| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongyan Feng, Ning Tu, Ke Wang, Xiaowei Ma, Zhentao Zhang, Zhongchun Liu, Zhen Cheng, Lihong B. Neuromelanin-targeted 18 F-P3BZA PET/MR imaging of the substantia nigra in rhesus macaques. EJNMMI research. vol 14. issue 1. 2024-09-03. PMID:39225971. |
neuromelanin is mostly located in dopaminergic neurons in the substantia nigra (sn) pars compacta, and can be detected by magnetic resonance imaging (mri). |
2024-09-03 |
2024-09-05 |
Not clear |
| Zahra Baridjavadi, Mahmoud Mahmoudi, Narges Abdollahi, Negar Ebadpour, Samaneh Mollazadeh, Dariush Haghmorad, Seyed-Alireza Esmaeil. The humoral immune landscape in Parkinson's disease: Unraveling antibody and B cell changes. Cell biochemistry and function. vol 42. issue 7. 2024-08-27. PMID:39189398. |
parkinson's disease (pd) is a complex neurodegenerative disorder characterized by the accumulation of α-synuclein (α-syn) in the brain and progressive loss of dopaminergic neurons in the substantia nigra (sn) region of the brain. |
2024-08-27 |
2024-08-30 |
Not clear |
| Ying He, Ruicheng Li, Yuxi Yu, Zhiran Xu, Jiaxin Gao, Cancan Wang, Chushen Huang, Zhongquan Q. HucMSC extracellular vesicles increasing SATB 1 to activate the Wnt/β-catenin pathway in 6-OHDA-induced Parkinson's disease model. IUBMB life. 2024-07-31. PMID:39082886. |
parkinson's disease (pd) is a degenerative disorder of the nervous system characterized by the loss of dopaminergic neurons and damage of neurons in the substantia nigra (sn) and striatum, resulting in impaired motor functions. |
2024-07-31 |
2024-08-02 |
mouse |
| Divya Bharathi Selvaraj, Anusiya Panneerselvam, Jemi Feiona Vergil Andrews, Mahesh Kandasam. Cysteamine HCl Administration Impedes Motor and Olfactory Functions, Accompanied by a Reduced Number of Dopaminergic Neurons, in Experimental Mice: A Preclinical Mimetic Relevant to Parkinson's Disease. Brain sciences. vol 14. issue 7. 2024-07-27. PMID:39061373. |
furthermore, we investigated the effect of cys-hcl on the number of dopaminergic tyrosine hydroxylase (th)-positive cells in the substantia nigra (sn) and olfactory bulb (ob) of the experimental mice using immunohistochemistry. |
2024-07-27 |
2024-07-29 |
mouse |
| Lennart Höfs, David Geißler-Lösch, Kristof M Wunderlich, Eva M Szegö, Chris Van den Haute, Veerle Baekelandt, Wolfgang Hoyer, Björn H Falkenburge. Evaluation of the Effect of β-Wrapin AS69 in a Mouse Model Based on Alpha-Synuclein Overexpression. Biomolecules. vol 14. issue 7. 2024-07-27. PMID:39062470. |
transduction with raav-αsyn resulted in αsyn pathology as reported by phospho-αsyn staining and caused degeneration of dopaminergic neurons in the sn. |
2024-07-27 |
2024-07-29 |
mouse |
| Yi Zhuo, Wen-Shui Li, Wen Lu, Xuan Li, Li-Te Ge, Yan Huang, Qing-Tao Gao, Yu-Jia Deng, Xin-Chen Jiang, Zi-Wei Lan, Que Deng, Yong-Heng Chen, Yi Xiao, Shuo Lu, Feng Jiang, Zuo Liu, Li Hu, Yu Liu, Yu Ding, Zheng-Wen He, De-An Tan, Da Duan, Ming L. TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson's disease models and patients. Military Medical Research. vol 11. issue 1. 2024-07-21. PMID:39034405. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra (sn). |
2024-07-21 |
2024-07-24 |
Not clear |
| Wessam H Elesawy, Ayman E El-Sahar, Rabab H Sayed, Ahmed M Ashour, Shuruq E Alsufyani, Hany H Arab, Esraa A Kandi. Repurposing ezetimibe as a neuroprotective agent in a rotenone-induced Parkinson's disease model in rats: Role of AMPK/SIRT-1/PGC-1α signaling and autophagy. International immunopharmacology. vol 138. 2024-07-09. PMID:38981225. |
