| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lilin Hu, Zilu Cheng, Huikuan Chu, Weijun Wang, Yu Jin, Ling Yan. TRIF-dependent signaling and its role in liver diseases. Frontiers in cell and developmental biology. vol 12. 2024-05-02. PMID:38694821. |
trif plays a pivotal role in regulating interferon beta 1 (ifn-β) response, nuclear factor kappa b (nf-κb) signaling, apoptosis, and necroptosis signaling mediated by tlr3 and tlr4. |
2024-05-02 |
2024-05-04 |
Not clear |
| M I Airapetov, S O Eresko, S A Shamaeva, N M Matveev, E R Bychkov, A A Lebedev, P D Shabano. Prolonged alcohol consumption influences microRNA expression in the nucleus accumbens of the rat brain. Biomeditsinskaia khimiia. vol 69. issue 4. 2023-09-14. PMID:37705484. |
we have investigated the expression levels of mir-let7b, mir-96, mir-182, mir-155, and the mrna content of hmgb1, tlr3, tlr4 in the nucleus accumbens (nac) of the brain of rats exposed to long-term alcoholization. |
2023-09-14 |
2023-10-07 |
rat |
| M I Airapetov, S O Eresko, P D Ignatova, D A Skabelkin, A A Mikhailova, D A Ganshina, A A Lebedev, E R Bychkov, P D Shabano. The effect of rifampicin on expression of the toll-like receptor system genes in the forebrain cortex of rats prenatally exposed to alcohol. Biomeditsinskaia khimiia. vol 69. issue 4. 2023-09-14. PMID:37705483. |
our study has shown that prenatal alcohol exposure (pae) induced long-term changes in the tlr system genes (tlr3, tlr4, ticam, hmgb1, cytokine genes) in the forebrain cortex of rat pups. |
2023-09-14 |
2023-10-07 |
rat |
| M I Airapetov, S O Eresko, D V Kochkin, A M Nosov, E R Bychkov, A A Lebedev, P D Shabano. [Ginsenosides affect the system of Toll-like receptors in the brain of rats under conditions of long-term alcohol withdrawal]. Biomeditsinskaia khimiia. vol 68. issue 6. 2022-12-27. PMID:36573411. |
a significant effect of ginsenosides on the level of tlr3 and tlr4 mrna in the nucleus accumbens was found, while in the hippocampus, ginsenosides significantly affected the level of tlr7 mrna. |
2022-12-27 |
2023-08-14 |
rat |
| Honglong Zhu, Yongxin Yang, Tao Wu, Yunxia Qi, Dongwei Huang, Rongwei Han, Sheng Chen, Jishun Tang, Man Ren, Xiaowei Zha. Bovine colostrum promoted ileal health in newborn lambs at 24 h after birth: insight from intestinal morphology and innate immunity. Animal : an international journal of animal bioscience. vol 16. issue 8. 2022-07-16. PMID:35841825. |
messenger rna (mrna) abundance of toll-like receptor (tlr)-2, tlr3, tlr4, tlr6, tlr7, tlr8 and tumour necrosis factor alpha in the ileum was lower in c24h than that in n24h lambs (p < 0.05). |
2022-07-16 |
2023-08-14 |
cattle |
| Jon Inglefield, Jason Catania, Andrea Harris, Thomas Hickey, Zhidong Ma, Jacob Minang, Katalin Baranji, Tarl Spangler, Jee Look, Christian Ruiz, Hang Lu, David Alleva, Joshua J Reece, Michael J Lac. Use of protective antigen of Bacillus anthracis as a model recombinant antigen to evaluate toll-like receptors 2, 3, 4, 7 and 9 agonists in mice using established functional antibody assays, antigen-specific antibody assays and cellular assays. Vaccine. 2022-06-30. PMID:35773119. |
to rpa, combined with aluminum hydroxide (alhydrogel; al(oh)3) or squalene (addavax™), was added one of 7 tlr agonists: tlr2 agonist pam3cyssk4 (pams), tlr3 agonist double stranded polyinosinic:polycytidylic acid (polyic), tlr4 agonists monophosphoryl lipid a (mpla) or glucopyranosyl lipid a (gla), tlr7-8 agonists 3m-052 or resiquimod (resiq), or tlr9 agonist cpg 7909 (cpg). |
2022-06-30 |
2023-08-14 |
mouse |
| Anja Pišlar, Biljana Božić Nedeljković, Mina Perić, Tanja Jakoš, Nace Zidar, Janko Ko. Cysteine Peptidase Cathepsin X as a Therapeutic Target for Simultaneous TLR3/4-mediated Microglia Activation. Molecular neurobiology. 2022-01-23. PMID:35066760. |
