| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gyan Watson Ray, Qiaoli Zeng, Phidelia Kusi, Hengli Zhang, Taotao Shao, Taili Yang, Yue Wei, Mianqin Li, Xiaoqun Che, Runmin Gu. Genetic and inflammatory factors underlying gestational diabetes mellitus: a review. Frontiers in endocrinology. vol 15. 2024-05-02. PMID:38694942. |
this review delves into the pivotal role of insulin function and the influence of genetic variants, including slc30a8, cdkal1, tcf7l2, irs1, and gck, in gdm development. |
2024-05-02 |
2024-05-04 |
Not clear |
| D N Isakova, S N Kolomeichuk, Yu A Petrova, M V Lyapina, I A Troshina, K A Voronin, I M Petro. Association of Polymorphic Variants of TCF7L2 and PPARG Genes with Metabolic Markers in Patients with Early Disorders of Carbohydrate Metabolism. Bulletin of experimental biology and medicine. 2024-03-16. PMID:38492104. |
we performed complex analysis of the association of polymorphic variants rs7903146 of the tcf7l2 gene and rs1801282 of the pparg gene with metabolic parameters, insulin resistance, and β-cell function in a group of patients with early signs of carbohydrate metabolism disturbances in a sample of tyumen citizens. |
2024-03-16 |
2024-03-19 |
Not clear |
| Parth Sha. Genomic Editing and Diabetes. Advances in experimental medicine and biology. vol 1396. 2022-12-01. PMID:36454469. |
there are several established genes such as abcc8, tcf7l2, slc2a2, and capn10 which are known to influence blood insulin and glucose levels. |
2022-12-01 |
2023-08-14 |
Not clear |
| Marcello C Laurenti, Praveer Arora, Chiara Dalla Man, James C Andrews, Robert A Rizza, Aleksey Matveyenko, Kent R Bailey, Claudio Cobelli, Adrian Vell. The relationship between insulin and glucagon concentrations in non-diabetic humans. Physiological reports. vol 10. issue 13. 2022-07-13. PMID:35822422. |
as part of a series of experiments to measure the effect of diabetes-associated genetic variation in tcf7l2 on islet cell function, hepatic vein insulin and glucagon concentrations were measured at 2-minute intervals during fasting and a hyperglycemic clamp. |
2022-07-13 |
2023-08-14 |
human |
| Mohammad Saeedi, Fatemeh Mehranfar, Fateme Ghorbani, Mohammadali Eskandari, Majid Ghorbani, Ali Babaeiza. Review of pharmaceutical and therapeutic approaches for type 2 diabetes and related disorders. Recent patents on biotechnology. 2022-01-28. PMID:35088682. |
various studies have revealed that insulin resistance, lessened insulin production has been associated with t2d, and they also show that this disease can have a genetic origin and is associated with different genes such as kcnq1, ppar-γ, calpain-10, adipor2, tcf7l2 that can be utilized as a therapeutic target. |
2022-01-28 |
2023-08-13 |
Not clear |
| Dina Mansour Aly, Om Prakash Dwivedi, Rashmi B Prasad, Annemari Käräjämäki, Rebecka Hjort, Manonanthini Thangam, Mikael Åkerlund, Anubha Mahajan, Miriam S Udler, Jose C Florez, Mark I McCarthy, Julia Brosnan, Olle Melander, Sofia Carlsson, Ola Hansson, Tiinamaija Tuomi, Leif Groop, Emma Ahlqvis. Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes. Nature genetics. vol 53. issue 11. 2021-11-08. PMID:34737425. |
the severe insulin-resistant subtype was uniquely associated with grs for fasting insulin but not with variants in the tcf7l2 locus or grs reflecting insulin secretion. |
2021-11-08 |
2023-08-13 |
Not clear |
| Xu Sun, Maomin Song, Rixing Bai, Shi Cheng, Ying Xing, Huisheng Yuan, Pilin Wang, Lisa Zho. Ileal interposition surgery-induced improvement of hyperglycemia and insulin resistance in Goto-Kakizaki rats by upregulation of TCF7L2 expression. Experimental and therapeutic medicine. vol 5. issue 5. 2021-10-21. PMID:23737909. |
