| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gyan Watson Ray, Qiaoli Zeng, Phidelia Kusi, Hengli Zhang, Taotao Shao, Taili Yang, Yue Wei, Mianqin Li, Xiaoqun Che, Runmin Gu. Genetic and inflammatory factors underlying gestational diabetes mellitus: a review. Frontiers in endocrinology. vol 15. 2024-05-02. PMID:38694942. |
this review delves into the pivotal role of insulin function and the influence of genetic variants, including slc30a8, cdkal1, tcf7l2, irs1, and gck, in gdm development. |
2024-05-02 |
2024-05-04 |
Not clear |
| F J Wei, C Y Cai, P Yu, J Lv, C Ling, W T Shi, H X Jiao, B C Chang, F H Yang, Y Tian, M S Li, Y H Wang, L Zou, J M Shi, L M Chen, W D L. Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients. Genetics and molecular research : GMR. vol 14. issue 4. 2016-09-19. PMID:26634513. |
we found that camta1, abi2, vhl, kat2b, pkhd1, esr1, tox, slc30a8, sfi1, and myh9 polymorphisms were associated with hba1c, fpg, and/or p2pg; gck, hhex, tcf7l2, kcnq1, and tbx5 polymorphisms were associated with insulin resistance-related traits; abcg2, slc2a9, and pkhd1 polymorphisms were associated with sua; camta1, vhl, kat2b, pon1, nub1, slitrk5, smad3, fto, fanca, and pcsk2 polymorphisms were associated with blood lipid traits; camta1, spag16, tox, kcnq1, acacb, and myh9 polymorphisms were associated with blood pressure; and ube2e3, spag16, slc2a9, cdkal1, cdkn2a/b, tcf7l2, smad3, and pnpla3 polymorphisms were associated with bmi (all p values <0.05). |
2016-09-19 |
2023-08-13 |
human |
| Yuedan Zhou, Soo-Young Park, Jing Su, Kathleen Bailey, Emilia Ottosson-Laakso, Liliya Shcherbina, Nikolay Oskolkov, Enming Zhang, Thomas Thevenin, João Fadista, Hedvig Bennet, Petter Vikman, Nils Wierup, Malin Fex, Johan Rung, Claes Wollheim, Marcelo Nobrega, Erik Renström, Leif Groop, Ola Hansso. TCF7L2 is a master regulator of insulin production and processing. Human molecular genetics. vol 23. issue 24. 2015-07-09. PMID:25015099. |
isl1 is a primary target of tcf7l2 and regulates proinsulin production and processing via mafa, pdx1, nkx6.1, pcsk1, pcsk2 and slc30a8, thereby providing evidence for a coordinated regulation of insulin production and processing. |
2015-07-09 |
2023-08-13 |
human |
| Antigone S Dimas, Vasiliki Lagou, Adam Barker, Joshua W Knowles, Reedik Mägi, Marie-France Hivert, Andrea Benazzo, Denis Rybin, Anne U Jackson, Heather M Stringham, Ci Song, Antje Fischer-Rosinsky, Trine Welløv Boesgaard, Niels Grarup, Fahim A Abbasi, Themistocles L Assimes, Ke Hao, Xia Yang, Cécile Lecoeur, Inês Barroso, Lori L Bonnycastle, Yvonne Böttcher, Suzannah Bumpstead, Peter S Chines, Michael R Erdos, Jurgen Graessler, Peter Kovacs, Mario A Morken, Narisu Narisu, Felicity Payne, Alena Stancakova, Amy J Swift, Anke Tönjes, Stefan R Bornstein, Stéphane Cauchi, Philippe Froguel, David Meyre, Peter E H Schwarz, Hans-Ulrich Häring, Ulf Smith, Michael Boehnke, Richard N Bergman, Francis S Collins, Karen L Mohlke, Jaakko Tuomilehto, Thomas Quertemous, Lars Lind, Torben Hansen, Oluf Pedersen, Mark Walker, Andreas F H Pfeiffer, Joachim Spranger, Michael Stumvoll, James B Meigs, Nicholas J Wareham, Johanna Kuusisto, Markku Laakso, Claudia Langenberg, Josée Dupuis, Richard M Watanabe, Jose C Florez, Erik Ingelsson, Mark I McCarthy, Inga Prokopenk. Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes. vol 63. issue 6. 2014-09-16. PMID:24296717. |
a fourth cluster (tcf7l2, slc30a8, hhex/ide, cdkal1, cdkn2a/2b) was defined by loci influencing insulin processing and secretion without a detectable change in fasting glucose levels. |
2014-09-16 |
2023-08-12 |
human |
| Stephanie-May Ruchat, Cathy E Elks, Ruth J F Loos, Marie-Claude Vohl, S John Weisnagel, Tuomo Rankinen, Claude Bouchard, Louis Péruss. Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies. Acta diabetologica. vol 46. issue 3. 2009-09-03. PMID:19082521. |
diabetes-associated variants in cdkal1, cdkn2b, hhex/ide, igf2bp2, kcnj11, slc30a8 and tcf7l2 are associated with physiological alterations leading to t2dm, such as glucose intolerance, impaired insulin secretion or insulin resistance, supporting their role in the disease aetiology. |
2009-09-03 |
2023-08-12 |
human |
| Axel Haupt, Martina Guthoff, Silke A Schäfer, Kerstin Kirchhoff, Fausto Machicao, Baptist Gallwitz, Harald Staiger, Norbert Stefan, Andreas Fritsche, Hans-Ulrich Härin. The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity. The Journal of clinical endocrinology and metabolism. vol 94. issue 5. 2009-05-28. PMID:19258404. |
we assessed whether the risk alleles in tcf7l2, cdkal1, hhex, slc30a8, igf2bp2, cdkn2a/2b, jazf1, and wfs1 reduce insulin secretion in an additive manner and whether their impact is influenced by insulin sensitivity. |
2009-05-28 |
2023-08-12 |
Not clear |