| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meghan Van Zandt, Deirdre Flanagan, Christopher Pittenge. Sex differences in the distribution and density of regulatory interneurons in the striatum. Frontiers in cellular neuroscience. vol 18. 2024-07-24. PMID:39045533. |
regulatory interneurons, such as cholinergic interneurons (cins) and parvalbumin-expressing gabaergic fast spiking interneurons (fsis), are implicated in human neuropsychiatric disorders such as ts, and ablation of these interneurons produces relevant behavioral pathology in male mice, but not in females. |
2024-07-24 |
2024-07-26 |
mouse |
| Meghan Van Zandt, Deirdre Flanagan, Christopher Pittenge. Sexual dimorphism in the distribution and density of regulatory interneurons in the striatum. bioRxiv : the preprint server for biology. 2024-03-11. PMID:38464268. |
regulatory interneurons, including cholinergic interneurons (cins) and parvalbumin-expressing gabaergic fast spiking interneurons (fsis), are implicated in human neuropsychiatric disorders such as ts, and ablation of these interneurons produces relevant behavioral pathology in male mice, but not in females. |
2024-03-11 |
2024-03-14 |
mouse |
| Melanie V Brady, Jessica Mariani, Yildiz Koca, Anna Szekely, Robert A King, Michael H Bloch, Angeli Landeros-Weisenberger, James F Leckman, Flora M Vaccarin. Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids. Molecular psychiatry. 2022-11-29. PMID:36447010. |
bg organoids from ts individuals manifested an impaired medial ganglionic eminence fate and a decreased differentiation of cholinergic and gabaergic interneurons. |
2022-11-29 |
2023-08-14 |
Not clear |
| Shigeru Ogata, Yuta Miyamoto, Naoki Shigematsu, Shigeyuki Esumi, Takaichi Fukud. The tail of the mouse striatum contains a novel large type of GABAergic neuron incorporated in a unique disinhibitory pathway that relays auditory signals to subcortical nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-09-14. PMID:36104279. |
we demonstrate in this paper that the ts of the male mouse contains gabaergic neurons of a novel type that were detected immunohistochemically with the neurofilament marker smi-32. |
2022-09-14 |
2023-08-14 |
mouse |
| Hilmar P Sigurdsson, Stephen R Jackson, Soyoung Kim, Katherine Dyke, Georgina M Jackso. A feasibility study for somatomotor cortical mapping in Tourette syndrome using neuronavigated transcranial magnetic stimulation. Cortex; a journal devoted to the study of the nervous system and behavior. vol 129. 2021-06-21. PMID:32474291. |
ts has been linked to a heightened sensitivity to somatic stimulation and altered processing of somatosensory information, and there is evidence to indicate that alterations in gabaergic function is likely to contribute to altered somatomotor function. |
2021-06-21 |
2023-08-13 |
Not clear |
| Joseph O'Neill, John C Piacentini, Bradley S Peterso. Cingulate role in Tourette syndrome. Handbook of clinical neurology. vol 166. 2020-04-13. PMID:31731911. |
loss of cortex may reflect excitotoxicity secondary to insufficient local gabaergic inhibition, a notion supported by the few relevant mrs and pet studies conducted to date, recommending continued development of gabaergic and glutamatergic pharmacologic agents to treat ts. |
2020-04-13 |
2023-08-13 |
monkey |
| Joseph O'Neill, John C Piacentini, Bradley S Peterso. Cingulate role in Tourette syndrome. Handbook of clinical neurology. vol 166. 2020-04-13. PMID:31731911. |
ts research using dti, mrs, and pet will no doubt continue to benefit in coming years from technological advances such as ultrahigh-field scanners, multichannel head coils, and novel (including gabaergic and glutamatergic) ligands. |
2020-04-13 |
2023-08-13 |
monkey |
| Tetsufumi Ito, Yasuro Atoj. Tectothalamic inhibitory projection neurons in the avian torus semicircularis. The Journal of comparative neurology. vol 524. issue 13. 2017-09-13. PMID:26850847. |
the ts contained two types of gabaergic neurons of different soma size. |
2017-09-13 |
2023-08-13 |
chicken |
| Shane B Johnson, Eric B Emmons, Rachel M Anderson, Ryan M Glanz, Sara A Romig-Martin, Nandakumar S Narayanan, Ryan T LaLumiere, Jason J Radle. A Basal Forebrain Site Coordinates the Modulation of Endocrine and Behavioral Stress Responses via Divergent Neural Pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 33. 2017-07-14. PMID:27535914. |
the pvh and ventrolateral periaqueductal gray were recipients of gabaergic outputs from the anteroventral bst that were necessary to restrain stress-induced hpa activation and passive coping behavior, respectively, during ts and forced swim tests. |
2017-07-14 |
2023-08-13 |
rat |
| Nicolaas A J Puts, Ashley D Harris, Deana Crocetti, Carrie Nettles, Harvey S Singer, Mark Tommerdahl, Richard A E Edden, Stewart H Mostofsk. Reduced GABAergic inhibition and abnormal sensory symptoms in children with Tourette syndrome. Journal of neurophysiology. vol 114. issue 2. 2016-04-25. PMID:26041822. |
our results show reduced primary sensorimotor cortex (sm1) gaba concentration in children with ts compared with healthy control subjects (hc), as well as patterns of impaired performance on tactile detection and adaptation tasks, consistent with altered gabaergic function. |
