| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shiela C Samson, Anthony Rojas, Rebecca G Zitnay, Keith R Carney, Wakeiyo Hettinga, Mary C Schaelling, Delphine Sicard, Wei Zhang, Melissa Gilbert-Ross, Grace K Dy, Michael J Cavnar, Muhammad Furqan, Robert F Browning, Abdul R Naqash, Bryan P Schneider, Ahmad Tarhini, Daniel J Tschumperlin, Alessandro Venosa, Adam I Marcus, Lyska L Emerson, Benjamin T Spike, Beatrice S Knudsen, Michelle C Mendoz. Tenascin-C in the early lung cancer tumor microenvironment promotes progression through integrin αvβ1 and FAK. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345541. |
here, we show that expression of the extracellular matrix protein tenascin-c (tnc) is increased in and promotes the earliest stages of luad development in oncogenic kras-driven lung cancer mouse models and in human luad. |
2024-09-30 |
2024-10-02 |
mouse |
| Kazuki Omori, Akinori Takada, Yutaka Toyomasu, Isao Tawara, Chihiro Shintoku, Kyoko Imanaka-Yoshida, Hajime Sakuma, Yoshihito Nomot. Expression of Tenascin-C Is Upregulated in the Early Stages of Radiation Pneumonitis/Fibrosis in a Novel Mouse Model. Current issues in molecular biology. vol 46. issue 9. 2024-09-27. PMID:39329927. |
we recently reported the upregulated expression of tenascin-c (tnc), an inflammation-associated extracellular matrix molecule, in surgically resected lung tissue, and elevated serum levels were elevated in a rild patient. |
2024-09-27 |
2024-09-29 |
mouse |
| Lianqin Sun, Lishan Liu, Juanjuan Jiang, Kang Liu, Jingfeng Zhu, Lin Wu, Xiaohan Lu, Zhimin Huang, Yanggang Yuan, Steven D Crowley, Huijuan Mao, Changying Xing, Jiafa Re. Transcription factor Twist1 drives fibroblast activation to promote kidney fibrosis via signaling proteins Prrx1/TNC. Kidney international. 2024-08-24. PMID:39181396. |
finally, mice with fibroblast-specific deletion of twist1 exhibited less prrx1 and tnc protein abundance, interstitial extracellular matrix deposition and kidney inflammation in both the unilateral ureteral obstruction and ischemic-reperfusion injury-induced kidney fibrotic models. |
2024-08-24 |
2024-08-28 |
mouse |
| Attila Kiss, Gyorgy L Nadasy, Alexander Fees, Zsuzsanna Arnold, Ibrahim Aykac, Christopher Dostal, Gábor T Szabó, Petra Lujza Szabó, Maria Szekeres, Peter Pokreisz, Laszlo Hunyady, Bruno K Podesse. Alterations in Coronary Resistance Artery Network Geometry in Diabetes and the Role of Tenascin C. Reviews in cardiovascular medicine. vol 24. issue 1. 2024-07-31. PMID:39076867. |
alterations in coronary resistance artery network geometry in diabetes and the role of tenascin c. geometrical alterations in the coronary resistance artery network and the potential involvement of tenascin c (tnc) extracellular matrix protein were investigated in diabetic and control mice. |
2024-07-31 |
2024-08-02 |
mouse |
| Ashu Shukla, Vyshak Suresh, Parul Chawla Gupta, Maryada Sharma, Uma Nahar Saikia, Jagat Ram, Manni Luthra-Guptasarm. A single chain variable fragment antibody (Tn 64) cognate to fibronectin type III repeats promotes corneal wound healing by inhibiting fibrosis. International immunopharmacology. vol 133. 2024-04-19. PMID:38640715. |
corneal wound healing requires epithelial reorganization and stromal extracellular matrix (ecm) remodeling, with ecm proteins such as tenascin c (tnc) regulating and maintaining corneal homeostasis. |
2024-04-19 |
2024-04-22 |
human |
| Yuanjun Huang, Miao Sun, Zhenhui Lu, Qiuling Zhong, Manli Tan, Qingjun Wei, Li Zhen. Role of integrin β1 and tenascin C mediate TGF-SMAD2/3 signaling in chondrogenic differentiation of BMSCs induced by type I collagen hydrogel. Regenerative biomaterials. vol 11. 2024-03-25. PMID:38525326. |
further analysis showed genes such as col2a1 and tenascin c (tnc) that interacted with itgb1 were significantly enriched in extracellular matrix (ecm) structural constituents in the chondrogenic induction group. |
2024-03-25 |
2024-03-27 |
Not clear |
