| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun-Xia Li, Jinzhong Liu, Fang L. Hinesol attenuates DSS-induced ulcerative colitis through the suppression of Src-mediated NF-κB and chemokine signaling pathway. Cell biochemistry and biophysics. 2024-07-08. PMID:38976102. |
moreover, in lps-stimulated raw 264.7 cells, src overexpression partially reversed the inhibition of hinesol on cell apoptosis, pro-inflammatory factors, and oxidative stress. |
2024-07-08 |
2024-07-11 |
mouse |
| Lutfiye Yildiz Ozer, Hend Salah Fayed, Johan Ericsson, Ayman Al Haj Ze. Development of a cancer metastasis-on-chip assay for high throughput drug screening. Frontiers in oncology. vol 13. 2024-01-19. PMID:38239643. |
in contrast, drugs with molecular targets: abl, kit, pdgf, src, and vegfr were enriched in the drug clusters showing a strong effect on tumor cell intravasation with less impact on cell invasion or cell proliferation, of which, imatinib, a multi-kinase inhibitor targeting bcr-abl/pdgfr/kit. |
2024-01-19 |
2024-01-21 |
Not clear |
| Edward P Retzbach, Stephanie A Sheehan, Harini Krishnan, Haiyan Zheng, Caifeng Zhao, Gary S Goldber. Independent effects of Src kinase and podoplanin on anchorage independent cell growth and migration. Molecular carcinogenesis. 2022-04-26. PMID:35472679. |
here, we analyzed the effects of an inducible src kinase construct in knockout cells with and without exogenous pdpn expression on cell morphology migration and anchorage independent growth. |
2022-04-26 |
2023-08-13 |
Not clear |
| Hong Ji, Bo Li, Shitai Zhang, Zheng He, Yang Zhou, Ling Ouyan. Crk-like adapter protein is overexpressed in cervical carcinoma, facilitates proliferation, invasion and chemoresistance, and regulates Src and Akt signaling. Oncology letters. vol 12. issue 5. 2020-09-30. PMID:27895735. |
treatment with the src inhibitor dasatinib eliminated the effect of crkl on cell invasion. |
2020-09-30 |
2023-08-13 |
human |
| Dadong Zhang, Heming Wu, Xiaomin Zhang, Xu Ding, Min Huang, Meiyu Geng, Hongwei Li, Zuoquan Xi. Phosphoglycerate Mutase 1 Predicts the Poor Prognosis of Oral Squamous Cell Carcinoma and is Associated with Cell Migration. Journal of Cancer. vol 8. issue 11. 2020-09-28. PMID:28819393. |
the effect on cell migration was abolished following pretreatment with an src inhibitor. |
2020-09-28 |
2023-08-13 |
Not clear |
| Wensheng Jiang, Zhiying Xu, Lili Yu, Jianpeng Che, Jie Zhang, Jun Yan. MicroRNA-144-3p suppressed TGF-β1-induced lung cancer cell invasion and adhesion by regulating the Src-Akt-Erk pathway. Cell biology international. 2019-11-20. PMID:31038242. |
the inhibition of src could block the promotive effects of mir-144-3p inhibitor and tgf-β1 on cell invasion and adhesion. |
2019-11-20 |
2023-08-13 |
Not clear |
| A José Alberto Hernández, V Liliana Reyes, Damaris Albores-García, Rocío Gómez, Emma S Calderón-Arand. MeHg affects the activation of FAK, Src, Rac1 and Cdc42, critical proteins for cell movement in PDGF-stimulated SH-SY5Y neuroblastoma cells. Toxicology. vol 394. 2018-10-19. PMID:29197552. |
here, we studied the effect of mehg (1, 10, 100, 500 and 1000nm) on cell migration, the formation of cell protrusions, focal adhesion location and the activation of fak, src, rac1 and cdc42 using the sh-sy5y neuroblastoma cell line stimulated with pdgf-bb (pdgf). |
2018-10-19 |
2023-08-13 |
Not clear |
| Jin Dai, Peter G Van Wie, Leonard Yenwong Fai, Donghern Kim, Lei Wang, Pratheeshkumar Poyil, Jia Luo, Zhuo Zhan. Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells. Toxicology and applied pharmacology. vol 311. 2017-05-23. PMID:27664007. |
apigenin treatment attenuated nedd9 expression at protein level, resulting in reduced phosphorylations of fak, src, and akt, leading to inhibition on cell migration, invasion, and metastasis of both dld1 and sw480 cells. |
2017-05-23 |
2023-08-13 |
Not clear |
| Guang-Zong Zhao, Long-Qiang Zhang, Yao Liu, Jun Fang, Hua-Zhuang Li, Ke-Hai Gao, Yun-Zhen Che. Effects of platelet-derived growth factor on chondrocyte proliferation, migration and apoptosis via regulation of GIT1 expression. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27220359. |
furthermore, the results indicated that pdgf promoted chondrocyte proliferation and migration, however, the effect on cell apoptosis induction was suppressed after adding the src inhibitor, pp2. |
2017-04-06 |
2023-08-13 |
Not clear |
| Xue Wu, Longlong Yang, Zhao Zheng, Zhenzhen Li, Jihong Shi, Yan Li, Shichao Han, Jianxin Gao, Chaowu Tang, Linlin Su, Dahai H. Src promotes cutaneous wound healing by regulating MMP-2 through the ERK pathway. International journal of molecular medicine. vol 37. issue 3. 2016-12-19. PMID:26821191. |
