| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanhui Chen, Zhongling Ke, Ying Ouyang, Ying Han, Dong Liang, Xueping Gao, Jie He, Yasong D. Clonidine Patch for Tourette Syndrome With Attention-Deficit/Hyperactivity Disorder. Psychiatry investigation. vol 21. issue 4. 2024-05-02. PMID:38695046. |
to explore the efficacy and safety of clonidine adhesive patch in tourette syndrome (ts) patients with comorbid attentiondeficit/hyperactivity disorder (adhd). |
2024-05-02 |
2024-05-04 |
Not clear |
| Shih-Fen Chen, Yuan-Chih Su, Ling-Yi Wang, Chung-Y Hsu, Yu-Chih She. Tourette's syndrome is associated with an increased risk of traumatic brain injury: A nationwide population-based cohort study. Parkinsonism & related disorders. vol 63. 2020-05-08. PMID:30833232. |
the study aimed to determine the risk of tbi in ts patients, the effects associated with concurrent psychiatric disorders (attention-deficit/hyperactivity disorder (adhd), obsessive-compulsive disorder (ocd), or depressive disorder), and the effects of medication treatment (antipsychotics, antidepressants, or clonidine) on the risk of tbi. |
2020-05-08 |
2023-08-13 |
Not clear |
| Julio Quezada, Keith A Coffma. Current Approaches and New Developments in the Pharmacological Management of Tourette Syndrome. CNS drugs. vol 32. issue 1. 2019-02-28. PMID:29335879. |
there are agents in a variety of other pharmacologic categories that have evidence for the treatment of ts and whose side-effect profiles are more tolerable than the antipsychotics; these include clonidine, guanfacine, baclofen, topiramate, botulinum toxin a, tetrabenazine, and deutetrabenazine. |
2019-02-28 |
2023-08-13 |
Not clear |
| Eric J Nordstrom, Katie C Bittner, Michael J McGrath, Clinton R Parks, Frank H Burto. "Hyperglutamatergic cortico-striato-thalamo-cortical circuit" breaker drugs alleviate tics in a transgenic circuit model of Tourette׳s syndrome. Brain research. vol 1629. 2016-09-22. PMID:26453289. |
as in ts, these d1ct-7 ("ticcy") transgenic mice׳s tics were alleviated by the ts drugs clonidine and dopamine d2 receptor antagonists; and their chronic glutamate-excited striatal motor output was unbalanced toward hyperactivity of the motoric direct pathway and inactivity of the cataleptic indirect pathway. |
2016-09-22 |
2023-08-13 |
mouse |
| Fuyong Jiao, Xiaoyan Zhang, Xipin Zhang, Jing Wan. Clinical observation on treatment of Tourette syndrome in Chinese children by clonidine adhesive patch. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. vol 20. issue 1. 2016-07-29. PMID:26602699. |
to evaluate the therapeutic effectiveness and safety of clonidine adhesive patch in treating tourette syndrome (ts). |
2016-07-29 |
2023-08-13 |
Not clear |
| Jack Hawksley, Andrea E Cavanna, Yoko Naga. The role of the autonomic nervous system in Tourette Syndrome. Frontiers in neuroscience. vol 9. 2015-06-15. PMID:26074752. |
pharmacological treatments which act on sympathetic tone are often helpful: for example, clonidine (an alpha-2 adrenoreceptor agonist) is often used as first choice medication for treating ts in children due to its good tolerability profile and potential usefulness for co-morbid attention-deficit and hyperactivity disorder. |
2015-06-15 |
2023-08-13 |
Not clear |
| Veit Roessner, Katja Schoenefeld, Judith Buse, Stephan Bender, Stefan Ehrlich, Alexander Müncha. Pharmacological treatment of tic disorders and Tourette Syndrome. Neuropharmacology. vol 68. 2013-09-09. PMID:22728760. |
in ts patients with comorbid attention deficit hyperactivity disorder (adhd) atomoxetine, stimulants or clonidine should be considered, or, if tics are severe, a combination of stimulants and risperidone. |
2013-09-09 |
2023-08-12 |
Not clear |
| Andrea Eugenio Cavanna, Claudia Selvini, Cristiano Termine, Umberto Balottin, Clare M Edd. Tolerability profile of clonidine in the treatment of adults with Tourette syndrome. Clinical neuropharmacology. vol 35. issue 6. 2013-08-26. PMID:23123691. |
clonidine, an alpha-2 adrenergic agonist, has been used to treat tourette syndrome (ts) for nearly 3 decades. |
2013-08-26 |
2023-08-12 |
Not clear |
| Andrea Eugenio Cavanna, Claudia Selvini, Cristiano Termine, Umberto Balottin, Clare M Edd. Tolerability profile of clonidine in the treatment of adults with Tourette syndrome. Clinical neuropharmacology. vol 35. issue 6. 2013-08-26. PMID:23123691. |
although clonidine is thought to have a low rate of adverse effects (aes), little is known about its tolerability profile in adult patients with ts. |
2013-08-26 |
2023-08-12 |
Not clear |
| Hua Kang, Yue-Fang Zhang, Fu-Yong Jiao, Xiang-Yang Guo, Xiao-Min Ga. [Efficacy of clonidine transdermal patch for treatment of Tourette's syndrome in children]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 11. issue 7. 2009-10-06. PMID:19650984. |
this study explored the efficacy and safety of clonidine transdermal patch for treating ts in children. |
2009-10-06 |
2023-08-12 |
Not clear |
| Panagiotis Oulis, Evangelos Karapoulios, Vasilios G Masdrakis, Anastasios V Kouzoupis, Nikolaos A Karakatsanis, Charalambos Papageorgiou, George N Papadimitriou, Constantin R Soldato. Levetiracetam in the treatment of antipsychotics-resistant Tourette syndrome. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 9. issue 1. 2008-07-02. PMID:17853302. |