here, we hypothesized that simultaneous tlr3 and tlr4 activation induces synergized microglia responses and that these phenotype changes affect cathepsin x expression and activity. |
2022-01-23 |
2023-08-13 |
Not clear |
| Anja Pišlar, Biljana Božić Nedeljković, Mina Perić, Tanja Jakoš, Nace Zidar, Janko Ko. Cysteine Peptidase Cathepsin X as a Therapeutic Target for Simultaneous TLR3/4-mediated Microglia Activation. Molecular neurobiology. 2022-01-23. PMID:35066760. |
murine microglia bv2 cells and primary murine microglia were exposed to the tlr3 ligand polyinosinic-polycytidylic acid (poly(i:c)) and the tlr4 ligand lipopolysaccharide (lps), individually and simultaneously. |
2022-01-23 |
2023-08-13 |
Not clear |
| Anja Pišlar, Biljana Božić Nedeljković, Mina Perić, Tanja Jakoš, Nace Zidar, Janko Ko. Cysteine Peptidase Cathepsin X as a Therapeutic Target for Simultaneous TLR3/4-mediated Microglia Activation. Molecular neurobiology. 2022-01-23. PMID:35066760. |
additionally, inhibiting the tlr3 and tlr4 common signaling pathway, pi3k, with ly294002 reduced the inflammatory responses of the poly(i:c)- and lps-activated microglia and recovered cathepsin x activity. |
2022-01-23 |
2023-08-13 |
Not clear |
| Shashank Vishwanath Adhikarla, Niraj Kumar Jha, Vineet Kumar Goswami, Ankur Sharma, Anuradha Bhardwaj, Abhijit Dey, Chiara Villa, Yatender Kumar, Saurabh Kumar Jh. TLR-Mediated Signal Transduction and Neurodegenerative Disorders. Brain sciences. vol 11. issue 11. 2021-11-30. PMID:34827372. |
this study is focused on the potential roles of various tlrs in various neurodegenerative diseases such as parkinson's disease (pd) and alzheimer's disease (ad), namely tlr2, tlr3, tlr4, tlr7, and tlr9 in ad and pd in human beings and a mouse model. |
2021-11-30 |
2023-08-13 |
mouse |
| Yingbo He, Natalie Taylor, Xiang Yao, Anindya Bhattachary. Mouse primary microglia respond differently to LPS and poly(I:C) in vitro. Scientific reports. vol 11. issue 1. 2021-11-01. PMID:34001933. |
microglia, cns resident innate immune cells, respond strongly to activation of tlr3 and tlr4, which recognize viral dsrna poly(i:c) and bacterial endotoxin lps, respectively. |
2021-11-01 |
2023-08-13 |
mouse |
| Pinku Mani Talukdar, Fazal Abdul, Michael Maes, Michael Berk, Ganesan Venkatasubramanian, Bindu M Kutty, Monojit Debnat. A proof-of-concept study of maternal immune activation mediated induction of Toll-like receptor (TLR) and inflammasome pathways leading to neuroprogressive changes and schizophrenia-like behaviours in offspring. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 52. 2021-11-01. PMID:34261013. |
the hippocampus of offspring rats showed increased expression of tlr3, tlr4, nlrp3, il1b, and il18 of poly (i:c) and tlr4, nlrp3, cas1, il1b, and il18 of lps-treated dams. |
2021-11-01 |
2023-08-13 |
rat |
| Jiandong Yang, Ming Zhou, Yun Zhong, Liqun Xu, Changjun Zeng, Xiaoling Zhao, Ming Zhan. Gene duplication and adaptive evolution of Toll-like receptor genes in birds. Developmental and comparative immunology. vol 119. 2021-10-11. PMID:33422554. |
environmental pressures had a greater effect on tlr1b, tlr2b, tlr3 and tlr4, while feeding habits were active in affecting tlr2a, tlr2b, tlr15 and tlr21. |
2021-10-11 |
2023-08-13 |
Not clear |
| Darshika J Udawatte, Alan L Rothma. Viral Suppression of RIPK1-Mediated Signaling. mBio. vol 12. issue 4. 2021-10-07. PMID:34372694. |
ripk1-mediated signaling governs the outcome of signaling pathways initiated by tumor necrosis factor receptor 1 (tnfr1), toll-like receptor 3 (tlr3), tlr4, retinoic acid-inducible gene 1 (rig-i)/melanoma differentiation-associated protein 5 (mda-5), and z-binding protein 1 (zbp1) by signaling for nf-κb activation, mitogen-associated protein kinase (mapk) and interferon regulatory factor 3/7 (irf3/7) phosphorylation, and cell death via apoptosis and necroptosis. |