we found that the overexpression of src accelerated keratinocyte migration in vitro and promoted wound healing in vivo without exerting a marked effect on cell proliferation. |
2016-12-19 |
2023-08-13 |
Not clear |
| Minh Q Huynh, Jennifer Goßmann, Stefan Gattenlöehner, Wolfram Klapper, Hans-Heinrich Wacker, Annette Ramaswamy, Alwina Bittner, Ulrich Kaiser, Andreas Neubaue. Expression and pro-survival function of phospholipase Cγ2 in diffuse large B-cell lymphoma. Leukemia & lymphoma. vol 56. issue 4. 2016-04-01. PMID:25012946. |
co-treatment with enzastaurin or the src inhibitor pp2 together with u73122 had an additive effect on cell proliferation compared to u73122 alone. |
2016-04-01 |
2023-08-13 |
Not clear |
| Long Li, Xiaojun Li, Xiaobing Han, Ting Yang, Jing Fu, Yunfeng Zhang, Wenli Go. An ovarian cancer model with positive ER: Reversion of ER antagonist resistance by Src blockade. Oncology reports. vol 32. issue 3. 2015-11-03. PMID:24968896. |
the effects of er and src blockade on cell cycle were assayed in estrogen receptor α (erα)-positive ovarian cancer. |
2015-11-03 |
2023-08-13 |
Not clear |
| Fauzia Chaudhary, Robert Lucito, Nicholas K Tonk. Missing-in-Metastasis regulates cell motility and invasion via PTPδ-mediated changes in SRC activity. The Biochemical journal. vol 465. issue 1. 2015-04-14. PMID:25287652. |
finally, the src inhibitor su6656 counteracted the effects of mim suppression on cell motility and invasion. |
2015-04-14 |
2023-08-13 |
human |
| Andrei V Karginov, Denis Tsygankov, Matthew Berginski, Pei-Hsuan Chu, Evan D Trudeau, Jason J Yi, Shawn Gomez, Timothy C Elston, Klaus M Hah. Dissecting motility signaling through activation of specific Src-effector complexes. Nature chemical biology. vol 10. issue 4. 2014-05-12. PMID:24609359. |
the overall effects of src activation on cell morphology and adhesion dynamics were first quantified, without restricting effector access. |
2014-05-12 |
2023-08-12 |
Not clear |
| Erik G Strungs, Louis M Luttrel. Arrestin-dependent activation of ERK and Src family kinases. Handbook of experimental pharmacology. vol 219. 2014-04-18. PMID:24292833. |
evidence suggests that arrestin-bound erk1/2 and src not only play regulatory roles in receptor desensitization and trafficking but also mediate longer term effects on cell growth, migration, proliferation, and survival. |
2014-04-18 |
2023-08-12 |
Not clear |
| Mingxuan Xie, Shaojin You, Qiong Chen, Xi Chen, Chengping H. Progesterone inhibits the migration and invasion of A549 lung cancer cells through membrane progesterone receptor α-mediated mechanisms. Oncology reports. vol 29. issue 5. 2014-03-05. PMID:23467643. |
furthermore, pp1 (an src pathway inhibitor), when co-incubated with p4, synchronously enhanced the inhibitory effects of p4 on cell migration and invasion. |
2014-03-05 |
2023-08-12 |
human |
| Salem Ghrebi, Douglas W Hamilton, J Douglas Waterfield, Donald M Brunett. The effect of surface topography on cell shape and early ERK1/2 signaling in macrophages; linkage with FAK and Src. Journal of biomedical materials research. Part A. vol 101. issue 7. 2013-10-29. PMID:23427018. |
the effect of surface topography on cell shape and early erk1/2 signaling in macrophages; linkage with fak and src. |
2013-10-29 |
2023-08-12 |
Not clear |
| J Lopez, C Hesling, J Prudent, N Popgeorgiev, R Gadet, I Mikaelian, R Rimokh, G Gillet, P Gonzal. Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik. Cell death and differentiation. vol 19. issue 9. 2013-06-19. PMID:22388352. |
in addition to its effects on cell proliferation and motility, src is often considered as an inhibitor of apoptosis, although this remains controversial. |
2013-06-19 |
2023-08-12 |
mouse |
| Xinlei Li, Yongqing Liu, Thomas A Haa. Skelemin in integrin α(IIb)β(3) mediated cell spreading. Biochemistry. vol 52. issue 4. 2013-03-25. PMID:23273221. |
thus, we propose that during early stages of cell spreading, skelemin exerts contractile force on cell spreading and modulates the attachment of cytoskeletal proteins and src to integrin clusters. |
2013-03-25 |
2023-08-12 |
Not clear |
| Jinu Abraham, Ying Xuan Chua, Jason M Glover, Jeffrey W Tyner, Marc M Loriaux, Aoife Kilcoyne, Francis J Giles, Laura D Nelon, Jennifer S Carew, Yongjian Ouyang, Joel E Michalek, Ranadip Pal, Brian J Druker, Brian P Rubin, Charles Kelle. An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma. Biochemical and biophysical research communications. vol 426. issue 3. 2013-02-07. PMID:22960170. |
treating the resistant primary cell cultures with a combination of pdgfra and src inhibitors had a strong additive effect on cell viability. |
2013-02-07 |
2023-08-12 |
mouse |