| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sandeep Sasidharan, Sabu John, Isha Puri, Muhammad Azhar, Mary Mallappalli. Octreotide Causing Hyperkalemia: A Case Report and Review of the Literature. Cureus. vol 16. issue 8. 2024-09-30. PMID:39347364. |
octreotide, a synthetic analog of somatostatin, is widely utilized for its inhibitory effects on various hormones, including growth hormone, insulin, and glucagon. |
2024-09-30 |
2024-10-02 |
Not clear |
| Ifrah I Ali, Crystal D'Souza, Saeed Tariq, Ernest A Adeghat. Adropin Is Expressed in Pancreatic Islet Cells and Reduces Glucagon Release in Diabetes Mellitus. International journal of molecular sciences. vol 25. issue 18. 2024-09-28. PMID:39337311. |
serum levels of insulin, glucagon pancreatic polypeptide (pp), and somatostatin were measured using a luminex |
2024-09-28 |
2024-10-01 |
rat |
| Nirun Hewawasam, Debalina Sakar, Olivia Bolton, Blerinda Delishaj, Maha Almutairi, Aileen King, Ayse S Dereli, Chloe Despontin, Patrick Gilon, Sue Reeves, Michael Patterson, Astrid Christine Hauge-Evan. The GHSR1a antagonist LEAP2 regulates islet hormone release in a sex-specific manner. The Journal of endocrinology. 2024-09-18. PMID:39292603. |
leap2 enhanced insulin secretion in islets from males (p<0.01) but not females (p<0.2), whilst ag-stimulated somatostatin release was significantly reversed by leap2 in males (p<0.001) but not females (p<0.2). |
2024-09-18 |
2024-09-21 |
mouse |
| Nirun Hewawasam, Debalina Sakar, Olivia Bolton, Blerinda Delishaj, Maha Almutairi, Aileen King, Ayse S Dereli, Chloe Despontin, Patrick Gilon, Sue Reeves, Michael Patterson, Astrid Christine Hauge-Evan. The GHSR1a antagonist LEAP2 regulates islet hormone release in a sex-specific manner. The Journal of endocrinology. 2024-09-18. PMID:39292603. |
our findings show that ag and leap2 regulate insulin and somatostatin release in an opposing and sex-dependent manner, which in males can be modulated by e2. |
2024-09-18 |
2024-09-21 |
mouse |
| Sara Heebøll, Gregers Wegener, Henning Grønbæk, Søren Nielse. Comparable glucagon-stimulated amino acid suppression in individuals with and without hepatic steatosis or steatohepatitis. American journal of physiology. Endocrinology and metabolism. 2024-09-18. PMID:39291967. |
we performed a somatostatin clamp with infusions of insulin and low-dose followed by high-dose glucagon. |
2024-09-18 |
2024-09-20 |
human |
| Gal Lenz, Lynn Miao, Ayelet Lenz, Jacob Mares, Janine Quijano, Heather N Zook, Hirotake Komatsu, Pablo Garcia, Kevin Ferreri, Hsun Teresa Ku, Fouad Kandee. Characterization of Human Pancreatic Islet Cells using a Single-Cell Western Blot Platform. Pancreas. 2024-09-11. PMID:39259841. |
in this study, we aimed to test the suitability of scwestern to detect protein markers for beta (insulin), alpha (glucagon), and delta (somatostatin) cells, the three major endocrine cell types in islets. |
2024-09-11 |
2024-09-14 |
human |
| Ho Yan Yeung, Iris Bea L Ramiro, Daniel B Andersen, Thomas Lund Koch, Alexander Hamilton, Walden E Bjørn-Yoshimoto, Samuel Espino, Sergey Y Vakhrushev, Kasper B Pedersen, Noortje de Haan, Agnes L Hipgrave Ederveen, Baldomero M Olivera, Jakob G Knudsen, Hans Bräuner-Osborne, Katrine T Schjoldager, Jens Juul Holst, Helena Safavi-Hemam. Fish-hunting cone snail disrupts prey's glucose homeostasis with weaponized mimetics of somatostatin and insulin. Nature communications. vol 15. issue 1. 2024-08-20. PMID:39164229. |
