| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dianxia Xing, Wenjin Zhang, Yan Liu, Hong Huang, Junjie Xi. Genes related to microglia polarization and immune infiltration in Alzheimer's Disease. Mammalian genome : official journal of the International Mammalian Genome Society. 2024-10-10. PMID:39390284. |
using gene expression omnibus (geo) datasets gse110226 (choroid plexus) and gse1297 (hippocampal ca1), we identified key genes-edn1, hhla2, kl, trem2, and wwtr1-associated with ad mechanisms and immune responses. |
2024-10-10 |
2024-10-13 |
Not clear |
| Li Deng, Shao-Yong Song, Wei-Ming Zhao, Xiao-Wen Meng, Hong Liu, Qing Zheng, Ke Peng, Fu-Hai J. Triggering Receptor Expressed on Myeloid Cells 2 Alleviated Sevoflurane-Induced Developmental Neurotoxicity via Microglial Pruning of Dendritic Spines in the CA1 Region of the Hippocampus. Neuroscience bulletin. 2024-07-30. PMID:39078595. |
trem2 exerts a protective role against neurocognitive impairments in mice after neonatal exposures to sevoflurane by enhancing microglia-mediated pruning of dendritic spines in ca1 neurons. |
2024-07-30 |
2024-08-02 |
mouse |
| Li Deng, Shao-Yong Song, Wei-Ming Zhao, Xiao-Wen Meng, Hong Liu, Qing Zheng, Ke Peng, Fu-Hai J. Triggering Receptor Expressed on Myeloid Cells 2 Alleviated Sevoflurane-Induced Developmental Neurotoxicity via Microglial Pruning of Dendritic Spines in the CA1 Region of the Hippocampus. Neuroscience bulletin. 2024-07-30. PMID:39078595. |
sevoflurane exposures upregulated the protein expression of trem2, increased microglia-mediated pruning of dendritic spines, and reduced synaptic multiplicity and excitability of ca1 neurons. |
2024-07-30 |
2024-08-02 |
mouse |
| Min Wu, Maolin Liao, Rongfeng Huang, Chunxiu Chen, Tian Tian, Hongying Wang, Jiayu Li, Jibin Li, Yuxiang Sun, Chaodong Wu, Qifu Li, Xiaoqiu Xia. Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia. Genes & diseases. vol 9. issue 2. 2022-02-28. PMID:35224156. |
dendritic complexity and spine density in the ca1 region were rescued after trem2 overexpression. |
2022-02-28 |
2023-08-13 |
mouse |
| Mei-Dan Wei, Yan-Xian Lan, Kun Lu, Yan Wang, Wen-Ying Che. Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in elderly male mice. Behavioural brain research. vol 397. 2021-11-15. PMID:32991925. |
in this study, we injected trem2 shrna into the hippocampal ca1 region to specifically knock down the expression of this protein in astrocytes. |
2021-11-15 |
2023-08-13 |
mouse |
| Mei-Dan Wei, Yan-Xian Lan, Kun Lu, Yan Wang, Wen-Ying Che. Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in elderly male mice. Behavioural brain research. vol 397. 2021-11-15. PMID:32991925. |
knocking down astrocytic trem2 can also rescue impaired long-term potentiation (ltp) induction in the hippocampal ca1 of elderly mice through a presynaptic mechanism. |
2021-11-15 |
2023-08-13 |
mouse |
| Yuhai Zhao, Surjyadipta Bhattacharjee, Brandon M Jones, Prerna Dua, Peter N Alexandrov, James M Hill, Walter J Luki. Regulation of TREM2 expression by an NF-кB-sensitive miRNA-34a. Neuroreport. vol 24. issue 6. 2013-09-17. PMID:23462268. |
in this study, we provide evidence that trem2 is downregulated in samples of sporadic alzheimer hippocampal ca1 compared with age-matched controls. |
2013-09-17 |
2023-08-12 |
human |