| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eric Witherspoon, Nicholas Zuczek, Gabrielle Williams, Briana Bernstein, Anjik Ghosh, Marko Culjat, Suhasini Kaushal, Patrick A Forcell. A single exposure to brivaracetam or perampanel does not cause cell death in neonatal rats. Frontiers in pediatrics. vol 12. 2024-10-01. PMID:39350791. |
brivaracetam (brv) and perampanel (per) are two newer generation anti-seizure medications and are of interest based on their mechanisms of action (sv2a modulator, ampa antagonist, respectively), as other drugs with these mechanisms of action do not trigger acute neurotoxicity. |
2024-10-01 |
2024-10-03 |
rat |
| Motohiro Okada, Kouji Fukuyama, Takashi Shiroyama, Yuto Ued. Brivaracetam prevents astroglial l-glutamate release associated with hemichannel through modulation of synaptic vesicle protein. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 138. 2021-07-22. PMID:33706129. |
to explore the antiepileptic/anticonvulsive mechanism of brivaracetam associated with sv2a modulation, this study determined concentration-dependent effects of brivaracetam on astroglial l-glutamate release associated with connexin43 (cx43), tumour-necrosis factor-α (tnfα) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa)/glutamate receptor of rat primary cultured astrocytes using ultra-high-performance liquid chromatography. |
2021-07-22 |
2023-08-13 |
rat |
| Ting Wu, Katsutoshi Ido, Makoto Ohgoh, Takahisa Hanad. Mode of seizure inhibition by sodium channel blockers, an SV2A ligand, and an AMPA receptor antagonist in a rat amygdala kindling model. Epilepsy research. vol 154. 2020-07-13. PMID:31035244. |
mode of seizure inhibition by sodium channel blockers, an sv2a ligand, and an ampa receptor antagonist in a rat amygdala kindling model. |
2020-07-13 |
2023-08-13 |
rat |
| Michael A Rogawski, Wolfgang Löscher, Jong M Rh. Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet. Cold Spring Harbor perspectives in medicine. vol 6. issue 5. 2017-12-07. PMID:26801895. |
asds act by modulation of voltage-gated ion channels, including sodium, calcium, and potassium channels; by enhancement of γ-aminobutyric acid (gaba)-mediated inhibition through effects on gabaa receptors, the gaba transporter 1 (gat1) gaba uptake transporter, or gaba transaminase; through interactions with elements of the synaptic release machinery, including synaptic vesicle 2a (sv2a) and α2δ; or by blockade of ionotropic glutamate receptors, including α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (ampa) receptors. |
2017-12-07 |
2023-08-13 |
Not clear |
| Silvia Olivera Bravo, Jeremy Henley, Daniel Rodriguez-Ithurrald. Acetylcholinesterase effects on glutamate receptors. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16429521. |
a selective potentiation of ampa receptors (ampar) binding in ampar-enriched layers undergoing synaptogenesis plus an increased surface expression of synaptic clusters of glur1, glur2, and sv2a was found. |
2006-02-24 |
2023-08-12 |
rat |