| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Irum Waheed, Talal Sikandri, Sumbal Zaheen, Muhammad Mahtab Aslam Khan Khakwani, Zhaowu An, Tingting Liu, Chaoyang Zhu, Jianshe We. Evaluating the Molecular Interactions between Type 2 Diabetes Mellitus and Parkinson's Disease: Role of Antidiabetic Drugs as Promising Therapeutics. ACS chemical neuroscience. 2025-03-05. PMID:40042145. |
it inhibits neuronal function through disrupted insulin signaling and oxidative stress, which ultimately lead to the loss of dopaminergic neurons in the substantia nigra (sn). |
2025-03-05 |
2025-03-07 |
Not clear |
| Feng Xue, Mei Zhang, Rui-Yue Zhao, Xiao-Wen Wang, Yu Gu, Ye Yang, Wen-Fang Che. Dectin-1 participates in neuroinflammation and dopaminergic neurodegeneration through synergistic signaling crosstalk with TLR4. Brain, behavior, and immunity. 2025-02-20. PMID:39978698. |
inhibition of dectin-1 by laminarin (lam) attenuated lps-induced dopaminergic neuronal damage in substantia nigra (sn) and behavioral deficits, and promoted the phenotypic transformation of microglia from m1 to m2. |
2025-02-20 |
2025-02-23 |
mouse |
| Feng Xue, Mei Zhang, Rui-Yue Zhao, Xiao-Wen Wang, Yu Gu, Ye Yang, Wen-Fang Che. Dectin-1 participates in neuroinflammation and dopaminergic neurodegeneration through synergistic signaling crosstalk with TLR4. Brain, behavior, and immunity. 2025-02-20. PMID:39978698. |
in conclusion, dectin-1-syk synergistic signaling crosstalk with tlr4/nf-κb promotes and maintains inflammatory phenotypes of m1 microglia which induces dopaminergic neuronal damage in sn. |
2025-02-20 |
2025-02-23 |
mouse |
| Alyssa M Wilson, Michelle M Jacobs, Tova Y Lambert, Aditi Valada, Gregory Meloni, Evan Gilmore, Jacinta Murray, Susan Morgello, Schahram Akbaria. Transcriptional impacts of substance use disorder and HIV on human ventral midbrain neurons and microglia. bioRxiv : the preprint server for biology. 2025-02-20. PMID:39974894. |
stepwise, progressive microglial dysregulation, coupled to altered sn dopaminergic and gabaergic signaling, was associated with sud/hiv dual diagnosis and further with lack of viral suppression in blood. |
2025-02-20 |
2025-02-23 |
human |
| Alyssa M Wilson, Michelle M Jacobs, Tova Y Lambert, Aditi Valada, Gregory Meloni, Evan Gilmore, Jacinta Murray, Susan Morgello, Schahram Akbaria. Transcriptional impacts of substance use disorder and HIV on human ventral midbrain neurons and microglia. bioRxiv : the preprint server for biology. 2025-02-20. PMID:39974894. |
we report hiv-related downregulation of monoamine reuptake transporters specifically in dopaminergic neurons regardless of sud status or viral load, and additional transcriptional signatures consistent with selective vulnerability of sn dopamine neurons. |
2025-02-20 |
2025-02-23 |
human |
| Rana M Merghany, Salma A El-Sawi, Asmaa F Aboul Naser, Mohamed A Salem, Shahira M Ezzat, Sherifa F A Moustafa, Meselhy R Meselh. Pelargonium graveolens Attenuates Rotenone-Induced Parkinson's Disease in a Rat Model: Role of MAO-B Inhibition and In Silico Study. Molecular neurobiology. 2025-02-08. PMID:39921688. |
parkinson's disease (pd), the second most common neurodegenerative condition, is primarily characterized by motor dysfunctions due to dopaminergic neuronal loss in the substantia nigra (sn), with oxidative stress playing a significant role in its progression. |
2025-02-08 |
2025-02-11 |
rat |
| M Garcia-Gomara, N Legarra-Marcos, M Serena, E Rojas-de-Miguel, M Espelosin, I Marcilla, A Perez-Mediavilla, M R Luquin, J L Lanciego, M A Burrel, M Cuadrado-Tejedor, A Garcia-Ost. FKBP5 Inhibition Ameliorates Neurodegeneration and Motor Dysfunction in the Neuromelanin-SNCA Mouse Model of Parkinson's Disease. Molecular therapy : the journal of the American Society of Gene Therapy. 2025-02-05. PMID:39905728. |
