| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zengyu Yao, Li Cai, Aimei Zhao, Lu Yang, Zhiyu Chen, Yu Zhang, Guiming Liang, Meng Luo, Xiuhong Xu, Guoping Zho. Electroacupuncture alleviates neuroinflammation by regulating microglia polarization via STAT6/PPARγ in ischemic stroke rats. Neuroscience. 2023-09-23. PMID:37741355. |
in contrast, inhibition of stat6 phosphorylation exacerbated neural damage, inhibited stat6/pparγ pathway activity, promoted microglia m1-type polarization and exacerbated neuroinflammation, resulting in an attenuated positive effect of ea intervention. |
2023-09-23 |
2023-10-07 |
rat |
| Zengyu Yao, Li Cai, Aimei Zhao, Lu Yang, Zhiyu Chen, Yu Zhang, Guiming Liang, Meng Luo, Xiuhong Xu, Guoping Zho. Electroacupuncture alleviates neuroinflammation by regulating microglia polarization via STAT6/PPARγ in ischemic stroke rats. Neuroscience. 2023-09-23. PMID:37741355. |
this study aimed to investigate further whether ea could modulate neuroinflammation by targeting the signal transducer and activator of transcription 6 (stat6) and peroxisome proliferator-activated receptor γ (pparγ) pathway, the key regulator of microglia. |
2023-09-23 |
2023-10-07 |
rat |
| Aihua Xu, Yang Yang, Yang Shao, Manyu Jiang, Yongxin Sun, Bo Fen. FHL2 regulates microglia M1/M2 polarization after spinal cord injury via PARP14-depended STAT1/6 pathway. International immunopharmacology. vol 124. issue Pt A. 2023-09-14. PMID:37708708. |
in vitro, fhl2 silencing promoted lps + ifn-γ-induced microglia m1 polarization through activating the stat1 pathway and alleviated il-4-induced microglia m2 polarization via inhibiting the stat6 pathway. |
2023-09-14 |
2023-10-07 |
mouse |
| Aihua Xu, Yang Yang, Yang Shao, Manyu Jiang, Yongxin Sun, Bo Fen. FHL2 regulates microglia M1/M2 polarization after spinal cord injury via PARP14-depended STAT1/6 pathway. International immunopharmacology. vol 124. issue Pt A. 2023-09-14. PMID:37708708. |
indeed, fhl2 deficiency increased the secretion of tnf-α and il-6, m1 microglia polarization, and the activation of stat1 pathway but decreased the secretion of il-10 and il-4, m2 microglia polarization, and the activation of the stat6 pathway in the spinal cord. |
2023-09-14 |
2023-10-07 |
mouse |
| Lizhi Pang, Madeline Dunterman, Songlin Guo, Fatima Khan, Yang Liu, Erfan Taefi, Atousa Bahrami, Changiz Geula, Wen-Hao Hsu, Craig Horbinski, Charles David James, Peiwen Che. Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma. Nature immunology. 2023-09-04. PMID:37667051. |
secreted tfpi2 interacts with its functional receptor cd51 on microglia to trigger the infiltration and immunosuppressive polarization of microglia through activation of stat6 signaling. |
2023-09-04 |
2023-09-07 |
mouse |
| Ai-Hua Xu, Yang Yang, Yang Shao, Man-Yu Jiang, Yong-Xin Su. Poly(ADP-ribose) polymerase family member 14 promotes functional recovery after spinal cord injury through regulating microglia M1/M2 polarization via STAT1/6 pathway. Neural regeneration research. vol 18. issue 8. 2023-02-08. PMID:36751810. |
in addition, parp14 overexpression made microglia more prone to m2 polarization and further activated the stat6 pathway. |
2023-02-08 |
2023-08-14 |
mouse |
| Jing Luo, Yuan Feng, Mingyue Li, Mingyu Yin, Feng Qin, Xiquan H. Repetitive Transcranial Magnetic Stimulation Improves Neurological Function and Promotes the Anti-inflammatory Polarization of Microglia in Ischemic Rats. Frontiers in cellular neuroscience. vol 16. 2022-05-02. PMID:35496902. |