fish-hunting cone snail disrupts prey's glucose homeostasis with weaponized mimetics of somatostatin and insulin. |
2024-08-20 |
2024-08-23 |
Not clear |
| Elisa Moser, Ayako Ura, Loreen Vogel, Katja Steiger, Carolin Mogler, Matthias Evert, Bruno Märkl, Klemens Scheidhauer, Marc Martignoni, Helmut Friess, Alexander von Werder, Ilaria Marinoni, Aurel Perren, Günter Klöppel, Atsuko Kasajim. ARX, PDX1, ISL1 and CDX2 expression distinguishes five subgroups of PanNETs with correlations to histology, hormone expression and outcome. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2024-08-15. PMID:39147030. |
185 pannets (non-functioning 165, functioning 20) resected between 1996 and 2023 were classified into five subgroups (a1, a2, b, c, d) by cluster analysis based on arx, pdx1, isl1 and cdx2 expression and correlated with trabecular vs. solid histology, expression of insulin, glucagon, pp, somatostatin, serotonin, gastrin, calcitonin, acth, daxx/atrx, men1 and alt status by fish, and disease-free survival (dfs). |
2024-08-15 |
2024-08-18 |
Not clear |
| Elisa Moser, Ayako Ura, Loreen Vogel, Katja Steiger, Carolin Mogler, Matthias Evert, Bruno Märkl, Klemens Scheidhauer, Marc Martignoni, Helmut Friess, Alexander von Werder, Ilaria Marinoni, Aurel Perren, Günter Klöppel, Atsuko Kasajim. ARX, PDX1, ISL1 and CDX2 expression distinguishes five subgroups of PanNETs with correlations to histology, hormone expression and outcome. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2024-08-15. PMID:39147030. |
b (18%, pdx1+/isl1+/arx-/cdx2-) showed solid histology, insulin and somatostatin expression (p<0.001). |
2024-08-15 |
2024-08-18 |
Not clear |
| Lihua Chen, Nannan Wang, Tongran Zhang, Feng Zhang, Wei Zhang, Hao Meng, Jingyi Chen, Zhiying Liao, Xiaopeng Xu, Zhuo Ma, Tao Xu, Huisheng Li. Directed differentiation of pancreatic δ cells from human pluripotent stem cells. Nature communications. vol 15. issue 1. 2024-07-28. PMID:39068220. |
these δ cells display mature rna profiles and fine secretory granules, secrete somatostatin in response to various stimuli, and suppress insulin secretion from in vitro co-cultured β cells and mouse β cells upon transplantation. |
2024-07-28 |
2024-08-02 |
mouse |
| Marianna Franchina, Federica Cavalcoli, Olga Falco, Marta La Milia, Alessandra Elvevi, Sara Massiron. Biochemical Markers for Neuroendocrine Tumors: Traditional Circulating Markers and Recent Development-A Comprehensive Review. Diagnostics (Basel, Switzerland). vol 14. issue 12. 2024-06-27. PMID:38928704. |
this review discusses these developments, focusing on both traditional markers such as cga and nse, as well as specific hormones like gastrin, insulin, somatostatin, glucagon, and vip. |
2024-06-27 |
2024-06-29 |
Not clear |
| Anna-Sophia Liselott Beyer, Daniel Kaemmerer, Jörg Sänger, Amelie Lup. Expression of FAM159B in Humans, Rats, and Mice: A Cross-species Examination. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2024-06-22. PMID:38907656. |
double-labeling immunohistochemistry revealed partial overlap of fam159b expression with that of insulin, glucagon, and somatostatin in human islets. |
2024-06-22 |
2024-06-25 |
mouse |
| Jorge Tamarit-Rodrigue. Regulatory Role of Fatty Acid Metabolism on Glucose-Induced Changes in Insulin and Glucagon Secretion by Pancreatic Islet Cells. International journal of molecular sciences. vol 25. issue 11. 2024-06-19. PMID:38892240. |
islet secretion of glucagon and somatostatin showed a similar dependence on palmitate anabolism as insulin. |
2024-06-19 |
2024-06-21 |
