| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Yu, Yujie Zhang, Hao Yao, Ziping Zhang, Xiao Yang, Wei Zhu, Jie X. ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway. Ecotoxicology and environmental safety. vol 280. 2024-06-08. PMID:38850708. |
both in vivo and in vitro, np group showed a decrease in the expression levels of erβ, tryptophan hydroxylase (tph1), and tryptophan hydroxylase-2 (tph2) genes and proteins, and reduced levels of da, ne, and 5-hydroxytryptophan (5-ht) neurotransmitters. |
2024-06-08 |
2024-06-11 |
rat |
| Jie Yu, Yujie Zhang, Hao Yao, Ziping Zhang, Xiao Yang, Wei Zhu, Jie X. ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway. Ecotoxicology and environmental safety. vol 280. 2024-06-08. PMID:38850708. |
the expression levels of erβ, tph1, tph2, 5-ht and 5-hitt proteins were decreased in the np group, suggesting np-induced depression-like behaviours as well as disturbances in the secretion of serum hormones and monoamine neurotransmitters. |
2024-06-08 |
2024-06-11 |
rat |
| Gabriela Souza Rodrigues Queiroz, Juliana Carron, Ligia Traldi Macedo, Carmen Silvia Passos Lima, Gustavo Jacob Lourenç. Influence of variants in serotonin modulating genes on the risk, aggressiveness, and prognosis of oropharynx cancer. Head & neck. 2023-05-09. PMID:37158249. |
single-nucleotide variations (snvs) in tph1 rs623580 (t>a), tph2 rs4570625 (g>t), and htr1d rs674386 (g>a) may affect 5-ht levels. |
2023-05-09 |
2023-08-14 |
Not clear |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
[alterations in the level of mrna of tph1, tph2 genes, tryptophan hydroxylase activity and serotonin metabolism in mouse brain five days after lipopolysaccharide administration]. |
2023-03-31 |
2023-08-14 |
mouse |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
tryptophan hydroxylases 1 and 2 (tph1 and tph2) play a key role in the synthesis of serotonin (5-ht), a hormone and neurotransmitter, in the peripheral organs and brain, respectively. |
2023-03-31 |
2023-08-14 |
mouse |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
in the frontal cortex, hippocampus, striatum, hypothalamus, and midbrain the concentrations of 5-ht and its main metabolite, 5-hydroxyindole acetic acid (5-hiaa), and tph activity were assayed using hplc, while tph1 and tph2 mrna were quantified using quantitative real-time rt-pcr. |
2023-03-31 |
2023-08-14 |
mouse |
| Sergey A Sinenko, Andrey A Kuzmin, Elena V Skvortsova, Sergey V Ponomartsev, Evgeniya V Efimova, Michael Bader, Natalia Alenina, Alexey N Tomili. Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses Cell Reprogramming into Pluripotent State. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902295. |
as serotonin is synthesized from tryptophan by the rate limiting enzymes tryptophan hydroxylase-1 and -2 (tph1 and tph2), we have assessed the reprogramming of tph1- and/or tph2-deficient mouse embryonic fibroblasts (mefs) to induced pluripotent stem cells (ipscs). |
2023-03-11 |
2023-08-14 |
mouse |
| Manoj Govindarajulu, Mital Y Patel, Donna M Wilder, Joseph B Long, Peethambaran Aru. Blast Exposure Dysregulates Nighttime Melatonin Synthesis and Signaling in the Pineal Gland: A Potential Mechanism of Blast-Induced Sleep Disruptions. Brain sciences. vol 12. issue 10. 2022-10-27. PMID:36291274. |
blast-exposed rats showed statistically significant decreases in tph1, aanat, asmt, and mtnr1b mrna levels, along with increased tph2 mrna, in the pineal gland samples collected at night at 6 h and 24 h. no significant changes in the mrna levels of these genes were noted at 1 month. |
2022-10-27 |
2023-08-14 |
rat |
| Giulia Sbrini, Sabrina I Hanswijk, Paola Brivio, Anthonieke Middelman, Michael Bader, Fabio Fumagalli, Natalia Alenina, Judith R Homberg, Francesca Calabres. Peripheral Serotonin Deficiency Affects Anxiety-like Behavior and the Molecular Response to an Acute Challenge in Rats. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563331. |
while the tph2 isoform is responsible for the production of serotonin in the brain, tph1 is expressed in peripheral organs. |
2022-05-14 |
2023-08-13 |
rat |
| Kuljeet Kaur, Alexis Redfairn-Ogunyemi, Kehinde Awe, Lanie Gardne. Interactions of TPH2 and TPH1 in Biosynthesis Pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552315. |
additionally, tph1's impact on serotonin synthesis production throughout the body will be discussed with regards to its involvement in neuropsychiatric disorders similar to tph2. |
2022-05-13 |
2023-08-13 |
Not clear |
| Kuljeet Kaur, Alexis Redfairn-Ogunyemi, Kehinde Awe, Lanie Gardne. Interactions of TPH2 and TPH1 in Biosynthesis Pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552315. |