| Kristin Glotzbach, Andreas Faissne. Substrate-bound and soluble domains of tenascin-C regulate differentiation, proliferation and migration of neural stem and progenitor cells. Frontiers in cellular neuroscience. vol 18. 2024-03-01. PMID:38425428. |
the extracellular matrix protein tenascin-c (tnc) is a promising candidate to regulate cell fate due to its expression in the developing central nervous system and in the adult neural stem cell niches. |
2024-03-01 |
2024-03-03 |
mouse |
| Nan Gu, Yao Wang, Gengtian Sun, He Zou, Nan Yang, Xin Sun, Zhihui Li. Exploring wound management in dental pulp: Utilizing single-cell RNA sequencing for global transcriptomic analysis in healthy and inflamed pulpal tissues. International wound journal. vol 21. issue 3. 2024-02-22. PMID:38385817. |
in addition, substantial increase inexpression of critical genes including col1a1, fn1, il-1b, il-6 and tnc was detected, indicating that the extracellular matrix (ecm) was actively remodelled and that a robust inflammatory response was present, both of which are vital for tissue repair. |
2024-02-22 |
2024-02-24 |
Not clear |
| Atsuko Yonemura, Takashi Semba, Jun Zhang, Yibo Fan, Noriko Yasuda-Yoshihara, Huaitao Wang, Tomoyuki Uchihara, Tadahito Yasuda, Akiho Nishimura, Lingfeng Fu, Xichen Hu, Feng Wei, Fumimasa Kitamura, Takahiko Akiyama, Kohei Yamashita, Kojiro Eto, Shiro Iwagami, Masaaki Iwatsuki, Yuji Miyamoto, Keisuke Matsusaki, Juntaro Yamasaki, Osamu Nagano, Hideyuki Saya, Shumei Song, Patrick Tan, Hideo Baba, Jaffer A Ajani, Takatsugu Ishimot. Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment. Cell reports. 2024-01-17. PMID:38232734. |
moreover, mesothelial-mesenchymal transition (mmt)-induced mesothelial cells strongly express extracellular matrix (ecm)-related genes, including tenascin-c (tnc), enhancing metastatic colonization. |
2024-01-17 |
2024-01-20 |
Not clear |
| Aya Elgendy, Mohamed El-Shayeb, Yasmine A Hassanein, Hossam M Elkad. Assessment of Tenascin C levels in the serum of patients with bronchial asthma. The Egyptian journal of immunology. vol 31. issue 1. 2024-01-15. PMID:38224032. |
tenascin c (tnc) is an extracellular matrix glycoprotein that promotes inflammatory cell migration from the interstitium to the airways. |
2024-01-15 |
2024-01-17 |
human |
| Yao Wu, Yongping Li, Zixin Hu, Yuan Li, Shixuan Zhang, Xinyue Bao, Yu Zhou, Yuan Gao, Yaping Li, Zhiwen Zhan. Extracellular Matrix-Trapped Bioinspired Lipoprotein Prolongs Tumor Retention to Potentiate Antitumor Immunity. Advanced materials (Deerfield Beach, Fla.). 2024-01-12. PMID:38216153. |
regarding the distinctively upregulated fibronectin (fn1) and tenascin c (tnc) in tumor stroma, we herein design a protease-activated fn1 and/or tnc binding peptide (ftf) and propose an extracellular matrix (ecm)-trapped bioinspired lipoprotein (bl) (ftf-bl-cp) that can be preferentially captured by the tnc and/or fn1 for tumor retention, and then be responsively dissociated from the matrix to potentiate the antitumor immunity. |
2024-01-12 |
2024-01-15 |
Not clear |
| L Ondrejčáková, M Gregová, K Bubová, L Šenolt, K Pavelk. Serum biomarkers and their relationship to axial spondyloarthritis associated with inflammatory bowel diseases. Autoimmunity reviews. 2024-01-03. PMID:38168574. |
additional candidate indicators of structural changes in spa patients include matrix metalloproteinase-3 (mmp-3), vascular endothelial growth factor (vegf), tenascin c (tnc), and cd74 igg. |
2024-01-03 |
2024-01-06 |
Not clear |
| Wujun Chen, Yanhong Wang, Chunling Ren, Sha Yu, Chao Wang, Jiyao Xing, Jiazhen Xu, Saisai Yan, Tingting Zhang, Qian Li, Xiaojin Peng, Yingchun Shao, Renshuai Zhang, Daijun Zhang, Dongming Xin. The role of TNC in atherosclerosis and drug development opportunities. International journal of biological sciences. vol 20. issue 1. 2024-01-02. PMID:38164188. |
tenascin c (tnc), a rich glycoprotein of the extracellular matrix, exhibits a pro-atherosclerosis or anti-atherosclerosis effect depending on its location. |
2024-01-02 |
2024-01-05 |
Not clear |