human |
| Jorge Tamarit-Rodrigue. Regulatory Role of Fatty Acid Metabolism on Glucose-Induced Changes in Insulin and Glucagon Secretion by Pancreatic Islet Cells. International journal of molecular sciences. vol 25. issue 11. 2024-06-19. PMID:38892240. |
our own data on the simultaneous stimulation of insulin, glucagon, and somatostatin by glucose, as well as their modification by 2-bromostearate in perifused rat islets, give support to the conclusion that increased ffa anabolism, rather than its mitochondrial oxidation, results in a potentiation of their stimulated release. |
2024-06-19 |
2024-06-21 |
human |
| Annabelle G Hayes, Mark J Penny, Karina Aivazian, Jerry R Greenfiel. Acute Interstitial Nephritis and Oxalate Nephropathy After Rapid Pasireotide Response in Treatment-resistant Acromegaly. JCEM case reports. vol 2. issue 5. 2024-05-21. PMID:38770226. |
pasireotide is known to impair insulin secretion but can also impair pancreatic exocrine function, hypothezised to result from high-affinity binding of somatostatin receptors 1, 2, 3, and 5. |
2024-05-21 |
2024-05-27 |
Not clear |
| Thomas G Hill, David J Hil. The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612880. |
this is mediated partly through circulatory feedback of the major secreted hormones, insulin and glucagon, but also by autocrine and paracrine actions within the islet by a range of other secreted products, including somatostatin, urocortin 3, serotonin, glucagon-like peptide-1, acetylcholine, and ghrelin. |
2024-04-13 |
2024-04-15 |
Not clear |
| Glyn M Noguchi, Vincent C Castillo, Cynthia J Donaldson, Marcus R Flisher, Ariana T Momen, Alan Saghatelian, Mark O Huisin. Urocortin3 contributes to paracrine inhibition of islet alpha cells in mice. The Journal of endocrinology. 2024-04-09. PMID:38593829. |
additionally, urocortin3 (ucn3) is a hormone that is co-released from beta cells with insulin and acts locally to potentiate somatostatin secretion from delta cells. |
2024-04-09 |
2024-04-12 |
mouse |
| Maria Salomon Estebanez, Chris Worth, Indraneel Banerje. Congenital Hyperinsulinism - Notes for the General Pediatrician. Indian pediatrics. 2024-04-08. PMID:38584412. |
specific medical therapies with diazoxide and/or somatostatin receptor analogues may be commenced after the finding of detectable insulin at hypoglycemia, a biochemical characteristic of chi. |
2024-04-08 |
2024-04-10 |
Not clear |
| Alison Murray, Sonia Priscila Rodas Marquez, Mansa Krishnamurthy, Oscar Lopez-Nunez, Juan P Gurria, Andrew T Trout, Susan Almazan, Krishnamallika Mutyala, Amy Shah, Jonathan Howel. Multifocal Insulinoma as the Unique Presenting Feature of MEN1 in an Adolescent. Hormone research in paediatrics. 2024-03-05. PMID:38442699. |
while the primary lesion stained for insulin and somatostatin by immunofluorescence (if), consistent with his clinical presentation, the additional tumors expressed glucagon, somatostatin, pancreatic polypeptide, and chromogranin a but were negative for insulin. |
2024-03-05 |
2024-03-08 |
Not clear |
| Ali H Shilleh, Katrina Viloria, Johannes Broichhagen, Jonathan E Campbell, David J Hodso. GLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells and delta cells. Peptides. 2024-02-15. PMID:38360354. |
glucagon-like peptide 1 receptor (glp1r) and glucose-dependent insulinotropic polypeptide receptor (gipr) are transmembrane receptors involved in insulin, glucagon and somatostatin secretion from the pancreatic islet. |
2024-02-15 |
2024-02-18 |
Not clear |