we found that this mouse strain develops naturally progressive motor dysfunction and dopaminergic neuronal loss in the sn with aging. |
2025-02-05 |
2025-02-07 |
mouse |
| Ankumoni Dutta, Rubina Roy, Mritunjay Pandey, Sushila Chhetry, Banashree Chetia Phukan, Abhideep Roy, Pallab Bhattacharya, Anupom Bora. Arsenic-induced mice model of Parkinson's disease: Revealing the neurotoxicity of arsenic through mitochondrial complexes inhibition and dopaminergic neurodegeneration in the substantia nigra region of brain. Brain research. 2025-02-05. PMID:39909295. |
however, the impact of arsenic toxicity on the dopaminergic neurons of substantia nigra (sn), the hallmark region which degenerates in pd, has not been shown yet. |
2025-02-05 |
2025-02-08 |
mouse |
| Ankumoni Dutta, Rubina Roy, Mritunjay Pandey, Sushila Chhetry, Banashree Chetia Phukan, Abhideep Roy, Pallab Bhattacharya, Anupom Bora. Arsenic-induced mice model of Parkinson's disease: Revealing the neurotoxicity of arsenic through mitochondrial complexes inhibition and dopaminergic neurodegeneration in the substantia nigra region of brain. Brain research. 2025-02-05. PMID:39909295. |
in the present study, administration of 20 mg/kg b.w., arsenic for 28 days caused significant loss of dopaminergic neurons and their terminals respectively in the sn and striatum regions of mice brain. |
2025-02-05 |
2025-02-08 |
mouse |
| Samantha Edwards, Frances Corrigan, Lyndsey Collins-Prain. Lasting Impact: Exploring the Brain Mechanisms that Link Traumatic Brain Injury to Parkinson's Disease. Molecular neurobiology. 2025-02-01. PMID:39891816. |
of note, many key parallels have been identified between the pathologies of pd and tbi; in particular, pd is characterised by loss of dopaminergic neurons from the substantia nigra (sn), accompanied by broader changes to dopaminergic signalling, disruption of the locus coeruleus (lc) and noradrenergic system, and accumulation of aggregated α-synuclein in lewy bodies, which spreads in a stereotypical pattern throughout the brain. |
2025-02-01 |
2025-02-04 |
Not clear |
| Samantha Edwards, Frances Corrigan, Lyndsey Collins-Prain. Lasting Impact: Exploring the Brain Mechanisms that Link Traumatic Brain Injury to Parkinson's Disease. Molecular neurobiology. 2025-02-01. PMID:39891816. |
widespread disruptions to the dopaminergic and noradrenergic systems, including progressive neuronal loss from the sn and lc, have been observed acutely following injury, some of which have also been identified chronically in tbi patients and preclinical models. |
2025-02-01 |
2025-02-04 |
Not clear |
| Rong Sha, Mingzhe Wu, Pengfei Wang, Ziyuan Chen, Wei Lei, Shimiao Wang, Shun Gong, Guobiao Liang, Rui Zhao, Yingqun Ta. Adolescent mice exposed to TBI developed PD-like pathology in middle age. Translational psychiatry. vol 15. issue 1. 2025-01-25. PMID:39863574. |
traumatic brain injury (tbi) is identified as a risk factor for parkinson's disease (pd), which is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2025-01-25 |
2025-01-28 |
mouse |
| Ardra Chakrabarti, Sonia Verm. Identifying potential genes driving ferroptosis in the substantia nigra and dopaminergic neurons in Parkinson's disease. Molecular and cellular neurosciences. 2025-01-23. PMID:39848553. |
parkinson's disease (pd) is a neurodegenerative disorder marked by dopaminergic (da) neuron degeneration in the substantia nigra (sn). |
2025-01-23 |
2025-01-26 |