tph1 shows a greater affinity for tryptophan, an amino acid used in the production of serotonin, and has a stronger enzymatic activity than tph2 for a developing brain stem. |
2022-05-13 |
2023-08-13 |
Not clear |
| Jessica Romero-Reyes, Edgar Ricardo Vázquez-Martínez, Daniel Bahena-Alvarez, Jessica López-Jiménez, Anayansi Molina-Hernández, Ignacio Camacho-Arroyo, Néstor Fabián Día. Differential localization of serotoninergic system elements in human amniotic epithelial cells†. Biology of reproduction. vol 105. issue 2. 2021-11-18. PMID:34057176. |
we found the expression of tryptophan hydroxylase type 1 (tph1), type 2 (tph2), serotonin transporter (sert), monoamine oxidase-a (maoa), as well as htr1d and htr7 receptors at mrna level in amnion tissue as well in haec. |
2021-11-18 |
2023-08-13 |
human |
| Lu Xiao, Junyan Yan, Ting Yang, Jiang Zhu, Tingyu Li, Hong Wei, Jie Che. Fecal Microbiome Transplantation from Children with Autism Spectrum Disorder Modulates Tryptophan and Serotonergic Synapse Metabolism and Induces Altered Behaviors in Germ-Free Mice. mSystems. vol 6. issue 2. 2021-10-28. PMID:33824200. |
western blotting detected the protein expression levels of tryptophan hydroxylase 1 (tph1), serotonin transporter (sert), and serotonin 1a receptor (5-ht1ar) in the colon and tph2, sert, and 5-ht1ar in the prefrontal cortex of mice. |
2021-10-28 |
2023-08-13 |
mouse |
| Ming-Fen Ho, Cheng Zhang, Lingxin Zhang, Lixuan Wei, Ying Zhou, Irene Moon, Jennifer R Geske, Doo-Sup Choi, Joanna Biernacka, Mark Frye, Zhexing Wen, Victor M Karpyak, Hu Li, Richard Weinshilbou. TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response. Molecular psychiatry. vol 26. issue 7. 2021-10-15. PMID:32753686. |
ethanol treatment resulted in decreased 5-ht concentrations in human induced pluripotent stem cell (ipsc)-derived neuron culture media, and the downregulation of gene expression of tspan5, ddc, maoa, maob, tph1, and tph2 in those cells. |
2021-10-15 |
2023-08-13 |
human |
| Nibal Betari, Kristoffer Sahlholm, Xavier Morató, Héctor Godoy-Marín, Olga Jáuregui, Knut Teigen, Francisco Ciruela, Jan Haavi. Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole- Frontiers in pharmacology. vol 11. 2020-12-17. PMID:33324221. |
5-ht synthesis is catalyzed by tryptophan hydroxylase (tph) which exists as two distinct isoforms; tph1 and tph2, which are responsible for peripheral and central 5-ht, respectively. |
2020-12-17 |
2023-08-13 |
Not clear |
| Nibal Betari, Kristoffer Sahlholm, Xavier Morató, Héctor Godoy-Marín, Olga Jáuregui, Knut Teigen, Francisco Ciruela, Jan Haavi. Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole- Frontiers in pharmacology. vol 11. 2020-12-17. PMID:33324221. |
the s-enantiomer of omeprazole, esomeprazole, has recently also been described as an inhibitor of monoamine oxidase-a (mao-a), the main enzyme responsible for 5-ht degradation, albeit with lower potency compared to the effect on tph1 and tph2. |
2020-12-17 |
2023-08-13 |
Not clear |
| Michael Bade. Inhibition of serotonin synthesis: A novel therapeutic paradigm. Pharmacology & therapeutics. vol 205. 2020-12-10. PMID:31629717. |
there are two independent serotonin systems in the body characterized by two isoforms of tph, tph1 and tph2. |
2020-12-10 |
2023-08-13 |
mouse |
| Michael Bade. Inhibition of serotonin synthesis: A novel therapeutic paradigm. Pharmacology & therapeutics. vol 205. 2020-12-10. PMID:31629717. |
while tph2 synthesizes serotonin in the brain, tph1 is expressed in the gut and in other peripheral tissues and supplies platelets in the circulation with serotonin. |
2020-12-10 |
2023-08-13 |
mouse |
| Walter J Lukiw, Evgeny I Rogae. Genetics of Aggression in Alzheimer's Disease (AD). Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:28443016. |
these genes encoded on five different chromosomes (chr) include the androgen receptor (ar; chrxq12), brain-derived neurotrophic factor (bdnf; chr11p14.1), catechol-o-methyl transferase (comt; chr22q11.21), neuronal specific nitric oxide synthase (nos1; chr12q24.22), dopamine beta-hydroxylase (dbh chr9q34.2) and tryptophan hydroxylase (tph1, chr11p15.1 and tph2, chr12q21.1). |
2020-10-01 |
2023-08-13 |
human |
| Susann Matthes, Valentina Mosienko, Elena Popova, Marion Rivalan, Michael Bader, Natalia Alenin. Targeted Manipulation of Brain Serotonin: RNAi-Mediated Knockdown of Tryptophan Hydroxylase 2 in Rats. ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:30977636. |
tph1, predominantly expressed in the gastrointestinal tract and pineal gland, mediates 5-ht biosynthesis in non-neuronal tissues, while tph2, mainly found in the raphe nuclei of the brain stem, is accountable for the production of 5-ht in the brain. |
2020-06-11 |
2023-08-13 |
rat |