as a severe neurological disorder, parkinson's disease (pd) is distinguished by dopaminergic neuronal degeneration in the substantia nigra (sn), culminating in motor impairments. |
2024-07-09 |
2024-07-12 |
rat |
| Damien Meng-Kiat Leow, Irwin Kee-Mun Cheah, Lucrecia Chen, Yang-Kai Ng, Crystal Jing-Jing Yeo, Barry Halliwell, Wei-Yi On. Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons. Antioxidants (Basel, Switzerland). vol 13. issue 6. 2024-06-27. PMID:38929132. |
cell death involving oxidative stress and mitochondrial dysfunction is a major cause of dopaminergic neuronal loss in the substantia nigra (sn) of parkinson's disease patients. |
2024-06-27 |
2024-06-29 |
human |
| Zhengyang Yao, Fengju Jia, Shuhua Wang, Qian Jiao, Xixun Du, Xi Chen, Hong Jian. The involvement of IRP2-induced ferroptosis through the p53-SLC7A11-ALOX12 pathway in Parkinson's disease. Free radical biology & medicine. 2024-06-27. PMID:38936518. |
iron deposits induced by increased tfr1 and dopaminergic neuronal loss were observed in the sn. |
2024-06-27 |
2024-06-30 |
mouse |
| Bruna da Silva Oliveira, Eliana Cristina de Brito Toscano, Larissa Katharina Sabino Abreu, Heliana de Barros Fernandes, Renan Florindo Amorim, Rodrigo Novaes Ferreira, Caroline Amaral Machado, Brener Cunha Carvalho, Maria Carolina Machado da Silva, Antônio Carlos Pinheiro de Oliveira, Milene Alvarenga Rachid, Natália Pessoa Rocha, Antônio Lúcio Teixeira, Elizabeth Ribeiro da Silva, Aline Silva de Mirand. Nigrostriatal Inflammation Is Associated with Nonmotor Symptoms in an Experimental Model of Prodromal Parkinson's Disease. Neuroscience. vol 549. 2024-05-22. PMID:38750924. |
intranasal mptp infusion was able to cause the loss of dopaminergic neurons in the substantia nigra (sn). |
2024-05-22 |
2024-05-27 |
mouse |
| Xia-Yin Cao, Yi Liu, Jia-Shuo Kan, Xin-Xing Huang, Piniel Alphayo Kambey, Can-Tang Zhang, Jin Ga. Microglial SIX2 suppresses lipopolysaccharide (LPS)-induced neuroinflammation by up-regulating FXYD2 expression. Brain research bulletin. 2024-04-30. PMID:38688414. |
parkinson's disease (pd) is a severe neurodegenerative disease associated with the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2024-04-30 |
2024-05-03 |
Not clear |
| Noelia Morales-Prieto, Rebekah Bevans, Adam O'Mahony, Aaron Barron, Conor Giles Doran, Erin McCarthy, Ruth M Concannon, Susan R Goulding, Cathal M McCarthy, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. Human α-synuclein overexpression upregulates SKOR1 in a rat model of simulated nigrostriatal ageing. Aging cell. 2024-03-26. PMID:38529808. |
parkinson's disease (pd) is characterised by progressive loss of dopaminergic (da) neurons from the substantia nigra (sn) and α-synuclein (αsyn) accumulation. |
2024-03-26 |
2024-03-28 |
human |
| Jianing Shen, Junhua Xie, Liyuan Ye, Jian Mao, Shihao Sun, Weiwei Chen, Sijia Wei, Sisi Ruan, Linhai Wang, Hangcui Hu, Jingjing Wei, Yao Zheng, Zhouyan Xi, Ke Wang, Yan X. Neuroprotective effect of green tea extract (-)-epigallocatechin-3-gallate in a preformed fibril-induced mouse model of Parkinson's disease. Neuroreport. 2024-03-25. PMID:38526966. |
parkinson's disease (pd) is the second most common neurodegenerative disease characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2024-03-25 |
2024-03-28 |
mouse |
