| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard Wismayer, Rosie Matthews, Celina Whalley, Julius Kiwanuka, Fredrick Elishama Kakembo, Steve Thorn, Henry Wabinga, Michael Odida, Ian Tomlinso. Determination of the frequency and distribution of APC, PIK3CA, and SMAD4 gene mutations in Ugandan patients with colorectal cancer. BMC cancer. vol 24. issue 1. 2024-10-01. PMID:39350061. |
in our population, there is a scarcity of genetic oncological studies, therefore, we investigated the mutational status of crc tissues, focusing in particular on the adenomatous polyposis coli (apc), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca), and smad4 genes. |
2024-10-01 |
2024-10-03 |
Not clear |
| Xin He, Xin Zhang, Xin Zhao, Xiaoju Li, Ke Chen, Yingying Liao, Xiechen Feng, Yiyan Zo. Botulinum toxin combined with static progressive stretching improves fibrous stiffness of knee joint in rats through TGF-β1/Smad pathway. Biomolecules & biomedicine. 2024-07-22. PMID:39038240. |
the therapeutic effect of each intervention was assessed by the range of motion (rom) of the knee joint, joint stiffness, the number of total cells, and collagen deposition in the posterior joint capsule, as well as the protein level expressions of tgf-β1, smad2, smad3, smad4, p-smad2/3, collagen i and iii, and alpha smooth muscle actin (α-sma) in the posterior joint capsule in the tgf-β1/smad pathway. |
2024-07-22 |
2024-07-25 |
rat |
| Taito Itoh, Yuko Omori, Mitsuru Seino, Katsuya Hirose, Fumiko Date, Yusuke Ono, Yusuke Mizukami, Shuichi Aoki, Masaharu Ishida, Masamichi Mizuma, Takanori Morikawa, Ryota Higuchi, Goro Honda, Yasunobu Okamura, Kengo Kinoshita, Michiaki Unno, Toru Furukaw. Gene rearrangement and expression of PRKACA and PRKACB governs morpho-biology of pancreatobiliary oncocytic neoplasms. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2023-10-23. PMID:37871652. |
we analyzed prkaca/b fusion genes including atp1b1-prkaca, dnajb1-prkaca, and atp1b1-prkacb by reverse transcription pcr (rt-pcr); mrna expression of fusion genes and non-rearranged prkaca/b genes by quantitative rt-pcr; mutations in kras, braf, and gnas by targeted sequencing or droplet digital pcr; and the expression of camp-dependent protein kinase catalytic subunit alpha (prkaca) and beta (prkacb), phosphorylated-creb, and aberrations of p16, p53, smad4, stk11, and β-catenin by immunohistochemistry. |
2023-10-23 |
2023-11-08 |
Not clear |
| Efstathios T Pavlidis, Konstantinos G Sapalidis, Theodoros E Pavlidi. Modern aspects of the management of pancreatic intraductal papillary mucinous neoplasms: a narrative review. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 63. issue 3. 2023-01-02. PMID:36588487. |
the genes most frequently altered include kirsten rat sarcoma viral proto-oncogene (kras), tumor protein p53 (tp53), cyclin-dependent kinase inhibitor 2a (cdkn2a), smad family member 4 (smad4), and guanine nucleotide-binding protein, alpha stimulating (gnas). |
2023-01-02 |
2023-08-14 |
rat |
| Huajie Song, Jianqun Wang, Xiaojing Wang, Boling Yuan, Dan Li, Anpei Hu, Yanhua Guo, Shuang Cai, Shikai Jin, Yi Zhou, Qilan Li, Guo Chen, Haiyang Gao, Liduan Zheng, Qiangsong Ton. HNF4A-AS1-encoded small peptide promotes self-renewal and aggressiveness of neuroblastoma stem cells via eEF1A1-repressed SMAD4 transactivation. Oncogene. 2022-03-23. PMID:35318442. |
mechanistically, spep1 directly interacted with eukaryotic translation elongation factor 1 alpha 1 (eef1a1) to facilitate its binding to smad family member 4 (smad4), resulting in repression of smad4 transactivation and transcriptional upregulation of stem cell genes associated with tumor progression. |
2022-03-23 |
2023-08-13 |
Not clear |
| Lea Landolt, Jessica Furriol, Janka Babickova, Lavina Ahmed, Øystein Eikrem, Trude Skogstrand, Andreas Scherer, Salwa Suliman, Sabine Leh, James B Lorens, Gro Gausdal, Hans-Peter Marti, Tarig Osma. AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction. Physiological reports. vol 7. issue 10. 2020-06-08. PMID:31134766. |
