| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui-Hui Wu, Jia-Min Du, Peng Liu, Fan-Liang Meng, Yue-Yan Li, Wen-Jing Li, Shuang-Xi Wang, Nai-Li Du, Yan Zheng, Liang Zhang, Hui-Yun Wang, Yi-Ran Liu, Chun-Hong Song, Xi Ni, Ying Li, Guo-Hai S. LDHA contributes to nicotine induced cardiac fibrosis through autophagy flux impairment. International immunopharmacology. vol 136. 2024-06-08. PMID:38850787. |
nicotine treatment impaired autophagy flux by regulating the ampk/mtor signaling pathway, impeding the nuclear translocation of transcription factor eb (tfeb), and reducing the activity of cathepsin b (ctsb). |
2024-06-08 |
2024-06-11 |
rat |
| Bin Ye, Quan Wang, Haixia Hu, Yilin Shen, Cui Fan, Penghui Chen, Yan Ma, Hao Wu, Mingliang Xian. Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR. Autophagy. vol 15. issue 6. 2020-06-15. PMID:30706760. |
abbreviations: 3-nt: 3-nitrotyrosine; 4-hne: 4-hydroxynonenal; 8-ohdg: 8-hydroxy-2'-deoxyguanosine; abr: auditory brainstem response; app: amyloid beta (a4) precursor protein; clear: coordinated lysosomal expression and regulation; ctsb: cathespin b; ctsd: cathespin d; samr1: senescence-accelerated mouse/resistance 1; samp8: senescence-accelerated mouse/prone 8; mapk1/erk2: mitogen-activated protein kinase 1; mtor: mechanistic target of rapamycin kinase; sgn: spiral ganglion neuron; sqstm1/p62: sequestosome 1; tem: transmission electron microscope; tfeb: transcription factor eb. |
2020-06-15 |
2023-08-13 |
mouse |
| Paola Rusmini, Katia Cortese, Valeria Crippa, Riccardo Cristofani, Maria Elena Cicardi, Veronica Ferrari, Giulia Vezzoli, Barbara Tedesco, Marco Meroni, Elio Messi, Margherita Piccolella, Mariarita Galbiati, Massimiliano Garrè, Elena Morelli, Thomas Vaccari, Angelo Polett. Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration. Autophagy. vol 15. issue 4. 2020-05-11. PMID:30335591. |
abbreviations: als: amyotrophic lateral sclerosis; ar: androgen receptor; atg: autophagy related; av: autophagic vacuole; bag3: bcl2-associated athanogene 3; becn1: beclin 1, autophagy related; casa: chaperone-assisted selective autophagy; ctsb: cathepsin b; dapi: 4',6-diamidino-2-phenylindole; dmem: dulbecco's modified eagle's medium; egfp: enhanced green fluorescent protein; fals, familial amyotrophic lateral sclerosis; fra: filter retardation assay; gapdh: glyceraldehyde-3-phosphate dehydrogenase; gla: galactosidase, alpha; hd: huntington disease; hipscs: human induced pluripotent stem cells; hspa8: heat shock protein a8; hspb8: heat shock protein b8; if: immunofluorescence analysis; lamp1: lysosomal-associated membrane protein 1; lamp2a: lysosomal-associated membrane protein 2a; lgals3: lectin, galactose binding, soluble 3; llome: l-leucyl-l-leucine methyl ester; lmp: lysosomal membrane permeabilization; lys: lysosomes; map1lc3b: microtubule-associated protein 1 light chain 3 beta; mcoln1: mucolipin 1; mrna: messenger rna; mtor: mechanistic target of rapamycin kinase; nds: neurodegenerative diseases; nsc34: neuroblastoma x spinal cord 34; pbs: phosphate-buffered saline; pd: parkinson disease; polyq: polyglutamine; ppargc1a: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; ppp3cb: protein phosphatase 3, catalytic subunit, beta isoform; rt-qpcr: real-time quantitative polymerase chain reaction; sbma: spinal and bulbar muscular atrophy; scas: spinocerebellar ataxias; sirna: small interfering rna; slc2a8: solute carrier family 2, (facilitated glucose transporter), member 8; smnpcs: small molecules neural progenitors cells; sod1: superoxide dismutase 1; sqstm1/p62: sequestosome 1; sted: stimulated emission depletion; stub1: stip1 homology and u-box containing protein 1; tardbp/tdp-43: tar dna binding protein; tfeb: transcription factor eb; tpp1: tripeptidyl peptidase i; treh: trehalase (brush-border membrane glycoprotein); wb: western blotting; zkscan3: zinc finger with krab and scan domains 3. |
2020-05-11 |
2023-08-13 |
human |