2016-04-25 |
2023-08-13 |
human |
| Nicolaas A J Puts, Ashley D Harris, Deana Crocetti, Carrie Nettles, Harvey S Singer, Mark Tommerdahl, Richard A E Edden, Stewart H Mostofsk. Reduced GABAergic inhibition and abnormal sensory symptoms in children with Tourette syndrome. Journal of neurophysiology. vol 114. issue 2. 2016-04-25. PMID:26041822. |
furthermore, there are multiple lines of evidence suggesting that a deficit in gabaergic transmission may contribute to symptoms found in ts. |
2016-04-25 |
2023-08-13 |
human |
| b' Susana Garc\\xc3\\xada-Cerro, Paula Mart\\xc3\\xadnez, Ver\\xc3\\xb3nica Vidal, Andrea Corrales, Jes\\xc3\\xbas Fl\\xc3\\xb3rez, Rebeca Vidal, Noem\\xc3\\xad Rueda, Mar\\xc3\\xada L Arbon\\xc3\\xa9s, Carmen Mart\\xc3\\xadnez-Cu\\xc3\\xa. Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome. PloS one. vol 9. issue 9. 2015-05-15. PMID:25188425.' |
concomitant with these functional improvements, normalization of the dyrk1a expression level in ts mice restored the proliferation and differentiation of hippocampal cells in the adult dentate gyrus (dg) and the density of gabaergic and glutamatergic synapse markers in the molecular layer of the hippocampus. |
2015-05-15 |
2023-08-13 |
mouse |
| Maya Bronfeld, Michal Israelashvili, Izhar Bar-Ga. Pharmacological animal models of Tourette syndrome. Neuroscience and biobehavioral reviews. vol 37. issue 6. 2014-01-10. PMID:23089155. |
animal models support the notion of cbg dysfunction as the neural mechanism underlying ts, and suggest that it may be derived from either direct deficits of local striatal gabaergic networks or a dysfunction of the neuromodulator systems controlling them. |
2014-01-10 |
2023-08-12 |
Not clear |
| Maya Bronfeld, Dorin Yael, Katya Belelovsky, Izhar Bar-Ga. Motor tics evoked by striatal disinhibition in the rat. Frontiers in systems neuroscience. vol 7. 2013-09-25. PMID:24065893. |
disruption of local striatal gabaergic connectivity has been associated with ts and was found to induce abnormal movements in model animals. |
2013-09-25 |
2023-08-12 |
rat |
| Carmen Martínez-Cué, Paula Martínez, Noemí Rueda, Rebeca Vidal, Susana García, Verónica Vidal, Andrea Corrales, Juan A Montero, Ángel Pazos, Jesús Flórez, Rodolfo Gasser, Andrew W Thomas, Michael Honer, Frédéric Knoflach, Jose Luis Trejo, Joseph G Wettstein, Maria-Clemencia Hernánde. Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 9. 2013-04-22. PMID:23447605. |
these data demonstrate that reducing gabaergic inhibition with ro4938581 can reverse functional and neuromorphological deficits of ts mice by facilitating brain plasticity and support the potential therapeutic use of selective gaba(a) α5 nams to treat cognitive dysfunction in ds. |
2013-04-22 |
2023-08-12 |
mouse |
| Carmen Martínez-Cué, Paula Martínez, Noemí Rueda, Rebeca Vidal, Susana García, Verónica Vidal, Andrea Corrales, Juan A Montero, Ángel Pazos, Jesús Flórez, Rodolfo Gasser, Andrew W Thomas, Michael Honer, Frédéric Knoflach, Jose Luis Trejo, Joseph G Wettstein, Maria-Clemencia Hernánde. Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 9. 2013-04-22. PMID:23447605. |
we also show that ro4938581 normalized the high density of gabaergic synapse markers in the molecular layer of the hippocampus of ts mice. |
2013-04-22 |
2023-08-12 |
mouse |
| b' V Vidal, S Garc\\xc3\\xada, P Mart\\xc3\\xadnez, A Corrales, J Fl\\xc3\\xb3rez, N Rueda, A Sharma, C Mart\\xc3\\xadnez-Cu\\xc3\\xa. Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome. Neuroscience. vol 220. 2012-12-14. PMID:22728103.' |
altered gabaergic transmission appears to contribute to the mechanisms responsible for the cognitive impairments in ts mice. |
2012-12-14 |
2023-08-12 |
mouse |
| Panagiotis Oulis, Evangelos Karapoulios, Vasilios G Masdrakis, Anastasios V Kouzoupis, Nikolaos A Karakatsanis, Charalambos Papageorgiou, George N Papadimitriou, Constantin R Soldato. Levetiracetam in the treatment of antipsychotics-resistant Tourette syndrome. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 9. issue 1. 2008-07-02. PMID:17853302. |
levetiracetam, an anti-epileptic agent that enhances gabaergic neurotransmission, is one of the newest alternative treatments of tourette syndrome (ts). |
2008-07-02 |
2023-08-12 |
Not clear |
| Mark L Dallas, Lucy Atkinson, Carol J Milligan, Neil P Morris, David I Lewis, Susan A Deuchars, Jim Deuchar. Localization and function of the Kv3.1b subunit in the rat medulla oblongata: focus on the nucleus tractus solitarii. The Journal of physiology. vol 562. issue Pt 3. 2005-05-26. PMID:15528247. |
in the nucleus of the solitary tract (nts), kv3.1b-ir neurones were predominantly located close to the tractus solitarius (ts) and could be gabaergic or glutamatergic. |
2005-05-26 |
2023-08-12 |
rat |
| Monsheel S K Sodhi, Elaine Sanders-Bus. Serotonin and brain development. International review of neurobiology. vol 59. 2004-05-10. PMID:15006487. |
the serotonergic system interacts with brain-derived neurotrophic factor (bdnf), s100beta, and other chemical messengers, in addition to ts cross talk with the gabaergic, glutamatergic, and dopaminergic neurotransmitter systems. |
2004-05-10 |
2023-08-12 |
Not clear |