reduced ihc staining for vimentin (vim) and alpha smooth muscle actin (αsma), as well as reduced mrna abundance of key regulators of fibrosis such as transforming growth factor (tgfβ), matrix metalloproteinase 2 (mmp2), smad2, smad4, myofibroblast activation (aldh1a2, crlf1), and emt (snai1,2, twist), in ligated bemcentinib-treated kidneys was compatible with reduced (partial) emt induction. |
2020-06-08 |
2023-08-13 |
mouse |
| T Xu, Y X Wu, J X Sun, F C Wang, Z Q Cui, X H X. The role of miR-145 in promoting the fibrosis of pulmonary fibroblasts. Journal of biological regulators and homeostatic agents. vol 33. issue 5. 2019-11-06. PMID:31637903. |
in addition, the qpcr (quantitative real-time polymerase chain reaction) and western blot were applied to detect the mrna and protein expressions of mir-145, tgf-β1 (transforming growth factor beta 1), smad3, smad4, mmp2 (matrix metalloproteinase 2), fn1 (fibronectin 1), eln (elastin) and coli α1 (collagen type i alpha 1) signaling molecules in tgf-β/smad fibrosis pathway. |
2019-11-06 |
2023-08-13 |
Not clear |
| Liang Li, Mahesh Sapkota, Ming Gao, Hyukjae Choi, Yunjo So. Macrolactin F inhibits RANKL-mediated osteoclastogenesis by suppressing Akt, MAPK and NFATc1 pathways and promotes osteoblastogenesis through a BMP-2/smad/Akt/Runx2 signaling pathway. European journal of pharmacology. vol 815. 2018-07-05. PMID:28919027. |
interestingly, mf promoted pre-osteoblast cell differentiation on alizarin red-mineralization activity, alkaline phosphatase (alp) activity, and the expression of osteoblastogenic markers including runx2, osterix, smad4, alp, type i collagen alpha 1 (col1α), osteopontin (opn), and osteocalcin (ocn) via activation of the bmp-2/smad/akt/runx2 pathway on mc3t3-e1. |
2018-07-05 |
2023-08-13 |
Not clear |
| Po-Ju Chen, Jung-Kai Tseng, Yi-Ling Lin, Yi-Hsieng Samuel Wu, Yi-Tse Hsiao, Jr-Wei Chen, Yi-Chen Che. Protective Effects of Functional Chicken Liver Hydrolysates against Liver Fibrogenesis: Antioxidation, Anti-inflammation, and Antifibrosis. Journal of agricultural and food chemistry. vol 65. issue 24. 2017-07-03. PMID:28561587. |
a significant up-regulation of transforming growth factor-beta (tgf-β) and smad family member 4 (smad4) caused by taa treatment further enhanced alpha smooth muscle actin (αsma) gene and protein expressions. |
2017-07-03 |
2023-08-13 |
rat |
| Zheyu Niu, Mengyi Wang, Li Zhou, Lutian Yao, Quan Liao, Yupei Zha. Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer. Scientific reports. vol 5. 2016-10-24. PMID:26530532. |
in an in vitro study, the regulation of grp78 in the pdac cell lines affected the proliferation, migration, and invasion of pdac cells through the regulation of cyclind1, cyclin-dependent kinase (cdk) 4, cdk6, phospho-signal transducer, activator of transcription 3 (p-stat3), janus kinase 2 (jak2), ras homolog gene family member a (rhoa), rho-associated kinase 1 (rock1), and sterile alpha motif domain containing protein 4 (smad4). |
2016-10-24 |
2023-08-13 |
Not clear |
| Carmen Chak-Lui Wong, Aki Pui-Wah Tse, Yan-Ping Huang, Yan-Ting Zhu, David Kung-Chun Chiu, Robin Kit-Ho Lai, Sandy Leung-Kuen Au, Alan Ka-Lun Kai, Joyce Man-Fong Lee, Larry Lai Wei, Felice Ho-Ching Tsang, Regina Cheuk-Lam Lo, Jue Shi, Yong-Ping Zheng, Chun-Ming Wong, Irene Oi-Lin N. Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma. Hepatology (Baltimore, Md.). vol 60. issue 5. 2014-12-30. PMID:25048396. |
we found not only that loxl2 was regulated by hypoxia/hypoxia-inducible factor 1 alpha (hif-1α), but also that tgf-β activated loxl2 transcription through mothers against decapentaplegic homolog 4 (smad4), whereas two frequently underexpressed mirna families, mir-26 and mir-29, cooperatively suppressed loxl2 transcription through interacting with the 3' untranslated region of loxl2. |
2014-12-30 |
2023-08-13 |
Not clear |
| Xu Zhang, Min Xie, Yan Gao, Hua-Hua Wei, Jia-Qun Zhen. [Study on the effect and mechanism of hypoxia on the histological structure of rat's lung]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 43. issue 1. 2012-08-06. PMID:22455120. |
