| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pernille Bogetofte Thomasen, Alena Salasova, Kasper Kjaer-Sorensen, Lucie Woloszczukov\\xc3\\xa1, Josef Lavick\\xc3\\xbd, Hande Login, Jeppe Tranberg-Jensen, Sergio Almeida, Sander Beel, Michaela Kavkov\\xc3\\xa1, Per Qvist, Mads Kjolby, Peter Lund Ovesen, Stella Nolte, Benedicte Vestergaard, Andreea-Cornelia Udrea, Lene Niemann Nejsum, Moses V Chao, Philip Van Damme, Jan Krivanek, Jeremy Dasen, Claus Oxvig, Anders Nykjae. SorCS2 binds progranulin to regulate motor neuron development. Cell reports. vol 42. issue 11. 2023-10-28. PMID:37897724. |
in mice, sorcs2 and pgrn are co-expressed by newborn mns from embryonic day 9.5 until adulthood. |
2023-10-28 |
2023-11-08 |
mouse |
| Pernille Bogetofte Thomasen, Alena Salasova, Kasper Kjaer-Sorensen, Lucie Woloszczukov\\xc3\\xa1, Josef Lavick\\xc3\\xbd, Hande Login, Jeppe Tranberg-Jensen, Sergio Almeida, Sander Beel, Michaela Kavkov\\xc3\\xa1, Per Qvist, Mads Kjolby, Peter Lund Ovesen, Stella Nolte, Benedicte Vestergaard, Andreea-Cornelia Udrea, Lene Niemann Nejsum, Moses V Chao, Philip Van Damme, Jan Krivanek, Jeremy Dasen, Claus Oxvig, Anders Nykjae. SorCS2 binds progranulin to regulate motor neuron development. Cell reports. vol 42. issue 11. 2023-10-28. PMID:37897724. |
here, we identify sorcs2 as a progranulin (pgrn) receptor that is required for mn diversification and axon outgrowth in zebrafish and mice. |
2023-10-28 |
2023-11-08 |
mouse |
| Pernille Bogetofte Thomasen, Alena Salasova, Kasper Kjaer-Sorensen, Lucie Woloszczukov\\xc3\\xa1, Josef Lavick\\xc3\\xbd, Hande Login, Jeppe Tranberg-Jensen, Sergio Almeida, Sander Beel, Michaela Kavkov\\xc3\\xa1, Per Qvist, Mads Kjolby, Peter Lund Ovesen, Stella Nolte, Benedicte Vestergaard, Andreea-Cornelia Udrea, Lene Niemann Nejsum, Moses V Chao, Philip Van Damme, Jan Krivanek, Jeremy Dasen, Claus Oxvig, Anders Nykjae. SorCS2 binds progranulin to regulate motor neuron development. Cell reports. vol 42. issue 11. 2023-10-28. PMID:37897724. |
we further show that sorcs2 binds pgrn to control its secretion, signaling, and conversion into granulins. |
2023-10-28 |
2023-11-08 |
mouse |