| Lihong Deng, Wei Wei, Chunxia Qiao, Yubing Yin, Xiaojing Li, Hua Yu, Lingqi Jian, Xiaohong Ma, Liansheng Zhao, Qiang Wang, Wei Deng, Wanjun Guo, Tao L. Dynamic aberrances of substantia nigra-relevant coactivation patterns in first-episode treatment-naïve patients with schizophrenia. Psychological medicine. 2024-03-25. PMID:38523252. |
this study investigates the dynamic coactivation patterns (caps) associated with the substantia nigra (sn), a key dopaminergic nucleus, in first-episode treatment-naïve patients with schizophrenia (fes). |
2024-03-25 |
2024-03-27 |
Not clear |
| A Amini, F Esmaeili, M Golpic. Possible role of lncRNAs in amelioration of Parkinson's disease symptoms by transplantation of dopaminergic cells. NPJ Parkinson's disease. vol 10. issue 1. 2024-03-13. PMID:38472261. |
behavioral and histopathological examinations revealed that cell transplantation partially compensated dopaminergic cell degeneration in st and substantia nigra (sn) of pd rats. |
2024-03-13 |
2024-03-15 |
rat |
| Ziliang He, Yeye Hu, Ying Zhang, Jing Xie, Zhiqiang Niu, Guigui Yang, Ji Zhang, Zixuan Zhao, Shuai Wei, Haifeng Wu, Weicheng H. Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 127. 2024-03-12. PMID:38471370. |
parkinson's disease (pd), a neurodegenerative disorder, is characterized by motor symptoms due to the progressive loss of dopaminergic neurons in the substantia nigra (sn) and striatum (str), alongside neuroinflammation. |
2024-03-12 |
2024-03-15 |
Not clear |
| Yina Jia, Jing Li, Yutong Wang, Yiqing Ma, Lei Chen, Huaqi Zhang, Meilan Xue, Hui Lian. Folic Acid Rescues Dopaminergic Neurons in MPTP-Induced Mice by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment. Journal of agricultural and food chemistry. 2024-03-07. PMID:38453725. |
parkinson's disease (pd) is marked by the degeneration of dopaminergic neurons of the substantia nigra (sn), with neuroinflammation and mitochondrial dysfunction being key contributors. |
2024-03-07 |
2024-03-10 |
mouse |
| Marta Esteves, Ana Clara Cristóvão, Ana Vale, Marta Machado-Pereira, Raquel Ferreira, Liliana Bernardin. MicroRNA-124-3p Modulates Alpha-Synuclein Expression Levels in a Paraquat-Induced in vivo Model for Parkinson's Disease. Neurochemical research. 2024-03-07. PMID:38451434. |
moreover, mir-124-3p was able to counteract the reduced levels of pituitary homeobox 3 (pitx3), a protein required for the dopaminergic phenotype, induced by pq in the sn. |
2024-03-07 |
2024-03-09 |
rat |
| Alex I Wiesman, Victoria Madge, Edward A Fon, Alain Dagher, D Louis Collins, Sylvain Baille. Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease. medRxiv : the preprint server for health sciences. 2024-02-26. PMID:38405952. |
parkinson's disease (pd) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (sn) and the locus coeruleus (lc), respectively, resulting in motor and cognitive impairments. |
2024-02-26 |
2024-02-28 |
Not clear |
| Qing He, Shuzhen Zhang, Jian Wang, Tengfei Ma, Ding Ma, Li Wu, Mengxi Zhou, Lei Zhao, Yajing Chen, Jianren Liu, Wei Che. The Synergistic Effect Study of Lipopolysaccharide (LPS) and A53T-α-Synuclein: Intranasal LPS Exposure on the A53T-α-Synuclein Transgenic Mouse Model of Parkinson's Disease. Molecular neurobiology. 2024-02-17. PMID:38367134. |
according to our results, after intranasal administration of lps, a53t-α-syn mice showed severe progressive anosmia, hypokinesia, selective dopaminergic (daergic) neuronal losses, decreased striatal dopamine (da) level, and enhanced α-synuclein accumulation within the substantia nigra (sn) in an age-dependent way. |
2024-02-17 |
2024-02-20 |
mouse |