ileal interposition surgery-induced improvement of hyperglycemia and insulin resistance in goto-kakizaki rats by upregulation of tcf7l2 expression. |
2021-10-21 |
2023-08-12 |
rat |
| Xu Sun, Maomin Song, Rixing Bai, Shi Cheng, Ying Xing, Huisheng Yuan, Pilin Wang, Lisa Zho. Ileal interposition surgery-induced improvement of hyperglycemia and insulin resistance in Goto-Kakizaki rats by upregulation of TCF7L2 expression. Experimental and therapeutic medicine. vol 5. issue 5. 2021-10-21. PMID:23737909. |
the aim of this study was to investigate the effects of ileal interposition (it) on glucose and insulin resistance (ir) in type 2 diabetic mellitus (t2dm), and the role of t-cell factor 7-like 2 (tcf7l2), formerly known as tcf4, in the downregulation of hyperglycemia following it. |
2021-10-21 |
2023-08-12 |
rat |
| Zhensheng Zhang, Li Xu, Xiao X. The role of transcription factor 7-like 2 in metabolic disorders. Obesity reviews : an official journal of the International Association for the Study of Obesity. vol 22. issue 5. 2021-10-15. PMID:33615650. |
in islets, tcf7l2 not only affects the insulin secretion of the β-cells but also has an impact on other cells. |
2021-10-15 |
2023-08-13 |
Not clear |
| Duan Liu, Thanh Thanh Le Nguyen, Huanyao Gao, Huaizhi Huang, Daniel C Kim, Brenna Sharp, Zhenqing Ye, Jeong-Heon Lee, Brandon J Coombes, Tamas Ordog, Liewei Wang, Joanna M Biernacka, Mark A Frye, Richard M Weinshilbou. TCF7L2 lncRNA: a link between bipolar disorder and body mass index through glucocorticoid signaling. Molecular psychiatry. 2021-09-25. PMID:34535768. |
in astrocytes, knockdown of the lncrna-tcf7l2 resulted in decreased expression of the parent gene, tcf7l2, as well as alterations in the expression of a series of genes involved in insulin signaling and diabetes. |
2021-09-25 |
2023-08-13 |
human |
| Laura Potasso, Nikolaos Perakakis, Apostolia Lamprinou, Elektra Polyzou, Dimitrios Kassanos, Andreas Peter, Günter Päth, Jochen Seufert, Katharina Laubne. Clinical Impact of the TCF7L2 Gene rs7903146 Type 2 Diabetes Mellitus Risk Polymorphism in Women with Gestational Diabetes Mellitus: Impaired Glycemic Control and Increased Need of Insulin Therapy. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 128. issue 10. 2021-07-28. PMID:31546272. |
clinical impact of the tcf7l2 gene rs7903146 type 2 diabetes mellitus risk polymorphism in women with gestational diabetes mellitus: impaired glycemic control and increased need of insulin therapy. |
2021-07-28 |
2023-08-13 |
Not clear |
| Jing Chen, Chong Ning, Jingjing Mu, Dongnan Li, Yan Ma, Xianjun Men. Role of Wnt signaling pathways in type 2 diabetes mellitus. Molecular and cellular biochemistry. vol 476. issue 5. 2021-07-28. PMID:33566231. |
β-catenin/transcription factor 7-like 2 (tcf7l2)-mediated and calcineurin/nuclear factor of activated t cells-mediated target genes were involved in insulin synthesis and secretion, insulin degradation, pancreatic β-cell growth and regeneration, and functional application of pancreatic β-cells. |
2021-07-28 |
2023-08-13 |
Not clear |
| Witold Bauer, Edyta Adamska-Patruno, Urszula Krasowska, Monika Moroz, Joanna Fiedorczuk, Przemyslaw Czajkowski, Dorota Bielska, Maria Gorska, Adam Kretowsk. Dietary Macronutrient Intake May Influence the Effects of TCF7L2 rs7901695 Genetic Variants on Glucose Homeostasis and Obesity-Related Parameters: A Cross-Sectional Population-Based Study. Nutrients. vol 13. issue 6. 2021-07-28. PMID:34200102. |
we recruited 810 participants (47.5% men and 52.5% women), 18-79 years old (mean age, 42.1 (±14.5) years), who were genotyped for the common tcf7l2 rs7901695 single-nucleotide polymorphism (snp), and anthropometric measurements, body composition, body fat distribution (visceral (vat) and subcutaneous adipose tissue (sat) content), blood glucose and insulin concentrations after fasting and during ogtts, and hba1c were assessed. |