rtms inhibits the activation of transcription factors nuclear factor kappa b (nf-κb) and signal transducer and activator of transcription 6 (stat6) and promotes the anti-inflammatory polarization of microglia. |
2022-05-02 |
2023-08-13 |
rat |
| Siwen Ding, Yuze Cao, Xiaoyu Lu, Huixue Zhang, Lin Cong, Tingting Yi, Mei Xu, Lihua Wan. Dedicator of cytokinesis 2 (DOCK2) silencing protects against cerebral ischemia/reperfusion by modulating microglia polarization via the activation of the STAT6 signaling pathway. Neuroscience. 2022-04-08. PMID:35395356. |
dedicator of cytokinesis 2 (dock2) silencing protects against cerebral ischemia/reperfusion by modulating microglia polarization via the activation of the stat6 signaling pathway. |
2022-04-08 |
2023-08-13 |
mouse |
| Siwen Ding, Yuze Cao, Xiaoyu Lu, Huixue Zhang, Lin Cong, Tingting Yi, Mei Xu, Lihua Wan. Dedicator of cytokinesis 2 (DOCK2) silencing protects against cerebral ischemia/reperfusion by modulating microglia polarization via the activation of the STAT6 signaling pathway. Neuroscience. 2022-04-08. PMID:35395356. |
in conclusion, dock2 downregulation protected against cerebral ischemia/reperfusion by modulating microglia polarization via the activation of the stat6 signaling pathway. |
2022-04-08 |
2023-08-13 |
mouse |
| Siwen Ding, Yuze Cao, Xiaoyu Lu, Huixue Zhang, Lin Cong, Tingting Yi, Mei Xu, Lihua Wan. Dedicator of cytokinesis 2 (DOCK2) silencing protects against cerebral ischemia/reperfusion by modulating microglia polarization via the activation of the STAT6 signaling pathway. Neuroscience. 2022-04-08. PMID:35395356. |
dock2 knockdown-induced microglial cell polarization towards m2 phenotype was partly abrogated by the stat6 inhibitor as1517499. |
2022-04-08 |
2023-08-13 |
mouse |
| Lushuang Xie, Ning Zhang, Qun Zhang, Chenyu Li, Aaron F Sandhu, George Williams Iii, Sirui Lin, PeiRan Lv, Yi Liu, Qiaofeng Wu, Shuguang Y. Inflammatory factors and amyloid β-induced microglial polarization promote inflammatory crosstalk with astrocytes. Aging. vol 12. issue 22. 2021-04-27. PMID:33196457. |
nuclear factor κb p65 was upregulated in m1 microglia and pro-inflammatory astrocytes, while stat6 was upregulated in m2 microglia and anti-inflammatory astrocytes. |
2021-04-27 |
2023-08-13 |
rat |
| Wei Cai, Xuejiao Dai, Jie Chen, Jingyan Zhao, Mingyue Xu, Lili Zhang, Boyu Yang, Wenting Zhang, Marcelo Rocha, Toshimasa Nakao, Julia Kofler, Yejie Shi, R Anne Stetler, Xiaoming Hu, Jun Che. STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice. JCI insight. vol 4. issue 20. 2020-10-15. PMID:31619589. |
combined in vivo analyses using bm chimeras and in vitro experiments using microglia/macrophage-neuron cocultures confirmed that stat6 activation in both microglia and macrophages was essential for neuroprotection. |
2020-10-15 |
2023-08-13 |
mouse |
| Zengyang Pei, Shenghao Wang, Qi L. Sevoflurane suppresses microglial M2 polarization. Neuroscience letters. vol 655. 2018-01-01. PMID:28687236. |
mechanistically, it was shown that sevoflurane suppresses stat6 phosphorylation in primary microglia. |
2018-01-01 |
2023-08-13 |
human |
| Zhongwang Yu, Dingya Sun, Jifeng Feng, Weixing Tan, Xue Fang, Ming Zhao, Xiaolin Zhao, Yingyan Pu, Aijun Huang, Zhenghua Xiang, Li Cao, Cheng H. MSX3 Switches Microglia Polarization and Protects from Inflammation-Induced Demyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 16. 2015-07-16. PMID:25904788. |