Not clear |
| Fen-Fen Xu, Zhan Liu, Xiao-Xia Fang, Bei-Bei Cao, Yan Huang, Yu-Ping Peng, Yi-Hua Qi. Microglia-derived exosomal ciRS-7 mediates IL-17A effect of promoting neurodegeneration via miR-7 and SNCA targets in an experimental Parkinson's disease. International immunopharmacology. vol 148. 2025-01-20. PMID:39832458. |
parkinson' s disease (pd) is a chronic neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2025-01-20 |
2025-01-23 |
mouse |
| Fen-Fen Xu, Zhan Liu, Xiao-Xia Fang, Bei-Bei Cao, Yan Huang, Yu-Ping Peng, Yi-Hua Qi. Microglia-derived exosomal ciRS-7 mediates IL-17A effect of promoting neurodegeneration via miR-7 and SNCA targets in an experimental Parkinson's disease. International immunopharmacology. vol 148. 2025-01-20. PMID:39832458. |
injection with exosomes derived from il-17a-treated bv-2 altered cirs-7, mir-7 and snca expression in sn in mptp-intoxicated mice and promoted nigrostriatal dopaminergic neurodegeneration and motor impairment. |
2025-01-20 |
2025-01-23 |
mouse |
| Paula Trujillo, Kaitlyn R O'Rourke, Olivia C Roman, Alexander K Song, Kilian Hett, Amy Cooper, Bonnie K Black, Manus J Donahue, Cyndya A Shibao, Italo Biaggioni, Daniel O Claasse. Central Involvement in Pure Autonomic Failure: Insights from Neuromelanin-Sensitive Magnetic Resonance Imaging and Movement disorders : official journal of the Movement Disorder Society. 2025-01-18. PMID:39825743. |
central involvement in pure autonomic failure: insights from neuromelanin-sensitive magnetic resonance imaging and central synucleinopathies, including parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa), involve alpha-synuclein accumulation and dopaminergic cell loss in the substantia nigra (sn) and locus coeruleus (lc). |
2025-01-18 |
2025-01-21 |
Not clear |
| Satya Eswari Jujjavarapu, Arnav Mishr. Unravelling the Role of Tyrosine and Tyrosine Hydroxylase in Parkinson's Disease: Exploring Nanoparticle-based Gene Therapies. CNS & neurological disorders drug targets. 2025-01-15. PMID:39812066. |
the pathogenesis comes from the breakdown of dopaminergic neurons within substantia nigra (sn) by the action of tyrosinase enzyme and subsequent accumulation of α-synuclein within the neurons. |
2025-01-15 |
2025-01-17 |
Not clear |
| Ayuka Ehara, Nozomi Ito, Kazuhiko Nakadate, Nobuko Tokud. Localization of Melanocortin 1 Receptor in the Substantia Nigra. International journal of molecular sciences. vol 26. issue 1. 2025-01-11. PMID:39796093. |
recent findings have revealed that melanocortin 1 receptor (mc1r) deficiency leads to parkinson's disease-like dopaminergic neurodegeneration in the substantia nigra (sn). |
2025-01-11 |
2025-01-14 |
Not clear |
| Ayuka Ehara, Nozomi Ito, Kazuhiko Nakadate, Nobuko Tokud. Localization of Melanocortin 1 Receptor in the Substantia Nigra. International journal of molecular sciences. vol 26. issue 1. 2025-01-11. PMID:39796093. |
our findings reveal that mc1r was slightly present in dopaminergic neurons in the ventral tier of sn pars compacta dorsal (vsncd), a region particularly vulnerable to pd-related neurodegeneration. |
2025-01-11 |
2025-01-14 |
Not clear |
| Nehal Shawky Nagy, Mohamed Helal, Eman Sheta Alsawy, Mohamad Moustafa Ali, Soheir Salem Al-Sherif, Amina Essawy Essaw. Paracentrotus lividus sea urchin gonadal extract mitigates neurotoxicity and inflammatory signaling in a rat model of Parkinson's disease. PloS one. vol 19. issue 12. 2024-12-18. PMID:39693313. |
parkinson's disease, characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn), is exacerbated by oxidative stress and neuroinflammation. |
2024-12-18 |
2024-12-21 |
rat |