2021-07-28 |
2023-08-13 |
human |
| Marcello C Laurenti, Chiara Dalla Man, Ron T Varghese, James C Andrews, Robert A Rizza, Aleksey Matveyenko, Giuseppe De Nicolao, Claudio Cobelli, Adrian Vell. Diabetes-associated genetic variation in TCF7L2 alters pulsatile insulin secretion in humans. JCI insight. vol 5. issue 7. 2021-05-19. PMID:32182220. |
diabetes-associated genetic variation in tcf7l2 alters pulsatile insulin secretion in humans. |
2021-05-19 |
2023-08-13 |
human |
| Marcello C Laurenti, Chiara Dalla Man, Ron T Varghese, James C Andrews, Robert A Rizza, Aleksey Matveyenko, Giuseppe De Nicolao, Claudio Cobelli, Adrian Vell. Diabetes-associated genetic variation in TCF7L2 alters pulsatile insulin secretion in humans. JCI insight. vol 5. issue 7. 2021-05-19. PMID:32182220. |
we hypothesized that the t allele at rs7903146 in tcf7l2, previously associated with β cell dysfunction, would be associated with changes in these insulin pulse characteristics.methodstwenty-nine nondiabetic subjects (age 46 ± 2, bmi 28 ± 1 kg/m2) participated in this study. |
2021-05-19 |
2023-08-13 |
human |
| Marcello C Laurenti, Chiara Dalla Man, Ron T Varghese, James C Andrews, Robert A Rizza, Aleksey Matveyenko, Giuseppe De Nicolao, Claudio Cobelli, Adrian Vell. Diabetes-associated genetic variation in TCF7L2 alters pulsatile insulin secretion in humans. JCI insight. vol 5. issue 7. 2021-05-19. PMID:32182220. |
fdi decreased in response to hyperglycemia in the cc genotype group, perhaps reflecting less entrainment of insulin secretion during fasting.conclusiondiabetes-associated variation in tcf7l2 is associated with decreased orderliness and pulse dispersion, unchanged by hyperglycemia. |
2021-05-19 |
2023-08-13 |
human |
| Yingying Ye, Mohammad Barghouth, Cheng Luan, Abdulla Kazim, Yuedan Zhou, Lena Eliasson, Enming Zhang, Ola Hansson, Thomas Thevenin, Erik Renströ. The TCF7L2-dependent high-voltage activated calcium channel subunit α2δ-1 controls calcium signaling in rodent pancreatic beta-cells. Molecular and cellular endocrinology. vol 502. 2020-11-19. PMID:31805307. |
the transcription factor tcf7l2 remains the most important diabetes gene identified to date and genetic risk carriers exhibit lower insulin secretion. |
2020-11-19 |
2023-08-13 |
Not clear |
| Ranran Li, Jianjun Ou, Li Li, Ye Yang, Jingping Zhao, Renrong W. The Wnt Signaling Pathway Effector TCF7L2 Mediates Olanzapine-Induced Weight Gain and Insulin Resistance. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:29713286. |
the wnt signaling pathway effector tcf7l2 mediates olanzapine-induced weight gain and insulin resistance. |
2020-09-30 |
2023-08-13 |
mouse |
| Ranran Li, Jianjun Ou, Li Li, Ye Yang, Jingping Zhao, Renrong W. The Wnt Signaling Pathway Effector TCF7L2 Mediates Olanzapine-Induced Weight Gain and Insulin Resistance. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:29713286. |
olanzapine challenge induced remarkably increased body weight, fasting insulin, homeostasis model assessment-insulin resistance index, and tcf7l2 protein expression in liver, skeletal muscle, and adipose tissues. |
2020-09-30 |
2023-08-13 |
mouse |
| Ranran Li, Jianjun Ou, Li Li, Ye Yang, Jingping Zhao, Renrong W. The Wnt Signaling Pathway Effector TCF7L2 Mediates Olanzapine-Induced Weight Gain and Insulin Resistance. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:29713286. |
in addition, we found that olanzapine-induced body weight gain and insulin resistance actively influence the expression of tcf7l2 in liver and skeletal muscle, and elevated level of insulin determines the increased expression of tcf7l2 in adipose tissue. |
2020-09-30 |
2023-08-13 |
mouse |