we present the case of a 23-year-old female patient suffering from ts since the age of 7, who exhibited poor response to a variety of agents (haloperidol, pimozide, clonidine and various adjunctive agents) and had four hospitalizations during the previous 2 years due to the deterioration of her clinical state. |
2008-07-02 |
2023-08-12 |
Not clear |
| Neal R Swerdlow, Michele J Bongiovanni, Laura Tochen, Jody M Shoemake. Separable noradrenergic and dopaminergic regulation of prepulse inhibition in rats: implications for predictive validity and Tourette Syndrome. Psychopharmacology. vol 186. issue 2. 2006-10-20. PMID:16583235. |
the hypothesis that ppi may be regulated by norepinephrine, or by interactions between dopamine and norepinephrine substrates, was tested in a series of experiments with the alpha-2 agonist, clonidine, which is used clinically to treat tourette syndrome (ts). |
2006-10-20 |
2023-08-12 |
rat |
| Roseli Gedanke Shavitt, Ana Gabriela Hounie, Maria Conceição Rosário Campos, Eurípedes C Migue. Tourette's Syndrome. The Psychiatric clinics of North America. vol 29. issue 2. 2006-07-12. PMID:16650718. |
alfa-adrenergic agents such as guanfacine and clonidine are first-choice treatments for ts; typical antipsychotics are more effective but are troublesome because of their long-term side-effect profiles. |
2006-07-12 |
2023-08-12 |
Not clear |
| Gary R Gaffney, Paul J Perry, Brian C Lund, Kristine A Bever-Stille, Stephan Arndt, Samuel Kuperma. Risperidone versus clonidine in the treatment of children and adolescents with Tourette's syndrome. Journal of the American Academy of Child and Adolescent Psychiatry. vol 41. issue 3. 2002-05-07. PMID:11886028. |
to evaluate the efficacy and tolerability of risperidone in comparison with clonidine in the treatment of children and adolescents with tourette's syndrome (ts). |
2002-05-07 |
2023-08-12 |
Not clear |
| . Treatment of ADHD in children with tics: a randomized controlled trial. Neurology. vol 58. issue 4. 2002-04-15. PMID:11865128. |
the treatment of children with attention deficit hyperactivity disorder (adhd) and tourette syndrome (ts) has been problematic because methylphenidate (mph)--the most commonly used drug to treat adhd--has been reported to worsen tics and because clonidine (clon)--the most commonly prescribed alternative--has unproven efficacy. |
2002-04-15 |
2023-08-12 |
Not clear |
| G Stöber, J Hebebrand, S Cichon, M Brüss, H Bönisch, G Lehmkuhl, F Poustka, M Schmidt, H Remschmidt, P Propping, M M Nöthe. Tourette syndrome and the norepinephrine transporter gene: results of a systematic mutation screening. American journal of medical genetics. vol 88. issue 2. 1999-06-28. PMID:10206236. |
involvement of central norepinephrine mechanisms is suggested by central norepinephrinic hyperactivity in patients with ts and by the therapeutic effects of the presynaptic alpha2-adrenergic agonist clonidine. |
1999-06-28 |
2023-08-12 |
Not clear |
| M S Hedrick, M R Dwinell, P L Janssen, J Pizarro, G E Bisgar. Differential respiratory muscle recruitment induced by clonidine in awake goats. Journal of applied physiology (Bethesda, Md. : 1985). vol 84. issue 4. 1998-05-05. PMID:9516185. |
during dysrhythmic breathing episodes induced by clonidine, ts and abd activities were attenuated or abolished, whereas diaphragm and parasternal intercostal activities were unchanged. |
1998-05-05 |
2023-08-12 |
Not clear |
| D J Bennett, S J De Serres, R B Stei. Gain of the triceps surae stretch reflex in decerebrate and spinal cats during postural and locomotor activities. The Journal of physiology. vol 496 ( Pt 3). 1997-03-10. PMID:8930848. |
the triceps surae (ts) stretch reflex was measured in decerebrate cats during crossed extensor stimulation and after spinalization during rhythmic locomotor activity induced by clonidine and manual perineal stimulation. |
1997-03-10 |
2023-08-12 |
cat |
| H S Singer, J Brown, S Quaskey, L A Rosenberg, E D Mellits, M B Denckl. The treatment of attention-deficit hyperactivity disorder in Tourette's syndrome: a double-blind placebo-controlled study with clonidine and desipramine. Pediatrics. vol 95. issue 1. 1995-06-30. PMID:7770313. |
because psychostimulants can exacerbate preexisting motor/phonic tics in individuals with tourette's syndrome (ts), a clinical trial was performed to examine the ability of clonidine and desipramine to modify attention-deficit hyperactivity disorder (adhd) behaviors in children with ts + adhd. |
1995-06-30 |
2023-08-12 |
Not clear |
| J F Leckman, D J Cohe. Recent advances in Gilles de la Tourette syndrome: implications for clinical practice and future research. Psychiatric developments. vol 1. issue 3. 1984-05-11. PMID:6324164. |
the most robust metabolic findings are the lowered csf hva in many ts patients, and the positive response of symptoms to dopamine blockers and clonidine particularly, which would be consistent with dopamine receptor hypersensitivity and possible noradrenergic-dopaminergic interactions in ts. |
1984-05-11 |
2023-08-12 |
Not clear |