergic marker, tyrosine hydroxylase (th), was detected in both presumptive adrenal medulla and sympathetic ganglion cells, but with significantly stronger immunostaining in the former. |
2016-09-29 |
2023-08-13 |
mouse |
| Natasa Spasojevic, Predrag Jovanovic, Sladjana Dronja. Differential regulation of catecholamine synthesis and transport in rat adrenal medulla by fluoxetine treatment. Anais da Academia Brasileira de Ciencias. vol 87. issue 1. 2016-01-19. PMID:25651155. |
in the present study the effects of chronic fluoxetine treatment on tyrosine hydroxylase, a rate-limiting enzyme in catecholamine synthesis, as well as a norepinephrine transporter and vesicular monoamine transporter 2 gene expressions in adrenal medulla of animals exposed to chronic unpredictable mild stress (cums) for 4 weeks, were investigated. |
2016-01-19 |
2023-08-13 |
rat |
| Necla Kudrick, Owen Chan, Edmund F La Gamma, Juhye Lena Kim, Arnold William Tank, Carol Sterling, Bistra B Nankov. Posttranscriptional regulation of adrenal TH gene expression contributes to the maladaptive responses triggered by insulin-induced recurrent hypoglycemia. Physiological reports. vol 3. issue 2. 2015-02-25. PMID:25713330. |
acute metabolic stress such as insulin-induced hypoglycemia triggers a counterregulatory response during which the release of catecholamines (epinephrine), the activation of tyrosine hydroxylase (th) enzyme and subsequent compensatory catecholamine biosynthesis occur in the adrenal medulla. |
2015-02-25 |
2023-08-13 |
rat |
| P Jovanovic, N Spasojevic, B Stefanovic, N Bozovic, N Jasnic, J Djordjevic, S Dronja. Peripheral oxytocin treatment affects the rat adreno-medullary catecholamine content modulating expression of vesicular monoamine transporter 2. Peptides. vol 51. 2014-09-02. PMID:24239562. |
in order to assess the effect of peripheral oxytocin treatment on adreno-medullary catecholamine we measured epinephrine and norepinephrine content and gene expression of tyrosine hydroxylase (th), norepinephrine transporter (net) and vesicular monoamine transporter 2 (vmat2) in the adrenal medulla. |
2014-09-02 |
2023-08-12 |
rat |
| Han Zhang, Nobuyuki Yanagihara, Yumiko Toyohira, Keita Takahashi, Hirohide Inagaki, Noriaki Satoh, Xiaoja Li, Xiumei Goa, Masato Tsutsui, Kojiro Takahaish. Stimulatory effect of nobiletin, a citrus polymethoxy flavone, on catecholamine synthesis through Ser19 and Ser40 phosphorylation of tyrosine hydroxylase in cultured bovine adrenal medullary cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 1. 2014-08-25. PMID:24043291. |
the present findings suggest that nobiletin, by itself, stimulates catecholamine synthesis through tyrosine hydroxylase phosphorylation at ser(19) and ser(40), whereas it inhibits catecholamine synthesis induced by acetylcholine in bovine adrenal medulla. |
2014-08-25 |
2023-08-12 |
cattle |
| T A Slotkin, W L Whitmore, L Lerea, R J Slepetis, S J Weigel, P A Trepanier, F J Seidle. Role of ornithine decarboxylase and the polyamines in nervous system development: Short-term postnatal administration of α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 1. issue 1. 2014-06-02. PMID:24875600. |
development of the adrenal medulla, a peripheral catecholaminergic tissue which displays approximately the same developmental profile as do sympathetic neurons but which does not develop axonal projections, was not slowed by dfmo treatment; similarly, central noradrenergic and dopaminergic neurons, which undergo the majority of axonal outgrowth and synaptogenesis during the second to third postnatal week (just after the period in which polyamines returned to control levels), developed normally as assessed by measurements of transmitter levels, tyrosine hydroxylase activity and synaptosomal uptake of [(3)h]norepinephrine or [(3)h]dopamine. |
2014-06-02 |
2023-08-13 |
rat |
| Lin Kooi Ong, Liying Guan, Hanafi Damanhuri, Ann K Goodchild, Larisa Bobrovskaya, Phillip W Dickson, Peter R Dunkle. Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla. Journal of neurochemistry. vol 128. issue 4. 2014-04-08. PMID:24117713. |
neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla. |
2014-04-08 |
2023-08-12 |
rat |
| Ljubica Gavrilović, Vesna Stojiljković, Jelena Kasapović, Nataša Popović, Snežana B Pajović, Sladjana Dronja. Treadmill exercise does not change gene expression of adrenal catecholamine biosynthetic enzymes in chronically stressed rats. Anais da Academia Brasileira de Ciencias. vol 85. issue 3. 2014-01-27. PMID:23903565. |
this study aimed to investigate physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase, dopamine-ß-hydroxylase and phenylethanolamine n-methyltransferase) and cyclic adenosine monophosphate response element-binding (creb) in the adrenal medulla, concentrations of catecholamines and corticosterone (cort) in the plasma and the weight of adrenal glands of chronically psychosocially stressed adult rats exposed daily to 20 min treadmill running for 12 weeks. |
2014-01-27 |
2023-08-12 |
rat |
| S Qiu, Y Du, L Wang, C H. Chromaffin cells of the adrenal gland in the beagle dog. Anatomia, histologia, embryologia. vol 42. issue 2. 2013-12-10. PMID:22762393. |
the presence of chromaffin cells in the adrenal medulla, three zones of the adrenal cortex and capsule was identified by staining with h&e, chromium salts and th (tyrosine hydroxylase) antibody. |
2013-12-10 |
2023-08-12 |
dog |