objective; to observe the effect of intermittent normobaric hypoxia on the expression of transforming growth factor betal (tgf-beta1), smad4, collagen i (col i), tumor necrosis factor alpha (tnf-alpha) and on the changes in the histological structure of spf sd rat's lung. |
2012-08-06 |
2023-08-12 |
rat |
| Dirk Zboralski, Miriam Böckmann, Marc Zapatka, Sabine Hoppe, Anna Schöneck, Stephan A Hahn, Wolff Schmiegel, Irmgard Schwarte-Waldhof. Divergent mechanisms underlie Smad4-mediated positive regulation of the three genes encoding the basement membrane component laminin-332 (laminin-5). BMC cancer. vol 8. 2008-11-18. PMID:18664273. |
laminin-332 (laminin-5), a heterotrimeric bm component composed of alpha 3-, beta 3- and gamma 2-chains, has recently been identified as a target structure of smad4 and represents the first example for expression control of an essential bm component by a tumor and invasion suppressor. |
2008-11-18 |
2023-08-12 |
Not clear |
| Chenbei Chang, Ali H Brivanlou, Richard M Harlan. Function of the two Xenopus smad4s in early frog development. The Journal of biological chemistry. vol 281. issue 41. 2006-11-27. PMID:16908518. |
two smad4 genes (alpha and beta/10, or smad4 and smad4.2) have been isolated from xenopus, and conflicting data are reported for smad4beta/10 actions in mesodermal and neural induction. |
2006-11-27 |
2023-08-12 |
xenopus_laevis |
| Tristan A Rodriguez, Duncan B Sparrow, Annabelle N Scott, Sarah L Withington, Jost I Preis, Jan Michalicek, Melanie Clements, Tania E Tsang, Toshi Shioda, Rosa S P Beddington, Sally L Dunwoodi. Cited1 is required in trophoblasts for placental development and for embryo growth and survival. Molecular and cellular biology. vol 24. issue 1. 2004-01-21. PMID:14673158. |
cited1 is a transcriptional cofactor that interacts with smad4, estrogen receptors alpha and beta, tfap2, and cbp/p300. |
2004-01-21 |
2023-08-12 |
mouse |
| Liyu Wu, Yalei Wu, Bill Gathings, Mei Wan, Xuelin Li, William Grizzle, Zhiyong Liu, Chongyuan Lu, Zhengkuan Mao, Xu Ca. Smad4 as a transcription corepressor for estrogen receptor alpha. The Journal of biological chemistry. vol 278. issue 17. 2003-07-16. PMID:12576474. |
smad4 as a transcription corepressor for estrogen receptor alpha. |
2003-07-16 |
2023-08-12 |
human |
| Liyu Wu, Yalei Wu, Bill Gathings, Mei Wan, Xuelin Li, William Grizzle, Zhiyong Liu, Chongyuan Lu, Zhengkuan Mao, Xu Ca. Smad4 as a transcription corepressor for estrogen receptor alpha. The Journal of biological chemistry. vol 278. issue 17. 2003-07-16. PMID:12576474. |
upon examining the molecular mechanisms, we found that smad4, a common signal transducer in the bone morphogenetic protein (bmp)/transforming growth factor-beta (tgf-beta) signaling pathway, functions as a transcription corepressor for human estrogen receptor alpha (eralpha). |
2003-07-16 |
2023-08-12 |
human |
| Zhan Xiao, Robert Latek, Harvey F Lodis. An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity. Oncogene. vol 22. issue 7. 2003-03-14. PMID:12592392. |
smad4 displays specific binding to importin alpha through its mh1 domain, which was abrogated by loss-of-function mutations in smad4 nls. |
2003-03-14 |
2023-08-12 |
Not clear |
| A Gemma, K Takenaka, Y Hosoya, K Matuda, M Seike, F Kurimoto, Y Ono, K Uematsu, Y Takeda, S Hibino, A Yoshimura, M Shibuya, S Kudo. Altered expression of several genes in highly metastatic subpopulations of a human pulmonary adenocarcinoma cell line. European journal of cancer (Oxford, England : 1990). vol 37. issue 12. 2001-09-06. PMID:11506965. |
the expression of matrix metalloproteinase-2 (mmp-2), plasminogen activator inhibitor-1 (pai-1) and interleukin-1 (il-1 alpha) were upregulated in the highly metastatic subpopulations, while the expression of carcinoembryonic antigen (cea), caspase-5, fas ligand, prk/fnk, cyclin e, cyclin b1, ki-67, proliferating cell nuclear antigen (pcna), smad4, macrophage proinflammatory human chemokine-3 alpha (mip-3 alpha)/larc, met and cd44 were downregulated. |
2001-09-06 |
2023-08-12 |
human |