2021-10-07 |
2023-08-13 |
Not clear |
| Ryota Sato, Tatjana Reuter, Ryosuke Hiranuma, Takuma Shibata, Ryutaro Fukui, Yuji Motoi, Yusuke Murakami, Hiroki Tsukamoto, Satoshi Yamazaki, Kaiwen Liu, Shin-Ichiroh Saitoh, Eicke Latz, Kensuke Miyak. The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages. International immunology. vol 32. issue 12. 2021-09-28. PMID:32840578. |
tissue macrophages such as red pulp macrophages in the spleen, kupffer cells in the liver, microglia in the brain, alveolar macrophages in the lung and adipose tissue macrophages all expressed tlr2, tlr4 and tlr3. |
2021-09-28 |
2023-08-13 |
Not clear |
| Xia Li, Hualan Zhou, Dianxuan Guo, Youdong Hu, Xiang Fang, Ying Chen, Fenglin Zhan. Oxidative stress and inflammation: Early predictive indicators of multiple recurrent coronary in-stent chronic total occlusions in elderly patients after coronary stenting. IUBMB life. vol 72. issue 5. 2021-08-17. PMID:32022379. |
we determined the expression levels of endothelial progenitor cell (epc), stromal cell-derived factor-1α (sdf-1α), vascular endothelial growth factor (vegf), nitric oxide (no), toll-like receptor 2 (tlr2), toll-like receptor 3 (tlr3), toll-like receptor 4 (tlr4), and soluble st2 (sst2) in elderly patients with multiple recurrent coronary in-stent chronic total occlusions after coronary stenting. |
2021-08-17 |
2023-08-13 |
Not clear |
| A M Hamieh, G Mallaret, M Meleine, A Lashermes, S Roumeau, L Boudieu, J Barbier, Y Aissouni, D Ardid, A T Gewirtz, F A Carvalho, F Marchan. Toll-like receptor 5 knock-out mice exhibit a specific low level of anxiety. Brain, behavior, and immunity. vol 93. 2021-05-27. PMID:33516921. |
nor there were significant changes in the expression of some cytokines (il-6, il-10 and tnf-α) and other tlrs (tlr2, tlr3 and tlr4) in the prefrontal cortex, amygdala and hippocampus of tlr5 ko mice compared to wt mice. |
2021-05-27 |
2023-08-13 |
mouse |
| Mohammad Jafari, Alimohamad Asghari, Ali-Akbar Delbandi, Maryam Jalessi, Mir Hadi Jazayeri, Reza Samarei, Nader Taji. Priming TLR3 and TLR4 in human adipose- and olfactory mucosa-derived mesenchymal stromal cells and comparison of their cytokine secretions. Cytotechnology. vol 72. issue 1. 2021-02-01. PMID:31898754. |
priming tlr3 and tlr4 in human adipose- and olfactory mucosa-derived mesenchymal stromal cells and comparison of their cytokine secretions. |
2021-02-01 |
2023-08-13 |
human |
| Mohammad Jafari, Alimohamad Asghari, Ali-Akbar Delbandi, Maryam Jalessi, Mir Hadi Jazayeri, Reza Samarei, Nader Taji. Priming TLR3 and TLR4 in human adipose- and olfactory mucosa-derived mesenchymal stromal cells and comparison of their cytokine secretions. Cytotechnology. vol 72. issue 1. 2021-02-01. PMID:31898754. |
human olfactory ecto-mesenchymal stem cells (oe-mscs) and adipose tissue (at-mscs), in terms of their immunosuppressive effects before and after tlr3 and tlr4 stimulation through low-level and short-term tlr-priming protocol. |
2021-02-01 |
2023-08-13 |
human |
| Xiaolong Wang, Hao Yu, Changliang Wang, Yang Liu, Jiabin You, Pengfei Wang, Guohui Xu, Hui Shen, Hui Yao, Xinze Lan, Rui Zhao, Xu Wu, Guohua Zhan. Chronic ethanol exposure induces neuroinflammation in H4 cells through TLR3 / NF-κB pathway and anxiety-like behavior in male C57BL/6 mice. Toxicology. vol 446. 2021-01-14. PMID:33161052. |
western blotting was used to detect the expression of tlr3, tlr4, nf-κb, il-1β, il-6, and tnf-α in the mouse hippocampus and h4 cells. |
2021-01-14 |
2023-08-13 |
mouse |