| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuenan Ban, Xiaolan Yang, Dandan Tan, Chen Gong, Yuan Gao, Jinxian Yuan, Yangmei Chen, You Wang, Tao X. Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy. Neurochemistry international. 2024-03-30. PMID:38555055. |
importantly, subsequent behavioral analyses and local field potential (lfp) analyses of a tle mouse model demonstrated that the downregulation of hippocampal sorbs2 could prolong the latency to spontaneous recurrent seizures (srss) and protect against srss. |
2024-03-30 |
2024-04-02 |
mouse |
| Yuenan Ban, Xiaolan Yang, Dandan Tan, Chen Gong, Yuan Gao, Jinxian Yuan, Yangmei Chen, You Wang, Tao X. Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy. Neurochemistry international. 2024-03-30. PMID:38555055. |
therefore, reducing the expression of hippocampal sorbs2 could restrain epileptogenesis and the development of tle. |
2024-03-30 |
2024-04-02 |
mouse |
| Yuenan Ban, Xiaolan Yang, Dandan Tan, Chen Gong, Yuan Gao, Jinxian Yuan, Yangmei Chen, You Wang, Tao X. Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy. Neurochemistry international. 2024-03-30. PMID:38555055. |
first, we found that the expression of sorbs2 was obviously increased in the hippocampus and cortex of a tle mouse model and in the temporal cortex of tle patients, indicating an abnormal expression pattern of sorbs2 in tle. |
2024-03-30 |
2024-04-02 |
mouse |
| Yuenan Ban, Xiaolan Yang, Dandan Tan, Chen Gong, Yuan Gao, Jinxian Yuan, Yangmei Chen, You Wang, Tao X. Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy. Neurochemistry international. 2024-03-30. PMID:38555055. |
we also found that the knockdown of sorbs2 in the hippocampus could decrease excitatory synaptic transmission in pyramidal neurons (pns) in the hippocampal ca1 region and reduce the expression levels of the ampar subunits glua1 and glua2. |
2024-03-30 |
2024-04-02 |
mouse |