| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adela Kratochvilova, Lucia Knopfova, Janka Gregorkova, Reinhard Gruber, Eva Janeckova, Yang Chai, Eva Matalov. FasL impacts Tgfb signaling in osteoblastic cells. Cells & development. 2024-06-09. PMID:38810946. |
tgfb subfamily members (tgfb1, tgfb2, tgfb3) represent major components in osteogenic pathways and extracellular matrix. |
2024-06-09 |
2024-06-11 |
Not clear |
| Bianca Quiñones-Pérez, Grace E VanNoy, Meghan C Towne, Yiping Shen, Michael N Singh, Pankaj B Agrawal, Sharon E Smit. Three-generation family with novel contiguous gene deletion on chromosome 2p22 associated with thoracic aortic aneurysm syndrome. American journal of medical genetics. Part A. vol 176. issue 3. 2019-02-28. PMID:29350460. |
dysregulation of the tgf-ß pathway has been implicated in the pathogenesis of inherited disorders predisposing to thoracic aortic aneurysms syndromes (taas) including marfan syndrome (mfs; fbn1) and loeys-dietz syndrome (lds; tgfbr1, tgfbr2, tgfb2, tgfb3, smad2, smad3). |
2019-02-28 |
2023-08-13 |
Not clear |
| Yi Liu, Hua Song, Jing Pan, Jing Zha. Comprehensive gene expression analysis reveals multiple signal pathways associated with prostate cancer. Journal of applied genetics. vol 55. issue 1. 2015-04-17. PMID:24154878. |
after pathway and ppi network analysis, we found these hormone-related degs participated in several important signaling pathways including tgf-β (tgfb2, tgfb3 and tgfbr2), mapk (tgfb2, tgfb3 and tgfbr2), insulin (pik3r3, shc1 and eif4ebp1), and p53 signaling pathways (ccnd2 and cdkn1a). |
2015-04-17 |
2023-08-12 |
human |
| Jesus Alvarez, Philip Sohn, Xin Zeng, Thomas Doetschman, David J Robbins, Rosa Serr. TGFbeta2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression. Development (Cambridge, England). vol 129. issue 8. 2002-06-13. PMID:11934857. |
this report tests the hypothesis that tgfbeta signaling is required for the effects of hedgehog on hypertrophic differentiation and expression of pthrp: we show that sonic hedgehog (shh), a functional substitute for ihh, stimulates expression of tgfb2 and tgfb3 mrna in the perichondrium of embryonic mouse metatarsal bones grown in organ cultures and that tgfbeta signaling in the perichondrium is required for inhibition of differentiation and regulation of pthrp expression by shh. |
2002-06-13 |
2023-08-12 |
mouse |