| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
we show that hfd intake decreased alpha diversity and altered the community composition of the gut microbiome in association with obesity, increased brainstem tph2, htr1a and slc6a4 mrna expression, including in the caudal part of the dorsomedial dorsal raphe nucleus (cdrd), a subregion previously associated with stress- and anxiety-related behavioral responses, and, finally, increased anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
we found that tph2, htr1a and slc6a4 mrna expression were increased in subregions of the dorsal raphe nucleus in the hfd, relative to control diet. |
2024-05-05 |
2024-05-08 |
rat |
| Ani Gasparyan, Francisco Navarrete, Jorge Manzanare. The administration of sertraline plus naltrexone reduces ethanol consumption and motivation in a long-lasting animal model of post-traumatic stress disorder. Neuropharmacology. vol 189. 2021-06-04. PMID:33819457. |
furthermore, relative gene expression analyses of tyrosine hydroxylase (th), mu-opioid receptor (oprm1) and 5-hydroxitryptamine transporter (slc6a4) were performed in the ventral tegmental area (vta), nucleus accumbens (nacc) and dorsal raphe nucleus (dr), respectively. |
2021-06-04 |
2023-08-13 |
mouse |
| Nina C Donner, Sofia M Davies, Stephanie D Fitz, Drake M Kienzle, Anantha Shekhar, Christopher A Lowr. Crh receptor priming in the bed nucleus of the stria terminalis (BNST) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31415826. |
since the bnst projects heavily to the dorsal raphe nucleus (dr), the main source of brain serotonin, we here tested the hypothesis that such repeated, anxiety-inducing activation of crh receptors in the bnst alters the expression of serotonergic genes in the dr, including tph2, the gene encoding the rate-limiting enzyme for brain serotonin synthesis, and slc6a4, the gene encoding the serotonin transporter (sert). |
2021-01-04 |
2023-08-13 |
rat |
| Margaret W Lieb, Magdalena Weidner, Mathew R Arnold, Kelsey M Loupy, Kadi T Nguyen, James E Hassell, K'Loni S Schnabel, Raphael Kern, Heidi E W Day, Klaus-Peter Lesch, Jonas Waider, Christopher A Lowr. Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice. Behavioural brain research. vol 373. 2020-09-14. PMID:31319134. |
for example, maternal separation increased slc6a4 mrna expression in the dorsal part of the dorsal raphe nucleus in tph2 heterozygous mice, but not in wild-type or knockout mice. |
2020-09-14 |
2023-08-13 |
mouse |
| Zhong-Min Wu, Chun-Hua Zheng, Zhen-Hua Zhu, Feng-Tian Wu, Gui-Lian Ni, Yong Lian. SiRNA-mediated serotonin transporter knockdown in the dorsal raphe nucleus rescues single prolonged stress-induced hippocampal autophagy in rats. Journal of the neurological sciences. vol 360. 2016-10-05. PMID:26723990. |
to this end, we infused slc6a4 sirnas into the dorsal raphe nucleus (drn) to knockdown sert gene expression after a single prolonged stress (sps) treatment in rats. |
2016-10-05 |
2023-08-13 |
rat |
| Steven C Wyler, Lauren J Donovan, Mia Yeager, Evan Deneri. Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25642596. |
moreover, pet-1 globally controls acquisition of 5-ht reuptake in dorsal raphe 5-ht neurons by coordinating expression of slc6a4 and slc22a3. |
2016-04-19 |
2023-08-13 |
Not clear |
| Katherine L Gardner, Matthew W Hale, Stafford L Lightman, Paul M Plotsky, Christopher A Lowr. Adverse early life experience and social stress during adulthood interact to increase serotonin transporter mRNA expression. Brain research. vol 1305. 2010-01-05. PMID:19781533. |
to evaluate the effects of early life experience, adverse experiences during adulthood, and potential interactions between these factors on serotonin transporter (slc6a4) mrna expression, we investigated in rats the effects of maternal separation (180 min/day from days 2 to 14 of life; ms180), neonatal handing (15 min/day from days 2 to 14 of life; ms15), or normal animal facility rearing (afr) control conditions with or without subsequent exposure to adult social defeat on slc6a4 mrna expression in the dorsal raphe nucleus (dr) and caudal linear nucleus. |
2010-01-05 |
2023-08-12 |
rat |