| Wujun Chen, Yudong Wu, Jie Wang, Wanpeng Yu, Xin Shen, Kai Zhao, Bing Liang, Xiaokun Hu, Shuai Wang, Hongfei Jiang, Xinlin Liu, Miao Zhang, Xiaohui Xing, Chao Wang, Dongming Xin. Clinical advances in TNC delivery vectors and their conjugate agents. Pharmacology & therapeutics. 2023-12-11. PMID:38081519. |
tenascin c (tnc), a glycoprotein that is abundant in the tumor extracellular matrix (ecm), is strongly overexpressed in tumor tissues but virtually undetectable in most normal tissues. |
2023-12-11 |
2023-12-17 |
human |
| Satoru Furuhashi, Yoshifumi Morita, Akio Matsumoto, Shinya Ida, Ryuta Muraki, Ryo Kitajima, Makoto Takeda, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuch. Tenascin C in pancreatic cancer-associated fibroblasts enhances epithelial mesenchymal transition and is associated with resistance to immune checkpoint inhibitor. American journal of cancer research. vol 13. issue 11. 2023-12-07. PMID:38058842. |
tenascin c (tnc) is an extracellular matrix glycoprotein that is highly expressed in cancer stroma and is associated with tumor progression in pancreatic adenocarcinoma (paad). |
2023-12-07 |
2023-12-10 |
Not clear |
| Alissa Domaingo, Philipp Jokesch, Alexandra Schweiger, Martha Gschwandtner, Tanja Gerlza, Manuel Koch, Kim S Midwood, Andreas J Kung. Chemokine Binding to Tenascin-C Influences Chemokine-Induced Immune Cell Migration. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834140. |
tenascin-c (tnc) is a complex glycoprotein of the extracellular matrix (ecm) involved in a plethora of (patho-)physiological processes, such as oncogenesis and inflammation. |
2023-10-14 |
2023-10-15 |
Not clear |
| Xiaoyu Zou, He Zhang, Jamie M Benson, Hanyuan Gao, David L Burris, Joseph M Fox, Xinqiao Ji. Modeling the Maturation of the Vocal Fold Lamina Propria Using a Bioorthogonally Tunable Hydrogel Platform. Advanced healthcare materials. 2023-08-02. PMID:37530909. |
compared to the nlp controls, slp7 conditions upregulated the expression of fibrous matrix proteins (col i, dcn, and fn eda), classic fibroblastic markers (tnc, fap, and fsp1), and matrix remodeling enzymes (mmp2, timp1, and has3). |
2023-08-02 |
2023-08-14 |
Not clear |
| Linnaeus Bundalian, Yin-Yuan Su, Siwei Chen, Akhil Velluva, Anna Sophia Kirstein, Antje Garten, Saskia Biskup, Florian Battke, Dennis Lal, Henrike O Heyne, Konrad Platzer, Chen-Ching Lin, Johannes R Lemke, Diana Le Du. Epilepsies of presumed genetic etiology show enrichment of rare variants that occur in the general population. American journal of human genetics. 2023-06-27. PMID:37369202. |
moreover, we found that genes harboring qrvs, e.g., hsgp2, flna, or tnc, encode proteins that are involved in structuring the brain extracellular matrix. |
2023-06-27 |
2023-08-14 |
Not clear |
| Martha Gschwandtner, Anís N Gammage, Claire Deligne, Linda F M Mies, Alissa Domaingo, Devardarssen Murdamoothoo, Thomas Loustau, Anja Schwenzer, Rupert Derler, Raphael Carapito, Manuel Koch, Matthias Mörgelin, Gertraud Orend, Andreas J Kungl, Kim S Midwoo. Investigating Chemokine-Matrix Networks in Breast Cancer: Tenascin-C Sets the Tone for CCL2. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37176074. |
here, we study the interplay between the matrix molecule tenascin-c (tnc) and chemokine ccl2, both elevated in and associated with the progression of breast cancer and playing key roles in myeloid immune responses. |
2023-05-14 |
2023-08-14 |
Not clear |
| Ahmed Alghamdi, Ali H Alyami, Raad M M Althaqafi, Ahmed Alzeyadi, Faisal S Alrubaei, Almuhanad A Alyami, Mohamed S Singer, Abdulelah A Saati, Wasn T Alotaibi, Maha O Alshari. Cytokines' Role in the Pathogenesis and Their Targeting for the Prevention of Frozen Shoulder: A Narrative Review. Cureus. vol 15. issue 3. 2023-04-14. PMID:37056530. |
different pathways of transforming growth factor- β (tgf-β) stimulation, resulting in overexpression of the fibrotic factors as tenascin c (tnc), fibronectin 1, collagen i (col 1) and collagen iii (col iii), and matrix metalloproteinases (mmps) in the capsular or synovial/capsular fibroblasts. |
2023-04-14 |
2023-08-14 |
Not clear |