mechanically, chromatin immunoprecipitation assays also indicated that msx3 directly regulated three key genes associated with microglia m2 polarization, including pparg, stat6, and jak3. |
2015-07-16 |
2023-08-13 |
Not clear |
| Eunha Jang, Shinrye Lee, Jong-Heon Kim, Jae-Hong Kim, Jung-Wan Seo, Won-Ha Lee, Kiyoshi Mori, Kazuwa Nakao, Kyoungho Su. Secreted protein lipocalin-2 promotes microglial M1 polarization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 3. 2013-04-26. PMID:23207546. |
lcn2 inhibited phosphorylation of stat6 in il-4-stimulated microglia, suggesting lcn2 suppression of the canonical m2 signaling. |
2013-04-26 |
2023-08-12 |
mouse |
| Soo Jung Park, Jee Hoon Lee, Hee Young Kim, Youn Hee Choi, Jung Sup Park, Young Ho Suh, Sang Myun Park, Eun-hye Joe, Ilo Jo. Astrocytes, but not microglia, rapidly sense H₂O₂via STAT6 phosphorylation, resulting in cyclooxygenase-2 expression and prostaglandin release. Journal of immunology (Baltimore, Md. : 1950). vol 188. issue 10. 2012-08-07. PMID:22504638. |
accordingly, our results indicate that ros-induced stat6 phosphorylation in astrocytes can modulate the functions of neighboring cells, including microglia, through cyclooxygenase-2 induction and subsequent release of pgs. |
2012-08-07 |
2023-08-12 |
Not clear |
| Soo Jung Park, Jee Hoon Lee, Hee Young Kim, Youn Hee Choi, Jung Sup Park, Young Ho Suh, Sang Myun Park, Eun-hye Joe, Ilo Jo. Astrocytes, but not microglia, rapidly sense H₂O₂via STAT6 phosphorylation, resulting in cyclooxygenase-2 expression and prostaglandin release. Journal of immunology (Baltimore, Md. : 1950). vol 188. issue 10. 2012-08-07. PMID:22504638. |
astrocytes, but not microglia, rapidly sense h₂o₂via stat6 phosphorylation, resulting in cyclooxygenase-2 expression and prostaglandin release. |
2012-08-07 |
2023-08-12 |
Not clear |
| Soo Jung Park, Jee Hoon Lee, Hee Young Kim, Youn Hee Choi, Jung Sup Park, Young Ho Suh, Sang Myun Park, Eun-hye Joe, Ilo Jo. Astrocytes, but not microglia, rapidly sense H₂O₂via STAT6 phosphorylation, resulting in cyclooxygenase-2 expression and prostaglandin release. Journal of immunology (Baltimore, Md. : 1950). vol 188. issue 10. 2012-08-07. PMID:22504638. |
differences in the sensitivity of stat6 in astrocytes (highly sensitive) and microglia (insensitive) to phosphorylation following brief exposure to h(2)o(2) suggest that astrocytes can act as sentinels for certain stimuli, including h(2)o(2) and ros, refining the canonical notion that microglia are the first line of defense against external stimuli. |
2012-08-07 |
2023-08-12 |
Not clear |
| Soo Jung Park, Jee Hoon Lee, Hee Young Kim, Youn Hee Choi, Jung Sup Park, Young Ho Suh, Sang Myun Park, Eun-hye Joe, Ilo Jo. Astrocytes, but not microglia, rapidly sense H₂O₂via STAT6 phosphorylation, resulting in cyclooxygenase-2 expression and prostaglandin release. Journal of immunology (Baltimore, Md. : 1950). vol 188. issue 10. 2012-08-07. PMID:22504638. |
in the current study, we demonstrated that astrocytes sense h(2)o(2) by rapidly phosphorylating the transcription factor stat6, a response not observed in microglia. |
2012-08-07 |
2023-08-12 |
Not clear |
| Thomas Zeis, Ursula Graumann, Richard Reynolds, Nicole Schaeren-Wiemer. Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection. Brain : a journal of neurology. vol 131. issue Pt 1. 2008-03-06. PMID:18056737. |
immunofluorescence colocalization analysis revealed expression of stat6, jak1, il-4r and il-13r mainly in oligodendrocytes, whereas stat4 expression was detected predominantly in microglia. |
2008-03-06 |
2023-08-12 |
Not clear |